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Role of muscle strengthening protein in reducing life span

04-Aug-2021

Key points from article :

Protein CaMKII has been shown to improve muscle strength and fitness through a chemical reaction known as oxidation.

Aging-related oxidative stress leads to excessive activation of CaMKII, leading to tissue damage.

A study of mice with oxidized CaMKII showed better physical performance, compared to genetically modified ones with oxidation-resistant CaMKII.

However, a biopsy of the muscle tissue showed an increased expression of pathways related to inflammation, diabetes, seizure, and obesity.

In a similar experiment, fruitflies were genetically modified by inserting an oxidation site into their CaMKII gene using CRISPR.

Despite having better physical performance, genetically modified flies died at a younger age- Dr. Wang, co-lead.

Treatments designed to specifically target gene regulators such as CaMKII may work better to combat age-related illnesses.

Study by Johns Hopkins School of Medicine published in Nature Communications.

Activation of CaMKII improved muscle fitness but increased the risk of ageing

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Academic

Associate Professor of Functional Anatomy and Evolution

Publisher

News information and storytelling from and about Johns Hopkins University

Academic

Director, Department of Medicine, Johns Hopkins University School of Medicine

Journal

Journal covering all topics in physics, chemistry, and biology.

Academic

Research associate at Johns Hopkins School of Medicine