Join the club for FREE to access the whole archive and other member benefits.

Tailoring stem cell fate to promote nerve growth and healing

Hydrogels mimicking cellular niche could revolutionize the treatment of brain & spinal injuries

20-Feb-2024

Key points from article :

Injuries to the brain/spinal cord don't heal easily due to the formation of fluid-filled cavities and scars that prevent tissue regeneration.

Researchers created an artificial cell environment that could promote the regeneration of nerves.

Showed that positively charged hydrogels can promote the survival and growth of stem cells.

Charge strength influences stem cell differentiation into nerve or glial cells.

Growth factor FGF2 increases the survival and division rate of the cells, but slows differentiation.

"In future, we intend to add peptides or matrix molecules to simulate the natural environment of the cells even more efficiently," - Kristin Glotzbach, co-author of the study.

Researchers also plan to develop 3D gels that could fill cavities after brain injuries.

Study by Ruhr University Bochum and TU Dortmund University, published in American Chemical Society Journal.

Mentioned in this article:

Click on resource name for more details.

Journal of the American Chemical Society (JACS)

Scientific journal providing information from the all fields of chemistry.

Kristin Glotzbach

Researcher at Ruhr University Bochum

Ruhr-University Bochum (RUB)

Public research university.

TU Dortmund University

Public research university

Topics mentioned on this page:
Regenerative Medicine, Stem Cells
Tailoring stem cell fate to promote nerve growth and healing