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Synthetic fisetin used to identify new target in fight against Alzheimer's

05-Aug-2020

Key points from article :

Fisetin occurs naturally in fruits and vegetables and is also candidate senolytic.

CMS121 is a synthetic version of fisetin.

Previous studies showed how the drug protects against brain degeneration associated with Alzheimer’s disease.

Middle-aged mice given daily doses of CMS121 outperformed controls in memory and behaviour tests.

Treated mice exhibited a few key differences surrounding the brain's metabolism of fatty molecules called lipids.

Lipid peroxidation was inhibited by lowering levels of a key lipid-producing molecule, called fatty acid synthetase (FASN).

Human subjects found to have higher amounts of the FASN molecule than healthy controls of a similar age,

Research by Salk Institute published in the journal Redox Biology.

CMS121 lowered levels of fatty acid synthetase (FASN) which inhibited lipid peroxidation

Mentioned in this article:

Journal

Journal on health and diseases redox biology