New mRNA therapy could reverse signs of skin ageing

Scientists used mRNA therapy targeting ATF3 to rejuvenate skin

Cellular senescence surprisingly supports meniscus repair in rats

Early removal of these cells slows recovery, highlighting their short-term benefits

Cell reprogramming rejuvenates ageing neurons in mice

Scientists enhance brain function and protect against neurodegeneration

Unlocking cellular health: Booster therapeutics targets protein imbalance in ageing

New proteasome-activating drugs aim to tackle neurodegenerative diseases and extend healthy lifespan

Arda therapeutics pioneers new approach to combat chronic diseases and ageing

Targeted cell depletion offers a transformative strategy to treat diseases at their root

Stanford scientists unlock key to reviving ageing brain cells

Glucose regulation may hold the key to restoring neuron growth

TransVision Madrid 2024: pioneering longevity in Europe

Madrid becomes Europe's hub for advancing life extension and healthy ageing

The quest to rebuild the human brain

A groundbreaking approach to extend life through brain tissue renewal

Partial reprogramming rejuvenates the ageing mouse brain, improving memory

This breakthrough offers hope for combating age-related cognitive decline

Harold Katcher on the development, results and future of E5

Now back in full control, Katcher is looking to market its topical application

New investigational drug shows promise in reversing age-related liver damage

Blocking cell death pathway rejuvenates livers in mice, offering potential treatment for humans

Reason reports back from Rejuvenation Startup Summit 2024

A great summary of 25 speakers who are in various stages of platform building, drug discovery and clinical trials

Seragon's anti-aging drug candidate extends healthspan and lifespan in mice

SRN-901 increases longevity gene expression and reduces aging activity

Jamie Justice provides an update on XPRIZE Healthspan competition entrants

Already over 200 organisations have pre-registered - this is going to be exciting to follow

The remaining lifespan of old mice, equivalent to a human age of 77 years, doubled

Therapy used OSKM genes to potentially extend lifespan and reverse ageing signs

Telomere-based interventions offer promising avenues for combating ageing

Telomere research is in its early stages, with much to be discovered

Lifespan.io speaks to Cyclarity’s CEO for an update on its novel atherosclerosis treatment

The company is developing a drug called UDP-003 to treat the disease

Scientists found a way to make old cells young again in a lab

They used special proteins to erase "marks" on DNA that build up with age

Mice regain vision through partial cellular reprogramming of retinal cells

While age ultimately caught up, study demonstrates potential of the novel treatment

UK biotech races US giants for longevity breakthrough

British researchers and startups vie to outpace tech billionaires in the fight against ageing

Eye-opening discovery: a potential non-invasive solution for age-related vision loss

Deglycating enzymes could offer an affordable, effective, and non-invasive treatment for presbyopia

Chemical cocktail able to reprogram cells to reverse ageing, without the need for gene therapy

David Sinclair and team discovers potential new approach to treat age-related diseases and promote healthy aging

Videregen seeks $10m funding for clinical trials of regenerated organs and tissues

Ground-breaking technology to advance the development of a bio-engineered thymus & lung disease treatments

FSU researcher and Lento Bio collaborate to treat age-related vision loss

Aims to cure presbyopia by restoring elasticity of the lens & inhibiting ageing process

Pioneering Heart Repair Technique: Reprogramming Adult Fibroblasts In Vivo

Potential for manipulating fibroblasts to improve heart healing and regeneration after heart attack

Life bio's gene therapy reboots cells, offering hope for vision loss and beyond

Epigenetic reprogramming restored in primates, now paving way for human trials

Unveiling the future of age reversal: meet Yuri Deigin, founder of YouthBio Therapeutics

Tissue-specific gene therapies & rejuvenating factors to extend lifespan and combat age-related diseases

Neocortical grafting platform in brain repair

Multilayered architecture resulted in physiological and behavioural improvements. Could it help regenerate the ageing brain in future?

Partial Cellular Reprogramming in Very Old Mice Doubles Remaining Life Expectancy

Shown to work at a cellular level in humans, too, so a therapeutic could be developed soon

Dissociation of longevity targeted cell reprogram and somatic identity loss: An exploration

Most genes regulating cellular rejuvenation were not related to the increased occurrence of cancer

Focal Biosciences launched by PSI and Apollo Health Ventures

Aims to treat age-related diseases using advanced cellular reprogramming technologies

Therapeutic plasma exchange (TPE) rejuvenates multiple markers of gene expression

TPE causes systematic rejuvenation in human body by influencing multiple factors

mRNA delivers mutated proteins - regenerates cardiomyocytes post a heart attack

Stemin and YAP5SA notably restores normal cardiac pumping in mice

JuvLife Division raises 3.7 million euros for making antiaging product with Chrysea

Metabolites induce autophagy, stimulate cellular regeneration for healthy ageing

Lifespan.io interviews João Pedro de Magalhães about theories of, and curing, ageing

The one thing I hope he's wrong about is that it won't happen in his lifetime - we just need some exponential oomph!

