Lifespan.io speaks to Cyclarity’s CEO for an update on its novel atherosclerosis treatment
Lifespan.io (LEAF) - 19-Feb-2024The company is developing a drug called UDP-003 to treat the disease
Steve Hill
Editor in Chief and Director of the board at LEAF
Since late 2016 I have been a Director of the board at the Life extension advocacy foundation, a New York Based 501(c)(3) organization which fundraises for research, provides educational materials about biology, covers biotech news, and organizes conferences and events in support of biotechnology focused on ending the diseases of aging.
As part of my duties I am responsible for content creation and managing social media for our organization. To date I have written over 300 scientific articles covering a range of topics within aging research and scientific advocacy, and I manage a small team of writers producing regular content for our news website.
See also: 
Lifespan.io (LEAF)
- Supporting the development of biotechnologies focused on ending age-related diseases
Details last updated 08-Feb-2019
Articles written by Steve Hill
Senolytics-a risky proposition in aging and repair mechanisms
Lifespan.io (LEAF) - 19-Oct-2022The study is a caution for scientists engaging in self-experimentation with senolytics
BioNTech begins human trials for mRNA therapy targeting colon cancer and melanoma
Lifespan.io (LEAF) - 10-Sep-2021mRNA cocktail treatment shows anti-tumor effect without toxic side effects in mice
mTOR inhibitors reversed immune ageing to treat viral infections in older adults
Lifespan.io (LEAF) - 21-May-2021Much needed approach to improve immune function during the COVID pandemic
Lifespan.io crowd-funds clinical trial to determine the effects of Rapamycin
Lifespan.io (LEAF) - 17-May-2021PEARL: Participatory Evaluation of Aging with Rapamycin for Longevity
NMNH is a newer, faster and better NAD+ precursor
Lifespan.io (LEAF) - 19-Mar-2021Surpasses other existing precursors with an independent pathway to enter cells
Glucosamine, a supplement to prevent overall and cause-specific deaths
Lifespan.io (LEAF) - 28-Feb-2021Human and animal research supports longevity benefits of glucosamine and chondroitin supplements
NAD+ reduces age-related amyloidosis and mitochondrial dysfunction
Lifespan.io (LEAF) - 05-Feb-2021Boosting NAD+ levels improves health span and can treat age-related diseases
Whole-body senescent cell removal improved brain health in mice
Lifespan.io (LEAF) - 22-Jan-2021Senolytic drug and cancer drug with quercetin improved age-related cognition
Human trial results of resveratrol may benefit heart health
Lifespan.io (LEAF) - 30-Nov-2020Daily supplementation with resveratrol proved to improve heart function
Dilution of old blood restores healthy brain function
Lifespan.io (LEAF) - 17-Nov-2020Reduces neuroinflammation & promotes neurogenesis in aged brains of mice
Unity Biotechnology launches clinical trial of a new senolytic
Lifespan.io (LEAF) - 13-Oct-2020A new approach to treat diabetic macular oedema
Flavonoid found in redcurrants reduces senescence in brain cells
Lifespan.io (LEAF) - 28-Sep-2020Mice study also saw improved cognitive abilities
Everything you ever wanted to know about AKG (but were afraid to ask)
Lifespan.io (LEAF) - 07-Sep-2020A great summary of the history,biochemistry and life-extending potential of alpha-ketoglutarate
90 % of herpes simplex virus 1 eliminated in infected cells
Lifespan.io (LEAF) - 19-Aug-2020Successful in mice, new approach may ease immune burden of herpes in humans in the future
A step closer to reversing pulmonary fibrosis via telomerase gene therapy
Lifespan.io (LEAF) - 12-Aug-2020Study in mice revealed great progress and potential for curing fibrotic diseases in humans
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Benefits of caloric restriction in intestinal stem cells
