Metformin may minimize muscle loss in extended periods of bed rest

Lifespan.io (LEAF) - 24-Jul-2023

Improvements seen in muscle size and collagen deposits in older people with atrophy

Diabetes medication metformin could lower long COVID risk by 41%, study suggests

New Scientist - 09-Jun-2023

Metformin may function as an anti-inflammatory and potentially reduce the viral load of SARS-CoV-2

Unraveling the long-term impacts of metformin on lifespan: a 20-year study

Live Forever Club - 16-May-2023

Extensive analysis reveals an initial benefit to longevity that diminishes, then reverses, over time

Peter Attia comments on Danish metformin study that does not find benefit to general population

Peter Attia website - 11-Mar-2023

Original study was subject to bias due to exclusion of participants who progressed to multiple therapies

Metformin misinterpreted as antiaging drug via animal studies, TAME heads for future trials

SENS Research Foundation - 04-Oct-2022

More than 90% of drugs safe and effective when tested in experimental animals fail in human testing

NIH awarded OMRF $3 million to study anti-aging abilities of a diabetic drug

Oklahoma Medical Research Foundation (OMRF) - 13-Jul-2022

Investigation of ability of metformin, a diabetic drug to slow the process of aging

Theranos ceased for fooling investors with a blood-testing device that never worked

BBC - 04-Jan-2022

Founder convicted of wire fraud and sentenced to several years in prison

Anti-5G products claims to be protective but actually emit harmful radiation

Independent - 18-Dec-2021

Dutch authorities warned the use of these necklaces, bracelets and sleep masks

Illegal yohimbine and synephrine pills found online without health warning labels

Guardian - 25-Aug-2021

Products promising weight loss are for sale on internet; users may face health complications

Lifespan.io interviews Dr. Nir Barzilai about metformin, longevity genes and more

Lifespan.io (LEAF) - 29-Jun-2021

Optimistic on ageing research and a breakthrough human trial to extend healthspan

Has Metformin received too much of an attention as an anti ageing drug?

Fight Aging! - 14-Jan-2021

Studies show promise with metformin - tiny positive outcomes with side effects

Activewear brand Lorna Jane makes 'anti-virus' claims: taken to court

BBC - 23-Dec-2020

Such claims made by trusted companies without a scientific basis mislead the public

Nurse turned healer made false claims to cure the incurable

Metro - 04-Dec-2020

Not only is there no cure for AD, worse, there could be harmful ingredients in miracle tonics

Age limits health span benefits of metformin in worms

Medical Xpress - 12-Nov-2020

Scientists link metformin toxicity with age in young,old non diabetic organisms

Metformin with Resistance Training- To do or not to do?

Lifespan.io (LEAF) - 29-Oct-2020

Metformin might inhibit muscle building but makes gene expression more youthful

Josh Mitteldorf on monitoring blood glucose while taking metformin and berberine

Aging Matters - 31-Aug-2020

Eating habits and exercise alter blood glucose levels - wearables may help get a rough idea

Bayshore latest drug maker to recall metformin after carcinogens found

FiercePharma - 21-Aug-2020

A good example of why you have to be careful buying meds - even big pharma has problems.

Crowdsourced samples of metformin from USA contain unacceptable levels of NDMA

New York Times - 27-May-2020

Found only in extended-release versions of metformin, immediate-release versions are okay

Metformin alleviates inflammaging by promoting autophagy

Lifespan.io (LEAF) - 14-May-2020

With the positive results, drug holds great promise for promoting healthy ageing

Metformin repairs metabolic and mitochondrial defects in myotonic dystrophy

Lifespan.io (LEAF) - 16-Apr-2020

New hope for sufferers of disorders that negatively impact metabolism

NHS warns the public about Gwyneth Paltrow and her Goop lab

Huffington Post - 30-Jan-2020

She's not a doctor or scientist, so listen to the people who are

Can we treat the ageing process or not? That's the question

UCSF - 02-Jan-2020

John Newman, UCSF asst prof & Buck Institute researcher, explains upcoming ageing interventions

Calorie restriction can restore myelin on demyelinated nerves

Lifespan.io (LEAF) - 22-Nov-2019

Tested in mouse model - but it's a good starting point

Treating with rapamycin improves blood flow to the brain in rats

Science Daily - 06-Nov-2019

Blood circulation in the brain didn't deteriorate even a bit for 15 months

US doctor opens online anti-ageing clinic

CNBC - 06-Oct-2019

We need proactive longevity doctors in the UK to advise on best approaches at an individual level