YouthBio Therapeutics unveils its board, with João Pedro de Magalhães as CSO

Another company enters the cellular reprogramming race - hopefully at least one will cross the finishing line

Biological age of human skin cells reduced by 30 years (transcriptome and methylation clocks)

Transient reprogramming is progressing fast - how long before the first skincare product is launched?

Elastrin Therapeutics secures $10 million of funding for its calcification removal platform

Initially targeting stiffened arteries in cardiovascular disease, this could have wider implications

Long-term partial reprogramming reversed ageing process in mice

Yamanaka factors restored youthfullness in aged cells, raised hope for new anti-ageing therapies

Altos Labs comes out of stealth with $3 billion of capital

Huge backing that cellular reprogramming can have a significant impact on health and ageing

NewLimit, a new biotech launches to slowdown or reverse ageing

Aims to extend healthspan and cure ageing with affordable epigenetic therapies

Reversible reprogramming regenerates cardiac tissue after a heart attack

Possibility of regeneration: A boon to the broad rejuvenation field

A promising approach to rejuvenate aged mesenchymal cells by chromatin

Short-term treatment of mesenchymal cells with acetate resulted to enhanced stem cell

Restoration of youthful gene expression can be achieved alternatively

Possible ways of using reprogramming techniques to develop therapies

Michael Greve promises 300m euros to advance rejuvenation startups

Kizoo Technology Ventures helps to bring rejuvenation therapies from lab to clinic

Brain cells reprogrammed to neurons within the brain of mice

In vivo conversion of astrocytes could possibly bring brain regeneration therapies in the near future

Reprogramming turns aged human cells young again

Stanford University research published in New York Times - age-reversal is no longer fringe science!

SENISCA secures 1.3 million pounds to transform anti-ageing technology

Spin out company from University of Exeter step forward towards precision medicine for age-related diseases

Elastrin's novel therapies to reverse age-related vascular damage

Advancing technologies for tissue and organ rejuvenation with seed funding from Kizoo

Goya et al review progress in cell reprogramming

Considers whether, and impact if, epigenetic clock is one component of a modular ageing mechanism

Protein that regulates muscle function in ageing discovered

Blocking it improved muscle strength & function while endurance was also boosted in mice

Vision loss due to age & glaucoma reversed in mice

David Sinclair says findings are 'transformative for the care of age-related vision diseases'

Memory retrieval made possible with a resetting drug

An experimental drug restores age related memory loss and brain function in mice

Skin regeneration reactivated in adult mice

New skin was able to produce fur - might eventually become a treatment for baldness, who knows

LEAF interviews the Conboys about rejuvenating mice by diluting blood plasma

This could be a cheap first generation rejuvenation treatment - but wait for clinical trials

ThirdLaw may have designed a way to break crosslinks to reverse tissue ageing

Whoever controls the shape of a molecule controls what it can do

Fountain secured $6 million Series A-1 financing from Khosla Ventures

With a total of $11 million, more in vivo preclinical drug testing to be expected

Mice vision restored by reprogramming fibroblasts to photoreceptors

Important study in developing cheap and effective treatments for retinopathies

A new faster technique restores vision in mice with retinal degeneration

Researchers plan clinical trials of this in humans to treat retinal diseases

Donor supercentenarian’s cells help unlock mysteries of super-longevity

Evidence of cellular age reversal demonstrated in this gateway research

NAD+ replenishment improves and restores fertility in women

This provides simple, safe way to rejuvenate egg cells as shown in aged mice study

LEAF interviews Hanadie Yousef, co-founder and CEO of Juvena Therapeutics

Muscle regeneration would have a huge hit on healthspan - getting people more mobile again

Novo Biosciences CEO talks about drug candidate for tissue regeneration

Regrowing damaged organs would help many people live longer, healthier lives

British and Israeli teams join to reverse ageing of blood vessels

British Heart Foundation working on anti-ageing research? It must be mainstream now!

LEAF interviews AgeX Therapeutics CEO Dr. Michael West

May only be a few years away from implementing induced tissue regeneration in humans

Lysoclear is making progress towards a cure for macular degeneration

Has cleared protein build up in vivo - has funding to develop clinical candidates

Michael West examines how to safely revive telomerase

It powers foetal development and telomere length, but also cancers

Reversing epigenetic changes rejuvenated mice with progeria

Could turning back the clock on genes make us live much longer?

