Gut bacteria may hold the key to living longer and healthier lives

Metabolic pathways like the pentose phosphate pathway aid healthy ageing

TRexBio raises $84M to develop immune therapies targeting inflammation

Funding strengthens their capacity to address unmet needs in immune-related diseases

Mapping the body’s hidden landscape: the Human Cell Atlas revolutionizes medicine

New cell maps reveal fresh insights into health and disease

Cytomos raises £5 million to expand innovative cell analysis

Their technology reduces costs and accelerates drug development by six months

Unlocking the secrets of weight regain

DNA changes in fat cells may explain rebound weight gain after treatment

Men and women age differently because of their unique chromosomes and hormones

Understanding these factors may lead to more personalised treatments

Can machine learning discover lifespan-extending drugs for mice?

This highlights promising paths for potential anti-ageing therapies

Gut bacteria and sirtuins may help treat neurodegenerative diseases

Adjusting this axis with diet, probiotics, and supplements could benefit brain health

Can muscle strength predict longevity in the oldest old?

Mortality decreases gradually with increased strength, suggesting every strength gain counts

New non-profit funds neuroscience and biology health research

Initiatives like The Human Phenotype project aim to improve disease diagnostics and predictions

Unexpected cell transfer found in fecal transplants, aids gut repair

New findings show a possible role for donor gut lining cells in healing

New drug trial aims to reduce cancer treatment resistance

In trials on mice, the drug reduced tumors, promising new cancer treatments

Transferring an aged gut microbiome to young mice triggered ageing signs

Signs include sluggish metabolism, inflamed blood vessels, and a weakened gut

Fruit flies' lifespan extended by 30% through protein manipulation

Targeting certain proteins might prevent age-related diseases in the future

BSRA Appoints Sally Bird as New Chief Executive

Marks a new chapter for the organisation as it continues its mission to help people live longer, healthier lives

Slow changes in DNA may be the reason why some animals live much longer

DNA stability might be key to unlocking the science of anti-ageing and longevity

Hunting for a new gold standard in longevity

Ora biomedical’s high-tech screening could uncover life-extending compounds beyond rapamycin’s reach

Your organs have unique “ages” that could reveal hidden health risks

This could shape future healthcare and longevity strategies

Social animals, like monkeys and elephants, live longer than those living alone

Social bonds improve resilience and adaptability in various species

Muscle strength linked to longer life for people aged 90 and above

Even small improvements in strength can have significant health benefits

Ageing might be a continuation of development rather than just wear and tear

This approach offers new insights into how and why we age

Eating healthy, moving more, and sleeping well can slow down ageing

Anti-inflammatory diets, high physical activity, and healthy sleep patterns work best together

Unlocking the secrets of skin: new discovery could reverse ageing

New insights into skin development promise advances in regeneration and ageing

Genes vs. diet: what really drives longevity?

New study finds calorie restriction aids longevity, but genetics may hold the ultimate key

Tolerance bio raises $17.2M for thymus-based immune disease treatments

They use stem cell technology to regenerate the thymus and aim to slow its natural decline

Brain removes toxins through special channels while you sleep

This process occurs mainly at night and may help prevent Alzheimer’s

Epigenetic age predicts mortality risk better than chronological age

Lifestyle factors influence epigenetic ageing, highlighting the importance of health

Harold Katcher publishes results of plasma-derived fraction (E5) experiment in Aging Cell

E5 treatment extended lifespan & improves health in ageing rats

Unlocking the Secrets to a Longer Life through Calorie Restriction

A major study shows genetics and immunity are key to the lifespan benefits of calorie restriction

Generous donations propel next phase of mouse rejuvenation research

Support from Didier Coeurnelle enables groundbreaking longevity studies to advance

Cheekage: A simple test predicts ageing speed and mortality risk

US researchers unveil a groundbreaking tool using cheek cells to estimate biological age

What supercentenarians reveal about living beyond 110 years of age

Their survival might even be connected to the time of year they’re born or die

Stem cell therapy shows promise in slowing ageing and preventing disease

Mesenchymal stem cells may revolutionize healthcare by combating inflammation and ageing

Epigenetic clocks reveal hidden health risks linked to biological ageing

This study may help personalise health strategies for individuals at higher risk

Axolotls, known for their regeneration skills, show early-life epigenetic ageing

Their abilities help reset biological age, offering insights for human longevity research

Oral bacteria linked to higher risk of head and neck cancer

New research highlights the role of gum disease-related microbes in increasing cancer susceptibility

Breakthrough anti-ageing drug preserves key cellular processes

Researchers discover a compound that slows ageing by boosting protein maintenance

The secrets of the Greenland Shark's longevity

The ancient genome of the longest-living vertebrate may reveal new insights into ageing

Cracking the code of wrinkles: insights from human tissue models

Groundbreaking research reveals how compressive forces and dehydration drive wrinkle formation

Healthy centenarians have lower NLRP3 levels, protecting them from ageing effects

NLRP3 is a part of immune system that plays a key role in chronic inflammation

Fibroblasts lose ability to support skin structure as we age

Aged fibroblasts accumulate proteins internally instead of secreting them

Blood biomarkers offer insights into ageing, but their reliability varies

Epigenetic clocks show promise for studying ageing in both mice and humans

Food dye turns tissues transparent, revolutionizing medical imaging

Food dye reveals hidden organs and veins by making tissues transparent

Unlocking longevity: the discovery of OSER1

A breakthrough protein linked to ageing could lead to new treatments for age-related diseases

Changes in IgG glycosylation due to ageing influence immune responses

Diseases like Alzheimer's and cardiovascular conditions show distinct IgG glycosylation

Cortex Discovery unveils first AI-discovered drug to extend lifespan

CortexW1 boosts lifespan of worms by 33%, highlighting AI's role in longevity research

Clock.bio: New biotech startup aims to extend human healthspan by 20 years

Revolutionary approach to reverse ageing process with CRISPR gene editing technology

Dr. Sajad Zalzala reports on PEARL rapamycin trial results

Safety of rapamycin looks good and lean muscle mass among biomarkers trending towards improvement

Breakthrough DNA repair protein could revolutionize cancer treatments

Newly discovered protein may lead to cancer vaccines and advanced DNA repair

Revolutionary SPARXS technique accelerates DNA research by decades

New method speeds up DNA analysis, unlocking advances in genetics and medicine

Metabolomics reveals key metabolic changes associated with ageing and frailty

This could lead to improved diagnostics and therapies for frailty

Gut fungi in long-lived people may hold clues to longevity and healthy ageing

The fungi might play a role in longevity by interacting with beneficial bacteria

Doubts raised about effectiveness of anti-ageing research for humans

Large investments continue, but human research outcomes remain uncertain

Ageing isn’t gradual but happens in two major bursts at ages 44 and 60

The findings may explain why health problems often increase at these ages

Horse gut bacteria can predict their future health and racing success

Early antibiotic use may have a negative impact on their health

Urolithin A, a natural compound, could be a key player in promoting healthy ageing

It enhances mitochondrial health, but does not significantly increase ATP

Understanding the immune system's journey from birth to old age

Advanced technologies like flow cytometry provide deeper insights

Ageing impacts the gut microbiome, influencing blood cell production and immunity

Research points to potential treatments targeting the gut microbiome to improve health

Lord Lebedev: Longevity research could benefit the UK's ageing population

Research could significantly boost the UK economy and healthcare system

Blood proteins predict the 10-year risk of developing 67 diseases

Research highlights the potential of proteomics in disease prediction

Newly developed epigenetic clock 'CellPopAge' can accurately measure cellular age

Study also identified that compounds Torin2 and dactolisib extend Drosophila lifespan

Natural peptide restores immune balance, reversing age-related inflammation

PEPITEM supplementation shows promise for extending healthy lifespan

Breakthrough drug extends lifespan of mice by 25% - safety already demonstrated in humans

Interleukin-11 antibody shows promise as an anti-ageing treatment that could revolutionise human longevity

Drinking coffee surprisingly helps the immune system stay young and strong

It lowers inflammatory markers and combats harmful cell pathways

Gut microbes influence our immunity and overall health from birth to old age

Balanced diets improve gut health, while processed foods harm it

International Longevity Alliance keeps growing with more organisations from around the world

Transhumanists Africa is the latest federated member to join the longevity-promoting alliance

Each body part ages differently, but they also influence each other

Lifestyle and chronic diseases play a role, with the brain acting as a central hub

TruDiagnostic launches a novel epigenetic ageing test to analyse 11 organs

Findings indicate that each organ system has its unique ageing trajectory

AlidaBio secures funding for new technology to analyze RNA modifications

This could eventually lead to new ways to prevent and treat age-related diseases

Drugs like metformin and resveratrol might hold the key to extending human lifespan

With the ongoing increase in human life expectancy, the quest for effective anti-aging solutions is accelerating

Midlife inflammation, even in healthy people, slows down walking speed in later life

The longer the inflammation lasted, the slower the walking speed became

Intermittent fasting with protein pacing beats calorie restriction

Proved to be superior for weight loss, gut health, and metabolic improvements

Burning calories linked to longer life in mice- could exercise be the key for humans too?

