Key points from article :
Scientists alleviated symptoms of the rare premature aging disease ataxia-telangiectasia (A-T) using NAD+ supplementation in mouse.
In fibroblasts from A-T patients, discovered elevated levels of cellular senescence.
Found lots of DNA fragments floating around in the cytoplasm.
NAD+ supplementation does not tackle the upstream cause of A-T, but it may alleviate the symptoms.
Replenishing NAD+ levels using NR (nicotinamide riboside) lowered cytoplasmic DNA, improved mitochondrial health.
Led to a decline in senescence and DNA breakage markers.
Lesser activation of microglia and astrocytes.
A notable improvement of certain motor functions in ATM-deficient mice.
In healthy control mice, especially in younger ones, NR treatment caused inflammation and DNA breakage markers to go up.
NAD+ supplementation for healthy young humans remains to be determined.
A viable strategy against particular age-related diseases, and aging in general.
Research by National Institute on Aging published in Aging Cell.