Lifespan.io (LEAF) - 05-Aug-2020One should still consume adequate nutrition while reducing calorie intake
15% reduction in 10 year all-cause mortality with glucosamine supplementation
Lifespan.io (LEAF) - 31-Jul-2020Based on almost half a million people this is a large prospective cohort study
Researchers grow gut organoids to identify protein critical for repair
Lifespan.io (LEAF) - 27-Jul-2020NRG1 treatment boosted activity of gut stem cells - could help protect gut during chemotherapy
Scientists go where no gene-editing tool has gone before
Lifespan.io (LEAF) - 14-Jul-2020DddA able to target mitochondrial DNA (mtDNA) by splitting in half and hitching a ride
Blood factor created by exercise can be transfused to sedentary mice for same mental benefits
Lifespan.io (LEAF) - 13-Jul-2020Another point for the "good" factors argument, though removing "bad" factors likely to be important too
Red meat may increase heart disease risk
Lifespan.io (LEAF) - 10-Jul-2020Particularly, its metabolic byproduct affects vascular ageing as studied in mice and humans
Transplanting youthful white blood cells reduces inflammation in mice
Lifespan.io (LEAF) - 08-Jul-2020Targeting immunosenescence could provide benefits throughout the body
How LDL cholesterol enter our cells elucidated
Lifespan.io (LEAF) - 02-Jul-2020Two proteins serve as the doorway, becoming new potential targets for drug discovery
Trial of Rejuvant supplement claims 8 year age reversal
Lifespan.io (LEAF) - 30-Jun-2020If randomised clinical trial replicates results then I might add it to my stack
Senescent cell inflammatory signals as a new possible biomarker
Lifespan.io (LEAF) - 29-Jun-2020It could measure biological age and relative health
Two drug molecules delivered via nanoparticles to combat atherosclerosis
Lifespan.io (LEAF) - 26-Jun-2020Success in mice model gives hope for fighting cholesterol-associated inflammatory diseases
Immunotherapy as new approach to battle senescent cells
Lifespan.io (LEAF) - 23-Jun-2020Successful in mice, it may help treat many age-related disease in human
Is it possible to predict biological age with gut microbiome?
Lifespan.io (LEAF) - 19-Jun-2020Models and anti-ageing intervention design enables new ageing clock development
LEAF interviews the Conboys about rejuvenating mice by diluting blood plasma
Lifespan.io (LEAF) - 16-Jun-2020This could be a cheap first generation rejuvenation treatment - but wait for clinical trials
Niacin inhibits brain tumor growth in mice
Lifespan.io (LEAF) - 10-Jun-2020A promising anti-cancer immunotherapy approach, and alternative to traditional drugs
Human trial proves niacin to be an effective NAD+ booster
Lifespan.io (LEAF) - 08-Jun-2020Also a cheaper treatment for mitochondrial myopathy than NR and NMN supplements
Could a vaccine be an alternative to senolytic drugs?
Lifespan.io (LEAF) - 29-May-2020New study in mice demonstrates an intriguing possibility with senescent cells research
The role of NAD+ in resisting age-related circadian rhythm disturbance
Lifespan.io (LEAF) - 25-May-2020Study in mice shows link between the two, could help improve sleep quality in humans
A new novel senolytic agent, R406, discovered
Lifespan.io (LEAF) - 22-May-2020Intriguingly destroys senescent cells without inducing cell destruction
Age-related changes in gut microbiota cause cognitive decline in aged rats
Lifespan.io (LEAF) - 20-May-2020Restoring microbiome could be one strategy to support healthy longevity
Orion College ageing research receives 1 million UK pounds from Jim Mellon
Lifespan.io (LEAF) - 18-May-2020He believes in the importance of boosting immunoresilience among elderly
NAD+ more than doubled after 10 weeks of resistance training
Lifespan.io (LEAF) - 13-May-2020Not yet too late to reap the benefits of exercise as seen in middle-aged individuals
Should WHO use a new framework for the diagnosis and treatment of age-related diseases?
