Senescence halts cell division but can promote inflammation, aiding cancer growth
Live Forever Club - 24-Nov-2024Therapies targeting senescence cells show promise for controlling cancer progression
Senescent Cells News Archive
Senescence fuels heart disease: new ways to tackle ageing cells
Live Forever Club - 09-Nov-2024Targeting senescent cells may prevent disease progression and show promise
Cellular senescence surprisingly supports meniscus repair in rats
Live Forever Club - 05-Nov-2024Early removal of these cells slows recovery, highlighting their short-term benefits
Air pollution, particularly PM2.5, accelerates ageing and increases disease risk
Live Forever Club - 26-Sep-2024You can protect yourself by wearing masks, using air purifiers, and avoiding polluted areas
Five Alarm Bio's small molecules fight ageing and improve longevity
Live Forever Club - 11-Sep-2024FAB1 compound reduces ageing markers in cells while FAB15 accelerates wound healing
Senolytic drugs show promise for bone health in postmenopausal women
Mayo Clinic - 02-Jul-2024But, senolytic therapy may not be a universal solution for age-related bone loss
Senescent cells, traditionally linked to ageing, surprisingly play vital roles in body
Science - 20-Jun-2024This could have implications for developing new therapies
New drug delivery system targets cells in the bodies that are linked to ageing
Live Forever Club - 13-Jun-2024This offers a safer, more effective treatment for age-related diseases
Keto diet accelerated organ aging in mice due to increased senescent cells
New Scientist - 17-May-2024Switching the mice back to a standard diet reduced the damage
Clearing senescent cells improves immediate immunity to influenza in aged mice
Live Forever Club - 14-May-2024It may hinder the development of long-lasting protection against future infections
Rubedo secures $40 million to advance its age-targeting treatments into clinical trials
Longevity Technology - 22-Apr-2024Potentially leading to breakthroughs in managing chronic diseases
Urine-derived stem cells release anti-ageing molecules that changed mice ageing
Live Forever Club - 31-Mar-2024The discovery reveals the body's potential for self-rejuvenation
SENISCA secures 3.7 million euros to fight aging with RNA-based therapies
Longevity Technology - 18-Mar-2024Developing senotherapeutics to target cellular senescence and treat age-related diseases
Senolytic drugs offered mixed clues about their potential impact on ageing
Fight Aging! - 04-Mar-2024While modifying immune cell populations, the drugs also increased ageing biomarkers
Researchers explore the potential of sound waves for anti-ageing
Lifespan.io (LEAF) - 09-Feb-2024Originally used to fight cancer, sound waves surprisingly revive old cells
Mice who sipped green tea all their lives lived longer and stayed healthier
Live Forever Club - 04-Feb-2024Green tea improved gut health and boosted the immune system in mice
T cells engineered to target and remove damaged cells in mice
Medical News Today - 31-Jan-2024The treated mice showed better health, including improved metabolism and activity
Having too much iron in your body can damage organs like lungs and kidneys
Live Forever Club - 28-Jan-2024This could impact how much iron we get from food or supplements
New immune cells can recognise and eliminate a specific protein on ageing cells
Live Forever Club - 25-Jan-2024In mice, this therapy was shown to reduce the number of senescent cells
A new method called FAST studies cellular ageing in cultured cells
Live Forever Club - 18-Jan-2024FAST is precise and works with different cell types and microscopes
Ageing eyes face a double whammy of senescent cells and weakened defenses
Live Forever Club - 19-Dec-2023Senolytic intervention helps to repair the protective barrier of the eyes
Fisetin in berries and apples could shield your heart in later years
Live Forever Club - 19-Dec-2023Supplementation reduced the buildup of senescent cells in the arteries of aged mice
Your daily choices, whether at the gym or in your meals, can redefine your age
Live Forever Club - 15-Dec-2023Cellular senescence can be significantly mitigated by a holistic lifestyle
Senescent cell weakness exploited by new anti-aging therapy
Singularity Hub - 07-Nov-2023FDA-approved drug kills zombie cells and improves organ function in elderly mice
