Regular exercise improves brain health and delays dementia by 18 months
The Guardian - 19-Nov-2024Fitness reduces dementia risk by 35%, even for people with genetic risk factors
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Fitness reduces dementia risk by 35%, even for people with genetic risk factors
A study links diabetes and specific biomarkers to faster brain shrinkage and earlier MCI onset
Adjusting this axis with diet, probiotics, and supplements could benefit brain health
New research highlights the potential brain health benefits of adding olive oil to your diet
Aliada’s BBB technology aims to transform CNS drug delivery
New research shows infrequent workouts can offer brain health benefits equal to regular exercise
Oxford study reveals associations between lifetime cannabis use and brain structure
Scientists enhance brain function and protect against neurodegeneration
The drug 'donanemab' remains available for private treatment in England
Clinical study showed its accuracy, aiming to replace invasive methods like PET scans
The test is faster, cheaper, and over 93% accurate, offering quicker diagnosis
This process occurs mainly at night and may help prevent Alzheimer’s
Glucose regulation may hold the key to restoring neuron growth
Researchers discover a compound that slows ageing by boosting protein maintenance
Researchers hope to develop new drug targets and improve current treatments
Early clinical trials showed safety and effectiveness, with more trials planned for 2025
Doctors warn of serious brain injuries as the controversial combat sport gains popularity worldwide
Eating more berries and dark chocolate could lower dementia risk by 28%
Researchers identify genetic markers that could lead to a faster and affordable test for ALS
New study reveals metformin’s potential to delay brain aging
Food for the brain charity launches a test to track brain health through antioxidant levels
New research adds vision loss and high cholesterol to dementia risk factors
It provides insights into the disease and suggests new prevention strategies
Adding fish to a vegetarian diet may boost longevity in seniors
However, modern changes like processed foods are starting to affect their health
A groundbreaking approach to extend life through brain tissue renewal
This breakthrough offers hope for combating age-related cognitive decline
More research needed to confirm definitive link, but study emphasizes importance of healthy diet
First scottish patient to undergo the treatment experienced immediate tremor reduction
Novel brain implant technology aimed at helping patients with speech loss
Targeting prostaglandin biology could lead to breakthrough parkinson’s therapies
Dataset may hold valuable insights to unlock neurological mysteries
Protective gene variants in immunity & cellular cleanup prevent Alzheimer's in old age
Regular video conversations can reduce loneliness and boost emotional well-being
Funding fuels R&D, and collaboration focus on improving diagnosis and treatment options
Large-scale trials aim to enable timely access to support and potential treatments
Funds to advance compounds that target mTORC1 pathway for treating rare and age-related conditions
Providing a promising target for interventions aimed at promoting healthy ageing
iPSC-based therapy set for phase 1 trials to replace lost neurons and modify disease course
Researchers tracked changes in brains, including protein levels & brain shrinkage
Investment fuels its blood-brain barrier-crossing tech for better drug delivery
Exploring how ageing genes impact brain health and disease
Potential for improved treatments for diseases like Alzheimer's and Parkinson's
Portable Produodopa pump delivers steady medication, offering ease & relief for Parkinson's sufferers
Neurostimulation enhanced memory especially in those with memory issues, paving way for future treatments
Oral therapy improved energy & daily activities in MS and Parkinson's patients in phase 2 trial
They found 11 proteins in blood that could spot future dementia with 90% accuracy
Al101 shows promise in boosting brain health for early Alzheimer’s patients
It could be used to study Down syndrome, Alzheimer's, and even new medicines
Once hailed as a breakthrough, Aduhelm faces final curtain after limited use and insurance hurdles
Vesper's main drug, called VES001, is a pill that can reach the brain directly
This could pave the way for routine screening of individuals over 50
New therapies combat age-related brain diseases by restoring blood vessel heath
People taking multivitamins scored better on memory tests than others
Research sheds light on the benefits of calorie restriction
New study finds 15 hidden risks and protective lifestyle habits of early dementia
Interplay between these systems suggests potential for targeted interventions
Vitamin D deficiency, depression, and diabetes are some among the preventable risk factors
This app could help identify those at risk sooner for timely intervention
Anthrobots bridge neuron gaps and fight disease, paving the way for regenerative medicine
