Senescent Cells News Archive

Urine-derived stem cells release anti-ageing molecules that changed mice ageing

Live Forever Club - 31-Mar-2024

The discovery reveals the body's potential for self-rejuvenation

SENISCA secures 3.7 million euros to fight aging with RNA-based therapies

Longevity Technology - 18-Mar-2024

Developing senotherapeutics to target cellular senescence and treat age-related diseases

Senolytic drugs offered mixed clues about their potential impact on ageing

Fight Aging! - 04-Mar-2024

While modifying immune cell populations, the drugs also increased ageing biomarkers

Researchers explore the potential of sound waves for anti-ageing

Lifespan.io (LEAF) - 09-Feb-2024

Originally used to fight cancer, sound waves surprisingly revive old cells

Mice who sipped green tea all their lives lived longer and stayed healthier

Live Forever Club - 04-Feb-2024

Green tea improved gut health and boosted the immune system in mice

Having too much iron in your body can damage organs like lungs and kidneys

Live Forever Club - 28-Jan-2024

This could impact how much iron we get from food or supplements

New immune cells can recognise and eliminate a specific protein on ageing cells

Live Forever Club - 25-Jan-2024

In mice, this therapy was shown to reduce the number of senescent cells

A new method called FAST studies cellular ageing in cultured cells

Live Forever Club - 18-Jan-2024

FAST is precise and works with different cell types and microscopes

Ageing eyes face a double whammy of senescent cells and weakened defenses

Live Forever Club - 19-Dec-2023

Senolytic intervention helps to repair the protective barrier of the eyes

Fisetin in berries and apples could shield your heart in later years

Live Forever Club - 19-Dec-2023

Supplementation reduced the buildup of senescent cells in the arteries of aged mice

Your daily choices, whether at the gym or in your meals, can redefine your age

Live Forever Club - 15-Dec-2023

Cellular senescence can be significantly mitigated by a holistic lifestyle

Senescent cell weakness exploited by new anti-aging therapy

Singularity Hub - 07-Nov-2023

FDA-approved drug kills zombie cells and improves organ function in elderly mice

Senolytics may rejuvenate heart cells and prevent age-related heart disease

Live Forever Club - 02-Nov-2023

Drugs have the potential to revolutionise the way we treat age-related diseases

New peptide-based technology selectively erases ageing cells

Ulsan National Institute of Science and Technology (UNIST) - 14-Sep-2023

Mitochondria targeting could lead to new treatments for age-related diseases

Phase I trial shows early promise in clearing senescent cells in Alzheimer's

Wake Forest Baptist Health - 07-Sep-2023

The treatment was well-tolerated with no significant changes in brain function

Senolytics have gender-specific effects on ageing in young mice

Lifespan.io (LEAF) - 30-Aug-2023

More research is needed to determine the safety and efficacy of senolytics in humans

AI identifies new senolytics that could treat age-related diseases

Lifespan.io (LEAF) - 09-Aug-2023

Three natural compounds identified, paving the way for new treatments

Experimental vaccine promises to slow down or prevent Alzheimer's in mice

American Heart Association - 30-Jul-2023

Vaccine not only reduced inflammation, but also improved behavior and awareness in mice

Tiny sea creature unlocks the secrets of healing and aging

Phys.org - 30-Jun-2023

Insights on the evolution of ageing and may help advance regenerative medicine

AI unveils economical pathway to discover new senolytics to combat age-related diseases

The University of Edinburgh - 14-Jun-2023

Artificial intelligence identifies herbal compounds to safely eliminate senescent cells

UNITY Biotech's lead compound lags behind the Regeneron’s eye drug

Biospace - 27-May-2023

UBX1325 showed disappointing results in phase II macular degeneration trial - further analysis is required

AI-driven breakthrough in senolytic drug discovery

Lifespan.io (LEAF) - 04-May-2023

Machine learning successfully identifies promising senolytic compounds to target ageing and age-related diseases

Unity Biotechnology's diabetic macular edema senolytic treatment shows promise at 48-week endpoint

FierceBiotech - 24-Apr-2023

Corporate shift towards ophthalmology puts senolytics head-to-head against existing treatments

Endurance Exercise Training May Help Prevent Accumulation of Senescent Cells in Colon Mucosa