Senolytics may rejuvenate heart cells and prevent age-related heart disease
Live Forever Club - 02-Nov-2023Drugs have the potential to revolutionise the way we treat age-related diseases
New peptide-based technology selectively erases ageing cells
Ulsan National Institute of Science and Technology (UNIST) - 14-Sep-2023Mitochondria targeting could lead to new treatments for age-related diseases
Phase I trial shows early promise in clearing senescent cells in Alzheimer's
Wake Forest Baptist Health - 07-Sep-2023The treatment was well-tolerated with no significant changes in brain function
Senolytics have gender-specific effects on ageing in young mice
Lifespan.io (LEAF) - 30-Aug-2023More research is needed to determine the safety and efficacy of senolytics in humans
AI identifies new senolytics that could treat age-related diseases
Lifespan.io (LEAF) - 09-Aug-2023Three natural compounds identified, paving the way for new treatments
Experimental vaccine promises to slow down or prevent Alzheimer's in mice
American Heart Association - 30-Jul-2023Vaccine not only reduced inflammation, but also improved behavior and awareness in mice
Tiny sea creature unlocks the secrets of healing and aging
Phys.org - 30-Jun-2023Insights on the evolution of ageing and may help advance regenerative medicine
AI unveils economical pathway to discover new senolytics to combat age-related diseases
The University of Edinburgh - 14-Jun-2023Artificial intelligence identifies herbal compounds to safely eliminate senescent cells
UNITY Biotech's lead compound lags behind the Regeneron’s eye drug
Biospace - 27-May-2023UBX1325 showed disappointing results in phase II macular degeneration trial - further analysis is required
AI-driven breakthrough in senolytic drug discovery
Lifespan.io (LEAF) - 04-May-2023Machine learning successfully identifies promising senolytic compounds to target ageing and age-related diseases
Unity Biotechnology's diabetic macular edema senolytic treatment shows promise at 48-week endpoint
FierceBiotech - 24-Apr-2023Corporate shift towards ophthalmology puts senolytics head-to-head against existing treatments
Endurance Exercise Training May Help Prevent Accumulation of Senescent Cells in Colon Mucosa
Live Forever Club - 20-Mar-2023Age-related increase in inflammatory markers p16 and IL-6 was not observed in endurance athletes
AKL Therapeutics’ investigational oral senotherapeutics drug APPA beneficial for osteoarthritis
Longevity Technology - 20-Mar-2023Senescent cells have become one of the most promising targets for healthy aging research
Rubedo's lead compound targets inflammatory skin disease with selective senolytic approach
Business Wire - 20-Mar-2023Rubedo is planning first-in-human studies in multiple skin indications driven by chronic inflammation
SRF Scientists have discovered the "Iron Fist" strategy to deal with senescent cells
SENS Research Foundation - 09-Mar-2023Scientists are working to bring these new rejuvenation biotechnologies of senolytics to aging humans
Reversal of cell senescence using low frequency ultrasound
Live Forever Club - 27-Jan-2023Novel therapy killed some senescent cells, rejuvenated others, without harming healthy cells
Cellular Senescence Network (SenNet) to identify and characterize senescent cells
Nature Aging - 20-Dec-2022Grand plan includes creation of imaging datasets, new tools, techniques, and biomarker panels
Targeting senescent cells could be a useful approach for slowing/treating Alzheimer’s disease
Salk Institute - 01-Dec-2022How senescent neurons lead to Alzheimer’s disease, effect on removal and drugs needed for therapy
Novel experiment explores a new way of reducing senescent cell burden
Live Forever Club - 12-Nov-2022BDNF-TrkB pathway shows a lot of promise in lowering senescent cells in older organs
Senolytics-a risky proposition in aging and repair mechanisms
Lifespan.io (LEAF) - 19-Oct-2022The study is a caution for scientists engaging in self-experimentation with senolytics
$2.5M seed financing round closed by Cleara Biotech-targets cellular senescence
Longevity Technology - 03-Oct-2022Cleara’s novel FOXO4-based treatment approach-ability to eliminate biomarker-positive scarred cells
Regenerative therapies and senolytics help to rejuvenate the heart’s capacity to regenerate