Spinal implant could lead to significant improvements in the lives of people
Enhanced immune cells target inflammation and protein buildup, offering cognitive improvements
People with a faster biological age tend to have poorer memory
Smart socks detect distress and alert carers, helping patients to live more independently
Aspen Neuroscience's ANPD001 aims to replace lost neurons and improve motor function
Gut-brain connection opens doors for early detection and treatment of brain diseases
Revolutionary approach for safer and accessible brain stimulation therapies
CST-3056 targets cognitive decline in Alzheimer’s with a phase I trial in 2024
Research findings may lead to new treatments for the most common cause of dementia
Aims for Alzheimer's drugs that target brain's predominant cells, astrocytes
Too much or too little HDL cholesterol may increase the risk of dementia
New breakthrough cell therapy offers potential for slowing disease progression
Findings could have implications for understanding brain ageing and Alzheimer's
Lead antibody shows promising preclinical data & is set for clinical development
Metabolic syndrome increased the risk of developing dementia by 12%
The treatment was well-tolerated with no significant changes in brain function
The test could identify drugs that reverse or slow down DNA damage and disease
PF4 from platelets enhanced learning and memory in both young and old mice
New treatment approach could be more effective in lowering the risk of serious side effects
Vaccine not only reduced inflammation, but also improved behavior and awareness in mice
New Alzheimer's drug benefits early-stage patients; concern remain about affordability and serious risks
Bemdaneprocel shows positive phase I results, advances to Phase II trial in early 2024
Researchers suggest that sleep problems should be considered a modifiable risk factor for dementia in healthy older adults
Dr. Angel Wong, lead author, concludes that any increase in dementia risk due to shorter sleep duration is likely very small
The test may lead to easier, non-invasive diagnostic methods
Company is seeking funds to advance from preclinical tests to human trials
Benefits of psychedelic drugs or AI compounds may outperform clinical drugs with fewer side effects; clinical trials yet to confirm
Associations between telomere length and endophenotypes could help treat neurodegenerative disease
People are less likely to die the more often they socialise
Multilayered architecture resulted in physiological and behavioural improvements. Could it help regenerate the ageing brain in future?
The study was observational, no cause and effect can be determined
Prevention is important as once dementia is diagnosed, it is very difficult to slow or reverse
Modifying gut microbiota with antibiotics reduced inflammation and tau-linked damage
CST-103 and CST-107 improve cognition and safety in neurodegenerative disease patients
Report provides analysis on different parts of the brain, including lesions associated with Alzheimer’s disease
New antibody approach aims to slow or halt Huntington’s disease progression
Current research identified drug candidate, big data analysis confirmed an association, and lab work demonstrated a biological effect
This one-off treatment could nullify the complications that you get with chronic medications
How senescent neurons lead to Alzheimer’s disease, effect on removal and drugs needed for therapy
Study suggests we should maintain cardiorespiratory fitness early in life to benefit higher cognitive functions later
The midlife study showed that the cognitive decliners age faster
Medin deposits are indeed a cause of blood vessel damage, one of the causes of Alzheimer's disease
Education could be a vital tool to narrow down the differences in risk of dementia
Historic moment for dementia research-large clinical trial to successfully slow cognitive decline
Cognitive decline and dementia in older people accelerated by exposure to emissions
A target for Alzheimer’s disease therapy may lie in plasmapheresis or blood dialysis
Positive results in lab tests suggest the drug may improve lifespan and life quality
Imipramine or olanzapine block APOE4 and reverses Alzheimer’s disease
The acquisition strengthens the Fujirebio Neuro Center, making it a leading hub in diagnostics
Progressive disease can be prevented by boosting Vit-D to normal levels
Cautioned the use of rapamycin in Alzheimer's patients, as it downregulated Trem2 & reduced β-amyloid clearance
Cognitive decline, dementia, and mortality can be reduced by blood pressure control
Oligodendrogenesis and memory function in the aged brain can be improved by young CSF
Activating similar mechanism without stressing the cells could treat dementia
Guarantees higher efficacy, convenience and potential safety than other anti-Aβ therapies
Epigenitic and brain aging markers provide insights on accelerated cognitive decline
Lomecel-B targets homing and microglia recruitment rather than differentiation
Mapping the brain and creating charts could be used as a helpful clinical tool for other clinicians, psychiatrists and researchers
