Key points from article :
Resveratrol reduces the occurrence of DNA double-strand breaks (DSBs).
Prolongs lifespan in genetically modified mice that are prone to carcinogenic mutations.
High numbers of DSBs have been found in pre-cancerous cells.
DSBs are very detrimental to genomic stability but are relatively rare.
γH2AX holds the broken DNA ends together and halts cellular division to make time for the repair.
One appearance of a γH2AX histone corresponds to a single DSB.
Mouse embryonic fibroblast cells (MEFs) treated with resveratrol maintained genomic stability.
Similar results with chlorogenic acid, a polyphenol found in coffee.
Mice fed a diet containing melinjo resveratrol exhibited a significantly longer lifespan than the control group.
Research by National Cancer Center Research Institute, Japan, published in Scientific Reports.
