Steve Hill
Editor in Chief and Director of the board at LEAF
Since late 2016 I have been a Director of the board at the Life extension advocacy foundation, a New York Based 501(c)(3) organization which fundraises for research, provides educational materials about biology, covers biotech news, and organizes conferences and events in support of biotechnology focused on ending the diseases of aging.
As part of my duties I am responsible for content creation and managing social media for our organization. To date I have written over 300 scientific articles covering a range of topics within aging research and scientific advocacy, and I manage a small team of writers producing regular content for our news website.
See also: 
Lifespan.io (LEAF)
- Supporting the development of biotechnologies focused on ending age-related diseases
Details last updated 08-Feb-2019
Articles written by Steve Hill
Lifespan.io speaks to Cyclarity’s CEO for an update on its novel atherosclerosis treatment
Lifespan.io (LEAF) - 19-Feb-2024
The company is developing a drug called UDP-003 to treat the disease
Read more...Senolytics-a risky proposition in aging and repair mechanisms
Lifespan.io (LEAF) - 19-Oct-2022
The study is a caution for scientists engaging in self-experimentation with senolytics
Read more...BioNTech begins human trials for mRNA therapy targeting colon cancer and melanoma
Lifespan.io (LEAF) - 10-Sep-2021
mRNA cocktail treatment shows anti-tumor effect without toxic side effects in mice
Read more...mTOR inhibitors reversed immune ageing to treat viral infections in older adults
Lifespan.io (LEAF) - 21-May-2021
Much needed approach to improve immune function during the COVID pandemic
Read more...Lifespan.io crowd-funds clinical trial to determine the effects of Rapamycin
Lifespan.io (LEAF) - 17-May-2021
PEARL: Participatory Evaluation of Aging with Rapamycin for Longevity
Read more...NMNH is a newer, faster and better NAD+ precursor
Lifespan.io (LEAF) - 19-Mar-2021
Surpasses other existing precursors with an independent pathway to enter cells
Read more...Glucosamine, a supplement to prevent overall and cause-specific deaths
Lifespan.io (LEAF) - 28-Feb-2021
Human and animal research supports longevity benefits of glucosamine and chondroitin supplements
Read more...NAD+ reduces age-related amyloidosis and mitochondrial dysfunction
Lifespan.io (LEAF) - 05-Feb-2021
Boosting NAD+ levels improves health span and can treat age-related diseases
Read more...Whole-body senescent cell removal improved brain health in mice
Lifespan.io (LEAF) - 22-Jan-2021
Senolytic drug and cancer drug with quercetin improved age-related cognition
Read more...Human trial results of resveratrol may benefit heart health
Lifespan.io (LEAF) - 30-Nov-2020
Daily supplementation with resveratrol proved to improve heart function
Read more...Dilution of old blood restores healthy brain function
Lifespan.io (LEAF) - 17-Nov-2020
Reduces neuroinflammation & promotes neurogenesis in aged brains of mice
Read more...Unity Biotechnology launches clinical trial of a new senolytic
Lifespan.io (LEAF) - 13-Oct-2020
A new approach to treat diabetic macular oedema
Read more...Flavonoid found in redcurrants reduces senescence in brain cells
Lifespan.io (LEAF) - 28-Sep-2020
Mice study also saw improved cognitive abilities
Read more...Everything you ever wanted to know about AKG (but were afraid to ask)
Lifespan.io (LEAF) - 07-Sep-2020
A great summary of the history,biochemistry and life-extending potential of alpha-ketoglutarate
Read more...90 % of herpes simplex virus 1 eliminated in infected cells
Lifespan.io (LEAF) - 19-Aug-2020
Successful in mice, new approach may ease immune burden of herpes in humans in the future
Read more...A step closer to reversing pulmonary fibrosis via telomerase gene therapy
Lifespan.io (LEAF) - 12-Aug-2020
Study in mice revealed great progress and potential for curing fibrotic diseases in humans
Read more...Benefits of caloric restriction in intestinal stem cells
Lifespan.io (LEAF) - 05-Aug-2020
One should still consume adequate nutrition while reducing calorie intake
