Key points from article :
Fisetin occurs naturally in fruits and vegetables and is also candidate senolytic.
CMS121 is a synthetic version of fisetin.
Previous studies showed how the drug protects against brain degeneration associated with Alzheimer’s disease.
Middle-aged mice given daily doses of CMS121 outperformed controls in memory and behaviour tests.
Treated mice exhibited a few key differences surrounding the brain's metabolism of fatty molecules called lipids.
Lipid peroxidation was inhibited by lowering levels of a key lipid-producing molecule, called fatty acid synthetase (FASN).
Human subjects found to have higher amounts of the FASN molecule than healthy controls of a similar age,
Research by Salk Institute published in the journal Redox Biology.