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AgeCurve got its Cell Tree Age/Rings patent approved by the UKIPO on June 24, 2025. The team filed this in September 2022 and shared details in Geroscience journal. With just £125k funding and a small team, they achieved what usually needs big money and big labs.
The tool, Cell Tree Rings, uses data from somatic mutations across thousands of single cells to map cell lineage trees. This helps track genome instability, which is a main sign of aging. Existing aging clocks miss somatic mutation data, which can lead to wrong age estimates and affect trial results.
Using single-cell RNA sequencing, they combine mutation data with cell behavior, improving diagnostics and therapies. AgeCurve is working with Healthy Longevity Clinic to turn these insights into tests that doctors can use. The patent covers the UK, EU, and US, allowing new products in aging and cell therapy. The team says somatic mutations don't fully explain aging, but ignoring them is a mistake.