Read more...15% reduction in 10 year all-cause mortality with glucosamine supplementation
Lifespan.io (LEAF) - 31-Jul-2020
Based on almost half a million people this is a large prospective cohort study
Read more...Researchers grow gut organoids to identify protein critical for repair
Lifespan.io (LEAF) - 27-Jul-2020
NRG1 treatment boosted activity of gut stem cells - could help protect gut during chemotherapy
Read more...Scientists go where no gene-editing tool has gone before
Lifespan.io (LEAF) - 14-Jul-2020
DddA able to target mitochondrial DNA (mtDNA) by splitting in half and hitching a ride
Read more...Blood factor created by exercise can be transfused to sedentary mice for same mental benefits
Lifespan.io (LEAF) - 13-Jul-2020
Another point for the "good" factors argument, though removing "bad" factors likely to be important too
Read more...Red meat may increase heart disease risk
Lifespan.io (LEAF) - 10-Jul-2020
Particularly, its metabolic byproduct affects vascular ageing as studied in mice and humans
Read more...Transplanting youthful white blood cells reduces inflammation in mice
Lifespan.io (LEAF) - 08-Jul-2020
Targeting immunosenescence could provide benefits throughout the body
Read more...How LDL cholesterol enter our cells elucidated
Lifespan.io (LEAF) - 02-Jul-2020
Two proteins serve as the doorway, becoming new potential targets for drug discovery
Read more...Trial of Rejuvant supplement claims 8 year age reversal
Lifespan.io (LEAF) - 30-Jun-2020
If randomised clinical trial replicates results then I might add it to my stack
Read more...Senescent cell inflammatory signals as a new possible biomarker
Lifespan.io (LEAF) - 29-Jun-2020
It could measure biological age and relative health
Read more...Two drug molecules delivered via nanoparticles to combat atherosclerosis
Lifespan.io (LEAF) - 26-Jun-2020
Success in mice model gives hope for fighting cholesterol-associated inflammatory diseases
Read more...Immunotherapy as new approach to battle senescent cells
Lifespan.io (LEAF) - 23-Jun-2020
Successful in mice, it may help treat many age-related disease in human
Read more...Is it possible to predict biological age with gut microbiome?
Lifespan.io (LEAF) - 19-Jun-2020
Models and anti-ageing intervention design enables new ageing clock development
Read more...LEAF interviews the Conboys about rejuvenating mice by diluting blood plasma
Lifespan.io (LEAF) - 16-Jun-2020
This could be a cheap first generation rejuvenation treatment - but wait for clinical trials
Read more...Niacin inhibits brain tumor growth in mice
Lifespan.io (LEAF) - 10-Jun-2020
A promising anti-cancer immunotherapy approach, and alternative to traditional drugs
Read more...Human trial proves niacin to be an effective NAD+ booster
Lifespan.io (LEAF) - 08-Jun-2020
Also a cheaper treatment for mitochondrial myopathy than NR and NMN supplements
Read more...Could a vaccine be an alternative to senolytic drugs?
Lifespan.io (LEAF) - 29-May-2020
New study in mice demonstrates an intriguing possibility with senescent cells research
Read more...The role of NAD+ in resisting age-related circadian rhythm disturbance
Lifespan.io (LEAF) - 25-May-2020
Study in mice shows link between the two, could help improve sleep quality in humans
Read more...A new novel senolytic agent, R406, discovered
Lifespan.io (LEAF) - 22-May-2020
Intriguingly destroys senescent cells without inducing cell destruction
Read more...Age-related changes in gut microbiota cause cognitive decline in aged rats
Lifespan.io (LEAF) - 20-May-2020
Restoring microbiome could be one strategy to support healthy longevity
Read more...Orion College ageing research receives 1 million UK pounds from Jim Mellon
Lifespan.io (LEAF) - 18-May-2020
He believes in the importance of boosting immunoresilience among elderly
Read more...NAD+ more than doubled after 10 weeks of resistance training
Lifespan.io (LEAF) - 13-May-2020
Not yet too late to reap the benefits of exercise as seen in middle-aged individuals
Read more...Should WHO use a new framework for the diagnosis and treatment of age-related diseases?