Energy expenditure, not just eating less, lead to 20% longer life in mice

Telo-seq precisely measures telomere length and sequence on individual chromosomes

It can also help personalise treatments for telomere-related diseases

Low α-Klotho levels raise the risk of heart problems and death

This finding could lead to new ways to predict and prevent age-related illnesses

Ageing research funding: UK scientists call for urgent action

Public support can play a crucial role in accelerating progress

Pomegranate compound 'urolithin A' significantly boosts immunity

It could be a potential supplement for improving cancer immunotherapy

Mediterranean diet can help the immune system age gracefully

Study focuses on benefits of fruits, vegetables, whole grains, and healthy fats

New 'ageing clock' measures protein build-up to predict health and disease risk

Protein clumps hold potential for early disease detection, but more research is needed to develop a routine test

World record: Fern discovered with world's largest genome ever recorded

Its DNA stretches over 100 meters, which is 50 times bigger than the human genome

Eye muscles known as 'extraocular muscles' are remarkably resistant to aging

Findings hint at potential breakthroughs in muscle therapy

Matter Bio gets $7 million to fight aging through DNA repair

Company's approach involves detecting, correcting, and eliminating damaged cells

New immunotherapy shows promise in treating bone cancer in mice

The treatment was most effective when combined with a bone-strengthening drug

Turn Bio and HanAll partner to fight age-related eye and ear diseases

This technology could potentially improve the quality of life for many older individuals

PEDF protein, found in young blood, rejuvenates aging cells and tissues in mice

More research is needed, but this discovery offers hope for anti-aging therapies

Personalized nutrition app Zoe's claims face scrutiny over scientific validity

Experts raise concerns about the effectiveness of its methods

Clearing senescent cells improves immediate immunity to influenza in aged mice

It may hinder the development of long-lasting protection against future infections

Aging measured by randomness in cells, study finds

Random cellular chaos offers new hope for anti-ageing interventions

Google DeepMind's AlphaFold3 predicts how life's building blocks interact

The breakthrough could revolutionize drug discovery and disease treatment

Scientists zero in on molecules that could significantly extend healthy lifespan

Offering hope for longer, healthier lives for future healthcare

Seragon's anti-aging drug candidate extends healthspan and lifespan in mice

SRN-901 increases longevity gene expression and reduces aging activity

Scientists unveil genetic secrets to sharp minds in centenarians

Protective gene variants in immunity & cellular cleanup prevent Alzheimer's in old age

Josh Mitteldorf plans to self-experiment with high dosages of spermidine

Backed by science, this natural compound may be the key to living longer and better.

Timeline's Mitopure demonstrates potential to reverse immune system ageing

Research underscores potential to revolutionise approach to healthy ageing

Eat well, move well, live well: Healthy habits add five years to your life

Lifestyle choices reduces genetic risk of early death by 62%

Newly discovered enzyme plays vital role in stem cell longevity

This discovery could have important implications for understanding healthy ageing processes

Rare genetic mutation linked to short stature may hold clues to longer, healthier lives

People with Laron syndrome exhibit lower levels of a growth factor associated with ageing

Ageing immune systems linked to malfunctioning molecules within key cells

Research explain why we become more vulnerable to infections as we age

Decoding the immune system: how AI is revolutionizing disease research

AI unlocks new insights into the complexities of the immune system

Biological age measured using popular epigenetic clocks vary by 3 years during the day

Schedule blood tests at the same time of day when tracking biological age over time

Some everyday medications could lengthen life, while others like opioids might pose risks

Surprisingly, metformin does not reduce death risk

Stem cells could potentially rejuvenate the thymus gland in older individuals

Potential tool in boosting immune function and combating the effects of ageing

Blood protein analysis refines diabetes risk prediction and reveals potential drug targets

Analyzing blood proteins can improve our ability to identify those at risk for diabetes

Tiny carbon beads improve gut health and fight liver disease in rats and mice

Innovative approach to protect organs from harmful gut bacteria

Body's repair system falters with age as stem cells lose their regenerative power

Machine learning reveals widespread decline in stem cell potency with age

Gut microbiome company raises $34 million to advance disease treatments

This investment supports the development of innovative pill-based therapies that use healthy gut bacteria

Antibody treatment rejuvenates aged immune systems in mice

Researchers improved immune response to new infections and reduced overall inflammation

Scientists found cholesterol eating bacteria in the gut

Some bacteria may hold key to lower cholesterol and heart disease risk

Tardigrade protein helps human cells mimic survival superpower

Research reveals a potential way to make human cells more resistant to stress

Somatic mutations: Do these DNA changes hold the secrets to longevity?

The gradual buildup of DNA mutations may hold clues on how to combat age-related diseases

Novel antibody therapy rejuvenates aging immune systems in mice

Potential treatment approach to boost immunity and fight disease in older adults

Ani Biome receives funding to personalise gut health treatments for longevity

Company will use machine learning and gut health science to create custom solutions

Lifespan.io interviews David Sinclair about his Information Theory of Aging and much more

Backup code: ageing cells from epigenetic changes could potentially be reset to a youthful state

UCL study reveals cancer risk associated with vaping-induced DNA damage

Study finds concerning similarities in DNA damage between vapers and smokers

Extending quality life years: insights from the Global Healthspan Summit 2023

Event focused on extending quality life years through scientific innovation

UK study finds 14 prescription meds possibly linked to longer life

Viagra, cholesterol meds & estrogen replacements linked to longevity, but further research needed

Genomenon develops AI-powered tool to uncover links between genes and diseases

This new technology could improve the accuracy of genetic testing

Transplanted cells age at different rates depending on the host's age

Bodies of younger people could potentially rejuvenate older transplanted cells

Cell malfunctions can cause information leakage and trigger inflammation

The discovery may improve inflammation treatment and anti-ageing interventions

Argentine scientists explore young blood's anti-ageing effects in rats

The old rats that got young blood lived longer and looked healthier

Antibiotics for blindness: Gut bacteria linked to inherited eye diseases

CRB1 gene mutation weakens gut barrier, allowing bacteria to invade eyes

A protein called APOB, key to blood fat control, could influence your lifespan

Lowering APOB could potentially delay age-related diseases like Alzheimer's

Gut bacteria and blood molecules offer clues to why grip strength weakens with age

Research opens doors for future interventions to prevent muscle loss

Notre Dame tackles neurodegeneration with CZI support

Exploring how ageing genes impact brain health and disease

Harvard scientists created a tool that predicts how old your cells really are

This could lead to more accurate testing of anti-ageing interventions

New research links DNA damage to incomplete gene transcription in aging

DNA damage accumulated with age worsens gene expression, affecting lifespan-determining pathways

Skincare myths debunked: What products actually work for ageing skin?

To name a few, moisturizers with acidic pH and emollients with active ingredients can help

Scientists grew tiny heart-like tissues with CVD in a lab dish, using stem cells

Research has the potential to revolutionise heart disease treatment in older adults

Northwestern University launches the Human Longevity Laboratory to fight ageing

Researchers will work finding ways to live healthier and longer

Mouse models get a major boost as UK funds research on dementia and ageing

This collaboration aims to unlock the secrets of ageing and develop new therapies

Some gut viruses may help you deal with stress by fighting harmful bacteria

Under stress, the composition of gut viruses and bacteria changed in mice

Scientists found a way to make old cells young again in a lab

They used special proteins to erase "marks" on DNA that build up with age

Eating fermented foods like kimchi or yogurt might make you think clearer

Adding fermented foods to your diet is a safe way to support your gut

Space travel throws a curveball at astronauts' guts, challenging their health

Understanding the adaptation is crucial for protecting them on long missions

Anti-inflammatory benefits: fasting found to reduce risk of many diseases

Calorie restriction silences the NLRP3 inflammasome, a key driver of inflammation

Scientists found a "nose and gut trick" that could help us live longer

It helped mice live longer, look healthier, and have sharper minds

AI and quantum computing join forces to crack the code of life

This "physics-guided AI" approach promises deeper insights than current methods

The Hevolution Foundation's report proposes a radical shift in healthcare

Report suggests that our focus needs to move from lifespan to healthspan

Turns out, women have a secret weapon in the longevity game: their DNA!

Women have an advantage in longevity genes, especially those related to immunity

Simple at-home fingerprick test reveals thousands of health insights

Reading metabolic and immune responses, blood test paves way for early diagnosis & personalized medicine

Once helpful immune alarm bells, inflammasomes now fuel chronic diseases

Researchers are developing new treatments to turn down the inflammatory response

Halia Therapeutics' NLRP3 inhibitor shows promise in tackling chronic inflammation

Shown promising results in preclinical studies and early clinical trials

Skin microbiome diversity is linked to wrinkles and hydration

The findings pave the way for personalised skincare approaches

Ageing may be driven by disruptions in electrical signals between cells

Bioelectric signals could even promote tissue regeneration

Cambridge scientists are making significant strides in understanding ageing

Promising leads for potential anti-ageing interventions in the next decade

Epigenetic remodelling startup 'Moonwalks' out with $57M to develop targeted therapies

This, they claim, is safer and more precise than traditional gene editing methods

Activating SIRT6, a DNA repair protein, reduces damage in ageing cells

SIRT6 activation may be a potential therapeutic target for osteoarthritis

A cellular protein called HKDC1 tidies up mitochondria and lysosomes

This discovery paves the way for potential anti-ageing therapies

Ageing may not be just wear and tear, but a programmed continuation of development

Methylation patterns, measured by epigenetic clocks, offer novel insights

Josh Mitteldorf's new view of ageing shows body's fight for life

Study reveals two sides to ageing: a programmed decline and a desperate defense

Our sleep cycles and gut bacteria influence the brain's protective barrier

Interplay between these systems suggests potential for targeted interventions

El País interviews Altos Labs’ principal investigator Pura Muñoz Cánoves

Altos labs with a $3-billion budget pave the way for reversing aging and extending healthy lifespan

LEV Foundation announces plan for second Robust Mouse Rejuvenation study (RMR2)

Will look at combinations of partial cellular reprogramming, mesenchymal stem cells, serum albumin and deuterated fatty acids

Cambridge researchers continuously explore novel approaches to improve healthspan

Quest for people to live healthily for as long as possible will inevitably result in longer lives

Antioxidants and seasickness meds show promise in extending life in male mice

The gender-specific effects observed underscore the complexity of ageing

Our genes push for early babies, but at the cost of living shorter lives

But don't stress, modern factors like healthcare and lifestyle have a bigger impact than genes

SIRT2 overexpression does not significantly impact lifespan in mice

Study suggests a more nuanced role of this protein in the ageing

The reign of dinosaurs may have shaped how humans and other mammals age

Dinosaur-era pressures may have led to the loss of longevity genes

XPRIZE Launches a $101 Million Healthspan Competition

10 years of functional age-reversal in 65-80 year olds within the next 7 years... bring it on!!!