The approach may make testing more accessible for those without specialist healthcare access
Exception was for people with a cognitive impairment, study by Newcastle University shows
24-hour circardian regulation and good sleep hygeine can possibly delay the onset of dementia
Senolytics showed positive effects on rats but trials must confirm these findings on human brain
Interactions with mitochondrial & synaptic proteins highlight targets against Tau-mediated disease
Aiming to invest in 15-20 biotech firms, including Cambrian Biopharma, to target drivers of ageing
Exercise plasma boosts memory and dampens brain inflammation
Evident reversal of Dementia symptoms sustained cognitive improvement
A hot topic in longevity research is plasma exchange for Alzheimer’s disease
A 5-minute test can assess the early risk of getting dementia
Cases of anxiety and depression are now doubled when compared to pre-pandemic
In placebo controlled study, device improved brain processing and memory in patients
The atlas of the brain cells developed will help pave the way for future research in brain disorders
Brain implant detects patterns that proceed depression and then blocks the signals
Players saw a decline in both blood flow to brain and cognition, regardless of concussions
A novel therapeutic agent for treating Alzheimer's & neurodegenerative disorders
Keeping your brain active, whether through work or hobbies may delay dementia
Reliable and safe generation of a novel stem cell-based therapy for dementia
Algorithm detects dementia better than neurologists, soon with a single brain scan
Microbiome in the gut could potentially slow down brain aging and improve cognitive functions
Scientists restored memory in aged mice, and found a similar working mechanism in humans
As this human trial was small, a larger study is warranted to confirm its effectiveness
The $2.2 billion deal will focus on immune-based therapies for neurodegenerative diseases
SAK3, the first compound to target the activity in neurodegenerative disorders
A long way from a cure, but hopefully indicates that Alzheimer's isn't unassailable
Regulation of adult remyelination in mice by TET1-mediated DNA hydroxymethylation
Healthy diet and lifestyle of Tsimane slowed brain atrophy, lowering the risk of Alzheimer's & dementia
Intake of any alcoholic beverages linked to reduce grey matter volume - worsening brain function
Boosting a vital protein, Caveolin-1, this new technique offers hope against neurodegenerative diseases
Diet with fish, olive oil, nuts, legumes & vegetables reduces abnormal protein deposits in brain
Even short spikes in air pollutants may impair brain health in older men
Launched home test to track biological age; outcomes of unlicensed gene-therapy are yet to report
Traditional mind-body practices like qigong can be a right choice of exercise for the elderly
Cell therapy repairs brain damage from dementia and stroke in mice, soon to begin human trials
Sleeping for less than 6 hours in middle age could cause or increase the risk of dementia by 30%
In vivo conversion of astrocytes could possibly bring brain regeneration therapies in the near future
Abl1 gene as a potential drug target improved stem cell rejuvenation in aged mice
GrimAge predicts increased cellular ageing & mortality risk in people with major depression
Virus carries gene encoding protein into the brain -possible breakthrough treatment for neurodegenerative diseases
A potential application in humans for Parkinson's with nerve grafts made from own stem cells
Biomaterials can form superstructures to help regenerate patient derived neuronal cells
Too much or too little sleep increases the risk of Alzheimer's disease in older adults
Clinical trials in progress for potential targets of cancer and neurodegenerative diseases
Reprogrammed stem cells treated Parkinson's in rats; initiating clinical trials soon
With positive results in phase 2b, simufilam to begin phase III in second half of 2021
Despite age-related risk factors, super-agers had only a slight decrease in memory
Low intensity ultrasonic stimulation of brain successfully worked on 2 more patients
Conboys are planning a modified lifespan study - looking for funding
Senolytic drug and cancer drug with quercetin improved age-related cognition
EP2 receptor which causes inflammation & ageing was knocked down in a disease model
Patented compound on clinical trials to prove the benefits on human cognition
Clears plaque and slows clinical decline in patients with early-stage Alzheimer's
Novel approach with gold nanocatalyst technology to reverse neurodegenerative disease
Super agers with a rare gene mutation counteracts accumulation of aging proteins
Community involvement might be protective against depression in the elderly
Even slighter increase in blood pressure at any age is linked to cognitive impairment
Breathing fine particles can shrink your brain; there may be other causes too
Control neurogenesis by causing nerve stem cells to divide & thus help brain adapt in mice
Not only is there no cure for AD, worse, there could be harmful ingredients in miracle tonics