Longevity Technology - 17-Aug-2022Eliminating senescent cells rejuvenates the heart's capacity for regeneration in mice
Data from Phase 2 BEHOLD study of UBX1325 in DME patients-Unity Biotechnology
Ophthalmology Times - 12-Aug-2022Statistically significant treatment effect for both BCVA and CST was seen at both 12 and 18 weeks
New insight on the accumulation of senescent cells in humans
UPMC - 30-Jun-2022Oxidative DNA damage induce rapid senescence compared with shorter telomeres from repeated cell divisions
Exeter's company SENISCA raises £2 million to treat age-related chronic diseases
University of Exeter - 09-Jun-2022Funding might allow RNA-based rejuvenation tech to enter ex vivo lab tests
Senolytics may abate accelerated aging of cancer patients as seen in mice
Lifespan.io (LEAF) - 06-Jun-2022Radiation-induced damage may lessen by removing senescent cells but senolytics may not reverse the damage
New algorithm recognises senescent cells using physical morphology
Lifespan.io (LEAF) - 26-May-2022in vivo analysis in mice confirms the imaging results against p21 biomarker
Synergy of stem cell rejuvenation and senolytics promote longevity in fruit flies
Live Forever Club - 14-May-2022Combined approach surprisingly eliminated the negative effects of individual treatments
Benjamin Le Calvé as the new Chief Scientific Officer of Starkage Therapeutics
StarkAge Therapeutics - 10-May-2022Le Calvé will chair the Scientific Advisory Board and the Management Committee
Oral senolytics boosts geroprotective protein in mice and humans
Mayo Clinic - 15-Mar-2022Dasatinib+Quercetin restores a-klotho protein, which could combat ageing and disease in older people
SenoStem project to investigate whether prior delivery of senolytic improves stem cell treatment
SENS Research Foundation - 07-Feb-2022Both are leading first generation longevity treatments - even better if they strengthen each other
A natural cholesterol metabolite with senolytic effect in mice and humans
Buck Institute - 02-Feb-2022New class of senotherapeutic drugs that could possibly target various diseases and ageing
Dasatinib plus quercetin combination may help preserve cognitive abilities in elderly people
Lifespan.io (LEAF) - 27-Jan-2022Senolytics showed positive effects on rats but trials must confirm these findings on human brain
StarkAge receives 2 million euros to design safer senescence-targeted therapies
Longevity Technology - 19-Jan-2022Funding will ensure the development of a new immunotherapy for age-related diseases
Senolytics promotes wound healing in the aged but not in young mice
Lifespan.io (LEAF) - 22-Dec-2021Dasatinib plus quercetin slow down muscle regeneration in young mice
Anti-aging treatment: New vaccine by Japanese research can make this happen
Japan Times - 16-Dec-2021New research claims in removing zombie cells behind aging by vaccination
Procyanidin, a senotherapeutic compound from grape seed extends lifespan in mice
Lifespan.io (LEAF) - 14-Dec-2021Improved survival via eliminating old cells - potential candidate to slowdown ageing
SENISCA targets sensescence using a new ageing hallmark - dysregulated mRNA processing
Lifespan.io (LEAF) - 03-Nov-2021Lorna Harries believes dysregulated splicing as a breakthrough senotherapeutic target
University of Leicester proves feasibility of antibody based targeted senolytics
IFL Science - 28-Oct-2021New study results show clinical applications in pathological ageing
Senolytic drugs improved survival rates in coronavirus-infected mice
SENS Research Foundation - 07-Oct-2021Boosts immune response by clearing senescent cells; a potential treatment for COVID-19 in humans
Senolytic cocktail reduces age-related spinal disc degeneration in mice
Lifespan.io (LEAF) - 21-Sep-2021Dasatinib and quercetin combo preserves spinal discs to target age-related back pain
A single protein reversed senescence in skeletal muscle cells
University at Buffalo - 17-Sep-2021NANOG targets multiple ageing mechanisms - insights may help develop new therapies for age-related disorders
Hyperactivation of senescent cells can trigger cytokine storm
Lifespan.io (LEAF) - 13-Aug-2021Stimulated senescent human umbilical vein cells showed high susceptibility to inflammatory diseases
Longevity Technology interviews Aubrey de Grey about senolytics and other senotherapeutics