Gene regulation shifts with age, especially in species with shorter lifespans

CpG density may play a role in moderating the epigenetic drift

A fatty acid in beef and milk could be used to treat cancer

The acid eliminates tumours by activating immune cells to combat cancerous cells

C. elegans: A tiny worm that can help scientists understand how ageing works

The research could lead to new ways to slow down ageing in humans

Immune Resilience: a blueprint of your immune system that unveils the secrets of longevity

Science behind your body's ability to live longer, resist infections and survive diseases

Forward therapeutics secures $50m to develop next-gen small molecule immune therapies

Company's pipeline targets inflammation, promote healing, and restore quality of life

New mice with human-like telomeres could help us fight ageing and cancer

Model could be used to study the role of telomere length in several diseases

Frontier Bio's lab-grown blood vessel tech revolutionizes medical device testing

Promises a future without animal testing and the need for organ donors

Unravelling the complexities of aging: A comprehensive database of aging factors

A deep dive into the AgingReG curated database of aging regulatory relationships in humans

UC Davis researchers uncover a gene linked to longevity in Golden Retrievers

HER4 gene types added approximately 2 years to their lifespan

Gut microbes linked to the risk of Parkinson’s and Alzheimer’s diseases

Gut-brain connection opens doors for early detection and treatment of brain diseases

Gut bacteria linked to Alzheimer's disease in groundbreaking study

Research findings may lead to new treatments for the most common cause of dementia

New brain atlas reveals thousands of previously unknown cell types

Could lead to new insights into neurological and mental health conditions

CT scans of thymus may reveal immunological ageing

Researchers find link between thymus appearance and lifestyle factors, immune cell regeneration

Genetic profiling conducted by the mexico city prospective study highlights the value of genetic studies in diverse populations

Study reveals new insights into obesity, diabetes, and genetic diversity

Largest centenarian blood study identifies key factors for long life

Lower levels of glucose, creatinine, and uric acid linked to increased longevity

Why some people find it easier to be a vegetarian than others

Three gene variants more prevalent in vegetarians, impacting dietary choices

Buck Institute and Phenome Health team up to advance scientific wellness

Collaboration of data and discovery to extend healthspan for everyone

Lifespan.io reports back from Aging Research and Drug Discovery Meeting (ARDD 2023)

Key points from Arkadi Mazin's summary of 5 days of talks by geroscientists and biotech leaders

The Chan Zuckerberg Initiative to launch AI supercomputer for decoding biology

New AI technologies promise to accelerate scientific discoveries and cure diseases by the end of the century

New AI tool predicts genetic mutations that could cause disease

AlphaMissense is a game-changer in genetic research for human health

2024 Breakthrough Prize honors medical innovations transforming lives

Game-changing treatments for cancer, cystic fibrosis, and parkinson’s

Rejuve.Bio combines AI with fruit fly genetics to unlock the secrets of long life

Novel approach to identify ageing targets and fight age-related diseases

Naked mole rats' secret to long life could be unlocked for humans

Scientists transfer the longevity gene to mice, extending their lifespan by 4.4%

Human cell's memory erased to resemble embryonic stem cells

New reprogramming method addresses epigenetic challenges & sets a standard for cell therapy research

Human heart on a microchip: A revolutionary new tool for medical research

Organ on a chip may be more successful than mice models in translating science to the clinic

Epigenetic insights: developmental changes in DNA linked to lifespan in mammals

Universal clock based on methylation profiles to accurately predict age in all mammalian species

New, publicly available "unknome" database for poorly studied proteins

Many neglected proteins/genes have essential function, finding out may accelerate future research

Signalling pathways in aged cells found to impair the ability to repair and regenerate muscle cells

Study results offer insights on future drug discovery for disease related to muscle ageing

Epiterna receives 10m euros to extend lifespans of pets and people

Planning to test its therapies in dogs next year, with human treatments expected in the near future

If we can fix the bugs in human software, people could live to be 20,000 years old

Bill Gifford interviews João Pedro de Magalhães, professor of molecular biogerontology at the University of Birmingham

Intermittent fasting may help you lose weight and fight infections

T cells effectively fight pathogens using energy fuel as ketones, which are typically produced in fasting

Young blood slows down ageing process of older mice

Infusion of youthful blood increased lifespan by 5% and improved age-related gene alterations

Superior killer T-cells hold promise in remission and clearance of cancer

Multipronged T-cells recognize multiple target proteins and attack cancer in many ways

Your genes determine your food cravings and eating habits

Identifying genetic preferences may hold the key to personalized nutrition and healthy eating

System Age epigenetic clock captured different patterns of ageing

Novel method for precise estimation of biological age and disease risks with a single blood sample

Automating genetics research: A robotic system for handling C. elegans (with video)

WormPicker takes on time-consuming tasks including inspection, movement between petri dishes and genetic crossing

Hunter-gatherer diet unveils incredible gut microbiome diversity

A study of Tanzania's Hadza people reveals over a thousand new gut microorganism species

Reason reports back from Age-Related Disease Therapeutics Summit 2023

Many people believe lots of clinical trials of novel therapeutics targeting mechanisms of aging will start up in the next few years

The bowhead whale's secret to living over 200 years: Remarkable DNA repair mechanisms

Exceptional longevity and resistance to cancer holds potential implications for human health and ageing

Proprietary GHK-Cu formulation by Yuvan Research clinically proven to increase skin collagen density

Epigenetic breakthrough offers hope for anti-aging therapies, harnessing the power of naturally occurring peptide

Hevolution Foundation allocates over $20 Million to promote aging research through HF-AGE grant program

Nine innovative projects, spread over seven US institutions, set to receive funding

Longevity Med Summit - Best of the Rest

Key points from more of the excellent speakers at the summit

Gut instinct: Toddler microbiota linked to future obesity risk

Better understanding of composition and changes of gut microbiome could lead to potential interventions

Summary of Fabrizio d’Adda di Fagagna presentation at Longevity Med Summit

Telomeres become sinks of irreparable damage - antisense oligonucleotides could potentially provide a fix

Summary of Daniel E. Martin-Herranz presentation at Longevity Med Summit

Building a saliva-based epigenetic biomarker for systemic chronic inflammation (SCI)

Summary of Aubrey de Grey presentation at Longevity Med Summit

A quick introduction to the preventative maintenance approach, LEV Foundation and Robust Mouse Rejuvenation

TechCrunch interviews founders of NewLimit after it received another $40m of funding

Reprogramming the epigenetics of a cell could reverse a significant amount of the functional decline that we see with age

Summary of Max Unfried presentation at Longevity Med Summit

VitaDAO has already funded 17 projects - including research areas not supported by traditional government agencies

Summary of Gordan Lauc presentation at Longevity Med Summit

Glycans are the most neglected molecules of cellular communication

Pangenome: a new chapter in human DNA mapping embracing global diversity

Updated DNA map opens doors for more inclusive and effective medical treatments

VitaDAO provides $50,000 funding for ImmuneAGE Bio to accelerate its immune rejuvenation research

Will use its drug discovery platform to further development of lead compound, IA101

Unraveling the mysteries of aging: Epigenetic damage and the limits of cellular repair

Novel theory of biological systemic ageing suggests epigenetic ageing is inevitable

Pioneering longevity researcher joins SIRTLab to accelerate aging interventions

Nir Barzilai brings his expertise to boost the company's mission to extend healthspan by targeting age-related diseases

Live Forever Club becomes latest member of International Longevity Alliance (ILA)

Organisations share a common mission of healthy longevity for all through scientific research

Gut bacteria may have little or no impact on risk of chronic diseases or longevity

Further studies required to better characterize the association between gut microbiota and its metabolites

Poop pill: FDA approves first microbiota capsule to fight gut infections

Oral formulation offers a simpler way to restore gut balance & combat recurrent C.diff infections

Nuffield Council on Bioethics publishes its "The future of ageing" report

The report sets out an ethical framework and recommendations for research and innovation related to ageing

Maximon Longevity Prize 2023: Awarding Innovative Research Projects that Extend Human Lifespan

Apply now to showcase your translational longevity research and win CHF 50,000

Ageing speeds up gene reading, reducing its accuracy

Calorie restriction may extend lifespan by improving the quality of gene transcription

Gut Microbiome: The Secret to Longevity in Centenarians

A youthful gut microbiome may contribute to enhanced longevity and overall health in people living past 100

Meta-analysis studies relate autophagy mechanism with exercise in humans

The type of exercise can effect autophagy in humans, that in return can be an anti-aging strategy

Study shows it is critical for stem cells to prevent stress to preserve their health and longevity

Therapeutics to boost regulation of protein homeostasis may be beneficial across multiple organs and pathologies

Cellular ageing signs emerge earlier in women than men

Machine learning analysis of millions of biopsy reports has potential implications for disease risk and treatment

Hypothalamic protein called menin found to regulate ageing and cognitive deficits

Supplementing with the amino acid D-serine may reverse some anti-ageing effects

Lifespan.io interviews George Church about recent research and future anti-ageing treatments