Lifespan.io (LEAF) - 08-May-2020LEAF summarises and exchange of thoughts between leading aging researchers
LEAF interviews Dr. Ole Mensching about Apollo Health Ventures' Moonshot Venture
Lifespan.io (LEAF) - 06-May-2020VCs are starting to recognise ageing as a problem with a massive business opportunity
Telomerase activity restored in vitro and in mice
Lifespan.io (LEAF) - 27-Apr-2020Potential to support new therapies for dyskeratosis congenita, other age-related diseases
Refining certain drugs to be less toxic and to amplify their senolytic potential
Lifespan.io (LEAF) - 24-Apr-2020Tested in aged mice and turns out that it can rejuvenate tissue stem cells
How external factors could influence Alzheimer’s disease via the gut microbiome
Lifespan.io (LEAF) - 20-Apr-2020Early study into complex neurochemical relationship between brain, gut and inflammaging
Inhibiting p38 MAPK rejuvenates resolution response in elderly
Lifespan.io (LEAF) - 15-Apr-2020A new perspective on mitigating the effects of inflammaging, promoting health in older people
The importance of early life microbiome in gut protection
Lifespan.io (LEAF) - 10-Apr-2020Demonstrated in neonatal mice microbiome mediating an immune response
Dawn til dusk fasting improves blood biomarkers
Lifespan.io (LEAF) - 08-Apr-2020Small study (14 participants) with strict participation requirements, but interesting biomarker results
Senolytics may have the potential to treat asthma
Lifespan.io (LEAF) - 07-Apr-2020Will senolytics become the panacea to the whole Pandora's box by 100 years into future?
Gut enzyme prevents age-related loss of intestinal barrier integrity
Lifespan.io (LEAF) - 03-Apr-2020In animal models, IAP is found to prevent frailty and extend lifespan
CRISPR-Cas9 variants, key to overcoming major limitation in gene editing system
Lifespan.io (LEAF) - 31-Mar-2020Entire genome now targetable, open to interventions for use in combating diseases
Gut microbiota highly influenced by ageing and dietary fat intake
Lifespan.io (LEAF) - 30-Mar-2020Several short-term responses and alterations are evident in a mice study
Mitochondrial transplants are successful but benefits are short lived
Lifespan.io (LEAF) - 25-Mar-2020May be a solution to ageing related mitochondrial dysfunction which leads to diseases
Yamanaka factors plus 2 more resets cells age without destroying their identity
Lifespan.io (LEAF) - 24-Mar-2020Stanford University researchers spin out Turn Biotechnologies to develop therapies using OSKMLN
Review on the relationship between senescence and bone marrow cancer
Lifespan.io (LEAF) - 23-Mar-2020How senescence can fuel cancer development and how malignant cells induce senescence
Healthy old-people's poo improves gut microbiome of mice
Lifespan.io (LEAF) - 20-Mar-2020Healthy gut means healthy body. Thought there are alternative ways of increasing probiotic bacteria!
Metastudy reviews impact of mitochondrial aging on cardiovascular disease
Lifespan.io (LEAF) - 18-Mar-2020Still lots to discover, but SENS already looking at ways to stop it in its tracks
Diabetic retinopathy in mice, reversed by primitive stem cells
Lifespan.io (LEAF) - 17-Mar-2020This arrival of a more efficient stem cell type has high impact for regenerative medicine
Research demonstrates how visceral fat impairs cognitive ability
Lifespan.io (LEAF) - 10-Mar-2020More reasons to avoid excessive weight gain and other drivers of ageing as proven in mice
Cell therapy, possible gamechanger in diabetes treatment
Lifespan.io (LEAF) - 04-Mar-2020A success in mice trial, now to move forward to larger animals then human clinical trials
NMN restores neurovascular health, improves cerebral blood flow in ageing
Lifespan.io (LEAF) - 17-Feb-2020Mitochondria-targeted interventions in old mice could be key to age-related diseases.