An experimental drug restores age related memory loss and brain function in mice
Looking for volunteers in Plymouth area - travel expenses reimbursed
Study finds higher survival in societies that provide more support & care
Reduces neuroinflammation & promotes neurogenesis in aged brains of mice
Identifying early changes will help diagnose patients early and treat better
Altering gut microbiome might be helpful in preventing or delaying Alzheimer's
Microbiome altering might help in preventing or delaying Parkinson's and Alzheimer's
A less invasive approach of brain-computer interface than Neuralink
Brain scan show increased grey matter volumes in regions affected by ageing
Will explain why some brains age faster and make people susceptible to certain diseases
Triggers an increase in the same protein used by hibernating animals
CST-2032 targets early neurodegeneration with a novel multi-cell approach
People are now willing to say that treating ageing might help ameliorate age-related diseases
Declining muscle strength and ageing cognitive function are linked
CMS121 lowered levels of fatty acid synthetase (FASN) which inhibited lipid peroxidation
Early days but interesting alternative to chemicals which are handicapped by blood brain barrier
It is never too early or too late to prioritise reducing disease risks
Experts found a protein indicating the disease, providing early treatment in the future
This certainly is not a plus point for the anti-vaxx movement
Exosomes will help reduce complications of using living stem cells for brain repair
I'm sure there's more to exercise than this, but an interesting start to a potential wonder drug
Experiments in mice confirmed this, unraveling ageing mystery if it translates to humans
A Mediterranean diet may help you to keep your weight in check
PTB is the ultimate switch that controls conversion of a cell into a neuron
Study shows this certain thinking pattern is linked to release of harmful brain proteins
Still one of the most reliable interventions when improving long-term health
Air pollution could account for 10% of dementia cases worldwide
Restoring microbiome could be one strategy to support healthy longevity
It's never too late to start to exercise - even if your memory has already started to fade
Lead study linking caffeine and its disease-slowing potential
Sheds light to potential treatments for age-related cognitive decline, Alzheimer's
Study and procedure represent a milestone in personalized medicine for Parkinson's
New therapeutic personalized strategy could bring back movement to those suffering
Reduce the risk of getting dementia by two to four folds
This discovery could greatly reduce costs of diagnosing and studying the disease
Detecting blood drainage lags could eventually lead to faster treatment options
World-first research reveals how their brain adapts to ageing changes, still perform well
It restores neurovascular coupling associated with age-related decline in brain function
Early study into complex neurochemical relationship between brain, gut and inflammaging
More reasons to avoid excessive weight gain and other drivers of ageing as proven in mice
Curcumin when encapsulated in nanoparticles, gets better absorbed
After a successful phase 1 trial of the CVN424 done one mice, the company started phase 2 studies
Balanced diet, physical and mental exercise, still key to lowering dementia risks
Can speed up drug discovery process using artificial intelligence
Cellular senescence is now a top research topic and a very messy one in ageing research
But other soy products and other vegetable oils do not cause malfunctioning of genes
Researchers able to teach old mice new tricks ;)
If successful, will be the breakthrough of the decade, researchers say
People's eye changes over 10 years were correlated with the emergence of Alzheimer’s disease
First-in-human trial demonstrates safety and brain-target engagement for TREM2 therapy
Exercise program enrolled sedentary seniors and improved their memory in 12 weeks
Blood circulation in the brain didn't deteriorate even a bit for 15 months
Should seaweed be part of our daily supplement regime? Opinions welcome
Cerebrospinal fluid might be involved in the process of cleaning out the toxins
Except for neurodegenerative diseases, ex-footballers are less likely to die from other diseases
Groundbreaking drug is called aducanumab, which targets a protein called amyloid
People who walked slower had a worse state of lungs, teeth and immune system
According to the study, shortening in the telomere length have reflected in our brain structure
Drugs don't work, but the MemorEM cap has shown mental and physical improvements
Increases blood pressure between the ages of 36 and 43 were associated with brain shrinkage
Used brain stem cells of young and old rats for this research
Breakthrough will allow scientists to understand more profoundly how Alzheimer's disease progresses
Plasma proteins to the rescue of good-old memories in Alzheimer's
Seeing friends daily reduced the dementia risk, but seeing relatives did not
Does playing computer games at old age have an additive effect on MCI?