Is involved in many longevity companies ranging from improving gene therapy delivery to supplements

Thymmune Therapeutics raised $7 million in seed financing

Thymmune aims at developing therapies to treat several autoimmune diseases and organ transplant tolerance

Chroma secures new investment of 135M for Series B in genetic medicines

Epigenetic medicine approach avoids the pitfalls of traditional CRISPR method of gene editing

Five Alarm Bio raises seed investment to discover small molecule anti-aging drugs

No drug candidates yet, but great to see investors willing to support a broad attack on ageing

Challenging Inflammaging in the Pursuit of Healthy Ageing

Chronic inflammation is lurking behind many age-related diseases, but also offers up many targets to reduce it

AgeCurve Ltd uses Cell tree rings and somatic mutation to calculate biological age

Those running geroprotective trials, academic researchers, clinical trial could use Cell tree rings

Analysis of gut microbiome relationship with longevity

A strong genetic correlation between healthy diverse gut microbiome and healthy ageing was found

Effects of intermittent fasting: An exploration

12 months of IF results in a range of biomarker improvements, but no significant reduction in inflammatory markers

Open genes-comprehensive database of genes associated with aging and longevity

Open gene database simplifies the search for potential aging therapy targets

Centenarian gene could reverse heart ageing by ten years, study finds

Revolutionary discovery offers new hope for heart failure treatment

Heart's biological age can be delayed by 10 years by an anti-aging mutant gene discovered

Healthy mutant gene can reverse the decline of heart performance in older people

Lifespan.io summarises the proceedings of the Buck Institute's Longevity Summit

Another reminder of the amount of research, with multiple approaches, about to go into clinical trials

Dissociation of longevity targeted cell reprogram and somatic identity loss: An exploration

Most genes regulating cellular rejuvenation were not related to the increased occurrence of cancer

Gut microbiota in mice influence brain's dopamine levels, influencing the motivation for exercise

The study highlights the diversity of microbiota and their importance for human health and fitness

Gut microbiome linked to brain damage and neurodegeneration in mice

Modifying gut microbiota with antibiotics reduced inflammation and tau-linked damage

Genome length and the relationship with ageing: An analysis

Identifies a new target for ageing therapeutics - maintaining the abundance of long RNA transcripts

Longevity Technology speaks to BioAge's CEO about clinical trial progress

Had success in reducing muscle atrophy and discovered novel class of molecules to target cognitive decline

Microbiome and metabolic biomarkers can predict who will lose the most weight

Soon there will be a test to check what the best diet is for your individual microbiome

Nuclear homeostasis contributes to promote longevity and fertility, IMBB scientists

Cells fundamental quality control mechanism to safeguard the nucleus-promote longevity and fertility

SIRT6: Ageing, Metabolism, and Cardiovascular Diseases - A Review

SIRT6 has a vital role in cell metabolism which could lead to therapeutics for controlling senescence

Cellular Senescence Network (SenNet) to identify and characterize senescent cells

Grand plan includes creation of imaging datasets, new tools, techniques, and biomarker panels

Exploring cellular enlargement as a new hallmark of aging

Size of various cells (including red blood, adipocytes, brain, heart) is seen to increase with age-related diseases

Turn Bio reverses multiple hallmarks of aging in human skin

Epigenetic reprogramming restores the production of collagen and elastin

Large scale study identifies new risk loci associated with CAD (coronary artery disease)

The study outlines a list of genes and genetic variants for future study of common diseases

Microbes in your gut may affect your mental health

Gut bacteria indirectly produce hormones that influence the brain and can cause depression

RxCelerate acquires Methuselah Health and launches proteomics platform ProQuant

Next-generation proteomics technology to accelerate drug discovery and development

Casma Therapeutics secures $46m to advance ground-breaking therapies

Funding will accelerate development of autophagy-based treatments for challenging diseases

Australia became the first country to approve faecal microbiota transplants

It may help treat other conditions like ulcerative colitis and improve cancer therapy

Five Alarm Bio to develop drug treatment not to cure ageing but improve healthy lifespan

The company aims at treatments for a range of diseases associated with ageing and disabilities

Lifespan.io interviews NaNotics' CEO Lou Hawthorne to find out more about Nanots

Many conditions could be improved by removing signalling that prevents cells operating at their best

Reprogramming by cellular rejuvenation in mice increases lifespan and health

Partial reprogramming extends healthspan and lifespan by single or lifelong treatment

Scientists unveil role of genomic 'dark matter' in cancer detection and treatment

Early but promising finding that epigenetic changes alter the growth of cancer cells

Universal epigenetic clocks predict true biological age in any mammalian species

Shared methylation patterns across mammals showed an association between ageing & development process in evolution

Reason reports back from October's Rejuvenation Startup Summit

Some really exciting developments with quite a few in clinical trials

Senolytics-a risky proposition in aging and repair mechanisms

The study is a caution for scientists engaging in self-experimentation with senolytics

Microbiome differences were associated with increased frailty, not chronological age

Skin microbiome emerged as the primary reservoir for infection risk associated with frailty

Calico-Terray Therapeutics collaborate to discover and advance therapeutics for diseases of aging

Terray’s novel microarray technology, combines wet lab and computer-driven drug development

Mitochondria boosting therapy rejuvenates immune system of mice

If successful in humans it would improve the outcome of many age-related diseases

Same chronological age women are biologically younger than the men

Differences in biological aging between men and women - frequent smoking and larger body size of men

Researchers claim to have uncovered secret to immortality in jellyfish

what this means to humans? - a possibility to treat overwhelming aging disorders

NICE - faecal transplants can be offered for hard-to-treat C. difficile

A solution to reduce both antibiotic usage and antimicrobial resistance

Ageing-related drug screening made easy and reproducible with automated tech

Camera on each petri dish captures healthspan of many worms simultaneously

72% of Induced pluripotent stem cell lines were reported to have major UV damage

Whole genome sequencing-necessary to validate Stem cell lines used for therapy

Mitophagy activators shown to increase lifespan and healthspan in C.elegans

Vitalunga to usher the novel drug for hepatocellular carcinoma clinical trials

Review identifies thousands of genes that drives skin ageing

Addresses challenges like phenotype list compilation and associated genes

Study shows the link between hibernation and longer lifespans in bats

Overlap between the hibernation genes and the longevity genes links hibernation with longer life

Employing native bacteria as ideal chassis for therapeutic delivery and cure

Re-engineered native bacteria serve as chassis to introduce therapeutics into the gut

SIRT6, the longevity sirtuin proven to enhance healthy longevity

SIRT6 Activator is a safe way to repair the genetic damages that may occur due to aging

Epigenetic age acceleration could be used as a biomarker for healthy longevity

Accelerated biological aging associated with lower odds of living healthy and longer

Phase 2 clinical trial of lead drug candidate MYMD-1- a therapy for delaying aging

Sarcopenia drug trial shows no evidence of toxicity or safety issues

Age-related changes in retina linked to decline in 'youth' protein

Aging associated retinal disorders linked to loss of protective protein

Vitalunga creates oral drug to prevent diseases in aging adults

Positive results in lab tests suggest the drug may improve lifespan and life quality

The genetics of successful ageing: unlocking longevity genes in humans

APOE and FOXO3A had significant impact on longevity, but environmental factors also determine the fate of health while ageing

Improving protein function could lead to new treatments for diseases

This breakthrough could lead to new treatments for cancer and Alzheimer’s

Ageing versus longevity: epigenetic age correlated with only a few ageing hallmarks

Mitochondrial dysfunction & stem cell exhaustion accelerated the epigenetic clock, but senescent cells & telomere length did not

Hevolution Foundation to spend $1 billion annually on the biology of aging

Considering funding a $100 million age reversal X Prize and the TAME(metformin) trial

Not just vision - diet and eye health is linked to aging in fruitflies

Staring at gadget screens at night affects circadian clock and in turn lifespan

Lento bio to launch anti-glycation drugs targeting anti-aging and presbyopia

Lento Bio research into molecular aging damage by accelerating clinical assets

Height may be an unrecognised non-modifiable risk factor for several health issues

Largest height study ever: being tall increases risk of peripheral neuropathy, lowers heart risk

Epigenome editing - technology safer and reversible than CRISPR

Leaves DNA sequence unaltered while retaining the ability to specifically home

Longer lifespan lies in the mechanisms regulating gene expression

Pluripotency network can have negative and positive lifespan effects

The anti-malarial drug chloroquine increases lifespan in male mice

Chloroquine significantly interferes with the fundamental mechanisms behind autophagy

New algorithm recognises senescent cells using physical morphology

in vivo analysis in mice confirms the imaging results against p21 biomarker

Alchemab unveils AntiBERTa: A machine learning model to revolutionize antibody discovery

AntiBERTa's advanced AI model unlocks deeper insights into antibody structure and function

Buck researchers discover mitochondrial protein that can increase lifespan

In yeast, increasing Tom70 delays ageing related mitochondrial dysfunction

Lifespan.io interviews João Pedro de Magalhães about theories of, and curing, ageing

The one thing I hope he's wrong about is that it won't happen in his lifetime - we just need some exponential oomph!