LEAF interviews Lewis Gruber about targeting cancer and senescent cells
Lifespan.io (LEAF) - 11-Feb-2020Biomarker caused by glycolysis seen in all types of cancer - exciting possibilities
SASP Atlas created by team of researchers
Lifespan.io (LEAF) - 28-Jan-2020It is a comprehensive proteomic database of soluble proteins and exosomal cargo SASP factors
New discovery showed mitochondria found living in the blood
Lifespan.io (LEAF) - 27-Jan-2020Mitochondria living in the blood definitely has some functions, further research needed to discover
David Sinclair Ask Me Anything - best bits
Lifespan.io (LEAF) - 22-Jan-2020Always interesting to hear what Dr Sinclair has to say
4 categories of ageing identified: metabolic, liver, kidney, immune system
Lifespan.io (LEAF) - 14-Jan-2020Knowing which ageotype you are could help focus your efforts on where you're ageing most
Navigation using mental mind maps rejuvenated in old mice
Lifespan.io (LEAF) - 13-Jan-2020Researchers able to teach old mice new tricks ;)
Rapamycin causes mTOR inhibition having an impact on mammalian aging- Brian Kennedy
Lifespan.io (LEAF) - 04-Dec-2019mTOR pathway, part of the deregulated nutrient sensing hallmark of aging
Nicotinamide mononucleotide is safe for human use
Lifespan.io (LEAF) - 12-Nov-2019A Japanese study establishes safety of NMN despite previous results in animal studies
A protein that plays a key role in the making of cholesterol plaques: TRB1
Lifespan.io (LEAF) - 11-Nov-2019Still at an early stage in research - working on mouse models
High levels of glucuronic acid is a biomarker of ageing
Lifespan.io (LEAF) - 07-Oct-2019Glucuronic acid levels in the blood can be correlated with a lifespan, healthspan in humans and mice
LEAF interviews AgeX Therapeutics CEO Dr. Michael West
Lifespan.io (LEAF) - 30-Sep-2019May only be a few years away from implementing induced tissue regeneration in humans
3D grown exosomes shown to reduce signs of skin ageing
Lifespan.io (LEAF) - 25-Sep-2019Could be mass produced and applied as a cream without need for needles
LEAF interviews David Sinclair about NMN trials and epigenetics
Lifespan.io (LEAF) - 10-Sep-2019He's optimistic that human trials will convert the majority of people who are skeptical or unaware
Recalibration of signalling factors to more youthful levels in the blood
Lifespan.io (LEAF) - 03-Sep-2019Adjusting the levels of just two molecules in the blood could lead to significant rejuvenation
Skin regeneration in mice - 2 different methods but same pathway
Lifespan.io (LEAF) - 18-Jul-2019Retinoic acid could be a key ingredient in elixir of youth
Stem cell reactivation can improve tissue regeneration
Lifespan.io (LEAF) - 16-Jul-2019Just one pathway out of many that could improve tissue rejuvenation
Tissue engineered thymus organoids could replace thymic function
Lifespan.io (LEAF) - 05-Jun-2019And they can be located anywhere in the body
Telomerase therapy for neurodegeneration
Lifespan.io (LEAF) - 04-Jun-2019Telomerase gene therapy may be a potential solution for age-related neurodegenerative diseases
resTORbio Agrees Phase 3 Human Trials with FDA
Lifespan.io (LEAF) - 19-Mar-2019If successful, drug could be available in next few years
IMM-AGE measures biological age of the immune system
Lifespan.io (LEAF) - 15-Mar-2019Immunosenescence is a known factor in longevity
Samsara secures more funding for cellular rejuvenation drug research
Lifespan.io (LEAF) - 06-Mar-2019Drugs will need to work better than the free alternative - calorie restriction
