Join the club for FREE to access the whole archive and other member benefits.

Synthetic fisetin used to identify new target in fight against Alzheimer's

CMS121 lowered levels of fatty acid synthetase (FASN) which inhibited lipid peroxidation

05-Aug-2020

Key points from article :

Fisetin occurs naturally in fruits and vegetables and is also candidate senolytic.

CMS121 is a synthetic version of fisetin.

Previous studies showed how the drug protects against brain degeneration associated with Alzheimer’s disease.

Middle-aged mice given daily doses of CMS121 outperformed controls in memory and behaviour tests.

Treated mice exhibited a few key differences surrounding the brain's metabolism of fatty molecules called lipids.

Lipid peroxidation was inhibited by lowering levels of a key lipid-producing molecule, called fatty acid synthetase (FASN).

Human subjects found to have higher amounts of the FASN molecule than healthy controls of a similar age,

Research by Salk Institute published in the journal Redox Biology.

Mentioned in this article:

Click on resource name for more details.

Redox Biology

Journal on health and diseases redox biology

Salk Institute

Scientific research institute focused on neuroscience, genetics, immunology, plant biology and more

Topics mentioned on this page:
Alzheimer's Disease