Rapamycin shows a sixty percent life expectancy increase in mice model

Aging - 04-Oct-2019

Detailed history and review of current understanding of Rapamycin and longevity

Combination drug therapy increased the lifespan of Drosophila

Phys.org - 30-Sep-2019

Treatment combination consists of lithium, trametinib and rapamycin

Reason analyses a new review paper on metformin - he's not keen

Fight Aging! - 27-Sep-2019

There have been more negative results in mice than positive - surprising given the press it gets

Harvard associate professor looks at 5 common ageing myths

Washington Post - 20-Sep-2019

The science is changing all the time, we've still got a lot to learn

Customers report being deluded by Trusii water company

CNBC - 14-Sep-2019

Many customers left with thousands of dollars debt for the machines that didn't even work

From cryonic baths to ozone saunas, to the search of magic pill

Wired - 10-Sep-2019

In 2018 consumers spent $43 billion on anti-ageing products according to Orbis analysis

Biological age reversed with growth hormone and diabetes drugs cocktail

Nature - 05-Sep-2019

Small, uncontrolled trial, but (potentially) very exciting results

World's first anti-ageing trial received FDA approval

Longevity Technology - 04-Sep-2019

TAME trial lead by clinician Dr Nir Barzilai will begin in November

Reversing epigenetic changes rejuvenated mice with progeria

MIT Technology Review - 08-Aug-2019

Could turning back the clock on genes make us live much longer?

France to stop funding homeopathic care from 2021

Guardian - 10-Jul-2019

If only they’d spent the £114m last year on ageing research instead

It's time for considering drug-exercise interactions

New York Times - 19-Jun-2019

Interesting - metformin plus exercise did not have an additive effect

Minoxidil's potential to restore elastin - can it be more useful?

Fight Aging! - 14-Jun-2019

Needs to find minoxidil analogues that can restore elastin without side effects

Research into klotho is at a very interesting point

Fight Aging! - 03-Jun-2019

Research community is littered with interesting, promising foundations for therapies to treat aging

Scientists discover rapamycin's anti-ageing mechanism

Futurity - 24-May-2019

Triggers lysosomes to degrade harmful substances that collect in ageing cells

IV therapy is a waste of money, or worse

Guardian - 03-Mar-2019

Live Forever Manual rates IV therapy as "save your money"

Metformin gives diabetics longer life than non-diabetics

AGEIST - 03-Mar-2019

Great summary of the drugs history, benefits and risks

David Sinclair's admits taking NMN, resveratrol and Metformin

Next Big Future - 01-Feb-2019

Nothing too surprising in his daily supplement regime

BioViva developing an anti-aging vaccine

Precision Vaccinations - 12-Dec-2018

Developing a virus to express several anti-aging and regenerative factors

Plasma NAD+ Levels Decline Significantly with Age

Lifespan.io (LEAF) - 09-Nov-2018

We still need to understand it better but NAD+ is likely to be important in slowing aging

Crowdfunding NAD+ Mouse Lifespan Study

Lifespan.io (LEAF) - 18-Sep-2018

This project aims to observe if the NAD+ precursor has a positive effect over aging mice

NAD+ Repletion Shows Potential Against Aging

Lifespan.io (LEAF) - 05-Sep-2018

The precursor NMN has some rejuvenating effects over mice's metabolism and gene stability

Cibinetide Shows Promising Signs in Anti-Aging

CISION PR Newswire - 02-May-2018

Cibinetide works via activating the body's innate repair receptor (IRR)

Scientist slow aging in mice — are humans next?

New York Post - 23-Mar-2018

Molecule reactivates faltering blood flow in elderly mice.

Why NAD+ Declines With Age

Lifespan.io (LEAF) - 19-Mar-2018

Nicotinamide adenine dinucleotide is a vital component of cellular function.

Pol III enzyme shows anti-aging potential

New Atlas - 04-Dec-2017

RNA polymerase III (Pol III) is an enzyme essential for cell growth.

Klotho hormone shows promise as a cognitive enhancer

Scientific American - 08-Aug-2017

Klotho injections improved memory and motor skills of mice

Living Forever

Proto - 13-Jun-2017

Review of current thinking from the Massachusetts General Hospital - the largest teaching hospital of Harvard Medical School.