Live Forever Club - 20-Mar-2023

Age-related increase in inflammatory markers p16 and IL-6 was not observed in endurance athletes

AKL Therapeutics’ investigational oral senotherapeutics drug APPA beneficial for osteoarthritis

Longevity Technology - 20-Mar-2023

Senescent cells have become one of the most promising targets for healthy aging research

Rubedo's lead compound targets inflammatory skin disease with selective senolytic approach

Business Wire - 20-Mar-2023

Rubedo is planning first-in-human studies in multiple skin indications driven by chronic inflammation

SRF Scientists have discovered the "Iron Fist" strategy to deal with senescent cells

SENS Research Foundation - 09-Mar-2023

Scientists are working to bring these new rejuvenation biotechnologies of senolytics to aging humans

Reversal of cell senescence using low frequency ultrasound

Live Forever Club - 27-Jan-2023

Novel therapy killed some senescent cells, rejuvenated others, without harming healthy cells

Cellular Senescence Network (SenNet) to identify and characterize senescent cells

Nature Aging - 20-Dec-2022

Grand plan includes creation of imaging datasets, new tools, techniques, and biomarker panels

Targeting senescent cells could be a useful approach for slowing/treating Alzheimer’s disease

Salk Institute - 01-Dec-2022

How senescent neurons lead to Alzheimer’s disease, effect on removal and drugs needed for therapy

Novel experiment explores a new way of reducing senescent cell burden

Live Forever Club - 12-Nov-2022

BDNF-TrkB pathway shows a lot of promise in lowering senescent cells in older organs

Senolytics-a risky proposition in aging and repair mechanisms

Lifespan.io (LEAF) - 19-Oct-2022

The study is a caution for scientists engaging in self-experimentation with senolytics

$2.5M seed financing round closed by Cleara Biotech-targets cellular senescence

Longevity Technology - 03-Oct-2022

Cleara’s novel FOXO4-based treatment approach-ability to eliminate biomarker-positive scarred cells

Regenerative therapies and senolytics help to rejuvenate the heart’s capacity to regenerate

Longevity Technology - 17-Aug-2022

Eliminating senescent cells rejuvenates the heart's capacity for regeneration in mice

Data from Phase 2 BEHOLD study of UBX1325 in DME patients-Unity Biotechnology

Ophthalmology Times - 12-Aug-2022

Statistically significant treatment effect for both BCVA and CST was seen at both 12 and 18 weeks

New insight on the accumulation of senescent cells in humans

UPMC - 30-Jun-2022

Oxidative DNA damage induce rapid senescence compared with shorter telomeres from repeated cell divisions

Exeter's company SENISCA raises £2 million to treat age-related chronic diseases

University of Exeter - 09-Jun-2022

Funding might allow RNA-based rejuvenation tech to enter ex vivo lab tests

Senolytics may abate accelerated aging of cancer patients as seen in mice

Lifespan.io (LEAF) - 06-Jun-2022

Radiation-induced damage may lessen by removing senescent cells but senolytics may not reverse the damage

New algorithm recognises senescent cells using physical morphology

Lifespan.io (LEAF) - 26-May-2022

in vivo analysis in mice confirms the imaging results against p21 biomarker

Synergy of stem cell rejuvenation and senolytics promote longevity in fruit flies

Live Forever Club - 14-May-2022

Combined approach surprisingly eliminated the negative effects of individual treatments

Benjamin Le Calvé as the new Chief Scientific Officer of Starkage Therapeutics

StarkAge Therapeutics - 10-May-2022

Le Calvé will chair the Scientific Advisory Board and the Management Committee

Oral senolytics boosts geroprotective protein in mice and humans

Mayo Clinic - 15-Mar-2022

Dasatinib+Quercetin restores a-klotho protein, which could combat ageing and disease in older people

SenoStem project to investigate whether prior delivery of senolytic improves stem cell treatment

SENS Research Foundation - 07-Feb-2022

Both are leading first generation longevity treatments - even better if they strengthen each other

A natural cholesterol metabolite with senolytic effect in mice and humans

Buck Institute - 02-Feb-2022

New class of senotherapeutic drugs that could possibly target various diseases and ageing

Dasatinib plus quercetin combination may help preserve cognitive abilities in elderly people

Lifespan.io (LEAF) - 27-Jan-2022

Senolytics showed positive effects on rats but trials must confirm these findings on human brain