Universal stem cells avoid immune reaction in mice
Lifespan.io (LEAF) - 26-Feb-2019Could lead to off-the-shelf stem cell therapies
LEAF interviews Ichor Therapeutics CEO
Lifespan.io (LEAF) - 12-Feb-2019$16m raided, FoxBio partnership with Juvenescence, lots going on
LEAF report from the Longevity Leaders Conference
Lifespan.io (LEAF) - 06-Feb-2019Encouraging signs from big companies - more interviews to follow
GrimAge can calculate the time you have left to live
Lifespan.io (LEAF) - 31-Jan-2019Will enable faster analysis of anti-aging treatments
Mini-thymus used to produce and train T cells
Lifespan.io (LEAF) - 21-Jan-2019Able to regenerate ageing immune system, and reduce cost of immunotherapy
Cells of living mice rejuvenated using OSKM trigger in drinking water
Lifespan.io (LEAF) - 17-Jan-2019More support for the SENS approach of regular maintenance to stop ageing
Gut microbiome predicts age with 4 year accuracy
Lifespan.io (LEAF) - 15-Jan-2019It both affects and is affected by its host status
Senolytics for IPF human clinical trial results released
Lifespan.io (LEAF) - 07-Jan-2019Physical improvements recorded, but pulmonary function was unchcanged
Fisetin destroys senescent cells, but safe dosage not determined yet
Lifespan.io (LEAF) - 26-Dec-2018Includes table of fisetin content in range of fruits and vegetables
Human stem cell trial sees improvment in walking and lung function
Lifespan.io (LEAF) - 07-Dec-2018Reducing frailty allows people to keep moving and break the negative feedback cycle of aging.
Plasma NAD+ Levels Decline Significantly with Age
Lifespan.io (LEAF) - 09-Nov-2018We still need to understand it better but NAD+ is likely to be important in slowing aging
Crowdfunding NAD+ Mouse Lifespan Study
Lifespan.io (LEAF) - 18-Sep-2018This project aims to observe if the NAD+ precursor has a positive effect over aging mice
NAD+ Repletion Shows Potential Against Aging
Lifespan.io (LEAF) - 05-Sep-2018The precursor NMN has some rejuvenating effects over mice's metabolism and gene stability
Telomerase Gene Therapy Does Not Increase Cancer Risk
Lifespan.io (LEAF) - 27-Aug-2018New research proves telomerase therapy's safety by making its effects within the cell temporary
Cleara Biotech Joins the Race to Develop Senolytic Therapies
Lifespan.io (LEAF) - 09-Jul-2018This therapy uses a modified FOXO4 to promote apoptosis in senescent cells
LEAF interviews Dr. Nichola Conlon
Lifespan.io (LEAF) - 03-May-2018Look forward to seeing the results of the NAD supplement trial
Goldenrod Extract has a Marginal Senolytic Effect
Lifespan.io (LEAF) - 27-Apr-2018Solidago virgaurea (goldenrod) extracts studied in relation to cellular senescence. Administered...
Why NAD+ Declines With Age
Lifespan.io (LEAF) - 19-Mar-2018Nicotinamide adenine dinucleotide is a vital component of cellular function. Decrease level of N...
Could Filtering Our Aged Blood Keep us Young?
Lifespan.io (LEAF) - 18-Jan-2018Interview with Dr. Irina Conboy of Berkeley University. Youthful TGF-?1 signaling in old mice ca...
MCP-1 A Potential Aging Biomarker
Lifespan.io (LEAF) - 08-Jan-2018Reliable and fast ways to assess biological age are needed to determine the outcome of potential ...
Boosting Mitochondrial Quality Control to Combat Alzheimer's
Lifespan.io (LEAF) - 08-Dec-2017Diseases like Alzheimer’s are the result of the loss of proteostasis. This leads to the creation...
Is Immortality Possible? It is for some animals
Lifespan.io (LEAF) - 07-Nov-2017Some animals are in a state of negligible senescence. They see no decline of strength, mobility ...
