Highlights of Ending Age-Related Diseases 2020
Key points from 20 presentations from world-leading researchers
Reason
CEO of Repair Technologies and founder of Fight Aging
Reason is co-founder and CEO of Repair Biotechnologies. He is the founder and writer of Fight Aging!, a leading blog in the aging biotech community. Reason is also an active angel investor in the space. Previously, Reason was principal software engineer at technology startups. Reason has Masters degrees in Space Physics and Astrophysics.
According to submissions to the US Securities and Exchange Commission, his full legal name is "Reason".
Visit website: https://www.repairbiotechnologies.com/team/reason/
See also: 
Repair Biotechnologies
- Biotechnology company focused on developing drugs for cholesterol and aging-related diseases
Details last updated 30-Sep-2019
Reason is also referenced in the following:
Age-Related Disease Therapeutics Summit
31-May-2023 to 02-Jun-2023
Event about aging and aging related diseases organized by Hanson Wade
Clearing Free Cholesterol Reverses Atherosclerotic Plaques - Reason at Longevity Summit Dublin 2024
Reason delivered a keynote on how clearing free cholesterol reverses atherosclerotic plaques
Ending Age-Related Diseases (EARD) 2021
19-Aug-2021 to 22-Aug-2021
Hear the latest developments from the leading experts in rejuvenation biotechnology research
Healthy Masters International Conference
05-Nov-2022 to 06-Nov-2022
Healthy Masters conference about living longer and healthier life
Longevity Summit Dublin 2024
13-Jun-2024 to 16-Jun-2024
Event gathering Global Longevity and Rejuvenation community in Dublin by LEV Foundation (Dublin, Ireland)
Reason | How to Reverse Aging, Senolytics and Fighting Atherosclerosis
Live Longer World podcast #1 with Reason as a guest
Rejuvenation Startup Summit 2024
10-May-2024 to 11-May-2024
The leading networking event for rejuvenation startups, longevity investors and translational researchers by Forever Healthy Foundation
Reason Blog Posts
10-Sep-2020
Reason News
Reason reports back from Rejuvenation Startup Summit 2024
Fight Aging! - 13-May-2024A great summary of 25 speakers who are in various stages of platform building, drug discovery and clinical trials
Reason reports back from Age-Related Disease Therapeutics Summit 2023
Fight Aging! - 16-Jun-2023Many people believe lots of clinical trials of novel therapeutics targeting mechanisms of aging will start up in the next few years
Reason reports back from October's Rejuvenation Startup Summit
Fight Aging! - 19-Oct-2022Some really exciting developments with quite a few in clinical trials
Reason reviews progress in longevity research and treatments from 2021
Fight Aging! - 31-Dec-2021There is a phenomenal amount of work going on across the spectrum of ageing - something is going to work eventually!
Repair Bio's latest tech assists in clearance of excess cholesterol from blood
Longevity Technology - 08-Feb-2021CDP technology enters clinical trials soon to tackle the root cause of heart diseases
Can glucosamine reduce your risk of all cause mortality
West Virginia University - 01-Dec-2020But Reason is not yet convinced - definitely needs more, and bigger, studies
Reason examines the failure of Unity Biotechnology's phase 2 senolytics trial
Fight Aging! - 18-Aug-2020Disappointing first result - but lessons learnt and plenty of other strategies available
LEAF interviews Reason about his views on epigenetic clocks
Lifespan.io (LEAF) - 22-Jul-2020It does seem way to early to be settling for any single type of clock for rejuvenation research
Cryonicists get together in New York - Reason reports back
Fight Aging! - 25-Dec-2019No surprise there is a big overlap in interest in life extension from the cryonics community
Master Investor Magazine focuses on longevity in its Autumn edition
Master Investor - 01-Nov-2019Interesting articles and some useful investment opportunities
Reason analyses a new review paper on metformin - he's not keen
Fight Aging! - 27-Sep-2019There have been more negative results in mice than positive - surprising given the press it gets
Articles written by Reason
Reason reports back from Rejuvenation Startup Summit 2024
Fight Aging! - 13-May-2024A great summary of 25 speakers who are in various stages of platform building, drug discovery and clinical trials
Senolytic drugs offered mixed clues about their potential impact on ageing
Fight Aging! - 04-Mar-2024While modifying immune cell populations, the drugs also increased ageing biomarkers
Reason reports back from Age-Related Disease Therapeutics Summit 2023
Fight Aging! - 16-Jun-2023Many people believe lots of clinical trials of novel therapeutics targeting mechanisms of aging will start up in the next few years
Reason reports back from October's Rejuvenation Startup Summit
Fight Aging! - 19-Oct-2022Some really exciting developments with quite a few in clinical trials
Negative impacts of khavinson peptides and melatonin on thymic regrowth
Fight Aging! - 12-Sep-2022Self-experiment results- detrimental due to frequent doses or simply bad combo
Reason reviews progress in longevity research and treatments from 2021
Fight Aging! - 31-Dec-2021There is a phenomenal amount of work going on across the spectrum of ageing - something is going to work eventually!