If other vascular risk factors are targeted simultaneously, the outcome is better
A different approach to Alzheimer's that may be correct
Promising results in genetically altered mice with Alzheimer’s traits
The usual 3 are at the top of the list – diet, exercise and don’t smoke
Late linked to the accumulation TDP-43 protein rather than amyloid and tau
Smell could be another candidate for a biological age marker
50% improvement in complications of therapy, 19.2% in motor examinations and more
We're understanding more about the body's chemical and electrical signalling
Not a cure for dementia but might buy patients some time
Possible treatment for neurodegenerative diseases of old age
Another promising candidate not making it to the finish line
Patients on blood pressure lowering medication saw less accumulation of harmful brain lesions.
Reversal of brain cell damage knocked 6 years off disease development
Mental capacity not lost - just masked by inflammation
As more people suffer from dementia, men will be affected sooner
Keeping your gum healthy may save you from Alzheimer's disease
Improvements in laboratory technology enable mass screening of molecules like these
But builds up cognitive reserve to resist dementia for longer
A man in his 50s is the first of seven patients to receive the experimental therapy
Implantation of induced stem cells in brains with Parkinson’s disease is showing promising results in monkeys
High intensity pulse travelling towards the brain indicative of accelerated cognitive decline over the next decade.
Targeting brain function to address Parkinson’s and Alzheimer’s at their core
Alternative approaches to tau targets in neurodegenerative disorders
Large-scale Japanese studies report no effect of H2 over oxidative stress in brain tissue
New stem cell treatment for Parkinson's entered the human trial stage in August
There is a risk of developing brain tumours according to some experts
Advancing immune-based therapies for alzheimer’s and dementia
An US study found a strong link between high temperatures and suicide in wealthy countries
$ 80 million will be directed towards Alzheimer’s research and drug discovery
People over 50 years old has increased risk for dementia when they reach 130 mmHg
Oxford researchers found that physical improvement doesn’t translate in better mental health
Researchers measured biomarkers for Alzheimer’s in 70 volunteers aged 30 to 60.
People with IBD are at a 28% higher risk of developing Parkinson's disease.
Neurogenesis is the production of new neurons.
Brain is reliant on the vascular system in many ways.
1. Better idea of what tau proteins look like
“We are getting an increasingly sophisticated understanding of what is going on in these diseases” - David Reynolds - chief scientist at Alzheimer’s Research UK.
Traumatic brain injury (TBI) can come from falling, contact sports, traffic accidents or violence.
Will be successful than drugs targeting specific aspects of Alzheimer's
MIT researchers have exposed mice to a hum at 40 Hertz.
Treatment combined diabetes drugs GLP-1, GIP and glucagon.
Drug suppresses the effects of the Huntington’s mutation that causes irreversible damage to the brain.
Drinkers had less brain shrinkage and slightly better cognitive scores.
Quality of social connections are more important than quantity
Alzheimer’s is one of the top 10 deadliest diseases in the United States.
Current drugs help manage the symptoms, but do not prevent brain cells dying.
Older men and women who engage in regular sexual activity have better cognitive functioning.
Essentially reversing molecular damage caused by stress.
Drug may stop all neurodegenerative brain diseases, including dementia and Alzheimer’s disease.
Life expectancy of people with severe mental health problems today is the same as it was for the general population in 1950
Dementia causing diseases can be fought through research, it isn't an inevitable part of ageing
Study finds scouts or guides have better mental health in later life.
Relaunches as a clinical-stage company, with phase 1 clinical trials of lead compound for Alzheimer’s
Brain training industry careful about claims after Lumosity was fined $50 million dollars for lack of evidence.
Capsule placed under the skin releases antibody proteins that tag amyloid beta proteins for patient’s own immune system to attack.
More important to your health than how frequently you encounter stress.
Social isolation in later life can prove fatal by exacerbating health problems.
People with a serious mental health condition die 12-13 years younger.
Nilotinib has been used to treat patients with a certain type of leukaemia.
Real brain changes from meditation. Start slow as its easy to fail if you try to jump straight into 20 minutes of meditation a day
20 year old treatment rediscovered after late recovery in original patients
In a small trial, the drug slowed the progression of the disease and reduced deposits of amyloid plaques, the substances blamed for damaging the brains of people with Alzheimer’s.
Since 1970, life expectancy around the world has risen dramatically, with people living more than 10 years longer.
Dementia (including Parkinson’s and Alzheimer’s disease) more accurately defined as fatal brain failure: a terminal disease, like cancer, that physically kills patients, not simply a mental ailment that accompanies older age.