Non-invasive technique for gut health monitoring

Gene modification in bacteria using CRISPR array provide direct information of active gut genes

Anti-ageing substance in sea squirts improved brain health in older mice

Plasmalogen supplement reversed ageing signs in mice; might as well keeps you young

The Observer interviews Morgan Levine about ageing and her move to Altos Labs

When it comes to lifespan, you cannot blame 100% on genetics, just 10-30%

Study in mice says faecal transplants could possibly reverse ageing

Gut microbiome dictates and decides the health of your gut, eyes, and brain

First ever organ-on-a-chip functions like the human's body

Opens way for personalized therapy, drug testing, and clinical extrapolation

Epigenetic age identifies risk of dementia later in life

Epigenitic and brain aging markers provide insights on accelerated cognitive decline

Mammals have similar number of DNA mutations whatever their lifespan

Shorter lived animals have higher rate of mutations - could explain lower rates of cancer in larger mammals

Turn Bio raised funds to usher epigenetic reprogramming from bench to bedside

mRNA technology-reset aging to extend health span and improve quality of life

SENISCA to reverse senescence by targeting RNA splicing patterns

Lorna Harries details significant breakthroughs at fourth annual Longevity Leaders World Congress

Brain charts: showing the incredible growing and shrinking brain ability

Mapping the brain and creating charts could be used as a helpful clinical tool for other clinicians, psychiatrists and researchers

Genflow's sirtuin gene therapy can make old liver young again

Currently exploring the SIRT6 potential with University of Rochester’s Aging Research Center

Senior UCLA scientists public states aim to fight aging to impact numerous diseases

Great to see the concept of reversing aging becoming a mainstream ambition - it hasn't always been that way!

Yellow-bellied squirrels stop ageing process while hibernating every year

Organ preservation and life extension is possible when humans could also hibernate

University of Washington launches Rapamycin Study

Have you been taking rapamycin supplements recently? Please consider contributing to this study.

Maximon announces 50,000 CHF (approx. £40K) Longevity Prize for Translational Research

And by longevity it means "substantially increase health span or life span" - apply now!

Longevity.Technology looks at 12 key companies running age-related disease clinical trials in 2021

Approaches include senotherapeutics, stem cells and mitochondria. Eye disease is a common first target.

Limiting calories rewires immuno-metabolic function for longer healthspan in humans

Protein produced by macrophages was identified as a key player of calorie restriction

João Pedro de Magalhães provides cautious optimism in this Longevity Technology interview

Maybe a longevity drug within 5 years, but still lots more research needed into process of ageing

Google's parent company launched Isomorphic Labs to discover new drugs using AI

Building from Deepmind's AI research, Isomorphic promises medical breakthroughs

ChromaDex releases results of clinical trial demonstrating anti-inflammatory effects of NR

Gold-standard trial included 35 participants taking 1000mg of NR (or placebo) for a week

Daily supplementation with urolithin A helps treat muscle fatigue

Boosts mitrochondrial health & muscle activity in aged people and those who don't exercise enough

Biological age of single cells measured with high precision

Epigenetic age of individual cells helps tracking ageing process in various tissue types

Reason reviews progress in longevity research and treatments from 2021

There is a phenomenal amount of work going on across the spectrum of ageing - something is going to work eventually!

MyMD Pharmaceuticals begins phase 2 trial of TNF-inhibitor in January 2022

Potential oral treatment to prevent sarcopenia and frailty, and extend healthy lifespan

Interactive and comparative study of diet and drugs on the hepatic proteome

Dietary composition has a powerful impact on mitochondrial function

Rockfish that lives more than 200 years unveiled genes for longevity

Insights on longer-living species could offer the targets for extending lifespan in humans

A new model enter into telomere-mediated senescence to reduce genome damage

Telomeres repair can prevent senescence and genome instability

Gene-editing technology, CRISPR, selectively kills drug-resistant superbugs

A single dose of CRISPR Cas system cleared 99.9% of harmful bacterial in mice

SENISCA targets sensescence using a new ageing hallmark - dysregulated mRNA processing

Lorna Harries believes dysregulated splicing as a breakthrough senotherapeutic target

New study leading towards permanent youthful immune function

Significant alteration in lineage potential by NR treatment in mice

Revel pharmaceuticals restores tissue function using AGE-cleaving enzymes

A unique treatment approach for ageing; will soon begin trials in animals and human cadaver tissue

Mammalian brain cells mapped for better understanding of the neuronal disorders

The atlas of the brain cells developed will help pave the way for future research in brain disorders

Longevity Science Foundation to fund $1 billion for a 120-year human lifespan

The foundation's mission is to make longevity medicine accessible to everyone - fantastic news!

The Rejuvenome project plans to combine multiple anti-ageing interventions in mice

One drug doesn't fit all; combination therapies to address multiple ageing processes at once

Smart toilets could provide effortless monitoring of a range of biomarkers, not just gut health

Coprata and Toi Labs among companies looking to bring products to market in the next couple of years

Fewer mistakes in protein synthesis extends lifespan in simple microbes

Interestingly, rapamycin (and other drugs) also improves accuracy of protein production

Polygenic risk of age related diseases effect on human lifespan

Rare variants in non-coding RNAs are connected to various neurological disorders

Role of mature dendritic cells in thymic involution

Reversal of thymic aging possible through signaling based interventions

Complicated connection between protein shape and mitochondrial health, causing aging

The “bad” process of pore opening and the “good” process of UPRmt - connection revealed

New CRISPR based stem cell implant releases drug as required in arthritis

Reduced inflammation & bone damage in mice; relieves patients from their regular use of injections

Longest-lived bats unveiled secrets to longer and healthier lives

Novel genes increase DNA repair and limit damage to slow down ageing process

Summary of Eric Verdin presentation at End Age-Related Diseases 2021

Discusses causes and prevention of NAD depletion with a focus on CD38 consumption

Ubiquitination of cell proteins determines ageing and longevity in C. elegans

Levels of ubiquitin-tagged proteins affect lifespan - insights may find answers to longevity

Summary of Irina Conboy presentation at End Age-Related Diseases 2021

Very much looking forward to seeing published results on initial human pilot

SIRT6 variant plays a major role in preventing the aging process

Novel gene therapies to prevent the accelerated aging process

Scientists uncover patterns of metabolism in humans across the life course

Metabolism remained same throughout the mid-life and starts to decline only at 60 years

Hyperactivation of senescent cells can trigger cytokine storm

Stimulated senescent human umbilical vein cells showed high susceptibility to inflammatory diseases

Skeletal stem cells delay bone healing and foster inflammageing in older people

Treating with BMP2 and Csf1 antagonist in mice restored youthfulness to the aged skeletal system

New study links height loss and age-related cardiac deaths

Get the measuring tape out, here's another biomarker to track!

Gut microbes show potential to reverse aging-related deterioration in brain

Microbiome in the gut could potentially slow down brain aging and improve cognitive functions

Role of muscle strengthening protein in reducing life span

Activation of CaMKII improved muscle fitness but increased the risk of ageing

Scientists uncover mechanism that promotes ageing in mammalian stem cells

Evidence of cryptic transcription in older cells offers new strategies for longevity

Unique gut bacteria linked to healthy ageing in centenarians

Fuels bile acids to prevent infections, but more research is needed to confirm its impact on longevity

Scientists find dormant regenerative abilities of the inner ear in mice

Advanced gene therapies can reactivate hair cells, which are vital for hearing

Levels of fatty acids in blood predict death in older people

Myristic acid, benehic acid, and omega 3 increase lifespan; palmitoleic acid lowers lifespan

Being wealthy at midlife may give you a longer and healthier life

Lifespan differences exist even between rich and poor siblings/twins

Activation of telomerase gene prevents aging in certain types of cells

DNA region: VNTR2-1 plays a role in human aging and tumorigenesis

Scientists invent AI that predicts potential lifespan-extending compounds

Anti-ageing probability validated from a worm with human-like metabolism

Latest AI tool predicts proteins structures in just 10 minutes

Freely accessible software from GitHub to help scientists speedup their research process

Dr. Matt Kaeberlein argues for more funding for geroscience

Chair of American Aging Association disappointed ARPA-H may only receive half the requested funding

Treatments that delay ageing could be worth trillions of dollars to the US alone

As more people live longer (lifespan) it is essential that their health keeps up too (healthspan)

Castration leads to longer life in male sheep, mediated by low androgens

There may be less men queuing up for this first generation longevity treatment!

Unique adaptations contribute to the longevity of American lobster

Insights on longevity, neural, and immune adaptations are revealed by a lobster

Long-term caloric restriction prevents age-related adiposity in aged mice

Targeting SA-T cells: A promising intervention to control age-related chronic diseases

DNAm GrimAge is a strong predictor of mortality independent of genetic influences

Twin study allowed impact of lifestyle factors on epigenetic aging to be determined

Zoledronate - accidental discovery of drug use for life extension

Too early to tell whether off-patent drug's effects in fruit flies will be seen in humans

Lifespan.io interviews Dr. Nir Barzilai about metformin, longevity genes and more

Optimistic on ageing research and a breakthrough human trial to extend healthspan

Eating less than 800 calories a day favoured weight loss via hungry pathogens

Long-term safety of the diet is questionable as it alters the healthy gut microbiome

Embryos reset biological age back to zero in early stage of development

Rejuvenation process in germline cells may help find new therapies for age-related disorders

Antibiotics extended the lives of the flies and changed their gene activity

In future, we can locate the genes which are linked to the aging process

Tryptophan-deficient diet alters gut microbiome, causing unhealthy ageing

Reduced beneficial gut bacteria and increased systemic inflammation in aged mice

Youthful stem cells delayed ageing through their secretions in mice

Potential stem cell treatment for age-related diseases, if succeded in human trials

Senescent immune system is a therapeutic target to extend healthy ageing

Degraded DNA repair in immune cells can cause premature ageing in the whole body

Stem cell therapy: A potential avenue for reversing pituitary gland ageing

Slowing down natural ageing process of pituitary glands with stem cells

Catalysis of TET1 - necessary for myelin repair in young adults

Regulation of adult remyelination in mice by TET1-mediated DNA hydroxymethylation

