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Mysterious epigenetic marks and their impact on our life

Yamanaka factors may be the solution for reversing age-related diseases

21-May-2019

Key points from article :

Nobuaki Nagashima has Werner syndrome, which causes his body to age at super speed.

Nagashima at age of 43 looked as 80 years old man.

In 2008, there were only 1,487 documented Werner syndrome cases worldwide, with 1,128 of them in Japan.

In 2006 - 2007, Japanese researcher Yamanaka discovered 4 specific genes – Yamanaka factors.

Yamanaka factors when putting into an adult cell could rewind it to an earlier, embryonic state, a stem cell.

Yamanaka factors completely reset the epigenetic age of the cells to a prenatal stage.

Mentioned in this article:

Click on resource name for more details.

George Martin

Professor of Pathology and Adjunct Professor of Genome Sciences.

Salk Institute

Scientific research institute focused on neuroscience, genetics, immunology, plant biology and more

Shinya Yamanaka

Professor, Nobel prize winner and stem cell researcher, Senior scientific advisor to Altos Labs

Steve Horvath

Professor of Human Genetics & Biostatistics at UCLA

Topics mentioned on this page:
Ageing Research