Key points from article :
NMN supplementation elevates NAD+ levels and increases walking distance in healthy participants, with optimal dose of 600 mg/day.
Randomized, multicenter, double-blind, placebo-controlled clinical trial on 80 participants aged 40-65 years.
Three different doses of NMN were investigated: 300, 600, and 900 mg/day.
NAD+ levels increased significantly in all study groups compared to placebo and baseline, with largest increase in the initial 30 days.
Gains in walking distance were substantial, with both 600 and 900 mg/day groups adding about 150 meters: a 50% increase.
According to Aging.AI, changes in biological age were minimal in all the study groups.
Insulin resistance measurements based on the HOMA-IR test were statistically insignificant.
Health and quality of life questionnaire (SF-36) mostly followed the same dynamic as NAD+ levels and walking distance.
Require more studies with larger sample sizes, different endpoints, and longer follow-up periods.
Study published in GeroScience.
