Surprising health benefits of creatine beyond muscle gain
New Scientist - 22-Nov-2024Science-backed benefits for athletes and everyday people
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Science-backed benefits for athletes and everyday people
Initial focus on lowering cholesterol by targeting NAD+ metabolism
Proper nutrition, especially fruits and vegetables, remains key to prevent Scurvy
The findings open new avenues for therapies aimed at slowing the ageing process
Molecule "LaKe" simulates exercise effects, enhancing metabolic and brain health
Biotech advances human lactoferrin for better health and longevity
The funds will help expand their market reach, particularly into the US
It enhances mitochondrial health, but does not significantly increase ATP
Eating well and staying active are still the best ways to stay healthy
This raises concerns about manufacturing and regulatory practices in the industry
Findings question prior claims and emphasise the importance of a balanced diet
It could be a potential supplement for improving cancer immunotherapy
If you already have heart problems, fish oil might actually help protect your heart
Backed by science, this natural compound may be the key to living longer and better.
Fortified foods and supplements can increase niacin levels in the body
It could delay age-related diseases and improve the body's systems
Oral therapy improved energy & daily activities in MS and Parkinson's patients in phase 2 trial
The supplement aims to address the underlying causes of blood vessel ageing
People taking multivitamins scored better on memory tests than others
Company plans to bring their revolutionary Mitopure technology to the world
Separating hype from science about vitamin D supplements, deficiency, and potential benefits
The gender-specific effects observed underscore the complexity of ageing
Focus on diet, evidence-based medicine, and avoid the risks of unregulated supplements
Using AI to screen natural compounds and create novel longevity products
Findings underscore the importance of maintaining adequate vitamin D levels
NMN improved physical performance, muscle function, and insulin sensitivity
Urolithin A rejuvenated blood stem cells in mice, boosting infection defence
Study in mice finds that antioxidants stimulate the growth of cancer tumours
Low vitamin D was mainly linked to high mortality risk from stomach, prostate, bowel, and lung cancers
Aspirin found to increase the risk of brain bleeds in older healthy individuals
Aims to spread its life-enhancing solutions (including collagen booster) further across the globe
One vitamin D supplement a month slashed risk of major cardiovascular events by 9%
Anti-aging benefits found of taurine in animal studies, but no evidence to support supplementation in humans yet
Friends and family noticed their improved health and appearance, with no serious side effects
Explained the production and mechanisms of Urolithin A, and trial results of Timeline's Mitopure
The course of organ ageing can be mapped and predicted
Increases in NAD+, NAMPT enzyme and SIRT1 levels. Over 1 year reduction in biological age measured by GlycanAge.
Supplementing with the amino acid D-serine may reverse some anti-ageing effects
A meagre 250 mg/day of NMN ameliorated arterial stiffness which could protect against CVD risk
Longevity Technology interviews CEO Melanie Goldey
Taking too high of a supplement dose of any nutrient could potentially lead to adverse effects
Mixed in with some generic platitudes, he makes his case that NMN should be an FDA approved drug
Daily dose of 600mg orally elevated NAD+ levels and increased walking distance
Omega-3 fatty acids, folic acid, and co-enzyme Q10 may benefit heart, but beta-carotene shows harmful effects
NR fuels the energy levels of both cancer cells and cancer-fighting cells according to the study
Research reveals that nicotinamide riboside (NR) may fuel cancer spread
Likely to be discussions before stock is removed from sale - and should still be available in the UK
Caution advised in prescribing to elderly without heart risks
Small research group highlights the risk of rather thought safe natural therapy-turmeric supplement
SIRT6 Activator is a safe way to repair the genetic damages that may occur due to aging
Progressive disease can be prevented by boosting Vit-D to normal levels
Researchers used CRISPR to edit a gene in tomatoes, enabling them to produce vitamin
Mitopure will be offered inside Nestlé Health Science products
Plasmalogen supplement reversed ageing signs in mice; might as well keeps you young
New anti-ageing approach to ramp up NAD levels and life extension
Maximum lifespan of wild-type mice increased over 30% when supplementation started mid-life
Have you been taking rapamycin supplements recently? Please consider contributing to this study.