Is Aging a Gut Instinct?
Lifespan.io (LEAF) - 10-Oct-2017Initial source of age-related inflammation could be gut microbiota. As we age the gut microbiota...
Immune System Critical to Tissue Regeneration
Lifespan.io (LEAF) - 21-Sep-2017Study in salamanders finds heart tissue regeneration depends on presence of macrophages. Researc...
SRF to develop glucosepane-cleaving antibodies with Spiegel Lab
Lifespan.io (LEAF) - 17-Sep-2017Anti-glucosepane antibodies may offer new therapies for age-related diseases
New Drug Slows Down Heart Disease Progression
Lifespan.io (LEAF) - 14-Sep-2017PCSK9 inhibitors are an effective therapy for lowering LDL cholesterol. Combination of evolocuma...
Anti-Aging Pilot Studies Announced
Lifespan.io (LEAF) - 12-Sep-2017Non-profit Betterhumans known for its work in the transhumanist community announced its intention...
False Positives in Senescent Cell Detection
Lifespan.io (LEAF) - 19-Aug-2017Researchers commonly determine the presence of senescent cells through the use of the p16ink4a (p...
Reducing Inflammation Enhances Tissue Regeneration in Stem Cell Therapies
Lifespan.io (LEAF) - 22-Jul-2017With aging the immune response becomes deregulated and inflammation becomes excessive. Improving...
Compound in Strawberries Slows Aging in Mice
Lifespan.io (LEAF) - 13-Jul-2017Fisetin is a naturally occurring plant polyphenol from the flavonoid group. It is found in many ...
Treating Diabetes by Altering Other Cells to Produce Insulin
Lifespan.io (LEAF) - 04-Jul-2017Novel approach seeks to cure type 1 diabetes and to allow type 2 diabetics to stop using insulin ...
Treating Diseases with a Protein Missile System
Lifespan.io (LEAF) - 26-May-2017University of Dundee demonstrate AdPROM to target and destroy specific proteins within cells. Af...
Treating Osteoarthritis by Removing Senescent Cells
Lifespan.io (LEAF) - 03-May-2017Researchers used local clearance of senescent cells (in mice) to reduce the development of post-t...
Repairing Mitochondrial DNA for Age-related Diseases
Lifespan.io (LEAF) - 02-May-2017University of Sheffield has made progress in repairing the damage done to mitochondrial DNA (mtDN...
Geroprotectors: Magnesium
Lifespan.io (LEAF) - 26-Mar-2017Not everyone gets enough of this essential element which is vital for cellular processes. The da...
Hallmark of Aging Reversed by Senescent Cell Removal
Lifespan.io (LEAF) - 25-Mar-2017Study directly targets one of the mechanisms that senescent cells use to avoid apoptosis, Focuse...
Geroprotectors: Honokiol
Lifespan.io (LEAF) - 21-Feb-2017Honokiol is a lignan isolated from the bark, seed cones, and leaves of the trees of various Magno...
Geroprotectors: Glucosamine
Lifespan.io (LEAF) - 19-Feb-2017One of the most commonly used supplements frequently taken to promote joint health. Glucosamine ...
Geroprotectors: Quercetin
Lifespan.io (LEAF) - 31-Jan-2017In various studies quercetin has demonstrated antioxidant, anti-bacterial, anti-inflammatory and ...
Geroprotectors: Pterostilbene
Lifespan.io (LEAF) - 28-Jan-2017Pterostilbene boosts longevity and is available as a supplement
Forget blood transfusions, the fountain of youth could be closer to hand
Lifespan.io (LEAF) - 18-Jan-2017Attempts have been made to rejuvenate the body by transfusing old people with young blood. Recen...
Targeting Senescent Cells with Synthetic Biology
Lifespan.io (LEAF) - 09-Dec-2016CellAge is going to develop synthetic promoters which are specific to senescent cells, as promote...