Longevity Technology - 05-Aug-2021Most approaches have their limitations but good progress is being made on several fronts
Clearing out aged cells with senolytics can relieve jaw pain
University of Connecticut (UConn) - 07-Jul-2021Senolytics for cartilage and bone regeneration in jaw joints, proven effective in mice
Pro-repair microenvironment after injury is favored by targeting senescent cells
News Medical - 06-Jul-2021Senolytic drugs administration promotes locomotor and sensory recovery
Unity's senolytic drug reports positive phase 1 data in eye disease patients
FierceBiotech - 06-Jul-2021Begun phase 2 trial including patients with early stage of disease to test its safety and effectiveness
A 12-week strength-endurance training lowered senescence proteins in older people
Lifespan.io (LEAF) - 14-Jun-2021New study using biomarkers proved the importance of regular exercise again
Oisín raised $9.5M to advance senolytic therapies for kidney & age-related diseases
Longevity Technology - 28-May-2021Investigational therapy on old mice cleared senescent cells up to 70%, extending life by 20%
Natural compound may help treat intervertebral disc degeneration
Lifespan.io (LEAF) - 12-May-2021DHE slowed senescence in intervertebral discs of mice; but its use in anti-aging is still questionable
New immunotherapy clears out senescent cells to combat aging
Medical Xpress - 10-May-2021Activated immune cells can treat age-related chronic diseases - a potential alternative to senolytics
Low magnitude vibration to prevent/delay age-related bone loss in rats
Lifespan.io (LEAF) - 05-May-2021Vibration treatment eliminates senescence of bone cells - may not be applicable to other tissues
Raising awareness on senolytic drugs as a promising anti-ageing medicine
Longevity Technology - 30-Apr-2021Senolytic Therapy Network aims to take the senotherapeutics from lab to clinic
SenNet: a new NIH initiative to fight ageing
Lifespan.io (LEAF) - 06-Apr-2021Establishing a massive database on cellular senescence to improve human health
First ever non-invasive biomarker test to detect senolysis
Buck Institute - 02-Apr-2021Detectible senescence-specific biomarker allows development of new drugs for age-related conditions
Life Extension supplement to clear out senescent cells
GlobeNewswire - 23-Mar-2021New plant-based longevity pill that offers better access to many health benefits
Tackling multiple dysfunctions together can stop ageing signs
Lifespan.io (LEAF) - 12-Feb-2021NAD+ levels, senescence and chronic inflammation collectively influence ageing
Oisín Biotechnologies' gene therapy may be available in the next 5 years
Longevity Technology - 22-Jan-2021Results in mice suggest that it can increase median lifespan in humans by 15 years
Whole-body senescent cell removal improved brain health in mice
Lifespan.io (LEAF) - 22-Jan-2021Senolytic drug and cancer drug with quercetin improved age-related cognition
Rubedo to first work on lung diseases
Longevity Technology - 20-Jan-2021Their work will be critical amidst the COVID-19 pandemic - to move into clinical trials soon
Medical agent removes senescent cells to fix aging-related diseases
Japan Times - 16-Jan-2021With positive results in mice, scientists expect to slow down ageing in humans
LMC provides background and success outlook on 14 leading senolytic companies
Longevity Marketcap - 15-Dec-2020Comprehensive review of companies' clinical and financial state of play
Reversing heart damage with zombie cell-killing drug
British Heart Foundation (BHF) - 14-Dec-2020Senescence killing drug in mice might unveil new heart attack treatments
A new enzyme discovered to reverse cellular ageing
Phys.org - 30-Nov-2020Molecular simulations have discovered an enzyme with anti ageing and anti tumour effects
Targeting senescence might help fight cancers
Longevity Technology - 24-Nov-2020Senolytics to treat cancers - study finds correlation between senescence & survival
Oxygen therapy reversed the human age biologically
YAHOO! - 18-Nov-2020Not as easy as taking a pill, but a stunning result on both telomeres and senescent cells
Nature Biotechnology reviews the state of play of senolytics
Nature Biotechnology - 12-Nov-2020In August, Unity announced that its lead drug candidate had failed to beat a placebo in reducing joint pain and stiffness.