Lifespan.io (LEAF) - 08-May-2020
LEAF summarises and exchange of thoughts between leading aging researchers
Read more...LEAF interviews Dr. Ole Mensching about Apollo Health Ventures' Moonshot Venture
Lifespan.io (LEAF) - 06-May-2020
VCs are starting to recognise ageing as a problem with a massive business opportunity
Read more...Telomerase activity restored in vitro and in mice
Lifespan.io (LEAF) - 27-Apr-2020
Potential to support new therapies for dyskeratosis congenita, other age-related diseases
Read more...Refining certain drugs to be less toxic and to amplify their senolytic potential
Lifespan.io (LEAF) - 24-Apr-2020
Tested in aged mice and turns out that it can rejuvenate tissue stem cells
Read more...How external factors could influence Alzheimer’s disease via the gut microbiome
Lifespan.io (LEAF) - 20-Apr-2020
Early study into complex neurochemical relationship between brain, gut and inflammaging
Read more...Inhibiting p38 MAPK rejuvenates resolution response in elderly
Lifespan.io (LEAF) - 15-Apr-2020
A new perspective on mitigating the effects of inflammaging, promoting health in older people
Read more...The importance of early life microbiome in gut protection
Lifespan.io (LEAF) - 10-Apr-2020
Demonstrated in neonatal mice microbiome mediating an immune response
Read more...Dawn til dusk fasting improves blood biomarkers
Lifespan.io (LEAF) - 08-Apr-2020
Small study (14 participants) with strict participation requirements, but interesting biomarker results
Read more...Senolytics may have the potential to treat asthma
Lifespan.io (LEAF) - 07-Apr-2020
Will senolytics become the panacea to the whole Pandora's box by 100 years into future?
Read more...Gut enzyme prevents age-related loss of intestinal barrier integrity
Lifespan.io (LEAF) - 03-Apr-2020
In animal models, IAP is found to prevent frailty and extend lifespan
Read more...CRISPR-Cas9 variants, key to overcoming major limitation in gene editing system
Lifespan.io (LEAF) - 31-Mar-2020
Entire genome now targetable, open to interventions for use in combating diseases
Read more...Gut microbiota highly influenced by ageing and dietary fat intake
Lifespan.io (LEAF) - 30-Mar-2020
Several short-term responses and alterations are evident in a mice study
Read more...Mitochondrial transplants are successful but benefits are short lived
Lifespan.io (LEAF) - 25-Mar-2020
May be a solution to ageing related mitochondrial dysfunction which leads to diseases
Read more...Yamanaka factors plus 2 more resets cells age without destroying their identity
Lifespan.io (LEAF) - 24-Mar-2020
Stanford University researchers spin out Turn Biotechnologies to develop therapies using OSKMLN
Read more...Review on the relationship between senescence and bone marrow cancer
Lifespan.io (LEAF) - 23-Mar-2020
How senescence can fuel cancer development and how malignant cells induce senescence
Read more...Healthy old-people's poo improves gut microbiome of mice
Lifespan.io (LEAF) - 20-Mar-2020
Healthy gut means healthy body. Thought there are alternative ways of increasing probiotic bacteria!
Read more...Metastudy reviews impact of mitochondrial aging on cardiovascular disease
Lifespan.io (LEAF) - 18-Mar-2020
Still lots to discover, but SENS already looking at ways to stop it in its tracks
Read more...Diabetic retinopathy in mice, reversed by primitive stem cells
Lifespan.io (LEAF) - 17-Mar-2020
This arrival of a more efficient stem cell type has high impact for regenerative medicine
Read more...Research demonstrates how visceral fat impairs cognitive ability
Lifespan.io (LEAF) - 10-Mar-2020
More reasons to avoid excessive weight gain and other drivers of ageing as proven in mice
Read more...Cell therapy, possible gamechanger in diabetes treatment
Lifespan.io (LEAF) - 04-Mar-2020
A success in mice trial, now to move forward to larger animals then human clinical trials
Read more...NMN restores neurovascular health, improves cerebral blood flow in ageing
Lifespan.io (LEAF) - 17-Feb-2020
Mitochondria-targeted interventions in old mice could be key to age-related diseases.