DNA-damage or telomere shortening may not cause normal ageing

Rapamycin fails to extend lifespan in telomerase-deficient mice, while improving lifespan by 39% in normal mice

Geography affects gut microbiome in healthspan and longevity

One treatment does not fit all - diversified gut microbiota needs customizable medicine

SIRT6 restores energy in older mice, increasing lifespan by 30%

Overexpression of this protein delays frailty and overcomes age-related diseases

Excessive alcohol consumption makes women age faster

GrimAge clock presented accurate results on biological age than other epigenetic clocks

mTOR inhibitors reversed immune ageing to treat viral infections in older adults

Much needed approach to improve immune function during the COVID pandemic

SIRT6 overexpression delays ageing of heart cells in mice

Anti-ageing therapies targeting sirtuins may slow down multiple effects of human ageing

A snailfish modified its DNA for survival in the deep ocean

Yap hadal snailfish made extra genes to repair DNA & stay alive in high-pressure deep-sea waters

New immunotherapy clears out senescent cells to combat aging

Activated immune cells can treat age-related chronic diseases - a potential alternative to senolytics

Youthful gut microbiome rejuvenates ageing immune system

Restoring gut microbial health can reverse declining age-related immune fitness

Food odour nullifies lifespan benefits of dietary restriction in nematodes

You may have to avoid smelling, not just eating, food for CR to be effective

Intermittent fasting improves gut health to lower high blood pressure

Correcting gut dysbiosis alters bile acid levels & may help manage hypertension in rats

Klotho protein reversed muscle ageing in old, but not older mice

Potential future treatment strategy to prevent sarcopenia when supplemented at a young age

Genes correlated for diseases with similar age at onset

UK Biobank study reveals genetic links & potential treatment strategies for age-related diseases

Diet and lifestyle changes reversed epigenetic ageing in males

Dietary, exercise, sleep, supplements, and breathing regimen for 8 weeks reduced epigenetic age by 2 years.

Dog Aging Project invites participants to study canine health and longevity

Understanding the impact of genes, lifestyle, and environment on ageing

Latest CRISPR editing method can turn on/off gene expression

Allows to silence bad genes without modifying the DNA sequence and it is fully reversible

SenNet: a new NIH initiative to fight ageing

Establishing a massive database on cellular senescence to improve human health

'Rogue' protein assists cancer progression in humans

Inactivating Siglec-XII could lower the risk of cancer, but more research is still needed

2021 NIA's lifespan extension study results on mice out now

Longer lifespan in old male mice treated with 17‐α‐estradiol, but four other compounds had no effect

Wild Biotech's unique database maps new targets for human diseases

Huge database of wildlife gut microbiota could screen potential therapies within days

CAR Macrophages for cancer immunotherapy enters phase 1 trial

Gene modified macrophages may surpass CAR T cells in treating solid tumors

A low-calorie diet maintains youthful gut state & improves lifespan

Calorie restriction prevents age-related changes to the gut microbiome in mice

Gene modified immune cells prevent cancer metastasis in mice

Signaling distant sites to alert & activate cancer killing immune cells in advance

João Pedro de Magalhães discusses longevity pharmacology and importance of human trials

Advances in longevity pharmacology to revolutionize healthcare with personalized therapies

BioAge's anti-ageing drug to treat Covid-19 enters phase 2 trial

Reverses immune ageing and can prevent death from coronavirus infection in the elderly

Canada's largest study of ageing raises $9.6 M infrastructure fund

Federal funding for CLSA advances ageing research, promoting health and well-being of older adults

Flagellin vaccine can help reduce harmful gut bacteria

Favorable results in single person experiment calls for a larger and formal research

Longevity pharmacology promises to revolutionize healthcare industry

Despite challenges, many companies and clinical trials in longevity field are constantly evolving

Goya et al review progress in cell reprogramming

Considers whether, and impact if, epigenetic clock is one component of a modular ageing mechanism

Gut microbiome impacts healthy ageing and survival in humans

Microbiome becomes unique starting in the mid-life, correlates with blood metabolites

Immune system links personality traits to lifespan

Insights on this missing link may offer new interventions for health and longevity in the future

Super summary of 3rd Annual Longevity Therapeutics Summit

More and more companies making greater and greater progress - 2021 could be an exciting year

Can short-term immune memory impact longevity?

Less inflammation due to shorter immune memory prolonged life of blind mole rats

Stool transplants help skin cancer patients respond to immunotherapy

Poop to pill: fecal transplants restore healthy gut microbes boosting immunity to fight cancer

Proteins from parasitic worms could be the next anti-ageing therapy

Helminth parasites may provide protection against inflammation disorders

Lab-grown human muscle showed benefits of exercise

Tissue engineered muscle under simulated exercise prevented chronic inflammation

Automating healthy lifespan studies using nematodes

New automated system with AI searches genes, drugs to extend human healthy lifespan

Gerostate Alpha looks at ageing in an unbiased way

Instead of targeting specific hallmarks/pillars - they want to target ageing as a whole

New evidence on reversing cognitive ageing in aged mice

EP2 receptor which causes inflammation & ageing was knocked down in a disease model

Deactivating ageing gene KAT7 to slow down ageing

A potential therapeutic target for ageing, but still a long way to human trials

Genes may partly influence your eating habits, study finds

Dietary indices found heritable food and nutrient patterns among female twins

SRF's End Of Year Campaign receives $1M from Antonov Foundation

Raises a total of $2M dollars this year amidst the pandemic

Interview with National Institute on Aging Scientific Director

Most hallmarks of aging only described in mice, so far, but Luigi Ferrucci is still optimistic

A force of tissue stiffness could bring new changes to immune drugs

Tissue stiffness alter immune system response to chronic diseases and ageing

Turn Bio licenses mRNA technology to undo ageing effects

A revolutionary technology research to provide the cure for age-related diseases

Scientists find the reason for impaired DNA repair in aged cells

Unveiled the mechanisms for DNA impairment; laid foundation for future research

Progress on human ageing studies with Dunkin Hartley guinea pig

Animal model studies that help in better understanding musculoskeletal ageing

Andrew Steele shares his thoughts on ageing

Echoes some thoughts from his book "Ageless: The New Science of Getting Older Without Getting Old"

Engineered genes in gut bacteria might help you live longer

Green light activated E.coli genes, extending life in Caenorhabditis elegans

Points to consider in a biological clock

Biological clocks should make sure they're using 'causes' and not 'effects' of ageing

A gene mutation that protects and improves brain function

Super agers with a rare gene mutation counteracts accumulation of aging proteins

Data from individual cells holds the key to a longer & healthier life

Aim to intervene in ageing-related diseases before they cause harm. Sounds like curing ageing!

Highlights from eLife's Aging, Geroscience and Longevity Symposium

Authors covered biological age clocks, senescent cells, longevity genes, and more

Thymus regenerated from human cells in mice

Will help treat diseases due to immunodeficiency or autoimmunity

A new ageing clock that reveals your biological age

DeepMAge is an accurate ageing clock so far and could be a key in medicine

Early intervention before disease progression using glyhealth

Avenna's glyhealth alerts practitioners about subclinical chronic inflammation

Bioage's lead therapies moved closer to the clinic

Lead therapies of BioAge to treat age related diseases enter phase 2 trials

Genetically engineered T cells destroy pathogenic T cells in mice

Directing T cells to attack other T cells - a new treatment for autoimmune diseases?

Technology Networks interviews Prof Overall about the Human Proteome Project

Proteomics is integral to accurate diagnosis and treatment for personalised medicine

MIT professor Richard Young explains how Omega regulates gene expression

Using Epigenomic Controllers to alter DNA transcription rather than the genes themselves

Donations being triple matched for SENS end-of-year fundraiser

I've just donated to help #UnlockLongevity - these are the experts and they need funding!

Deepmind's AI program has decoded a protein mystery

Will help in developing designer meds, better crops & 'green enzymes' to counter pollution

Number of births may decide how fast you age

Less than 3, or more than 4, results in accelerated ageing after menopause

Hidden inflammapath in your mouth invites deadly diseases

Keystone Bio's first ever biologic on the planet to eliminate oral pathogen

Eye-opening facts about human skin ageing

Therapeutic strategies to combat human skin diseases at single-cell level

A new FDA approved drug offers hope to children with progeria

Zokinvy blocks production of a defective protein to lengthen the shortened life span

Transgenic obese mice that do not suffer from being fat

Scientists discover a pathway to attenuate the deleterious effects of obesity

A rare gene mutant variant found to protect liver by chance

Scientists found exciting benefits by inducing a gene mutation in mice

A drug that reverses ageing to help fight COVID

Elderly have a higher mortality risk with COVID - reversing ageing could reduce it

Chronic inflammation promotes NAD+ decline during aging

Senescent cells induce NAD+ decline via activation of CD8 macrophages

A new study links Alzheimer's to gut flora

Altering gut microbiome might be helpful in preventing or delaying Alzheimer's

Walnut - a super nut for a healthy heart

Decreases chronic inflammation and the risk of cardiovascular disease

Study links gut flora with Parkinson's and Alzheimer's

Microbiome altering might help in preventing or delaying Parkinson's and Alzheimer's

A novel approach unlocked a gene's purpose on immune system

Study in mice and humans found CRELD1 gene's role in immune cell aging

OTC drug Ibuprofen could reverse age associated inflammation

A study on mice supported ibuprofen for use in neurodegenerative diseases

Lack of gene coordination during aging calls for newer treatments

Researchers found a new link in aging from a 15yr old approach

Scientists discover a life threatening inflammatory disease

Called VEXAS- discovered using a novel genome first strategy

A step towards understanding the molecular mechanism of ageing

A core set of genetic regulators involved in ageing have been found

Mechanism underlying telomere restoration in T cells discovered

Telomere transfer from APCs boosts T cells lifespan-helpful in immunosenescence

Genes of some species might hold the key to human longevity

Studying organisms that live long will help identify crucial genes associated with ageing

Improving immune system in the elderly with the existing medicines

Repurposing the potential existing drugs might eliminate the risk of developing infections

Tumor regression achieved with single 3-pronged immunotherapy injection

IL-12 self-replicating RNA delivered in lipid nanoparticles (LNPs) shows good results in mice

Casma Therapeutics raises $50m to boost cellular waste management therapies

Novel autophagy-based approaches target muscular dystrophy and other challenging diseases

Everything you ever wanted to know about AKG (but were afraid to ask)

A great summary of the history,biochemistry and life-extending potential of alpha-ketoglutarate

Anti inflammatory peptides discovered in rice using Nuritas' AI program

Peptides reduce inflammaging and improve standardised physical tests

Longevity.Technology interviews Adam Freund - Calico’s Principal Investigator

Will be presenting a viable therapeutic strategy using IGF signaling at ARDD 2020

Body builder supplement AKG extends lifespan and healthspan of mice

Blood levels fall with age. NUS planning a clinical trial with middle-aged humans.

