Mitochondria damage linked to diabetes cell failure
Lifespan.io (LEAF) - 11-Feb-2025Blocking stress response restored cell identity in mice, suggesting new treatment possibilities
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Journalist, Lifespan.io
Arkadi is a seasoned journalist and op-ed author with a passion for learning and exploration. His interests span from politics to science and philosophy. Having studied economics and international relations, he is particularly interested in the social aspects of longevity and life extension. He strongly believes that life extension is an achievable and noble goal that has yet to take its rightful place on the very top of our civilization’s agenda – a situation he is eager to change.
Bi-lingual Hebrew and Russian copywriter, translator, editor, creative director, worked in network agencies (Saatchi&Saatchi, Grey), and in some smaller creative boutiques. Today actively freelancing. Highly experienced in marcom adaptation and transcreation, having collaborated continuously since 2007 with some of the world's leading transcreation agencies (Tag Europe, Text Appeal, Oliver) on major brands, inc. Microsoft, Intel, HP, Dove, Magnum, Rexona, Hilton, ClubMed, Adidas, H&M, British Airways, Sony, iRobot.
Visit website: https://www.lifespan.io/news/author/arkady-mazingmail-com/
See also
Supporting the development of biotechnologies focused on ending age-related diseases
Details last updated 26-Feb-2020
Blocking stress response restored cell identity in mice, suggesting new treatment possibilities
Toronto researchers reveal neural crest cells' hidden role in direct lineage transitions
Ora biomedical’s high-tech screening could uncover life-extending compounds beyond rapamycin’s reach
The ancient genome of the longest-living vertebrate may reveal new insights into ageing
Peter Diamandis shares insights on living longer through tech innovation
Small molecule unlocks youthful telomerase, reversing age-related decline in mice
Backup code: ageing cells from epigenetic changes could potentially be reset to a youthful state
Viagra, cholesterol meds & estrogen replacements linked to longevity, but further research needed
Originally used to fight cancer, sound waves surprisingly revive old cells
They used a drug called rapamycin in mice to boost the cell cleaning (autophagy)
AMIE surpassed human doctors in accuracy, empathy, and communication
While age ultimately caught up, study demonstrates potential of the novel treatment
The method enhances their abilities and promotes wound healing in aged skin
Could potentially predict all-cause mortality more accurately than BMI
Key points from Arkadi Mazin's summary of 5 days of talks by geroscientists and biotech leaders
Novel method for precise estimation of biological age and disease risks with a single blood sample
Potential for manipulating fibroblasts to improve heart healing and regeneration after heart attack
It is best to avoid alcohol altogether or limit consumption to very occasional, light drinking
Is involved in many longevity companies ranging from improving gene therapy delivery to supplements
Two promising techniques: mRNA delivery through CNP-created EVs and microneedles for EV application
Another reminder of the amount of research, with multiple approaches, about to go into clinical trials
The study highlights the diversity of microbiota and their importance for human health and fitness
Round 1 testing rapamycin, senolytic, HSCT & mTERT - could start seeing interesting results within 6 months
Daily dose of 600mg orally elevated NAD+ levels and increased walking distance
NR fuels the energy levels of both cancer cells and cancer-fighting cells according to the study
This approach did not kill the senescent cells instead, it was senomorphic
Many conditions could be improved by removing signalling that prevents cells operating at their best
Partial reprogramming extends healthspan and lifespan by single or lifelong treatment
Plasma concentrate alters methylation clock reducing biological age
Microneedle-based hair treatment substantially more effective than topical application
Upregulation of VEGF-A could be a potentially effective anti-aging therapy
Oligodendrogenesis and memory function in the aged brain can be improved by young CSF
The one thing I hope he's wrong about is that it won't happen in his lifetime - we just need some exponential oomph!
New anti-ageing approach to ramp up NAD levels and life extension
Maximum lifespan of wild-type mice increased over 30% when supplementation started mid-life
Elderly athletes had similar NAD+ levels as normal young people
Tailoring strategies to eliminate bad cells in age-related diseases
Improved survival via eliminating old cells - potential candidate to slowdown ageing
A hot topic in longevity research is plasma exchange for Alzheimer’s disease
Lorna Harries believes dysregulated splicing as a breakthrough senotherapeutic target
Noninvasive imaging technology used to observe aging on the cellular level
Calorie compensation can reach up to 50% in obese people - explains why it is so hard to lose fat
Dasatinib and quercetin combo preserves spinal discs to target age-related back pain
Tracks biological age from physical activity without requiring a blood test
Discusses animal trials, potential human trials, reeducating the FDA and improvements in technology
Targeting SA-T cells: A promising intervention to control age-related chronic diseases
Optimistic on ageing research and a breakthrough human trial to extend healthspan
Possible ways of using reprogramming techniques to develop therapies
Lowers age-related defects of blood stem cells & make stem cell transplants more effective
Boosting a vital protein, Caveolin-1, this new technique offers hope against neurodegenerative diseases
Delays age-related degeneration of hearing hair cells, still need a better cure
Traditional mind-body practices like qigong can be a right choice of exercise for the elderly
In vivo conversion of astrocytes could possibly bring brain regeneration therapies in the near future
Establishing a massive database on cellular senescence to improve human health
Benefits in older mice, but NR treatment in young mice increased inflammation and DNA damage
More and more companies making greater and greater progress - 2021 could be an exciting year
Reprogrammed stem cells treated Parkinson's in rats; initiating clinical trials soon
Scientists discover a pathway to attenuate the deleterious effects of obesity
Telomere transfer from APCs boosts T cells lifespan-helpful in immunosenescence
IL-12 self-replicating RNA delivered in lipid nanoparticles (LNPs) shows good results in mice
Its upregulation could be a new prospect for anti-ageing interventions
It may be a new hallmark of ageing, but it's been one of SENS' 7 strategies since it started
Even if it's an effect (not a cause) then REs could act as another biological clock
With genomic database and statistical tools, more interventions can be discovered
Confirmed in murine and human cell study, findings can aid development of new treatments
Showed impressive results based on experiments in vitro and in vivo, but more work to be done
The clock accurately predicts biological age & can help develop anti ageing drugs
A different perspective for preventing age-related bone loss that affects many
Raises hope to end the extensive physical and psychological suffering the condition brings
Experiments yielded promising results in efficacy, specificity, and non-toxicity
Believes life extension treatments may already exist - but need more clinical trials
It restores neurovascular coupling associated with age-related decline in brain function
Important study in developing cheap and effective treatments for retinopathies
Interesting method to make naturally useful RBCs smaller and more mobile
Variety of polyphenols had positive impact on genomic stability
A small study, but a big impact on the 7 participants who all recovered quickly
This provides simple, safe way to rejuvenate egg cells as shown in aged mice study