Different flavours of rapalogs targeting different age-related conditions
Elderly athletes had similar NAD+ levels as normal young people
Disease risk reduced by 30% in older people but its best to consult a doctor before taking supplements
Gold-standard trial included 35 participants taking 1000mg of NR (or placebo) for a week
Boosts mitrochondrial health & muscle activity in aged people and those who don't exercise enough
Labdoor's report indicate only the freshness of supplements; toxicity effects remain unclear
Improved survival via eliminating old cells - potential candidate to slowdown ageing
Significant alteration in lineage potential by NR treatment in mice
A rapamycin trial testing healthspan improvements in dogs; results may extrapolate to humans as well
Discusses causes and prevention of NAD depletion with a focus on CD38 consumption
Exercise & NMN have synergistic effect in boosting aerobic fitness, but long-term effects unknown
As this human trial was small, a larger study is warranted to confirm its effectiveness
Nutraceutical improves human performance by faster recovery from injury
DoNotAge's potent SIRT6 activator improves DNA repair and overall healthspan
Explains about human use of NMN-C, future of NAD boosters, and his personal longevity strategy
Lowers age-related defects of blood stem cells & make stem cell transplants more effective
PEARL: Participatory Evaluation of Aging with Rapamycin for Longevity
Delays age-related degeneration of hearing hair cells, still need a better cure
A 11-year long research in mice revealed 5 potential compounds to increase human longevity
Further studies to confirm clinical benefits of this anti-aging compound in a large sample
Jinfiniti's intracellular test measures NAD levels at home with a simple filter-paper kit
Long-term use of this supplement boosts NAD+ levels, lowering the risk of osteoporosis in mice
Longer lifespan in old male mice treated with 17‐α‐estradiol, but four other compounds had no effect
Benefits in older mice, but NR treatment in young mice increased inflammation and DNA damage
Prevents weight gain and extends healthspan in yeast and mammals without giving up on food
Findings from a small human trial suggest a potential healthy ageing supplement
New plant-based longevity pill that offers better access to many health benefits
Surpasses other existing precursors with an independent pathway to enter cells
Human and animal research supports longevity benefits of glucosamine and chondroitin supplements
Spermidine supplemented mice showed anti-ageing effects by preserving telomere length
NAD+ levels, senescence and chronic inflammation collectively influence ageing
Boosting NAD+ levels improves health span and can treat age-related diseases
Promotes healthy ageing with NR, and is safe and compatible with other supplements
Failed to mimic dietary restriction pathways on extending lifespan in progeroid mice
Supplement with science-based evidence on humans pioneering longevity industry
Drugs boosting NAD+ target toxic proteins by turning on the mitochondrial function
Patented compound on clinical trials to prove the benefits on human cognition
12 science-based ingredients acting together on multiple aging mechanisms
12 science-based ingredients act on 9 important processes to slow down ageing
NOVOS' nutraceutical with free longevity tests plans to launch in January 2021
A study in UK records shocking levels of vitamin D deficiency in certain groups
Antioxidant ergothioneine alleviates harmful effects of oxidative stress on telomere length
AKG with antiaging benefits is now proved to counter osteoporosis in rodents
But Reason is not yet convinced - definitely needs more, and bigger, studies
Daily supplementation with resveratrol proved to improve heart function
Prime Fifty's products will be sold along FutureYou Cambridge's supplements
Senescent cells induce NAD+ decline via activation of CD8 macrophages
Set to launch Participatory Evaluation of Aging with Rapamycin for Longevity (PEARL) trial
A study on mice supported ibuprofen for use in neurodegenerative diseases
Even if supplement really contains C60 it's likely to have degraded into toxic species
Restoring NAD homeostasis could help in ageing diseases with telomere dysfunction
Researchers found an advancement in healing muscles with glutamine
Quicksilver uses liposomal nanoparticles to deliver supplements-increases bioavailability
Discovered in, but not produced from, you-know-what - reduces risk of CVD and cancer
Definitely no harm in taking normal levels of vitamin D supplements - and could save your life
A great summary of the history,biochemistry and life-extending potential of alpha-ketoglutarate
Blood levels fall with age. NUS planning a clinical trial with middle-aged humans.
People are now willing to say that treating ageing might help ameliorate age-related diseases
Demonstrates safety as a NAD+ precursor dietary supplement, and also within a drug clinical trial
Nuchido's supplement boosts NAD+ four times higher than other products
Based on almost half a million people this is a large prospective cohort study
Supplementation with this anti-inflammatory drug can give us more benefits than we know
Maybe we need to develop senoplasts like resveratrol as well as senolytics
Better studies required to weigh benefits of cancer protection against risk of a GI bleed
If randomised clinical trial replicates results then I might add it to my stack
Supplementation also shown to reverse ovarian ageing
A promising anti-cancer immunotherapy approach, and alternative to traditional drugs
Also a cheaper treatment for mitochondrial myopathy than NR and NMN supplements
500 mg shown safe in clinical trials - lots more research underway
Study in mice shows link between the two, could help improve sleep quality in humans
NAD+ deficiency is for real and it happens in humans too
Not yet too late to reap the benefits of exercise as seen in middle-aged individuals
It restores neurovascular coupling associated with age-related decline in brain function
Vast potential when tapped for pharmaceutical medicine use as well
Advices on improving health should be considered especially in times of pandemic
Variety of polyphenols had positive impact on genomic stability
Great, conclusive list for those aiming to use natural substances to decelerate ageing
In animal models, IAP is found to prevent frailty and extend lifespan
Minimizes off-target effects along with boosting healthspan, as studied in old mice
mTOR, a pro-survival pathway for shorter telomeres and inhibition is deleterious
One portion of oily fish per week contains all the omega-3 fatty acids you need
This provides simple, safe way to rejuvenate egg cells as shown in aged mice study
Mitochondria-targeted interventions in old mice could be key to age-related diseases.