Reason reviews the research behind One Skin's senotherapeutic skin-care spray
Fight Aging! - 06-Nov-2020The anti-ageing peptide promotes skin health and reduces senescent cell markers
Say goodbye to fine lines and wrinkles with OneSkin
Longevity Technology - 21-Oct-2020Topical supplement which extends skin span-the period of time your skin is healthy and youthful
Pharma company teams with AI to develop anti aging solutions
Longevity Technology - 15-Oct-2020Taisho and Insilico collabs to identify novel targets for senolytic drugs
Unity Biotechnology launches clinical trial of a new senolytic
Lifespan.io (LEAF) - 13-Oct-2020A new approach to treat diabetic macular oedema
Flavonoid found in redcurrants reduces senescence in brain cells
Lifespan.io (LEAF) - 28-Sep-2020Mice study also saw improved cognitive abilities
Labiotech gathers feedback from European biotechs on Unity failure
Labiotech - 28-Aug-2020General feeling that failures are bound to happen - but that their approaches can succeed
New research with senolytics shows promising results
Longevity Technology - 25-Aug-2020Senolytic research is in its nascent stage but no reason why one shouldn't be hopeful
Reason examines the failure of Unity Biotechnology's phase 2 senolytics trial
Fight Aging! - 18-Aug-2020Disappointing first result - but lessons learnt and plenty of other strategies available
Exercise reduces inflammation caused by SASP but not the number of senescent cells
Fight Aging! - 31-Jul-2020Given senolytics are unlikely to ever clear every senescent cell, exercise will still minimise bad effects of those remaining
Taking the new path in the field of senolytics - SENISCA
Longevity Technology - 29-Jul-2020Old cells will be more young and beautiful
Longevity.Technology interviews Prof Faragher about his cellular senescence research
Longevity Technology - 15-Jul-2020Maybe we need to develop senoplasts like resveratrol as well as senolytics
LEAF interviews Alexander Fedintsev about weak v strong ECM hypothesis
Lifespan.io (LEAF) - 15-Jul-2020It may be a new hallmark of ageing, but it's been one of SENS' 7 strategies since it started
Senescent cell inflammatory signals as a new possible biomarker
Lifespan.io (LEAF) - 29-Jun-2020It could measure biological age and relative health
Immunotherapy as new approach to battle senescent cells
Lifespan.io (LEAF) - 23-Jun-2020Successful in mice, it may help treat many age-related disease in human
Harmful effects of senolytic drug Navitoclax in aged mice
Fight Aging! - 19-Jun-2020Short-term treatment of this drug demonstrated cytotoxicity among other risks
Genetically engineered T cells can be used to target and kill senescent cells
Medical Xpress - 17-Jun-2020Tested successfully in mice with liver fibrosis and lung cancer
Antiageing antibiotic targets senescent human fibroblasts
Health Europa - 10-Jun-2020Could lead to new drug discovery against senescent cells and extend lifespan
Could a vaccine be an alternative to senolytic drugs?
Lifespan.io (LEAF) - 29-May-2020New study in mice demonstrates an intriguing possibility with senescent cells research
Forever Healthy Foundation structured review of published senolytics research
Forever Healthy Foundation - 28-May-2020Little evidence of actual beneficial effects (rather than just biomarkers) so not recommended yet
A new novel senolytic agent, R406, discovered
Lifespan.io (LEAF) - 22-May-2020Intriguingly destroys senescent cells without inducing cell destruction
Prodrug reduces inflammation, restores physical function in aged mice
Lifespan.io (LEAF) - 12-May-2020Experiments yielded promising results in efficacy, specificity, and non-toxicity
Addressing treatment-related ageing in cancer with senolytics
Fight Aging! - 11-May-2020Hopes are up for it to directly help the cancer research community and patients
Refining certain drugs to be less toxic and to amplify their senolytic potential
Lifespan.io (LEAF) - 24-Apr-2020Tested in aged mice and turns out that it can rejuvenate tissue stem cells
Major mouse senolytics testing experiment is go!
