Key points from article :
Senolytics have a significant effect on the ability of older animals to perform basic cognitive tasks, right down to the neuronal level.
In this experiment, rats were trained to avoid a specific place through small electric shocks.
Older rats performed worse on this task than younger rats.
After D+Q administration, poorly perfomed rats had very similar response as younger rats.
Short-term memory and skill learning abilities were significantly improved.
Improvement retained even 5 weeks after ceasing the treatment.
A broad decrease in nearly all of the cytokines tested, including interleukins and interferon-γ.
IL-10, which increases with aging, was further increased with D+Q in both young and old animals.
Apical dendritic spines of aged animals given D+Q were thicker and substantially longer - increased ability to retain memory and knowledge.
D+Q treatment halved H3K9me3 while significantly increasing H3K27me3.
Study led by Adam Krzystyniak from Polish Academy of Sciences, published in Aging Journal.