IBM develops an online chemistry lab 'RoboRXN'

Will lower the cost & speed up the process of developing drugs

90 % of herpes simplex virus 1 eliminated in infected cells

Successful in mice, new approach may ease immune burden of herpes in humans in the future

Middle-aged mice live 10% longer with 4 days of CASIN injections

It would be interesting to see how long they lived with regular treatment through old-age

Gut microbiome of centenarians changes a few months before death

Causation vs correlation to be confirmed - but death affects ALL cells in the body, not just YOUR cells

A protein for regulating circadian cycle also fights cellular senescence

Its upregulation could be a new prospect for anti-ageing interventions

Low stress hormone levels promotes premature ageing

Balance is key to everything especially with human body

Genes of the oldest humans alive hold the key to human longevity

This time, focusing on the narrow population, the centenarians, would give us answers

Longitudinal DNA methylation is influenced by genetic, environmental factors

Decade-long studies of identical twins were able to reveal connections

VRK-1/AMPK cellular energy pathway linked to longer lifespan

Early days, but looking forward to seeing the results (in vivo) in mammals

Omega Therapeutics raises $85m for Epigenomic Controllers

New gene expression therapy for various targets, with clinical trial planned for 2021

Cohort study: Glucosamine reduces mortality by 15%

Supplementation with this anti-inflammatory drug can give us more benefits than we know

Abortion drug mifepristone may help extend the lifespan

Gains in fruit flies and roundworms give insights to extend human health and lifespan

LEAF interviews Reason about his views on epigenetic clocks

It does seem way to early to be settling for any single type of clock for rejuvenation research

Novel ageing pathway slows ageing of yeast cells in silico

It's a long way to go to having an effect in humans in vivo, but an interesting approach

Biological age of heart tissue 10 years younger then white blood cells

We need a single biological age figure as mortality risk applies to the whole body

Survey reveals unsettled views of ageing amongst researchers

Good news is that almost half the researchers believe age reversal is possible - unimaginable 5 years ago

LEAF interviews Stephanie Lederman, Executive Director of AFAR

"I would say that the science is now for this field" - I couldn't agree more

Lowering iron levels might hold the key to longevity

Study finds link between ageing and elevated blood iron levels

Continuous trickle of genomic instability can lead to multiple age-related diseases

Analysing mutations in individual cells will help determine its burden on ageing damage

Balancing blood iron levels is the key to living longer

Genes linked to iron metabolism were also responsible for age related diseases

LEAF interviews Alexander Fedintsev about weak v strong ECM hypothesis

It may be a new hallmark of ageing, but it's been one of SENS' 7 strategies since it started

The blood-brain barrier selectivity is impaired with age

Experiments in mice confirmed this, unraveling ageing mystery if it translates to humans

Transplanting youthful white blood cells reduces inflammation in mice

Targeting immunosenescence could provide benefits throughout the body

Ageing seems to increase the number of repetitive elements in our DNA

Even if it's an effect (not a cause) then REs could act as another biological clock

LEAF interviews Edwina Rogers, CEO of the Global Healthspan Policy Institute

It's a different set of skills required to convince government decision makers to change policies

A novel cell therapy to reverse age related impairments

Physical fitness and immune health restored in aged mice models

Role of immune cells in reversal of aging process- A study in mice models

Manipulation of Eosinophils in belly fat to promote healthy aging

Hormone in bone restores memory and ability to exercise in old mice

Exercising regularly increases this hormone and benefits muscle and brain

Low cortisol levels can trigger 'macrophaging'

Learning this age-induced disruption of macrophage functions powers pharmaceutical research

Trial of Rejuvant supplement claims 8 year age reversal

If randomised clinical trial replicates results then I might add it to my stack

Age-related diseases: Common genetic associations and therapeutic implications

With genomic database and statistical tools, more interventions can be discovered

Fewer genetic mutations gets few more years added to your lifespan

Will it be possible to remove such mutations from reproductive cells?

Scientists found a link to balance immunity and longevity

Gene changes in round worm lead an interesting evidence to longevity

Immunotherapy as new approach to battle senescent cells

Successful in mice, it may help treat many age-related disease in human

Forever Healthy Fellowship Program awarded to Dr. Tesfahun Admasu

His project researches on secondary senescent cells and SASP

Is it possible to predict biological age with gut microbiome?

Models and anti-ageing intervention design enables new ageing clock development

How lamins are linked to senescence and ageing

Connections have been elucidated but more research needed to confirm significant links

Gene mutations in DNA may impact lifespan and fertility

Study accelerated public awareness on genome sequencing & inspires new treatment approaches

Endless benefits of exercise also seen in gut microbiome

In both metabolic and physical levels, evidences gear towards positive effects

Peptides that shift gut bacteria can reduce heart attack risk in mice

Lowering the number of bad gut bacteria reduced artery plaques by 40% - wow!

SENS OncoSENS project suspended due to lack of funds and progress

It's important to keep funding basic research as no one knows where the answers will lie

Cellular pathway and mechanism leading to osteoporosis

Confirmed in murine and human cell study, findings can aid development of new treatments

Diluting blood rejuvenates old tissues in mice

There are things in blood that drives our ageing

Eating less to live longer? Study in fruit fly finds no benefit

Life extending benefit of dietary restriction might depend upon genetic makeup

Experts devise newest epigenetic clock for anti-ageing drugs discovery

Showed impressive results based on experiments in vitro and in vivo, but more work to be done

Scientists develop a new epigenetic clock

The clock accurately predicts biological age & can help develop anti ageing drugs

BSRA sponsors funding to repair bone fractures in the aged

Chernajovsky Foundation with BSRA funds for PEPITEM molecule to treat fractures

ThirdLaw may have designed a way to break crosslinks to reverse tissue ageing

Whoever controls the shape of a molecule controls what it can do

Experts develop new novel detection method for mitophagy

A discovery proven to be of help in therapeutic studies of neurodegeneration

Mice blood proteome analysis reveals new therapeutic target for osteoporosis

A different perspective for preventing age-related bone loss that affects many

Epigenetic clock of asthma patients reveals valuable information

There are lot more to discover and learn about asthma

Age-related changes in gut microbiota cause cognitive decline in aged rats

Restoring microbiome could be one strategy to support healthy longevity

Human gut microbiome is altered by shifting to a ketogenic diet

Potential research area to find treatment options for autoimmune diseases of the gut

An anti ageing protein found in yeast cells

Works by inhibiting protein metabolism

Orion College ageing research receives 1 million UK pounds from Jim Mellon

He believes in the importance of boosting immunoresilience among elderly

This enzyme helps reverse age-related neurodegeneration in mice

Sheds light to potential treatments for age-related cognitive decline, Alzheimer's

Metformin alleviates inflammaging by promoting autophagy

With the positive results, drug holds great promise for promoting healthy ageing

The effect of gut microbiota on cognitive decline in aged rats

First study investigating its effects in the normal ageing process

Immunai, to map immune system for better diagnosis, disease treatment

This application of machine learning will soon speed up drug development

AI and Genomics: Unlocking Potential with Caution

A report outlines how AI can advance genomics while addressing key challenges

Josh Mitteldorf stakes his reputation on major rejuvenation in a mammal

Imagine halving your age with 4 simple injections - at the very least it will buy more time

Should WHO use a new framework for the diagnosis and treatment of age-related diseases?

LEAF summarises and exchange of thoughts between leading aging researchers

LEAF interviews Daria Khaltourina about WHO classification of ageing

Believes life extension treatments may already exist - but need more clinical trials

Pace of human biological ageing can now be measured via blood test

Can aid future trials of therapies aiming at preventing diseases and slowing ageing

Commercial glycan test kit can tell the biological age using a dry blood spot

Analysing IgG glycosylation: is it the most accurate measure of biological age?

DunedinPoAm: a speedometer that tracks the rate of ageing using methylation biomarkers

A simple blood test could reveal if you are ageing faster or slower than your peers

Altering macrophage epigenetics to prevent lumbar disc degeneration

Findings can lead future treatments for age-related conditions caused by inflammaging

Coffee clearly does something to our DNA

Maybe it's good, maybe it's bad - still too early to say for sure

The integral role of gut microbiome in precision medicine

Huge potential in a more personalized diagnostics and diet-based disease interventions

GlycanAge offers free biological age blood tests in the UK

1,000 free tests available in May - but be quick, my names already on the list!

From the organisers for RAADFest - a free webinar - Eyes on the Prize

Will be discussing important advances in age reversal - looks interesting (and did I say FREE?!)

