Key points from article :
Scaffolding around nerve cells lead to loss of memory with ageing, but it is possible to reverse using genetic treatments.
Plasticity of the brain is partially turned off with perineuronal nets, which contain chondroitin sulphates.
As we age, the levels of chondroitin 6-sulphate decrease, leading to memory decline.
Researchers manipulated the chondroitin sulphate composition to restore neuroplasticity and alleviate age-related memory deficits.
Increasing chondroitin 6-sulphate using the viral vector restored memory and plasticity in aged mice similar to healthy mice.
“It may be possible to prevent humans from developing memory loss in old age,” - James Fawcett, Co-researcher.
Identified a potential drug, licensed for human use that can be taken by mouth.
In mice and rats, it can restore memory in ageing and also improves recovery in spinal cord injury.
Investigating in animal models of Alzheimer's disease.
Study by University of Cambridge & University of Leeds published in Molecular Psychiatry.
