Join the club for FREE to access the whole archive and other member benefits.

Millions of mature human cells can be produced in a mouse embryo


Key points from article :

Mass production of mature human cells inside mouse embryo is now possible.

Transiently inhibited mTOR kinase for 3 hours to shock the human primed cells to the naïve state.

Injected 10-12 naïve human stem cells into a mouse blastocyst when it was 3.5 days old.

Co-developed with the inner cell mass in the mouse blastocyst.

Produced millions of mature human cells in 17 days.

Unlike cells grown in vitro, cells grown in vivo behaved in the same way as the cells inside the body.

Potential to develop models with human cells of different organ systems to study various diseases.

Research by University at Buffalo published in Science Advances.

These mouse models can be used to study about diseases such as malaria and COVID-19

Mentioned in this article:

Tap on icon for description, click on resource name for more details.


Professor at Department of Physiology and Biophysics, School of Medicine & Biomedical Sciences, State University of New York at Buffalo


Journal that publishes original research and reviews in all disciplines of science


Largest public university in the State University of New York system