Read more...LEAF interviews Lewis Gruber about targeting cancer and senescent cells
Lifespan.io (LEAF) - 11-Feb-2020
Biomarker caused by glycolysis seen in all types of cancer - exciting possibilities
Read more...SASP Atlas created by team of researchers
Lifespan.io (LEAF) - 28-Jan-2020
It is a comprehensive proteomic database of soluble proteins and exosomal cargo SASP factors
Read more...New discovery showed mitochondria found living in the blood
Lifespan.io (LEAF) - 27-Jan-2020
Mitochondria living in the blood definitely has some functions, further research needed to discover
Read more...David Sinclair Ask Me Anything - best bits
Lifespan.io (LEAF) - 22-Jan-2020
Always interesting to hear what Dr Sinclair has to say
Read more...4 categories of ageing identified: metabolic, liver, kidney, immune system
Lifespan.io (LEAF) - 14-Jan-2020
Knowing which ageotype you are could help focus your efforts on where you're ageing most
Read more...Navigation using mental mind maps rejuvenated in old mice
Lifespan.io (LEAF) - 13-Jan-2020
Researchers able to teach old mice new tricks ;)
Read more...Rapamycin causes mTOR inhibition having an impact on mammalian aging- Brian Kennedy
Lifespan.io (LEAF) - 04-Dec-2019
mTOR pathway, part of the deregulated nutrient sensing hallmark of aging
Read more...Nicotinamide mononucleotide is safe for human use
Lifespan.io (LEAF) - 12-Nov-2019
A Japanese study establishes safety of NMN despite previous results in animal studies
Read more...A protein that plays a key role in the making of cholesterol plaques: TRB1
Lifespan.io (LEAF) - 11-Nov-2019
Still at an early stage in research - working on mouse models
Read more...High levels of glucuronic acid is a biomarker of ageing
Lifespan.io (LEAF) - 07-Oct-2019
Glucuronic acid levels in the blood can be correlated with a lifespan, healthspan in humans and mice
Read more...LEAF interviews AgeX Therapeutics CEO Dr. Michael West
Lifespan.io (LEAF) - 30-Sep-2019
May only be a few years away from implementing induced tissue regeneration in humans
Read more...3D grown exosomes shown to reduce signs of skin ageing
Lifespan.io (LEAF) - 25-Sep-2019
Could be mass produced and applied as a cream without need for needles
Read more...LEAF interviews David Sinclair about NMN trials and epigenetics
Lifespan.io (LEAF) - 10-Sep-2019
He's optimistic that human trials will convert the majority of people who are skeptical or unaware
Read more...Recalibration of signalling factors to more youthful levels in the blood
Lifespan.io (LEAF) - 03-Sep-2019
Adjusting the levels of just two molecules in the blood could lead to significant rejuvenation
Read more...Skin regeneration in mice - 2 different methods but same pathway
Lifespan.io (LEAF) - 18-Jul-2019
Retinoic acid could be a key ingredient in elixir of youth
Read more...Stem cell reactivation can improve tissue regeneration
Lifespan.io (LEAF) - 16-Jul-2019
Just one pathway out of many that could improve tissue rejuvenation
Read more...Tissue engineered thymus organoids could replace thymic function
Lifespan.io (LEAF) - 05-Jun-2019
And they can be located anywhere in the body
Read more...Telomerase therapy for neurodegeneration
Lifespan.io (LEAF) - 04-Jun-2019
Telomerase gene therapy may be a potential solution for age-related neurodegenerative diseases
Read more...resTORbio Agrees Phase 3 Human Trials with FDA
Lifespan.io (LEAF) - 19-Mar-2019
If successful, drug could be available in next few years
Read more...IMM-AGE measures biological age of the immune system
Lifespan.io (LEAF) - 15-Mar-2019
Immunosenescence is a known factor in longevity
Read more...Samsara secures more funding for cellular rejuvenation drug research
Lifespan.io (LEAF) - 06-Mar-2019
Drugs will need to work better than the free alternative - calorie restriction