Lifespan.io (LEAF) - 13-Apr-2020We'll almost certainly need a combination of drugs so look forward to seeing the results
Navitoclax improved, now a safer senolytic drug choice
Fight Aging! - 09-Apr-2020They found efficient way to increase its senolytic specificity, reduce platelet toxicity
Senolytics may have the potential to treat asthma
Lifespan.io (LEAF) - 07-Apr-2020Will senolytics become the panacea to the whole Pandora's box by 100 years into future?
Positive feedback look identified with ATM via NF-κB pathway back to cellular senescence
Lifespan.io (LEAF) - 02-Apr-2020As always, it's complicated, but controlling levels of ATM could be part of a therapy to combat ageing
Review on the relationship between senescence and bone marrow cancer
Lifespan.io (LEAF) - 23-Mar-2020How senescence can fuel cancer development and how malignant cells induce senescence
Senescent marker levels in different tissues among different age groups
Lifespan.io (LEAF) - 19-Mar-2020We need to recognize normal patterns in order to identify what's abnormal
Comprehensive history and explanation of senescent cells
The Scientist - 01-Mar-2020Including the latest on clinical trials of first-generation senolytics
Mitochondria plays a major role in cellular ageing
Medical Xpress - 20-Feb-2020HDAC inhibitor shows beneficial effects in mice but too toxic for healthy humans
How mitochondria drives senescence, affecting healthy ageing
EurekAlert! - 20-Feb-2020Potential target for drug-based interventions to delay cellular ageing identified
Can senolytics improve heart disease and repair damaged heart cells?
European Pharmaceutical Manufacturer - 18-Feb-2020Senescent cells seem to play a major role even in heart diseases
LEAF interviews Lewis Gruber about targeting cancer and senescent cells
Lifespan.io (LEAF) - 11-Feb-2020Biomarker caused by glycolysis seen in all types of cancer - exciting possibilities
Ageing in mice - the systemic burden of senescent cells matters
Fight Aging! - 06-Feb-2020Senescent cell burden is a marker of disease free years ahead of life
Underlying mechanisms of how cellular senescence leads to neurodegeneration
Buck Institute - 29-Jan-2020Cellular senescence is now a top research topic and a very messy one in ageing research
SASP Atlas created by team of researchers
Lifespan.io (LEAF) - 28-Jan-2020It is a comprehensive proteomic database of soluble proteins and exosomal cargo SASP factors
Berberine: the new entity that slowed down ageing in mice
Fight Aging! - 26-Dec-2019Just like rapamycin, berberine also slows down the senescent process
Scientists discover a master regulator of cellular senescence
Medical News Today - 19-Dec-2019Solving the mystery of ageing - still at the beginning
Dr. Michael Fossel interviewed by LEAF
Lifespan.io (LEAF) - 18-Nov-2019Fossel argues for telomerase therapy over senolytics
Blind mole rats can prevent age-related chronic inflammation
Fight Aging! - 01-Nov-2019They have a natural mechanism against cellular senescence and ageing
Senescent cells show cellular cannibalism in mouse and human cancer cells
Nature - 28-Oct-2019They're often called zombie cells - and turns out they are. Time to kill them with senolytics!
OncoSenX targets solid tumours with senolytics
Lifespan.io (LEAF) - 22-Oct-2019Phase 1 clinical trial starting early 2020
Cardiac glycosides may play a role as broad spectrum senolytics
Medical Research Council London Institute of Medical Sciences - 21-Oct-2019Is it really possible to develop a drug without side effects?