StarkAge receives 2 million euros to design safer senescence-targeted therapies

Longevity Technology - 19-Jan-2022

Funding will ensure the development of a new immunotherapy for age-related diseases

Senolytics promotes wound healing in the aged but not in young mice

Lifespan.io (LEAF) - 22-Dec-2021

Dasatinib plus quercetin slow down muscle regeneration in young mice

Anti-aging treatment: New vaccine by Japanese research can make this happen

Japan Times - 16-Dec-2021

New research claims in removing zombie cells behind aging by vaccination

Procyanidin, a senotherapeutic compound from grape seed extends lifespan in mice

Lifespan.io (LEAF) - 14-Dec-2021

Improved survival via eliminating old cells - potential candidate to slowdown ageing

SENISCA targets sensescence using a new ageing hallmark - dysregulated mRNA processing

Lifespan.io (LEAF) - 03-Nov-2021

Lorna Harries believes dysregulated splicing as a breakthrough senotherapeutic target

University of Leicester proves feasibility of antibody based targeted senolytics

IFL Science - 28-Oct-2021

New study results show clinical applications in pathological ageing

Senolytic drugs improved survival rates in coronavirus-infected mice

SENS Research Foundation - 07-Oct-2021

Boosts immune response by clearing senescent cells; a potential treatment for COVID-19 in humans

Senolytic cocktail reduces age-related spinal disc degeneration in mice

Lifespan.io (LEAF) - 21-Sep-2021

Dasatinib and quercetin combo preserves spinal discs to target age-related back pain

A single protein reversed senescence in skeletal muscle cells

University at Buffalo - 17-Sep-2021

NANOG targets multiple ageing mechanisms - insights may help develop new therapies for age-related disorders

Hyperactivation of senescent cells can trigger cytokine storm

Lifespan.io (LEAF) - 13-Aug-2021

Stimulated senescent human umbilical vein cells showed high susceptibility to inflammatory diseases

Longevity Technology interviews Aubrey de Grey about senolytics and other senotherapeutics

Longevity Technology - 05-Aug-2021

Most approaches have their limitations but good progress is being made on several fronts

Clearing out aged cells with senolytics can relieve jaw pain

University of Connecticut (UConn) - 07-Jul-2021

Senolytics for cartilage and bone regeneration in jaw joints, proven effective in mice

Pro-repair microenvironment after injury is favored by targeting senescent cells

News Medical - 06-Jul-2021

Senolytic drugs administration promotes locomotor and sensory recovery

Unity's senolytic drug reports positive phase 1 data in eye disease patients

FierceBiotech - 06-Jul-2021

Begun phase 2 trial including patients with early stage of disease to test its safety and effectiveness

A 12-week strength-endurance training lowered senescence proteins in older people

Lifespan.io (LEAF) - 14-Jun-2021

New study using biomarkers proved the importance of regular exercise again

Oisín raised $9.5M to advance senolytic therapies for kidney & age-related diseases

Longevity Technology - 28-May-2021

Investigational therapy on old mice cleared senescent cells up to 70%, extending life by 20%

Natural compound may help treat intervertebral disc degeneration

Lifespan.io (LEAF) - 12-May-2021

DHE slowed senescence in intervertebral discs of mice; but its use in anti-aging is still questionable

New immunotherapy clears out senescent cells to combat aging

Medical Xpress - 10-May-2021

Activated immune cells can treat age-related chronic diseases - a potential alternative to senolytics

Low magnitude vibration to prevent/delay age-related bone loss in rats

Lifespan.io (LEAF) - 05-May-2021

Vibration treatment eliminates senescence of bone cells - may not be applicable to other tissues

Raising awareness on senolytic drugs as a promising anti-ageing medicine

Longevity Technology - 30-Apr-2021

Senolytic Therapy Network aims to take the senotherapeutics from lab to clinic

SenNet: a new NIH initiative to fight ageing

Lifespan.io (LEAF) - 06-Apr-2021

Establishing a massive database on cellular senescence to improve human health

First ever non-invasive biomarker test to detect senolysis

Buck Institute - 02-Apr-2021

Detectible senescence-specific biomarker allows development of new drugs for age-related conditions

