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Boosting NAD+ levels with NR reverted symptoms of premature ageing disease

Benefits in older mice, but NR treatment in young mice increased inflammation and DNA damage


Key points from article :

Scientists alleviated symptoms of the rare premature aging disease ataxia-telangiectasia (A-T) using NAD+ supplementation in mouse.

In fibroblasts from A-T patients, discovered elevated levels of cellular senescence.

Found lots of DNA fragments floating around in the cytoplasm.

NAD+ supplementation does not tackle the upstream cause of A-T, but it may alleviate the symptoms.

Replenishing NAD+ levels using NR (nicotinamide riboside) lowered cytoplasmic DNA, improved mitochondrial health.

Led to a decline in senescence and DNA breakage markers.

Lesser activation of microglia and astrocytes.

A notable improvement of certain motor functions in ATM-deficient mice.

In healthy control mice, especially in younger ones, NR treatment caused inflammation and DNA breakage markers to go up.

NAD+ supplementation for healthy young humans remains to be determined.

A viable strategy against particular age-related diseases, and aging in general.

Research by National Institute on Aging published in Aging Cell.

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Aging Cell

Scientific Journal devoted to age related diseases.

National Institute on Aging (NIA)

Conducting and supporting research on aging and the health and well-being of older people.

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