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GlyNac supplementation reversed age-related damage in mid-life wild mice

22-Mar-2022

Key points from article :

Glutathione (GSH) is an intracellular antioxidant, the backbone of natural defenses against reactive oxygen species (ROS).

ROS accumulation is not a hallmark of aging, but it deeply affects other hallmarks.

GSH levels decline with age, so supplementing it could plausibly affect other processes of aging.

Mid-life mice received GlyNac (a combination of glycine and N-acetylcysteine) with food until death.

Mice on GlyNAC lived, on average, 24% longer than the controls; effect was equally strong in males and females.

GSH concentration in the old animals was 65% to 72% lower.

GlyNAC supplementation restored GSH synthesis; maintained GSH and TBARS at youthful levels.

Impressive results in mitochondrial function, mitophagy, nutrient sensing, and genomic stability.

This study might put glutathione on the list of the most promising life-extending molecules.

Study by Baylor College of Medicine, led by Rajagopal Sekhar, published in the journal Nutrients.

Maximum lifespan of wild-type mice increased over 30% when supplementation started mid-life

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Academia

Health sciences university.

Journal

Open access journal delivering informaton in the field of Human and Clinical Nutrition.

Academic

Endocrinologist and Associate Professor of Medicine at Baylor College of Medicine