Rapamycin can extend life in animals and reduce seizures

More research and better safety tracking are needed before wider use

Can lifestyle changes really prevent diabetes long term?

Lifestyle extended diabetes-free survival 3.5 years, metformin 2.5 years

Longevity clues: rapamycin shows lifespan boost

Drug mimics life-extending effects of calorie restriction across multiple vertebrate species

Crowdfunded trial tests rapamycin's potential in slowing human ageing

A year-long study finds the drug safe at low doses, with early signs of benefit—especially in women

Metformin did not help older frail adults walk better and caused many side effects

the study shows it should not be used for this purpose in older adults

Metformin may slow ageing by improving metabolism

It supports energy production and protects against age-related diseases

$7M grant is funding research on how rapamycin can help dogs live longer

Enrolling 580 dogs nationwide, researchers aim to uncover new aging insights

Rapamycin improves lifespan in mice, damage repair needs updates

Statistical analysis will clarify sex-specific differences and anomalies

Drugs that may extend dogs' lives can offer insights into human longevity

Scientists are testing drugs like LOY-002 and rapamycin to extend lifespan

Most over-the-counter retinol products don't significantly improve skin

Sunscreen, no smoking, and healthy habits are the best way to maintain skin health

Hunting for a new gold standard in longevity

Ora biomedical’s high-tech screening could uncover life-extending compounds beyond rapamycin’s reach

Exosome therapy: science or hype?

Exploring the promises and pitfalls of a booming beauty trend still shrouded in scientific mystery

Metformin: does it really slow ageing in animals, or just help health?

Despite positive results in monkeys, study lacks baseline data, which raises doubts

Common prescription medications can affect how long people live

Metformin (HR 1.01, CI 0.95–1.07) had a neutral effect on mortality

Diabetes drug metformin shows promise in slowing brain aging in monkeys

New study reveals metformin’s potential to delay brain aging

Dr. Sajad Zalzala reports on PEARL rapamycin trial results

Safety of rapamycin looks good and lean muscle mass among biomarkers trending towards improvement

Rapamycin, a molecule from soil, might help us live longer and healthier

It could delay age-related diseases and improve the body's systems

Metformin may minimize muscle loss in extended periods of bed rest

Improvements seen in muscle size and collagen deposits in older people with atrophy

Diabetes medication metformin could lower long COVID risk by 41%, study suggests

Metformin may function as an anti-inflammatory and potentially reduce the viral load of SARS-CoV-2

Uncovering the potential of rapamycin from off-label use reports

Friends and family noticed their improved health and appearance, with no serious side effects

Unraveling the long-term impacts of metformin on lifespan: a 20-year study

Extensive analysis reveals an initial benefit to longevity that diminishes, then reverses, over time

Peter Attia comments on Danish metformin study that does not find benefit to general population

Original study was subject to bias due to exclusion of participants who progressed to multiple therapies

Elizabeth Holmes sentenced to 11 years for defrauding Theranos investors with false claims

A restitution hearing will decide how much she must repay

Metformin misinterpreted as antiaging drug via animal studies, TAME heads for future trials

More than 90% of drugs safe and effective when tested in experimental animals fail in human testing

NIH awarded OMRF $3 million to study anti-aging abilities of a diabetic drug

Investigation of ability of metformin, a diabetic drug to slow the process of aging

Oral rapamycin aggravates Alzheimer's associated beta-amyloid plaques in mice

Cautioned the use of rapamycin in Alzheimer's patients, as it downregulated Trem2 & reduced β-amyloid clearance

University of Washington launches Rapamycin Study

Have you been taking rapamycin supplements recently? Please consider contributing to this study.

Tornado, new longevity biotech developing safer and effective mTOR inhibitors

Different flavours of rapalogs targeting different age-related conditions

Theranos ceased for fooling investors with a blood-testing device that never worked

Founder convicted of wire fraud and sentenced to several years in prison

Anti-5G products claims to be protective but actually emit harmful radiation

Dutch authorities warned the use of these necklaces, bracelets and sleep masks

First-ever true clinical trial to slow down ageing in dogs

A rapamycin trial testing healthspan improvements in dogs; results may extrapolate to humans as well

Illegal yohimbine and synephrine pills found online without health warning labels

Products promising weight loss are for sale on internet; users may face health complications

In-silico drug modelling for treatment of stroke

Rapamycin analogs may help prevent cerebral ischemia/reperfusion injury (CIRI)

Lifespan.io interviews Dr. Nir Barzilai about metformin, longevity genes and more

Optimistic on ageing research and a breakthrough human trial to extend healthspan

DNA-damage or telomere shortening may not cause normal ageing

Rapamycin fails to extend lifespan in telomerase-deficient mice, while improving lifespan by 39% in normal mice

Lifespan.io crowd-funds clinical trial to determine the effects of Rapamycin

PEARL: Participatory Evaluation of Aging with Rapamycin for Longevity

Rapamycin reduces hearing loss in aged mice but not entirely

Delays age-related degeneration of hearing hair cells, still need a better cure

Rapamycin might not be an alternative for calorie restriction

Failed to mimic dietary restriction pathways on extending lifespan in progeroid mice

Has Metformin received too much of an attention as an anti ageing drug?