Prolonging Life with Fecal Transplants

Josh Mitteldorf Blog - 10-Apr-2017

Middle-aged fish receiving a transplant of gut bacteria from young fish had in increased mean lifespan of 41%.

Ray Kurzweil talks about Physical Immortality

Aging Reversed - 03-Jan-2017

Ray talks about the singularity, AI and human hybrid thinking with neocortex connected to the cloud.

Eating a well aged cheese could help you live longer

Business Insider - 15-Nov-2016

Research published in Nature Medicine finds the compound spermidine improves cardiovascular health.

Boosting levels of antioxidant may help resist age-related decline

Kurzweil Network - 28-Oct-2016

Glutathione helps resist the toxic stresses of everyday life – levels decline with age.

Scientists discover elixir of youth

Independent - 27-Oct-2016

Natural compound, called NMN, found in avocado, broccoli, cucumber, cabbage and edamame has remarkable anti-ageing effects in mice.

Clinical research seeks fountain of youth

Japan News - 15-Sep-2016

Keio University running a human trial orally administered nicotinamide mononucleotide (NMN).

Heavy Isotopes and Slowed Aging

Fight Aging! - 01-Sep-2016

Raising short-lived species on a low dosage of heavy water appears to modestly slow aging.

Life extending drug tested on dogs

Deccan Chronicle - 15-Aug-2016

Anti-rejection drug rapamycin extend the life of mice by more than 25 per cent.

Scientist declares homeopathy a "therapeutic dead-end"

Independent - 19-Feb-2016

Eye-opening results for homeopathy clients - ineffective as a treatment method

Metformin, Gamma Rays or Chocolate?

Institute for Ethics and Emerging Technologies (IEET) - 26-Dec-2015

Brian Hanley discusses the safety of metformin aging clinical trial.

Metformin human trials planned

Diabetes.co.uk - 30-Nov-2015

Could significantly increase life expectancy and health span.

Seven Emerging Technologies That Will Change the World Forever

Institute for Ethics and Emerging Technologies (IEET) - 29-Sep-2015

Researchers gave the mice a compound called nicotinamide adenine dinucleotide or NAD for a week and found that the age indicators in two-year-old mice were restored to that of six-month-old mice. That would be like turning a 60-year-old human into a 20-ye

Weak doses of radiation prolong life of female flies

Medical Xpress - 24-Aug-2015

Hormesis, where moderate stress has a stimulating effect on an organism and enables the prolongation of life, was first discovered in 1888. This study with weak doses of gamma radiation prolonged the life of fruit flies by 5%.

Metformin seeks approval for first life extension drug trial

City AM - 09-Jul-2015

Existing diabetes drug has been show to delay aging so researchers are now applying to the US Food and Drug Administration (FDA) to run a human trial (Targeting Aging with Metformin, or TAME). Would set precedent for anti-ageing drug.

Study Examines Epigenetic Regulation

Science World Report - 26-May-2015

Addition of glycine for 10 days to 97 year old fibroblast cell line helped to restore respiratory function.

Pill of super-protective ‘heavy’ fat may be key to eternal youth

New Scientist - 13-May-2015

Hydrogen replaced with deuterium strengthens bonds between molecules in cell membranes – could reduce free radical damage. Initial trials to try to slow the progression of Friedreich’s ataxia.

Biologists discover the key mechanism that triggers human ageing

ScienceAlert - 01-May-2015

Accumulated alterations in the structure of heterochromatin may be a major underlying cause of cellular aging.

Broad Institute and Calico collaboration to find therapeutic approaches to diseases of aging

Calico - 17-Mar-2015

Calico is a Google-founded R&D company whose mission is to harness advanced technologies to increase our understanding of the biology that controls lifespan

Silicon Valley Is Trying to Make Humans Immortal—and Finding Some Success

Newsweek - 05-Mar-2015

Everyday drugs could give extra years of life

New Scientist - 01-Oct-2014

Rapamycin in mice

It may be possible to slow or even reverse the effects of ageing by stimulating mitochondrial activity through exercise, diet or drugs.

New Scientist - 22-Sep-2014

Survival benefits of metformin in non-diabetics: faulty analysis in a 2014 study

Science Media Centre - 08-Aug-2014

It's not logical to advise people without diabetes to take metformin