Key points from article :
Aging incurs many metabolic changes to the body, with skeletal muscles taking a heavy toll.
A new study analyzed what happens with NAD+ in our muscles as we age.
Subjects: 12 young people; 17 old people, 17 trained old people, and 12 physically impaired old people with normal, above-average, and abnormally low physical activity, respectively.
A deep metabolomic analysis recorded the levels of more than 100 metabolites.
NAD+ levels are correlated not only with age but also depended on physical activity.
Trained older adults were almost on par with the young group.
Lowest levels of NAD+ recorded in physically impaired older adults.
According to the researchers, “most metabolic changes that occur with age in muscle can be reversed with regular exercise training.”
Decline in NAD+ occurs in parallel with increased reactive oxygen species production.
More research is needed to establish a causal relationship.
Study by University of Amsterdam, led by Riekelt Houtkooper, published in Nature Aging.