Life Extension supplement to clear out senescent cells

GlobeNewswire - 23-Mar-2021

New plant-based longevity pill that offers better access to many health benefits

Tackling multiple dysfunctions together can stop ageing signs

Lifespan.io (LEAF) - 12-Feb-2021

NAD+ levels, senescence and chronic inflammation collectively influence ageing

Oisín Biotechnologies' gene therapy may be available in the next 5 years

Longevity Technology - 22-Jan-2021

Results in mice suggest that it can increase median lifespan in humans by 15 years

Whole-body senescent cell removal improved brain health in mice

Lifespan.io (LEAF) - 22-Jan-2021

Senolytic drug and cancer drug with quercetin improved age-related cognition

Rubedo to first work on lung diseases

Longevity Technology - 20-Jan-2021

Their work will be critical amidst the COVID-19 pandemic - to move into clinical trials soon

Medical agent removes senescent cells to fix aging-related diseases

Japan Times - 16-Jan-2021

With positive results in mice, scientists expect to slow down ageing in humans

LMC provides background and success outlook on 14 leading senolytic companies

Longevity Marketcap - 15-Dec-2020

Comprehensive review of companies' clinical and financial state of play

Reversing heart damage with zombie cell-killing drug

British Heart Foundation (BHF) - 14-Dec-2020

Senescence killing drug in mice might unveil new heart attack treatments

A new enzyme discovered to reverse cellular ageing

Phys.org - 30-Nov-2020

Molecular simulations have discovered an enzyme with anti ageing and anti tumour effects

Targeting senescence might help fight cancers

Longevity Technology - 24-Nov-2020

Senolytics to treat cancers - study finds correlation between senescence & survival

Oxygen therapy reversed the human age biologically

YAHOO! - 18-Nov-2020

Not as easy as taking a pill, but a stunning result on both telomeres and senescent cells

Nature Biotechnology reviews the state of play of senolytics

Nature Biotechnology - 12-Nov-2020

In August, Unity announced that its lead drug candidate had failed to beat a placebo in reducing joint pain and stiffness.

Reason reviews the research behind One Skin's senotherapeutic skin-care spray

Fight Aging! - 06-Nov-2020

The anti-ageing peptide promotes skin health and reduces senescent cell markers

Say goodbye to fine lines and wrinkles with OneSkin

Longevity Technology - 21-Oct-2020

Topical supplement which extends skin span-the period of time your skin is healthy and youthful

Pharma company teams with AI to develop anti aging solutions

Longevity Technology - 15-Oct-2020

Taisho and Insilico collabs to identify novel targets for senolytic drugs

Unity Biotechnology launches clinical trial of a new senolytic

Lifespan.io (LEAF) - 13-Oct-2020

A new approach to treat diabetic macular oedema

Flavonoid found in redcurrants reduces senescence in brain cells

Lifespan.io (LEAF) - 28-Sep-2020

Mice study also saw improved cognitive abilities

Labiotech gathers feedback from European biotechs on Unity failure

Labiotech - 28-Aug-2020

General feeling that failures are bound to happen - but that their approaches can succeed

New research with senolytics shows promising results

Longevity Technology - 25-Aug-2020

Senolytic research is in its nascent stage but no reason why one shouldn't be hopeful

Reason examines the failure of Unity Biotechnology's phase 2 senolytics trial

Fight Aging! - 18-Aug-2020

Disappointing first result - but lessons learnt and plenty of other strategies available

Exercise reduces inflammation caused by SASP but not the number of senescent cells

Fight Aging! - 31-Jul-2020

Given senolytics are unlikely to ever clear every senescent cell, exercise will still minimise bad effects of those remaining

Taking the new path in the field of senolytics - SENISCA

Longevity Technology - 29-Jul-2020

Old cells will be more young and beautiful

Longevity.Technology interviews Prof Faragher about his cellular senescence research

Longevity Technology - 15-Jul-2020

Maybe we need to develop senoplasts like resveratrol as well as senolytics

LEAF interviews Alexander Fedintsev about weak v strong ECM hypothesis

Lifespan.io (LEAF) - 15-Jul-2020

It may be a new hallmark of ageing, but it's been one of SENS' 7 strategies since it started

