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Niacin inhibits brain tumor growth in mice

A promising anti-cancer immunotherapy approach, and alternative to traditional drugs

10-Jun-2020

Key points from article :

A possible new role for niacin has been discovered in the fight against brain cancer.

When combined with chemotherapy it spurs immune cells to attack glioblastoma, a type of brain tumor.

This resulted in a significant slowing down of disease progression in the mice.

Untreated mice lived for just 40 days while mice given combination therapy lived for 150 days.

Concluding, niacin alone increased the survival time of mice.

Combining with chemotherapy drug, temozolomide, significantly increased survival time.

Niacin resets microglia, monocytes, and macrophages normally hijacked by glioblastoma.

It reactivates them so that they stopped supporting tumor and instead attacked it.

More research nedeed to confirm dosage, delivery and length of time in human trials.

Researchers from Cumming School of Medicine, University of Calgary.

Published in Science Translational Medicine.

Mentioned in this article:

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Cumming School of Medicine

Medical school in Calgary, Canada

Science Translational Medicine

Journal that publish papers with topics related to translational medicine

University of Calgary

Public Research university.

Topics mentioned on this page:
NAD+, Cancer