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Everything you ever wanted to know about AKG (but were afraid to ask)


Key points from article :

Alpha-ketoglutarate was discovered in 1937 by Krebs and Johnson.

The Krebs cycle is a series of chemical reactions that generates energy via the oxidation of acetate into CO2.

AKG is a naturally occurring endogenous intermediary metabolite - our own bodies create it.

Involved in a number of metabolic and cellular pathways:

- energy donor

- precursor in amino acid production

- cellular signalling

- regulates epigenetic processes, ten-eleven translocation enzymes & speed of the citric acid cycle

Also acts as a nitrogen scavenger preventing nitrogen overload and build-up of excessive ammonia.

2014 study showed that AKG extends the lifespan of adult C. elegans by roughly 50%.

Inhibits ATP synthase - reducing available ATP, decreases oxygen consumption, increases autophagy.

Likely increases lifespan by targeting ATP-2.

AKG does not directly interact with TOR - influences via the inhibition of ATP synthase.

Studies with starving yeast & bacteria, and in humans post-exercise, show elevated AKG levels.

A great summary of the history,biochemistry and life-extending potential of alpha-ketoglutarate