Senescent cell inflammatory signals as a new possible biomarker

Lifespan.io (LEAF) - 29-Jun-2020

It could measure biological age and relative health

Immunotherapy as new approach to battle senescent cells

Lifespan.io (LEAF) - 23-Jun-2020

Successful in mice, it may help treat many age-related disease in human

Harmful effects of senolytic drug Navitoclax in aged mice

Fight Aging! - 19-Jun-2020

Short-term treatment of this drug demonstrated cytotoxicity among other risks

Genetically engineered T cells can be used to target and kill senescent cells

Medical Xpress - 17-Jun-2020

Tested successfully in mice with liver fibrosis and lung cancer

Antiageing antibiotic targets senescent human fibroblasts

Health Europa - 10-Jun-2020

Could lead to new drug discovery against senescent cells and extend lifespan

Could a vaccine be an alternative to senolytic drugs?

Lifespan.io (LEAF) - 29-May-2020

New study in mice demonstrates an intriguing possibility with senescent cells research

Forever Healthy Foundation structured review of published senolytics research

Forever Healthy Foundation - 28-May-2020

Little evidence of actual beneficial effects (rather than just biomarkers) so not recommended yet

A new novel senolytic agent, R406, discovered

Lifespan.io (LEAF) - 22-May-2020

Intriguingly destroys senescent cells without inducing cell destruction

Prodrug reduces inflammation, restores physical function in aged mice

Lifespan.io (LEAF) - 12-May-2020

Experiments yielded promising results in efficacy, specificity, and non-toxicity

Addressing treatment-related ageing in cancer with senolytics

Fight Aging! - 11-May-2020

Hopes are up for it to directly help the cancer research community and patients

Refining certain drugs to be less toxic and to amplify their senolytic potential

Lifespan.io (LEAF) - 24-Apr-2020

Tested in aged mice and turns out that it can rejuvenate tissue stem cells

Major mouse senolytics testing experiment is go!

Lifespan.io (LEAF) - 13-Apr-2020

We'll almost certainly need a combination of drugs so look forward to seeing the results

Navitoclax improved, now a safer senolytic drug choice

Fight Aging! - 09-Apr-2020

They found efficient way to increase its senolytic specificity, reduce platelet toxicity

Senolytics may have the potential to treat asthma

Lifespan.io (LEAF) - 07-Apr-2020

Will senolytics become the panacea to the whole Pandora's box by 100 years into future?

Positive feedback look identified with ATM via NF-κB pathway back to cellular senescence

Lifespan.io (LEAF) - 02-Apr-2020

As always, it's complicated, but controlling levels of ATM could be part of a therapy to combat ageing

Review on the relationship between senescence and bone marrow cancer

Lifespan.io (LEAF) - 23-Mar-2020

How senescence can fuel cancer development and how malignant cells induce senescence

Senescent marker levels in different tissues among different age groups

Lifespan.io (LEAF) - 19-Mar-2020

We need to recognize normal patterns in order to identify what's abnormal

Comprehensive history and explanation of senescent cells

The Scientist - 01-Mar-2020

Including the latest on clinical trials of first-generation senolytics

Mitochondria plays a major role in cellular ageing

Medical Xpress - 20-Feb-2020

HDAC inhibitor shows beneficial effects in mice but too toxic for healthy humans

How mitochondria drives senescence, affecting healthy ageing

EurekAlert! - 20-Feb-2020

Potential target for drug-based interventions to delay cellular ageing identified

Can senolytics improve heart disease and repair damaged heart cells?

European Pharmaceutical Manufacturer - 18-Feb-2020

Senescent cells seem to play a major role even in heart diseases

LEAF interviews Lewis Gruber about targeting cancer and senescent cells

Lifespan.io (LEAF) - 11-Feb-2020

Biomarker caused by glycolysis seen in all types of cancer - exciting possibilities

Ageing in mice - the systemic burden of senescent cells matters

Fight Aging! - 06-Feb-2020

Senescent cell burden is a marker of disease free years ahead of life

Underlying mechanisms of how cellular senescence leads to neurodegeneration

Buck Institute - 29-Jan-2020

Cellular senescence is now a top research topic and a very messy one in ageing research

SASP Atlas created by team of researchers

Lifespan.io (LEAF) - 28-Jan-2020

It is a comprehensive proteomic database of soluble proteins and exosomal cargo SASP factors

