Reason Cherman

CEO of Repair Technologies and founder of Fight Aging

Reason is co-founder and CEO of Repair Biotechnologies. He is the founder and writer of Fight Aging!, a leading blog in the aging biotech community. Reason is also an active angel investor in the space. Previously, Reason was principal software engineer at technology startups. Reason has Masters degrees in Space Physics and Astrophysics.

Visit website: https://www.crunchbase.com/person/reason-cherman

See also: Company Repair Biotechnologies - Biotechnology company focused on developing drugs for cholesterol and aging-related diseases

Details last updated 30-Sep-2019

Reason Cherman is also referenced in the following:

Age-Related Disease Therapeutics Summit

31-May-2023 to 02-Jun-2023

Event about aging and aging related diseases organized by Hanson Wade

Ending Age-Related Diseases (EARD) 2021

19-Aug-2021 to 22-Aug-2021

Hear the latest developments from the leading experts in rejuvenation biotechnology research

Healthy Masters International Conference

05-Nov-2022 to 06-Nov-2022

Healthy Masters conference about living longer and healthier life

Reason | How to Reverse Aging, Senolytics and Fighting Atherosclerosis

Live Longer World podcast #1 with Reason as a guest

Rejuvenation Startup Summit 2024

10-May-2024 to 11-May-2024

The leading networking event for rejuvenation startups, longevity investors and translational researchers by Forever Healthy Foundation

Reason Cherman Blog Posts

10-Sep-2020

Highlights of Ending Age-Related Diseases 2020

Key points from 20 presentations from world-leading researchers

Reason Cherman News

Repair Bio's latest tech assists in clearance of excess cholesterol from blood

Longevity Technology - 08-Feb-2021

CDP technology enters clinical trials soon to tackle the root cause of heart diseases

Can glucosamine reduce your risk of all cause mortality

West Virginia University - 01-Dec-2020

But Reason is not yet convinced - definitely needs more, and bigger, studies

Reason examines the failure of Unity Biotechnology's phase 2 senolytics trial

Fight Aging! - 18-Aug-2020

Disappointing first result - but lessons learnt and plenty of other strategies available

LEAF interviews Reason about his views on epigenetic clocks

Lifespan.io (LEAF) - 22-Jul-2020

It does seem way to early to be settling for any single type of clock for rejuvenation research

Master Investor Magazine focuses on longevity in its Autumn edition

Master Investor - 01-Nov-2019

Interesting articles and some useful investment opportunities

Articles written by Reason Cherman

Senolytic drugs offered mixed clues about their potential impact on ageing

Fight Aging! - 04-Mar-2024

While modifying immune cell populations, the drugs also increased ageing biomarkers

Reason reports back from Age-Related Disease Therapeutics Summit 2023

Fight Aging! - 16-Jun-2023

Many people believe lots of clinical trials of novel therapeutics targeting mechanisms of aging will start up in the next few years

Reason reports back from October's Rejuvenation Startup Summit

Fight Aging! - 19-Oct-2022

Some really exciting developments with quite a few in clinical trials

Negative impacts of khavinson peptides and melatonin on thymic regrowth

Fight Aging! - 12-Sep-2022

Self-experiment results- detrimental due to frequent doses or simply bad combo

Reason reviews progress in longevity research and treatments from 2021

Fight Aging! - 31-Dec-2021

There is a phenomenal amount of work going on across the spectrum of ageing - something is going to work eventually!

The Rejuvenome project plans to combine multiple anti-ageing interventions in mice

Fight Aging! - 27-Sep-2021

One drug doesn't fit all; combination therapies to address multiple ageing processes at once

Role of Neuromuscular junction in ageing and neuro muscular diseases

Fight Aging! - 17-Aug-2021

Neuromuscular junction: A potential therapeutic target in neuromuscular injury

Frailty in old mice disappears with small extracellular vesicles from young mice stem cells

Fight Aging! - 09-Aug-2021

Molecular level benefits observed (inflammation, senescence) as well as physical ones

Geography affects gut microbiome in healthspan and longevity

Fight Aging! - 07-Jun-2021

One treatment does not fit all - diversified gut microbiota needs customizable medicine

Men (and, strangely, only men) in physical jobs live longer than their peers

Fight Aging! - 11-May-2021

Physically active work life and better lifestyle choices linked to long-term survival in men

Youthful gut microbiome rejuvenates ageing immune system

Fight Aging! - 05-May-2021

Restoring gut microbial health can reverse declining age-related immune fitness

Supplementation with nicotinamide riboside slows age-related bone loss

Fight Aging! - 14-Apr-2021

Long-term use of this supplement boosts NAD+ levels, lowering the risk of osteoporosis in mice

Could diluting blood with recombinant serum albumin reverse ageing?