Read more...Universal stem cells avoid immune reaction in mice
Lifespan.io (LEAF) - 26-Feb-2019
Could lead to off-the-shelf stem cell therapies
Read more...LEAF interviews Ichor Therapeutics CEO
Lifespan.io (LEAF) - 12-Feb-2019
$16m raided, FoxBio partnership with Juvenescence, lots going on
Read more...LEAF report from the Longevity Leaders Conference
Lifespan.io (LEAF) - 06-Feb-2019
Encouraging signs from big companies - more interviews to follow
Read more...GrimAge can calculate the time you have left to live
Lifespan.io (LEAF) - 31-Jan-2019
Will enable faster analysis of anti-aging treatments
Read more...Mini-thymus used to produce and train T cells
Lifespan.io (LEAF) - 21-Jan-2019
Able to regenerate ageing immune system, and reduce cost of immunotherapy
Read more...Cells of living mice rejuvenated using OSKM trigger in drinking water
Lifespan.io (LEAF) - 17-Jan-2019
More support for the SENS approach of regular maintenance to stop ageing
Read more...Gut microbiome predicts age with 4 year accuracy
Lifespan.io (LEAF) - 15-Jan-2019
It both affects and is affected by its host status
Read more...Senolytics for IPF human clinical trial results released
Lifespan.io (LEAF) - 07-Jan-2019
Physical improvements recorded, but pulmonary function was unchcanged
Read more...Fisetin destroys senescent cells, but safe dosage not determined yet
Lifespan.io (LEAF) - 26-Dec-2018
Includes table of fisetin content in range of fruits and vegetables
Read more...Human stem cell trial sees improvment in walking and lung function
Lifespan.io (LEAF) - 07-Dec-2018
Reducing frailty allows people to keep moving and break the negative feedback cycle of aging.
Read more...Plasma NAD+ Levels Decline Significantly with Age
Lifespan.io (LEAF) - 09-Nov-2018
We still need to understand it better but NAD+ is likely to be important in slowing aging
Read more...Crowdfunding NAD+ Mouse Lifespan Study
Lifespan.io (LEAF) - 18-Sep-2018
This project aims to observe if the NAD+ precursor has a positive effect over aging mice
Read more...NAD+ Repletion Shows Potential Against Aging
Lifespan.io (LEAF) - 05-Sep-2018
The precursor NMN has some rejuvenating effects over mice's metabolism and gene stability
Read more...Telomerase Gene Therapy Does Not Increase Cancer Risk
Lifespan.io (LEAF) - 27-Aug-2018
New research proves telomerase therapy's safety by making its effects within the cell temporary
Read more...Cleara Biotech Joins the Race to Develop Senolytic Therapies
Lifespan.io (LEAF) - 09-Jul-2018
This therapy uses a modified FOXO4 to promote apoptosis in senescent cells
Read more...LEAF interviews Dr. Nichola Conlon
Lifespan.io (LEAF) - 03-May-2018
Look forward to seeing the results of the NAD supplement trial
Read more...Goldenrod Extract has a Marginal Senolytic Effect
Lifespan.io (LEAF) - 27-Apr-2018
Solidago virgaurea (goldenrod) extracts studied in relation to cellular senescence. Administered...
Read more...Why NAD+ Declines With Age
Lifespan.io (LEAF) - 19-Mar-2018
Nicotinamide adenine dinucleotide is a vital component of cellular function. Decrease level of N...
Read more...Could Filtering Our Aged Blood Keep us Young?
Lifespan.io (LEAF) - 18-Jan-2018
Interview with Dr. Irina Conboy of Berkeley University. Youthful TGF-?1 signaling in old mice ca...
Read more...MCP-1 A Potential Aging Biomarker
Lifespan.io (LEAF) - 08-Jan-2018
Reliable and fast ways to assess biological age are needed to determine the outcome of potential ...
Read more...Boosting Mitochondrial Quality Control to Combat Alzheimer's
Lifespan.io (LEAF) - 08-Dec-2017
Diseases like Alzheimer’s are the result of the loss of proteostasis. This leads to the creation...
Read more...Is Immortality Possible? It is for some animals
Lifespan.io (LEAF) - 07-Nov-2017
Some animals are in a state of negligible senescence. They see no decline of strength, mobility ...