Heart drugs found to be anti-cancer
Medical Research Council London Institute of Medical Sciences - 21-Oct-2019Many drugs for heart diseases are broad-spectrum senolytics as tested in mice
Is senescent cell clearance a zero sum game?
SENS Research Foundation - 06-Oct-2019Research suggests senolytic treatments will be beneficial for at least a few decades
Ageing and cancer linked by a complex relationship
Medical News Today - 04-Oct-2019Does this mean that future therapies to slow down ageing may cause cancers as a side effect?
Senescent cells amplify blood clotting - now protein targets identified
Buck Institute - 24-Sep-2019Could help tackle venous thrombosis that becomes a bigger risk with age
Senolytics and their impact on anti-ageing
Technology Networks - 19-Sep-2019Once more confirmed, senolytics reduce senescent cells by that preventing their effect of ageing
Small Mayo Clinic trial successfully removes senescent cells from humans
Mayo Clinic - 18-Sep-2019Occasional senolytic use may be enough to keep senescent cells at bay
Recalibration of signalling factors to more youthful levels in the blood
Lifespan.io (LEAF) - 03-Sep-2019Adjusting the levels of just two molecules in the blood could lead to significant rejuvenation
Senolytics - Getting rid of faulty cells in body
Guardian - 02-Sep-2019Aims to prolong the healthspan as well as the lifespan
Nucleotides as a key element to cellular rejuvenation
Interesting Engineering - 28-Jul-2019Removing senescent cells will make us vulnerable to cancer
Development of drugs that might eliminate ageing cells
ScienceDaily - 25-Jul-2019Prevention of losing nucleotide synthesis ability would result in cells slowly ageing
Purging damaged brain stem cells can improve cognition in Alzheimer’s
National Institute on Aging - 23-May-2019Promising results in genetically altered mice with Alzheimer’s traits
Dr. Campisi talks about improvements in senolytics and ageing research
Lifespan.io (LEAF) - 03-Apr-2019Unlike cancer, you don't have to kill every senescent cell
Synthetic antibodies able to target senescent cells
University of Leicester - 06-Mar-2019nanoMIPs could improve the specificity of senolytics
UNITY Biotechnology expands trial of osteoarthritis senolytic
UNITY Biotechnology - 22-Jan-2019Initial results must be promising to enrol more patients at highest dosage
UNITY Biotechnologies Selects a New Senolytic Candidate
Lifespan.io (LEAF) - 14-Jan-2019Very early days but good to have more senolytics in the pipeline
Senolytics for IPF human clinical trial results released
Lifespan.io (LEAF) - 07-Jan-2019Physical improvements recorded, but pulmonary function was unchcanged
Senescent cells: short safety trial on humans successful
Science Daily - 07-Jan-2019Next step is to go to an actual large-scale human trial
Fisetin destroys senescent cells, but safe dosage not determined yet
Lifespan.io (LEAF) - 26-Dec-2018Includes table of fisetin content in range of fruits and vegetables
The path to an extended health span and a healthier death
MIT Technology Review - 23-Oct-2018Still a long way to go before expanding life span
Fisetin's potential to become the first line senolytic pill
Josh Mitteldorf Blog - 23-Oct-2018Mice fed with fisetin diets lived much longer
Natural product Fisetin slows aging in mice
ScienceDaily - 02-Oct-2018Fisetin is a very common natural product that has positive effects over health and aging
Senolytics staves off dementia in mice
Guardian - 19-Sep-2018Killing of senescent (aging) brain cells with an enzyme stopped the progress of dementia
Clearing out senescent cells may prevent symptoms of Alzheimer’s and Parkinson’s disease
Buck Institute - 19-Sep-2018Alternative approaches to tau targets in neurodegenerative disorders
Scientists reversed ageing by inhibiting gene pathways
Drug Target Review - 14-Sep-2018Findings could enhance the treatments to reverse dementia or destroy cancer cells
Molecule has anti-aging effects on vascular system