Adult neurons can grow with the help of a group of proteins

Potential to cure paraplegia and quadriplegia someday in the future

Chemicals identified to reverse mental decline

Mental capacity not lost - just masked by inflammation

Mini-thymus used to produce and train T cells

Able to regenerate ageing immune system, and reduce cost of immunotherapy

Cells of living mice rejuvenated using OSKM trigger in drinking water

More support for the SENS approach of regular maintenance to stop ageing

Oral treatment for wet age-related macular degeneration passes Phase 2a trials

Intriguing hint that this treatment may have potential for other age-related diseases

Reversing aging by removing wrinkles inside our cells

Virus-based treatment seeks to smooth cellular wrinkles in livers

XPO1 inhibition increases autophagy and lifespan

This treatment could be used to alleviate neurodegeneration and disease progression

Can autophagy boost your health?

Autophagy is the process by which cells degrade and recycle their components.

Anti-aging breakthrough could extend healthspan by making old cells young again

Instead of clearing out senescent cells scientists have found a way to rejuvenate them.

Scientists decipher mechanisms underlying the biology of aging

Used a combination of engineering, computer science and biology to analyze molecular processes.

Protein Signalling Implicated in Age-Related Hair Graying

Hair follicle undergoes repetitive cyclic regeneration.

Rejuvenating the Thymus to Prevent Age-related Diseases

Thymus gland produces the majority of body's T cells.

Scientists develop a chip that can regenerate damaged tissue

Can it convert only specific target cells?

BioTime's CEO: Human Aging Will Soon Become a Thing of the Past

Cells become dysfunctional or die with aging.

Treating Diseases with a Protein Missile System

University of Dundee demonstrate AdPROM to target and destroy specific proteins within cells.

Repairing Mitochondrial DNA for Age-related Diseases

University of Sheffield has made progress in repairing the damage done to mitochondrial DNA (mtDNA).

Induced Pluripotency to Enable Rejuvenation of Blood Production

Induced pluripotency appears to produce a form of cellular rejuvenation.

Exciting Therapy To Treat Age Related Blindness Moving To The Clinic

Ichor Therapeutics is a biotechnology company focused on developing drugs for age-related diseases.

Fight Aging predicts the sequence of arrival for meaningful antiaging therapies

Each treatment will target a different type of molecular damage in cells and tissues.

DNA repair and metabolism as determinants of species longevity

Mammalian lifespan differs by >100-fold

Scientists to ‘reset’ blood proteins in attempt to slow ageing process

Participants will have their blood passed through a machine that resets abnormal levels of proteins seen in older blood.

Removing mutated DNA from mitochondria to turn back the aging clock

Hundreds to thousands of mitochondria per cell each carrying its own mtDNA.

Mechanotherapy regenerates injured muscle tissue

Could replace or enhance drug- and cell-based regenerative treatments.

Self assembling biological tissue-like material grown in lab

QMUL create materials using peptides and proteins that self-assemble to form a dynamic tissue.

3D-printed guide helps regenerate complex nerves

Regrowth of nerves after injury or disease is very rare.

Investigating the Mechanisms of Remyelination

As well as diseases such as multiple sclerosis everyone suffers demyelination as part of aging.

Rejuvenation Biotechnology 2015 : Thoughts on Thymus Regeneration

Regeneration of the thymus is one of a number of possible ways to introduce much larger numbers of fresh new immune cells into an old body,

Axons grown across chronic spinal cord injury (SCI)

Deleting PTEN gene in mice neurons stimulated growth of axons across damaged nerve up to 1 year after the original injury.

Building and transplanting a bioengineered forelimb

Functioning rat forelimb grown using decellularization / recellularization (decel/recel) technique.

First human head transplant planned

Russian man to become first to undergo pioneering and controversial surgery.

Energy for muscles and brains controlled by a single protein

Salk scientists discover a single protein that energizes both muscles and the brain.

A simple, non-invasive gene therapy restores sight

Researchers have developed an new method for inserting genes into retina cells.

How to quickly generate a large quantity of personalized nerve cells

Embryonic stem cells (or ESCs) and induced pluripotent stem cells (iPSCs) are prized because they can replicate themselves indefinitely in a dish or differentiate into every cell type in the body.

Lifespan-extending drug given late in life reverses age-related heart disease in mice

Elderly mice suffering from age-related heart disease saw a significant improvement in cardiac function after being treated with the FDA-approved drug rapamycin for just three months.

Organ, tissue replacement could end aging by mid-2020s

Gene therapy: ‘Heart-healing virus’ trial starts