Two drug molecules delivered via nanoparticles to combat atherosclerosis

26-Jun-2020
KEY POINTS FROM ARTICLE:

Follow-up study on novel delivery method to combat atherosclerosis, published.
Researchers had used both cyclodextrin and statin molecules encapsulated in nanoparticles.
Created nanoparticles with a diameter of 100 nanometers, making it even more efficient.
Upon arrival, the payload is released into the atherosclerotic lesion.
The cyclodextrin then binds the cholesterol molecules present in the lesion to it.
This binding of the cholesterol appears to aid the macrophages present at the lesion site.
Combination of the two reduce cholesterol levels in established plaque in mice.
Statins also seem to inhibit the formation of foam cells.
Suggests that indigestible oxidized cholesterols, byproducts, somewhat reduced in abundance.
Researchers from Georgia Institute of Technology and Korea Advanced Institute of Science and Technology.
Published in American Chemical Society (ACS) NANO.

Success in mice model gives hope for fighting cholesterol-associated inflammatory diseases

Mentioned in this article:

Journal ACS Nano - Journal about nanoscience and nanotechnology.

Academia Georgia Tech - Public research university and institute of technology.

Academia KAIST - National university in Daejeon, South Korea.

Company Underdog Pharmaceuticals - Company developing simple and direct interventions targeting toxic forms of cholesterol for age-related diseases.

Read full article on Life Extension Advocacy Foundation (LEAF) website
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