Read more...Is Aging a Gut Instinct?
Lifespan.io (LEAF) - 10-Oct-2017
Initial source of age-related inflammation could be gut microbiota. As we age the gut microbiota...
Read more...Immune System Critical to Tissue Regeneration
Lifespan.io (LEAF) - 21-Sep-2017
Study in salamanders finds heart tissue regeneration depends on presence of macrophages. Researc...
Read more...SRF to develop glucosepane-cleaving antibodies with Spiegel Lab
Lifespan.io (LEAF) - 17-Sep-2017
Anti-glucosepane antibodies may offer new therapies for age-related diseases
Read more...New Drug Slows Down Heart Disease Progression
Lifespan.io (LEAF) - 14-Sep-2017
PCSK9 inhibitors are an effective therapy for lowering LDL cholesterol. Combination of evolocuma...
Read more...Anti-Aging Pilot Studies Announced
Lifespan.io (LEAF) - 12-Sep-2017
Non-profit Betterhumans known for its work in the transhumanist community announced its intention...
Read more...False Positives in Senescent Cell Detection
Lifespan.io (LEAF) - 19-Aug-2017
Researchers commonly determine the presence of senescent cells through the use of the p16ink4a (p...
Read more...Reducing Inflammation Enhances Tissue Regeneration in Stem Cell Therapies
Lifespan.io (LEAF) - 22-Jul-2017
With aging the immune response becomes deregulated and inflammation becomes excessive. Improving...
Read more...Compound in Strawberries Slows Aging in Mice
Lifespan.io (LEAF) - 13-Jul-2017
Fisetin is a naturally occurring plant polyphenol from the flavonoid group. It is found in many ...
Read more...Treating Diabetes by Altering Other Cells to Produce Insulin
Lifespan.io (LEAF) - 04-Jul-2017
Novel approach seeks to cure type 1 diabetes and to allow type 2 diabetics to stop using insulin ...
Read more...Treating Diseases with a Protein Missile System
Lifespan.io (LEAF) - 26-May-2017
University of Dundee demonstrate AdPROM to target and destroy specific proteins within cells. Af...
Read more...Treating Osteoarthritis by Removing Senescent Cells
Lifespan.io (LEAF) - 03-May-2017
Researchers used local clearance of senescent cells (in mice) to reduce the development of post-t...
Read more...Repairing Mitochondrial DNA for Age-related Diseases
Lifespan.io (LEAF) - 02-May-2017
University of Sheffield has made progress in repairing the damage done to mitochondrial DNA (mtDN...
Read more...Geroprotectors: Magnesium
Lifespan.io (LEAF) - 26-Mar-2017
Not everyone gets enough of this essential element which is vital for cellular processes. The da...
Read more...Hallmark of Aging Reversed by Senescent Cell Removal
Lifespan.io (LEAF) - 25-Mar-2017
Study directly targets one of the mechanisms that senescent cells use to avoid apoptosis, Focuse...
Read more...Geroprotectors: Honokiol
Lifespan.io (LEAF) - 21-Feb-2017
Honokiol is a lignan isolated from the bark, seed cones, and leaves of the trees of various Magno...
Read more...Geroprotectors: Glucosamine
Lifespan.io (LEAF) - 19-Feb-2017
One of the most commonly used supplements frequently taken to promote joint health. Glucosamine ...
Read more...Geroprotectors: Quercetin
Lifespan.io (LEAF) - 31-Jan-2017
In various studies quercetin has demonstrated antioxidant, anti-bacterial, anti-inflammatory and ...
Read more...Geroprotectors: Pterostilbene
Lifespan.io (LEAF) - 28-Jan-2017
Pterostilbene has antioxidant, anti-inflammatory and anticarcinogenic properties. Estimated cont...
Read more...Forget blood transfusions, the fountain of youth could be closer to hand
Lifespan.io (LEAF) - 18-Jan-2017
Attempts have been made to rejuvenate the body by transfusing old people with young blood. Recen...
Read more...Targeting Senescent Cells with Synthetic Biology
Lifespan.io (LEAF) - 09-Dec-2016
CellAge is going to develop synthetic promoters which are specific to senescent cells, as promote...
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