DNA alterations in rod photoreceptors, linked to age-related eye diseases

First study to look at DNA methylation changes as mice age and how it affects visual function

Nature to launch new journal dedicated to the broad spectrum of aging research

Anti-aging research is becoming main stream, because NOBODY is researching how to speed it up!

How external factors could influence Alzheimer’s disease via the gut microbiome

Early study into complex neurochemical relationship between brain, gut and inflammaging

Inhibiting p38 MAPK rejuvenates resolution response in elderly

A new perspective on mitigating the effects of inflammaging, promoting health in older people

The importance of early life microbiome in gut protection

Demonstrated in neonatal mice microbiome mediating an immune response

Dawn til dusk fasting improves blood biomarkers

Small study (14 participants) with strict participation requirements, but interesting biomarker results

Resveratrol reduced DNA double-strand breaks in mice cells

Variety of polyphenols had positive impact on genomic stability

Gut enzyme prevents age-related loss of intestinal barrier integrity

In animal models, IAP is found to prevent frailty and extend lifespan

Proposed strategy to protect elderly from gerolavic infections like COVID-19

To benefit long term global health and longevity, and enhance economic recovery

Gut microbiota highly influenced by ageing and dietary fat intake

Several short-term responses and alterations are evident in a mice study

Healthy old-people's poo improves gut microbiome of mice

Healthy gut means healthy body. Thought there are alternative ways of increasing probiotic bacteria!

Stability of splicing regulation, key to naked mole-rat longevity

Mechanism behind their exceptional lifespan and prolonged healthspan becoming clear

FDA issues safety alert for stool transplant after string of infections

Safety concerns alerted OpenBiome to recall unused materials and test donors in screening process

Why people should take up a career in the aging research industry

I think Victor is right, anti-aging is going to be the next big thing

The new quality control system that clears misfolded proteins outside cells

Opens new pathways for treatment of disorders such as Alzheimer's disease

Werner syndrome and normal aging epigenetic signatures differ

Werner syndrome, not merely accelerated normal aging as previously thought

Skin microbiome provides the best prediction of age

It will be more easy and convenient to take samples from skin and saliva, rather than fecal samples

Chronic inflammation leads to inflammaging

If we can slow down inflammaging we may be able to achieve longevity

David Sinclair Ask Me Anything - best bits

Always interesting to hear what Dr Sinclair has to say

Fight Aging! reports back from SENS Research Foundation Pitch Day

When some of these succeed in human trials even more money will pile in to fund further advances

An enzyme that prolongs lifespan in roundworms discovered

Results have been replicated in cultured human cells - a new hope for life extension?

Can we treat the ageing process or not? That's the question

John Newman, UCSF asst prof & Buck Institute researcher, explains upcoming ageing interventions

Longevity Leaders' latest report on how longevity is disrupting the world

An interesting collection of interviews and white-papers with industry leaders

Josh Mitteldorf argues for the minority view on methylation changes

Are epigenetic changes the cause or a symptom of ageing?

Scientists discover a master regulator of cellular senescence

Solving the mystery of ageing - still at the beginning

Rapamycin causes mTOR inhibition having an impact on mammalian aging- Brian Kennedy

mTOR pathway, part of the deregulated nutrient sensing hallmark of aging

Long live the dogs - an attempt to increase lifespan of man's best friend

Dog Aging Project plans to recruit dogs from all 50 states

Could immune cells be the secret to extreme longevity?

Unusually high concentrations of T helper cells found in supercentenarians bloodstream

High levels of killer cells in the immune system of supercentenarians

Relatively immune to infections and cancers - also get to live more than 110 years

Mr Senescence explains how to speed up ageing research

Long validation times in ageing research – experimental time is a bottleneck

Could you live longer with minimal brain activity?

Gene regulation calmed high neural activity and prolonged life in mice & roundworm

Huda Suliman explains the nuances of drug discovery in ageing research

Indications are less clear with anti-ageing compounds than with disease specific drugs

TAME Metformin Trial: An Editorial by Aubrey de Grey

Is it really the best use of $75M in the crusade against aging?

Protein misfolding ruins the young and beautiful cell

Presence of free radical damage significantly reduced the lifespan in worm model

LEAF Interviews the NIA's Deputy Director Dr. Ronald Kohanski

Systems biology discovers the networks that are essential for a living organism

Microbiome therapies can soon be personalized using a digestive tracker

Carbiotix and Food Marble partnered to correlate gut microbiome with digestive health data

Is senescent cell clearance a zero sum game?

Research suggests senolytic treatments will be beneficial for at least a few decades

Longevity.Technology interviews Buck Institute’s President and CEO Eric Verdin

Includes updates on NAPA Therapeutics and BHB Therapeutics

Skin cancer survival rate up jumps 10-fold in just 10 years

UK doctors announce that more than half of the patients can now survive advanced melanoma

Harvard associate professor looks at 5 common ageing myths

The science is changing all the time, we've still got a lot to learn

Interview with Aubrey de Grey - Longevity.Technology Exclusive

Great intro to life extension's leading advocate - Aubrey predicts radical change within 5 years

LEAF Interviews Dr. David Sinclair, Prof. of Genetics at Harvard Medical School

He started taking resveratrol in 2003, and now added NMN and some metformin

LEAF interviews David Sinclair about NMN trials and epigenetics

He's optimistic that human trials will convert the majority of people who are skeptical or unaware

Leukocyte telomere length found to be linked to DNA methylation (DNAm)

Yet more evidence that hallmarks of ageing are inter-related, not standalone actions

Gut and oral human microbiome, mapped

Study reveals links between bacterial genes and disease risk, key to future protection

Electrical stimulation therapy to ears improved body, sleep and mood

Newly discovered benefit of transcutaneous electrical nerve stimulation

Time to focus in on health extension rather than life extension

Longer healthspans will inevitably result in longer (and longer, and longer...) lifespans

Developmental stages of anti-ageing treatments

Two anti-ageing treatments in phase 3 clinical trials and four in phase 2 clinical trials

Right time to adopt "anti-ageing" lifestyle

Key molecular programs known to promote longevity do not last beyond midlife

Insilico and ARK enter a research collaboration on health-span and longevity

AI-based methods, to explore mechanisms of ageing and improving health-span

Mysterious epigenetic marks and their impact on our life

Yamanaka factors may be the solution for reversing age-related diseases

SIRT6 gene improves DNA repair and increases lifespans

Could it be tweaked to be even more efficient?

Juvenescence backs BYOMass with strategic investment

Advancing treatments for age-related diseases and healthy ageing

New class of drug destroys, not just inhibits, proteins

Cancer targeted first, but could clear out age-related proteins in future

resTORbio Agrees Phase 3 Human Trials with FDA

If successful, drug could be available in next few years

Reducing Inflamm-Aging by topical skin application, beneficial in chronically aged

Rejuvenating the skin can reverse “inflamm-aging may have profound health effects

Academy for Health and Lifespan Research Q&A with Harvard's David Sinclair

Rejuvenation human trials (cell reprogramming) possible in next 2 years

Aubrey de Grey shortens timeframe for human rejuvenation

Once proven in mice, demand and funding will surge

New academy to lobby government to combat ageing

Will campaign to treat ageing as a disease

Unlocking the secrets of ageing hidden in blood cells

Blood cells have their own agenda for ageing and other cells don't have a say in it

Aubrey de Grey predicts age reversal trials in 5 years

Not yet predicting the end of aging, but first generation damage repair therapies.

BioViva developing an anti-aging vaccine

Developing a virus to express several anti-aging and regenerative factors

2019 SRF Summer Scholars Program - applications open now

Great opportunity to work with some of the best minds in aging research

New study finds your genes may not influence your lifespan

Family tree data suggests hereditary genes contributed to no more than 7% of a person's lifespan

Josh Mitteldorf thinks his and Aubrey de Grey's views are converging

Even if signaling is fix, I suspect that there will be some damage already done that needs repairing

Stealthy Harvard startup wants to reverse aging

Rejuvenate Bio is cofounded by George Church of Harvard Medical School.

Casma Therapeutics develops drugs to enhance autophagy

Their approach addresses enzyme deficiencies, aiming to expand treatments for neurodegeneration

Undoing Aging 2018: an initiative to remember

45 speakers, scientists and entrepreneurs, presented their work.

Immunethep seeks funding to take its novel bacteria vaccine into clinical trials

Alexander Burik sensibly advises caution about any new type of treatment

Harvard’s David Sinclair Treats Aging as a Disease

WuXi interviews Harvard University’s David Sinclair

Carbiotix offers low-cost, personalized gut health testing service

New microbiome test kit provides customizable supplement dosing to fill the fibre gap

DanBrit acquires Enochian Biopharm to expand its immunotherapy pipeline

Will rebrand as Enochian and also move to Los Angeles

Molecule could revert cellular ageing

Non-coding RNA is never translated into protein.

Aging Research Half a Lifetime Ago: the Lost Decades of the 20th Century

Microbiome analysis: some gut bacteria reduces inflammation

Village peasant microbiome has low risk for atherosclerosis, obesity, diabetes and colitis

SRF has made progress in the fight against ageing

R&D phase in SENS repair approach has shown promising results

SRF to develop glucosepane-cleaving antibodies with Spiegel Lab

Anti-glucosepane antibodies may offer new therapies for age-related diseases

RNA splicing could help us prevent aging

Researchers wanted to find out the impact of RNA splicing on the ageing process

Young blood therapy - the real deal to longevity?

Transfusing youthful blood factors into an older patient could be a reality soon

Molecular clock reversed in mice using SIRT3 infusion

Could SIRT3 promotion in humans help with age-related oxidative stress?