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Regular exercise keeps your NAD+ up in the muscle even when you are old


Key points from article :

Aging incurs many metabolic changes to the body, with skeletal muscles taking a heavy toll.

A new study analyzed what happens with NAD+ in our muscles as we age.

Subjects: 12 young people; 17 old people, 17 trained old people, and 12 physically impaired old people with normal, above-average, and abnormally low physical activity, respectively.

A deep metabolomic analysis recorded the levels of more than 100 metabolites.

NAD+ levels are correlated not only with age but also depended on physical activity.

Trained older adults were almost on par with the young group.

Lowest levels of NAD+ recorded in physically impaired older adults.

According to the researchers, “most metabolic changes that occur with age in muscle can be reversed with regular exercise training.”

Decline in NAD+ occurs in parallel with increased reactive oxygen species production.

More research is needed to establish a causal relationship.

Study by University of Amsterdam, led by Riekelt Houtkooper, published in Nature Aging.

Elderly athletes had similar NAD+ levels as normal young people

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Journal spanning the entire spectrum of research into aging


Professor of Translational Metabolism at AMC.


Public research university