Medical Xpress - 10-Sep-2018β-Hydroxybutyrate and OCT4 slow down vascular aging, preventing disease
Cellular aging halted by hydrogen sulfide gas
Medical News Today - 07-Aug-20183 compounds designed to deliver minute amounts of hydrogen to mitochondria inhibit cellular aging
FoxBio is developing small molecule drugs to target ageing diseases
Business Wire - 12-Jul-2018Antoxerene partners with Juvenescence to discover drugs that clear senescent cells
Cleara Biotech Joins the Race to Develop Senolytic Therapies
Lifespan.io (LEAF) - 09-Jul-2018This therapy uses a modified FOXO4 to promote apoptosis in senescent cells
Oral senolytics have big impact on old mice
Mayo Clinic - 09-Jul-2018Senolytic cocktail caused improved physical condition of elderly mice
UNITY Treats First Patient with UBX0101
UNITY Biotechnology - 25-Jun-2018The company is going to test a new Senolytic drug in human trials
Gene that triggers senescence identified
University at Buffalo - 22-Jun-2018The gene for CD36 becomes more active in older cells and it may be key for the aging process
LEAF interviews Dr. Nichola Conlon
Lifespan.io (LEAF) - 03-May-2018Look forward to seeing the results of the NAD supplement trial
Escape from senescence boosts tumour growth
Nature - 20-Dec-2017Senescence is usually thought to be irreversible.
To stay young, kill zombie cells
Nature - 24-Oct-2017Proof-of-concept trials starting that pit senolytic drugs against a range of age-related ailments.
The first senolytic drugs to target senescent cells
Mayo Clinic - 05-Sep-2017New platform will help to identify additional drugs that target ageing processes more quickly
False Positives in Senescent Cell Detection
Lifespan.io (LEAF) - 19-Aug-2017Researchers commonly determine the presence of senescent cells through the use of the p16ink4a (p16) and ?-galactosidase biomarkers.
Planning Your Own Trial of Senolytic Drugs
Fight Aging! - 22-May-2017A guide for anyone considering self-experimentation.
Treating Osteoarthritis by Removing Senescent Cells
Lifespan.io (LEAF) - 03-May-2017Researchers used local clearance of senescent cells (in mice) to reduce the development of post-traumatic osteoarthritis and encourage tissue regeneration.
Hallmark of Aging Reversed by Senescent Cell Removal
Lifespan.io (LEAF) - 25-Mar-2017Study directly targets one of the mechanisms that senescent cells use to avoid apoptosis,
New protein discovered in aging and cancer
Medical Xpress - 07-Mar-2017Study describes a new way that senescent cells communicate via the expression of integrin membrane proteins.
Science-Backed Therapy Targeting Senescent Cells May Be Future Anti-Aging Serum
Medical Daily - 11-Jan-2017Growing older results in a build-up of the body’s senescent cells and naturally accumulate with age.
Anti-aging therapies targeting senescent cells: Facts and fiction
Cell - 29-Dec-2016Peter de Keizer of the Erasmus University Medical Center discusses strategy of removing senescent cells.
A Look at Ascendance Biomedical, Packaging Medical Tourism for Longevity Therapies
Fight Aging! - 28-Dec-2016It is focused on the twofold path of
Targeting Senescent Cells with Synthetic Biology
Lifespan.io (LEAF) - 09-Dec-2016CellAge is going to develop synthetic promoters which are specific to senescent cells, as promoters that are currently being used to track senescent cells are simply not good enough to be used in therapies.
This start-up believes it can slow the aging process
Washington Post - 28-Oct-2016Unity Biotechnology’s technology jump starts senescent cells into dividing again.
Clearing the Body’s Retired Cells Slows Aging and Extends Life
The Atlantic - 03-Feb-2016Cells accumulate damage in their DNA.
Secret to old age health could lie in purging worn-out cells
New Scientist - 16-Sep-2015Cells eventually stop dividing to replace damaged neighbours and to into senescence.
Senolytics, A New Class Of Drugs, Slows Aging Process
Medical Daily - 11-Mar-2015Senolytics, a new class of drugs, might dramatically slow the aging process and so change the face of old age.