There's still no clinically proven benefit from CBD use - but definitely risks
Needs to study more on NAD+ interventions in order to achieve significant benefits
Greatest reduction in colorectal cancer mortality by using aspirin more than 3 times per week
NAD+ drugs combat Werner Syndrome key symptoms such as early signs of ageing
CBD products developing companies are frustrated with the FDA's lack of of clear regulations
Do NAD+ supplements work? Probably. Do TIME+ pills have a demonstrable effect? More studies required.
When in doubt simply stick to the recommended therapy or ask your doctor
A Japanese study establishes safety of NMN despite previous results in animal studies
Detailed history and review of current understanding of Rapamycin and longevity
Includes updates on NAPA Therapeutics and BHB Therapeutics
Great video including rejuvenated mice inside David Sinclair's lab
He's optimistic that human trials will convert the majority of people who are skeptical or unaware
Low-dose aspirin can't be prescribed for healthy people over 70, even if they have high CVD risk
More evidence fish oil supplements don’t work – save your money!
A small trial but interesting results
Meta-study of a million people finds no evidence of multivitamins increasing lifespan
No convincing evidence to recommend dietary supplements for brain health
Urolithin A could help slow certain aging processes, improve the functioning of mitochondria
Optimal use of sunscreen prevents sunburns, skin cancers without affecting Vitamin D levels
It is important to maintain the amino acid balance in the body to lead a healthy life
No short-cut to a healthy diet
Supplement has a real physical health impact too = reduced inflammation
Even if their effect is uncertain, the product should at least contain what they say
Natural is not always good - please follow medical advice
Live Forever Manual rates IV therapy as "save your money"
Nothing too surprising in his daily supplement regime
People without cardiovascular disease do not benefit overall
Includes table of fisetin content in range of fruits and vegetables
Would be interesting to compare to people with low vitamin D blood levels
We still need to understand it better but NAD+ is likely to be important in slowing aging
Green tea supplements present a greater risk for people who are taking more concentrated extracts
Taking an aspirin per day may increase the risk of internal bleeding among the elderly
They cause severe and long-lasting disturbances over gene expression and native microbiome
Ray has opened up recently about his supplement regime.
NHS states that consuming Omega-3 through your diet is better than through supplements
Some supplements can actually be harmful in the long term
Look forward to seeing the results of the NAD supplement trial
Solidago virgaurea (goldenrod) extracts studied in relation to cellular senescence.
Possible cause of sarcopenia impaired processing of the essential amino acid leucine.
One if four people taking a herbal treatment alongside medication had a worrying drug reaction.
Eat a balanced, healthy diet rich in vitamin D containing foods
Sarcopenia is the deterioration of muscle mass and strength as part of aging.
Fisetin is a naturally occurring plant polyphenol from the flavonoid group.
Creatine is a small peptid and an important energy buffer in muscle cells.
Not everyone gets enough of this essential element which is vital for cellular processes.
Honokiol is a lignan isolated from the bark, seed cones, and leaves of the trees of various Magnolia species.
One of the most commonly used supplements frequently taken to promote joint health.
In various studies quercetin has demonstrated antioxidant, anti-bacterial, anti-inflammatory and anti-carcinogenic properties.
Pterostilbene has antioxidant, anti-inflammatory and anticarcinogenic properties.
Ray talks about the singularity, AI and human hybrid thinking with neocortex connected to the cloud.
Antioxidants most likely have little effect, but they could actually be harmful
Following healthy diet has more benefits, than taking vitamin supplements
Clinical trials are in progress - NMN could be the recipe of youth
NMN found in natural foods promotes antiaging and halts age associated diseases
Has two active ingredients, Nicotinamide Riboside and Pterostilbene, aimed at cellular detoxification, DNA repair, and energy production.
Nicotinamide riboside (NR) is a form of Vitamin B3.
Each targets a different anti-aging or pro-aging signaling pathway.
Sales of vitamins are higher than those of painkillers.
The focus is to find ways to keep up the NAD levels in tissues with ageing
EPFL researchers restore ability of mice organs to regenerate – also extending life.
Found six new groups of molecules that decelerate the chronological ageing of yeast
LA BioMed research saw reduction in soft plaque in arteries.
Some research suggests that a diet high in omega-3 fatty acids can protect brain health but a large clinical trial has found that omega-3 supplements do not slow cognitive decline in older people.
Enhanced AVLT delayed word recall, improved depression scores and decreased heart rate compared to placebo.