Berberine: the new entity that slowed down ageing in mice

Fight Aging! - 26-Dec-2019

Just like rapamycin, berberine also slows down the senescent process

Scientists discover a master regulator of cellular senescence

Medical News Today - 19-Dec-2019

Solving the mystery of ageing - still at the beginning

Dr. Michael Fossel interviewed by LEAF

Lifespan.io (LEAF) - 18-Nov-2019

Fossel argues for telomerase therapy over senolytics

Blind mole rats can prevent age-related chronic inflammation

Fight Aging! - 01-Nov-2019

They have a natural mechanism against cellular senescence and ageing

Senescent cells show cellular cannibalism in mouse and human cancer cells

Nature - 28-Oct-2019

They're often called zombie cells - and turns out they are. Time to kill them with senolytics!

OncoSenX targets solid tumours with senolytics

Lifespan.io (LEAF) - 22-Oct-2019

Phase 1 clinical trial starting early 2020

Cardiac glycosides may play a role as broad spectrum senolytics

Medical Research Council London Institute of Medical Sciences - 21-Oct-2019

Is it really possible to develop a drug without side effects?

Heart drugs found to be anti-cancer

Medical Research Council London Institute of Medical Sciences - 21-Oct-2019

Many drugs for heart diseases are broad-spectrum senolytics as tested in mice

Is senescent cell clearance a zero sum game?

SENS Research Foundation - 06-Oct-2019

Research suggests senolytic treatments will be beneficial for at least a few decades

Ageing and cancer linked by a complex relationship

Medical News Today - 04-Oct-2019

Does this mean that future therapies to slow down ageing may cause cancers as a side effect?

Senescent cells amplify blood clotting - now protein targets identified

Buck Institute - 24-Sep-2019

Could help tackle venous thrombosis that becomes a bigger risk with age

Senolytics and their impact on anti-ageing

Technology Networks - 19-Sep-2019

Once more confirmed, senolytics reduce senescent cells by that preventing their effect of ageing

Small Mayo Clinic trial successfully removes senescent cells from humans

Mayo Clinic - 18-Sep-2019

Occasional senolytic use may be enough to keep senescent cells at bay

Recalibration of signalling factors to more youthful levels in the blood

Lifespan.io (LEAF) - 03-Sep-2019

Adjusting the levels of just two molecules in the blood could lead to significant rejuvenation

Senolytics - Getting rid of faulty cells in body

Guardian - 02-Sep-2019

Aims to prolong the healthspan as well as the lifespan

Nucleotides as a key element to cellular rejuvenation

Interesting Engineering - 28-Jul-2019

Removing senescent cells will make us vulnerable to cancer

Development of drugs that might eliminate ageing cells

ScienceDaily - 25-Jul-2019

Prevention of losing nucleotide synthesis ability would result in cells slowly ageing

Purging damaged brain stem cells can improve cognition in Alzheimer’s

National Institute on Aging - 23-May-2019

Promising results in genetically altered mice with Alzheimer’s traits

Dr. Campisi talks about improvements in senolytics and ageing research

Lifespan.io (LEAF) - 03-Apr-2019

Unlike cancer, you don't have to kill every senescent cell

Synthetic antibodies able to target senescent cells

University of Leicester - 06-Mar-2019

nanoMIPs could improve the specificity of senolytics

UNITY Biotechnology expands trial of osteoarthritis senolytic

UNITY Biotechnology - 22-Jan-2019

Initial results must be promising to enrol more patients at highest dosage

UNITY Biotechnologies Selects a New Senolytic Candidate

Lifespan.io (LEAF) - 14-Jan-2019

Very early days but good to have more senolytics in the pipeline

Senolytics for IPF human clinical trial results released

Lifespan.io (LEAF) - 07-Jan-2019

Physical improvements recorded, but pulmonary function was unchcanged

Senescent cells: short safety trial on humans successful

Science Daily - 07-Jan-2019

Next step is to go to an actual large-scale human trial

Fisetin destroys senescent cells, but safe dosage not determined yet

Lifespan.io (LEAF) - 26-Dec-2018

Includes table of fisetin content in range of fruits and vegetables

The path to an extended health span and a healthier death

MIT Technology Review - 23-Oct-2018

Still a long way to go before expanding life span

Fisetin's potential to become the first line senolytic pill

Josh Mitteldorf Blog - 23-Oct-2018

Mice fed with fisetin diets lived much longer

Natural product Fisetin slows aging in mice

ScienceDaily - 02-Oct-2018

Fisetin is a very common natural product that has positive effects over health and aging

