Key points from article :
Vitamin B3 compounds (nicotinamide, niacin, nicotinamide riboside) act as precursors to enable the manufacture of nicotinamide adenine dinucleotide (NAD).
NAD+ levels decline in multiple organs with age, and this contributes to various age-related diseases.
NAD+ is synthetized, predominantly through NMN, to replenish the consumption by NADase.
Recent preclinical studies have demonstrated that the administration of NMN could compensate for the deficiency of NAD+.
NMN supplementation was able to effect diverse pharmacological activities in various diseases.
Human clinical trials shown single oral administration of 500 mg NMN safe and effectively metabolized.
Other trials looking at effect on glucose metabolism, endothelial function, blood lipids, and muscle tissue markers.
Regular moderate exercise, and particularly strength training, can also raise NAD levels.
Research by Sichuan University in Frontiers in Cell and Developmental Biology