Studies show promise with metformin - tiny positive outcomes with side effects

Activewear brand Lorna Jane makes 'anti-virus' claims: taken to court

Such claims made by trusted companies without a scientific basis mislead the public

Nurse turned healer made false claims to cure the incurable

Not only is there no cure for AD, worse, there could be harmful ingredients in miracle tonics

Ageless Rx to investigate role of Rapamycin in human longevity

Set to launch Participatory Evaluation of Aging with Rapamycin for Longevity (PEARL) trial

Age limits health span benefits of metformin in worms

Scientists link metformin toxicity with age in young,old non diabetic organisms

Metformin with Resistance Training- To do or not to do?

Metformin might inhibit muscle building but makes gene expression more youthful

Improving immune system in the elderly with the existing medicines

Repurposing the potential existing drugs might eliminate the risk of developing infections

Josh Mitteldorf on monitoring blood glucose while taking metformin and berberine

Eating habits and exercise alter blood glucose levels - wearables may help get a rough idea

$2M granted for clinical trial of Rapamycin in Alzheimer's

People are now willing to say that treating ageing might help ameliorate age-related diseases

Bayshore latest drug maker to recall metformin after carcinogens found

A good example of why you have to be careful buying meds - even big pharma has problems.

Crowdsourced samples of metformin from USA contain unacceptable levels of NDMA

Found only in extended-release versions of metformin, immediate-release versions are okay

An anti ageing protein found in yeast cells

Works by inhibiting protein metabolism

Metformin alleviates inflammaging by promoting autophagy

With the positive results, drug holds great promise for promoting healthy ageing

Metformin repairs metabolic and mitochondrial defects in myotonic dystrophy

New hope for sufferers of disorders that negatively impact metabolism

Benefits of intermittent rapamycin treatment in late-life

Minimizes off-target effects along with boosting healthspan, as studied in old mice

Rapamycin decreased survival and longevity in mice with short telomeres

mTOR, a pro-survival pathway for shorter telomeres and inhibition is deleterious

NHS warns the public about Gwyneth Paltrow and her Goop lab

She's not a doctor or scientist, so listen to the people who are

Can we treat the ageing process or not? That's the question

John Newman, UCSF asst prof & Buck Institute researcher, explains upcoming ageing interventions

Berberine: the new entity that slowed down ageing in mice

Just like rapamycin, berberine also slows down the senescent process

Rapamycin causes mTOR inhibition having an impact on mammalian aging- Brian Kennedy

mTOR pathway, part of the deregulated nutrient sensing hallmark of aging

"Rapamycin may slow ageing in human skin" says a new study

This topical application of rapamycin did not get absorbed in to bloodstream

Calorie restriction can restore myelin on demyelinated nerves

Tested in mouse model - but it's a good starting point

Treating with rapamycin improves blood flow to the brain in rats

Blood circulation in the brain didn't deteriorate even a bit for 15 months

US doctor opens online anti-ageing clinic

We need proactive longevity doctors in the UK to advise on best approaches at an individual level

Rapamycin shows a sixty percent life expectancy increase in mice model

Detailed history and review of current understanding of Rapamycin and longevity

Combination drug therapy increased the lifespan of Drosophila

Treatment combination consists of lithium, trametinib and rapamycin

Reason analyses a new review paper on metformin - he's not keen

There have been more negative results in mice than positive - surprising given the press it gets

Harvard associate professor looks at 5 common ageing myths

The science is changing all the time, we've still got a lot to learn

Customers report being deluded by Trusii water company

Many customers left with thousands of dollars debt for the machines that didn't even work

From cryonic baths to ozone saunas, to the search of magic pill

In 2018 consumers spent $43 billion on anti-ageing products according to Orbis analysis

Biological age reversed with growth hormone and diabetes drugs cocktail

Small, uncontrolled trial, but (potentially) very exciting results

World's first anti-ageing trial received FDA approval

TAME trial lead by clinician Dr Nir Barzilai will begin in November

Reversing epigenetic changes rejuvenated mice with progeria

Could turning back the clock on genes make us live much longer?

France to stop funding homeopathic care from 2021

If only they’d spent the £114m last year on ageing research instead

It's time for considering drug-exercise interactions

Interesting - metformin plus exercise did not have an additive effect

Minoxidil's potential to restore elastin - can it be more useful?

