Harold Katcher publishes results of plasma-derived fraction (E5) experiment in Aging Cell
Live Forever Club - 11-Oct-2024E5 treatment extended lifespan & improves health in ageing rats
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E5 treatment extended lifespan & improves health in ageing rats
As therapeutic plasma exchange gains popularity, experts urge caution in the quest for eternal youth
How TPE and IVIG could unlock the fountain of youth
More research is needed, but this discovery offers hope for anti-aging therapies
Researchers improved immune response to new infections and reduced overall inflammation
The old rats that got young blood lived longer and looked healthier
Pig plasma therapy could reverse aging in humans
PF4 from platelets enhanced learning and memory in both young and old mice
Infusion of youthful blood increased lifespan by 5% and improved age-related gene alterations
2 month life extension is equivalent of giving a 60 year-old human an extra 6 years of healthy life
Arthritis drug named anakinra found to reverse ageing effects in blood in mice
This approach did not kill the senescent cells instead, it was senomorphic
Plasma concentrate alters methylation clock reducing biological age
TPE causes systematic rejuvenation in human body by influencing multiple factors
Infusions of young blood plasma into mice, does not increase their lifespan
A target for Alzheimer’s disease therapy may lie in plasmapheresis or blood dialysis
Upregulation of VEGF-A could be a potentially effective anti-aging therapy
No mention of the Conboys, but it looks like it's based on their plasma dilution research
Treatments targeting faster-growing stem cells & low-quality blood cells can promote healthy ageing
Could eventually lead to treatments that reinvigorate immune cell production
Oligodendrogenesis and memory function in the aged brain can be improved by young CSF
Brain volume and lifestyle can increase difference between chronological and biological age
Rejuvenation continues after 4th dose - will be very interesting to see if max lifespan increases
Exercise plasma boosts memory and dampens brain inflammation
An injection of extracellular vesicles improve muscle regeneration
A hot topic in longevity research is plasma exchange for Alzheimer’s disease
Very much looking forward to seeing published results on initial human pilot
Lou Hawthorne, CEO of NaNotics, provides his account of TPE and feeling younger
"Very promising" results from pilot study, with phase 3 clinical trial planned
Disappointingly, no impact was observed on maximum lifespan - still looking for the next bridge
Instead of young blood transfusions, why not make your own blood more youthful?
Conboys are planning a modified lifespan study - looking for funding
Dilution Solution hypothesis better explains the effects of parabiotic experiment & TPE
Results aren't published in any journal but might be the first step towards more human studies
Many people were disappointed that Katcher didn't report lifespan impact - this is about to change
rGDF11 in clinic targets multiple age related disease therapies
Reduces neuroinflammation & promotes neurogenesis in aged brains of mice
Path to a new therapy- replacing blood with youthful factors might reverse ageing
Another point for the "good" factors argument, though removing "bad" factors likely to be important too
Targeting immunosenescence could provide benefits throughout the body
Benefits were seen, but overall results are not impressive
This could be a cheap first generation rejuvenation treatment - but wait for clinical trials
There are things in blood that drives our ageing
With phase 2 study announced, hopes are up for end-stage renal disease sufferers
Imagine halving your age with 4 simple injections - at the very least it will buy more time
No further clinical trials planned, but some interesting results from initial trial
Will this increase the tendency towards young blood transfusion?
Adjusting the levels of just two molecules in the blood could lead to significant rejuvenation
Plasma proteins to the rescue of good-old memories in Alzheimer's
Substance circulating in the veins of juvenile mice delayed death and kept the disease at bay
Two proteins may be responsible for improving brain cell growth
50% improvement in complications of therapy, 19.2% in motor examinations and more
Only 2 months after starting. Calling it a medical treatment may be contravened FDA guidance.
The jury is still out whether benefit is from good factors in the young blood, or diluting bad factors in the patient's old blood
GDF11 is a protein in the blood, which can stimulate cell growth and repair
Bill Faloon inviting people to join a pay-to-participate clinical trial.
Shows how promoters aggressively market unproven yet costly therapies
Interview with Dr. Irina Conboy of Berkeley University.
Injections of blood plasma from young rats improved autophagy and liver function in old rats.
16 people with mild or moderate Alzheimer’s disease received weekly injections of young plasma.
Update on Ambrosia trial that gives blood plasma from under 25s to older people.
Researchers inject mice with blood plasma from humans of different ages – babies, 22 and 66 years old.
Protein boosts blood stem cells, making them behave like those of younger people.
Mix of proteins in your blood is characteristic of your age.
Interview with Drs. Michael and Irina Conboy of the Department of Bioengineering at UC Berkeley.
Attempts have been made to rejuvenate the body by transfusing old people with young blood.
Swapping an older mouse’s ovaries for young ones reversed the effects of ageing on the immune system and metabolism.
Ambrosia (https://www.ambrosiaplasma.com/) young plasma trial is open to anyone 35 and older.
Mice received bone marrow transplants from young donors every 3 months from age 6 months.
In mice – but no reason to assume the same isn’t true in humans. Fractured bones healed faster and more effectively in old mice paired with younger mice.
Tony Wyss-Coray from Stanford University presents the results of tests in mice with video footage of old mice performing better in a standard maze test after receiving blood from younger mice. Benefits possibly come mainly from plasma.
Transfusing youthful blood factors into an older patient could be a reality soon