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Boosting NAD+ levels with NR reverted symptoms of premature ageing disease

31-Mar-2021

Key points from article :

Scientists alleviated symptoms of the rare premature aging disease ataxia-telangiectasia (A-T) using NAD+ supplementation in mouse.

In fibroblasts from A-T patients, discovered elevated levels of cellular senescence.

Found lots of DNA fragments floating around in the cytoplasm.

NAD+ supplementation does not tackle the upstream cause of A-T, but it may alleviate the symptoms.

Replenishing NAD+ levels using NR (nicotinamide riboside) lowered cytoplasmic DNA, improved mitochondrial health.

Led to a decline in senescence and DNA breakage markers.

Lesser activation of microglia and astrocytes.

A notable improvement of certain motor functions in ATM-deficient mice.

In healthy control mice, especially in younger ones, NR treatment caused inflammation and DNA breakage markers to go up.

NAD+ supplementation for healthy young humans remains to be determined.

A viable strategy against particular age-related diseases, and aging in general.

Research by National Institute on Aging published in Aging Cell.

Benefits in older mice, but NR treatment in young mice increased inflammation and DNA damage

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Journal

Scientific Journal devoted to age related diseases.

Institute

Conducting and supporting research on aging and the health and well-being of older people.