Senolytics staves off dementia in mice

Guardian - 19-Sep-2018

Killing of senescent (aging) brain cells with an enzyme stopped the progress of dementia

Clearing out senescent cells may prevent symptoms of Alzheimer’s and Parkinson’s disease

Buck Institute - 19-Sep-2018

Alternative approaches to tau targets in neurodegenerative disorders

Scientists reversed ageing by inhibiting gene pathways

Drug Target Review - 14-Sep-2018

Findings could enhance the treatments to reverse dementia or destroy cancer cells

Molecule has anti-aging effects on vascular system

Medical Xpress - 10-Sep-2018

β-Hydroxybutyrate and OCT4 slow down vascular aging, preventing disease

Cellular aging halted by hydrogen sulfide gas

Medical News Today - 07-Aug-2018

3 compounds designed to deliver minute amounts of hydrogen to mitochondria inhibit cellular aging

FoxBio is developing small molecule drugs to target ageing diseases

Business Wire - 12-Jul-2018

Antoxerene partners with Juvenescence to discover drugs that clear senescent cells

Cleara Biotech Joins the Race to Develop Senolytic Therapies

Lifespan.io (LEAF) - 09-Jul-2018

This therapy uses a modified FOXO4 to promote apoptosis in senescent cells

Oral senolytics have big impact on old mice

Mayo Clinic - 09-Jul-2018

Senolytic cocktail caused improved physical condition of elderly mice

UNITY Treats First Patient with UBX0101

UNITY Biotechnology - 25-Jun-2018

The company is going to test a new Senolytic drug in human trials

Gene that triggers senescence identified

University at Buffalo - 22-Jun-2018

The gene for CD36 becomes more active in older cells and it may be key for the aging process

LEAF interviews Dr. Nichola Conlon

Lifespan.io (LEAF) - 03-May-2018

Look forward to seeing the results of the NAD supplement trial

Escape from senescence boosts tumour growth

Nature - 20-Dec-2017

Senescence is usually thought to be irreversible.

To stay young, kill zombie cells

Nature - 24-Oct-2017

Proof-of-concept trials starting that pit senolytic drugs against a range of age-related ailments.

The first senolytic drugs to target senescent cells

Mayo Clinic - 05-Sep-2017

New platform will help to identify additional drugs that target ageing processes more quickly

False Positives in Senescent Cell Detection

Lifespan.io (LEAF) - 19-Aug-2017

Researchers commonly determine the presence of senescent cells through the use of the p16ink4a (p16) and ?-galactosidase biomarkers.

Planning Your Own Trial of Senolytic Drugs

Fight Aging! - 22-May-2017

A guide for anyone considering self-experimentation.

Treating Osteoarthritis by Removing Senescent Cells

Lifespan.io (LEAF) - 03-May-2017

Researchers used local clearance of senescent cells (in mice) to reduce the development of post-traumatic osteoarthritis and encourage tissue regeneration.

Hallmark of Aging Reversed by Senescent Cell Removal

Lifespan.io (LEAF) - 25-Mar-2017

Study directly targets one of the mechanisms that senescent cells use to avoid apoptosis,

New protein discovered in aging and cancer

Medical Xpress - 07-Mar-2017

Study describes a new way that senescent cells communicate via the expression of integrin membrane proteins.

Science-Backed Therapy Targeting Senescent Cells May Be Future Anti-Aging Serum

Medical Daily - 11-Jan-2017

Growing older results in a build-up of the body’s senescent cells and naturally accumulate with age.

Anti-aging therapies targeting senescent cells: Facts and fiction

Cell - 29-Dec-2016

Peter de Keizer of the Erasmus University Medical Center discusses strategy of removing senescent cells.

A Look at Ascendance Biomedical, Packaging Medical Tourism for Longevity Therapies

Fight Aging! - 28-Dec-2016

It is focused on the twofold path of

Targeting Senescent Cells with Synthetic Biology

Lifespan.io (LEAF) - 09-Dec-2016

CellAge is going to develop synthetic promoters which are specific to senescent cells, as promoters that are currently being used to track senescent cells are simply not good enough to be used in therapies.