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Beyond genetics: 15 risk factors increase risk of early dementia

Vitamin D deficiency, depression, and diabetes are some among the preventable risk factors

26-Dec-2023

Key points from article :

Vitamin D deficiency, depression and diabetes increase the risk of young-onset dementia, a major study suggests.

The study challenges the notion that genetics are the sole cause of the condition.

It looked at data from over 350,000 under-65s from across the UK.

Identified 15 risk factors, including alcohol abuse, stroke, social isolation and hearing impairment.

Those with a higher formal education were seen to be at less of a risk.

"This pioneering study shines important and much-needed light on factors that influence the risk of young-onset dementia," - David Llewellyn, Professor at University of Exeter.

Our research could "herald a new era" for interventions to reduce new cases, said Janice Ranson, one of the study's authors.

Study led by Maastricht University and University of Exeter Medical School, and was published in the Jama Neurology journal.

Mentioned in this article:

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David Llewellyn

Professor of Clinical Epidemiology and Digital Health at the University of Exeter, Alan Turing Institute Fellow.

JAMA Neurology

Scientific Journal providing information about neurologic disorders.

Janice Ranson

Senior Research Fellow at University of Exeter and Deputy Director of DEMON Network

Maastricht University

Public research university in Maastricht, Netherlands.

University of Exeter Medical School

Medical school in England and it is part of the University of Exeter.

Topics mentioned on this page:
Mental Health
Beyond genetics: 15 risk factors increase risk of early dementia