Fight Aging! - 06-Apr-2021

Disappointingly, no impact was observed on maximum lifespan - still looking for the next bridge

A low-calorie diet maintains youthful gut state & improves lifespan

Fight Aging! - 24-Mar-2021

Calorie restriction prevents age-related changes to the gut microbiome in mice

Flagellin vaccine can help reduce harmful gut bacteria

Fight Aging! - 03-Mar-2021

Favorable results in single person experiment calls for a larger and formal research

Reason examines the failure of Unity Biotechnology's phase 2 senolytics trial

Fight Aging! - 18-Aug-2020

Disappointing first result - but lessons learnt and plenty of other strategies available

Gut microbiome of centenarians changes a few months before death

Fight Aging! - 11-Aug-2020

Causation vs correlation to be confirmed - but death affects ALL cells in the body, not just YOUR cells

Exercise reduces inflammation caused by SASP but not the number of senescent cells

Fight Aging! - 31-Jul-2020

Given senolytics are unlikely to ever clear every senescent cell, exercise will still minimise bad effects of those remaining

Mice given ethanol in drinking water show many metabolic benefits

Fight Aging! - 29-Jul-2020

Perhaps all the benefits come their their increased physical activity - worth further investigation

Cohort study: Glucosamine reduces mortality by 15%

Fight Aging! - 28-Jul-2020

Supplementation with this anti-inflammatory drug can give us more benefits than we know

Biological age of heart tissue 10 years younger then white blood cells

Fight Aging! - 20-Jul-2020

We need a single biological age figure as mortality risk applies to the whole body

What are the odds of living up to 100 years?

Fight Aging! - 25-Jun-2020

Study of environmental factors leading to becoming centenarian opposes previous literature

Harmful effects of senolytic drug Navitoclax in aged mice

Fight Aging! - 19-Jun-2020

Short-term treatment of this drug demonstrated cytotoxicity among other risks

Could sea urchins hold the secrets of senescence and longevity?

Fight Aging! - 02-Jun-2020

Possible as these highly regenerative echinoids show extremes of biological ageing

Study reviews NMN as a therapy for NAD+ metabolism disorders

Fight Aging! - 29-May-2020

500 mg shown safe in clinical trials - lots more research underway

Calorie restriction rejuvenates 'brain immune cells' in mice

Fight Aging! - 27-May-2020

Still one of the most reliable interventions when improving long-term health

The effect of gut microbiota on cognitive decline in aged rats

Fight Aging! - 14-May-2020

First study investigating its effects in the normal ageing process

Addressing treatment-related ageing in cancer with senolytics

Fight Aging! - 11-May-2020

Hopes are up for it to directly help the cancer research community and patients

Navitoclax improved, now a safer senolytic drug choice

Fight Aging! - 09-Apr-2020

They found efficient way to increase its senolytic specificity, reduce platelet toxicity

Those with genetic variants for hypertension and obesity have shorter lifespans

Fight Aging! - 30-Mar-2020

Trans-ethnic biobanks are very useful to calculate polygenic risk scores

Benefits of intermittent rapamycin treatment in late-life

Fight Aging! - 23-Mar-2020

Minimizes off-target effects along with boosting healthspan, as studied in old mice

Study determines impact of lifestyle choices on expected age of death

Fight Aging! - 18-Mar-2020

Easier to understand in years, rather than percentages. Whole milk a surprisingly big factor.

Stability of splicing regulation, key to naked mole-rat longevity

Fight Aging! - 16-Mar-2020

Mechanism behind their exceptional lifespan and prolonged healthspan becoming clear

Cognitive and motor function improve with mitotherapy in aged mice

Fight Aging! - 06-Mar-2020

These are among other benefits revealing new insights into anti-aging research

Werner syndrome and normal aging epigenetic signatures differ

Fight Aging! - 17-Feb-2020

Werner syndrome, not merely accelerated normal aging as previously thought

Repletion of NAD+ has some degree of improvement on ageing in mice

Fight Aging! - 07-Feb-2020

Needs to study more on NAD+ interventions in order to achieve significant benefits

Ageing in mice - the systemic burden of senescent cells matters

Fight Aging! - 06-Feb-2020

Senescent cell burden is a marker of disease free years ahead of life

Fight Aging! reports back from SENS Research Foundation Pitch Day

Fight Aging! - 20-Jan-2020

When some of these succeed in human trials even more money will pile in to fund further advances

Berberine: the new entity that slowed down ageing in mice

Fight Aging! - 26-Dec-2019

Just like rapamycin, berberine also slows down the senescent process

Cryonicists get together in New York - Reason reports back

Fight Aging! - 25-Dec-2019

No surprise there is a big overlap in interest in life extension from the cryonics community

Autophagy may be the reason behind benefits of calorie restriction

Fight Aging! - 19-Dec-2019

Better to read on best practices of calorie restriction with optimal nutrition before you start

Aspirin as a prophylactic measure: reduces mortality in older adult participants

Fight Aging! - 13-Dec-2019

Greatest reduction in colorectal cancer mortality by using aspirin more than 3 times per week

Blind mole rats can prevent age-related chronic inflammation

Fight Aging! - 01-Nov-2019

They have a natural mechanism against cellular senescence and ageing

TAME Metformin Trial: An Editorial by Aubrey de Grey

Fight Aging! - 22-Oct-2019

Is it really the best use of $75M in the crusade against aging?

A potential genetic shield against ionizing radiation: Dsup

Fight Aging! - 11-Oct-2019

Picking up genes and proteins from other species to make a superhuman

Revitalizing the aged brain - research evidence in animal models

Fight Aging! - 08-Oct-2019

Will this increase the tendency towards young blood transfusion?

Long term physical exercise: protective against cardiovascular disease

Fight Aging! - 07-Oct-2019

Better to start exercising regularly at a pre-elderly age

Reason analyses a new review paper on metformin - he's not keen

Fight Aging! - 27-Sep-2019

There have been more negative results in mice than positive - surprising given the press it gets

Calorie restriction drugs may help you live longer

Fight Aging! - 15-Feb-2019

BHB therapeutics develops treatment to mimic the effects of good diet

Molecular clock reversed in mice using SIRT3 infusion

Fight Aging! - 31-Jan-2013

Could SIRT3 promotion in humans help with age-related oxidative stress?

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