Needs to find minoxidil analogues that can restore elastin without side effects

Research into klotho is at a very interesting point

Research community is littered with interesting, promising foundations for therapies to treat aging

Scientists discover rapamycin's anti-ageing mechanism

Triggers lysosomes to degrade harmful substances that collect in ageing cells

IV therapy is a waste of money, or worse

Live Forever Manual rates IV therapy as "save your money"

Metformin gives diabetics longer life than non-diabetics

Great summary of the drugs history, benefits and risks

David Sinclair's admits taking NMN, resveratrol and Metformin

Nothing too surprising in his daily supplement regime

BioViva developing an anti-aging vaccine

Developing a virus to express several anti-aging and regenerative factors

Plasma NAD+ Levels Decline Significantly with Age

We still need to understand it better but NAD+ is likely to be important in slowing aging

Crowdfunding NAD+ Mouse Lifespan Study

This project aims to observe if the NAD+ precursor has a positive effect over aging mice

NAD+ Repletion Shows Potential Against Aging

The precursor NMN has some rejuvenating effects over mice's metabolism and gene stability

Cibinetide Shows Promising Signs in Anti-Aging

Cibinetide works via activating the body's innate repair receptor (IRR)

Scientist slow aging in mice — are humans next?

Molecule reactivates faltering blood flow in elderly mice.

Why NAD+ Declines With Age

Nicotinamide adenine dinucleotide is a vital component of cellular function.

Pol III enzyme shows anti-aging potential

RNA polymerase III (Pol III) is an enzyme essential for cell growth.

Klotho hormone shows promise as a cognitive enhancer

Klotho injections improved memory and motor skills of mice

Prolonging Life with Fecal Transplants

Middle-aged fish receiving a transplant of gut bacteria from young fish had in increased mean lifespan of 41%.

Is This the Anti-Aging Pill We’ve All Been Waiting For?

Low-dose everolimus may boost flu response in elderly by rejuvenating immune function

Ray Kurzweil talks about Physical Immortality

Ray talks about the singularity, AI and human hybrid thinking with neocortex connected to the cloud.

Eating a well aged cheese could help you live longer

Research published in Nature Medicine finds the compound spermidine improves cardiovascular health.

Boosting levels of antioxidant may help resist age-related decline

Glutathione helps resist the toxic stresses of everyday life – levels decline with age.

Scientists discover elixir of youth

Natural compound, called NMN, found in avocado, broccoli, cucumber, cabbage and edamame has remarkable anti-ageing effects in mice.

Clinical research seeks fountain of youth

Keio University running a human trial orally administered nicotinamide mononucleotide (NMN).

Heavy Isotopes and Slowed Aging

Raising short-lived species on a low dosage of heavy water appears to modestly slow aging.

Life extending drug tested on dogs

Rapamycin shows promise in extending lifespan and improving heart health in early trials

Scientist declares homeopathy a "therapeutic dead-end"

Eye-opening results for homeopathy clients - ineffective as a treatment method

Metformin, Gamma Rays or Chocolate?

Brian Hanley discusses the safety of metformin aging clinical trial.

Metformin human trials planned

Could significantly increase life expectancy and health span.

Seven Emerging Technologies That Will Change the World Forever

Researchers gave the mice a compound called nicotinamide adenine dinucleotide or NAD for a week and found that the age indicators in two-year-old mice were restored to that of six-month-old mice. That would be like turning a 60-year-old human into a 20-ye

Weak doses of radiation prolong life of female flies

Hormesis, where moderate stress has a stimulating effect on an organism and enables the prolongation of life, was first discovered in 1888. This study with weak doses of gamma radiation prolonged the life of fruit flies by 5%.

Metformin seeks approval for first life extension drug trial

Existing diabetes drug has been show to delay aging so researchers are now applying to the US Food and Drug Administration (FDA) to run a human trial (Targeting Aging with Metformin, or TAME). Would set precedent for anti-ageing drug.

Study Examines Epigenetic Regulation

Addition of glycine for 10 days to 97 year old fibroblast cell line helped to restore respiratory function.

Pill of super-protective ‘heavy’ fat may be key to eternal youth

Hydrogen replaced with deuterium strengthens bonds between molecules in cell membranes – could reduce free radical damage. Initial trials to try to slow the progression of Friedreich’s ataxia.

Biologists discover the key mechanism that triggers human ageing

Accumulated alterations in the structure of heterochromatin may be a major underlying cause of cellular aging.

Broad Institute and Calico collaboration to find therapeutic approaches to diseases of aging

Calico is a Google-founded R&D company whose mission is to harness advanced technologies to increase our understanding of the biology that controls lifespan

Silicon Valley Is Trying to Make Humans Immortal—and Finding Some Success

Everyday drugs could give extra years of life

Rapamycin in mice The study was published in the Diabetes, Obesity and Metabolism journal

It may be possible to slow or even reverse the effects of ageing by stimulating mitochondrial activity through exercise, diet or drugs.

Survival benefits of metformin in non-diabetics: faulty analysis in a 2014 study

It's not logical to advise people without diabetes to take metformin

Lifespan-extending drug given late in life reverses age-related heart disease in mice

Rapamycin boosts heart function in aged mice after just 3 months of treatment