The Rejuvenome project plans to combine multiple anti-ageing interventions in mice
Fight Aging! - 27-Sep-2021One drug doesn't fit all; combination therapies to address multiple ageing processes at once
Role of Neuromuscular junction in ageing and neuro muscular diseases
Fight Aging! - 17-Aug-2021Neuromuscular junction: A potential therapeutic target in neuromuscular injury
Frailty in old mice disappears with small extracellular vesicles from young mice stem cells
Fight Aging! - 09-Aug-2021Molecular level benefits observed (inflammation, senescence) as well as physical ones
Geography affects gut microbiome in healthspan and longevity
Fight Aging! - 07-Jun-2021One treatment does not fit all - diversified gut microbiota needs customizable medicine
Men (and, strangely, only men) in physical jobs live longer than their peers
Fight Aging! - 11-May-2021Physically active work life and better lifestyle choices linked to long-term survival in men
Youthful gut microbiome rejuvenates ageing immune system
Fight Aging! - 05-May-2021Restoring gut microbial health can reverse declining age-related immune fitness
Supplementation with nicotinamide riboside slows age-related bone loss
Fight Aging! - 14-Apr-2021Long-term use of this supplement boosts NAD+ levels, lowering the risk of osteoporosis in mice
Could diluting blood with recombinant serum albumin reverse ageing?
Fight Aging! - 06-Apr-2021Disappointingly, no impact was observed on maximum lifespan - still looking for the next bridge
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A low-calorie diet maintains youthful gut state & improves lifespan
Fight Aging! - 24-Mar-2021Calorie restriction prevents age-related changes to the gut microbiome in mice
Flagellin vaccine can help reduce harmful gut bacteria
Fight Aging! - 03-Mar-2021Favorable results in single person experiment calls for a larger and formal research
Reason examines the failure of Unity Biotechnology's phase 2 senolytics trial
Fight Aging! - 18-Aug-2020Disappointing first result - but lessons learnt and plenty of other strategies available
Gut microbiome of centenarians changes a few months before death
Fight Aging! - 11-Aug-2020Causation vs correlation to be confirmed - but death affects ALL cells in the body, not just YOUR cells
Exercise reduces inflammation caused by SASP but not the number of senescent cells
Fight Aging! - 31-Jul-2020Given senolytics are unlikely to ever clear every senescent cell, exercise will still minimise bad effects of those remaining
Mice given ethanol in drinking water show many metabolic benefits
Fight Aging! - 29-Jul-2020Perhaps all the benefits come their their increased physical activity - worth further investigation
Cohort study: Glucosamine reduces mortality by 15%
Fight Aging! - 28-Jul-2020Supplementation with this anti-inflammatory drug can give us more benefits than we know
Biological age of heart tissue 10 years younger then white blood cells
Fight Aging! - 20-Jul-2020We need a single biological age figure as mortality risk applies to the whole body
What are the odds of living up to 100 years?
Fight Aging! - 25-Jun-2020Study of environmental factors leading to becoming centenarian opposes previous literature
Harmful effects of senolytic drug Navitoclax in aged mice
Fight Aging! - 19-Jun-2020Short-term treatment of this drug demonstrated cytotoxicity among other risks
Could sea urchins hold the secrets of senescence and longevity?
Fight Aging! - 02-Jun-2020Possible as these highly regenerative echinoids show extremes of biological ageing
Study reviews NMN as a therapy for NAD+ metabolism disorders
Fight Aging! - 29-May-2020500 mg shown safe in clinical trials - lots more research underway
Calorie restriction rejuvenates 'brain immune cells' in mice
Fight Aging! - 27-May-2020Still one of the most reliable interventions when improving long-term health
The effect of gut microbiota on cognitive decline in aged rats
Fight Aging! - 14-May-2020First study investigating its effects in the normal ageing process
Addressing treatment-related ageing in cancer with senolytics
Fight Aging! - 11-May-2020Hopes are up for it to directly help the cancer research community and patients
Navitoclax improved, now a safer senolytic drug choice
Fight Aging! - 09-Apr-2020They found efficient way to increase its senolytic specificity, reduce platelet toxicity
Those with genetic variants for hypertension and obesity have shorter lifespans
Fight Aging! - 30-Mar-2020Trans-ethnic biobanks are very useful to calculate polygenic risk scores
Benefits of intermittent rapamycin treatment in late-life
Fight Aging! - 23-Mar-2020Minimizes off-target effects along with boosting healthspan, as studied in old mice
Study determines impact of lifestyle choices on expected age of death
Fight Aging! - 18-Mar-2020Easier to understand in years, rather than percentages. Whole milk a surprisingly big factor.
Stability of splicing regulation, key to naked mole-rat longevity
Fight Aging! - 16-Mar-2020Mechanism behind their exceptional lifespan and prolonged healthspan becoming clear
Cognitive and motor function improve with mitotherapy in aged mice
Fight Aging! - 06-Mar-2020These are among other benefits revealing new insights into anti-aging research
Werner syndrome and normal aging epigenetic signatures differ
Fight Aging! - 17-Feb-2020Werner syndrome, not merely accelerated normal aging as previously thought
Repletion of NAD+ has some degree of improvement on ageing in mice
Fight Aging! - 07-Feb-2020Needs to study more on NAD+ interventions in order to achieve significant benefits
Ageing in mice - the systemic burden of senescent cells matters
Fight Aging! - 06-Feb-2020Senescent cell burden is a marker of disease free years ahead of life
Fight Aging! reports back from SENS Research Foundation Pitch Day
Fight Aging! - 20-Jan-2020When some of these succeed in human trials even more money will pile in to fund further advances
Berberine: the new entity that slowed down ageing in mice
Fight Aging! - 26-Dec-2019Just like rapamycin, berberine also slows down the senescent process
Cryonicists get together in New York - Reason reports back
Fight Aging! - 25-Dec-2019No surprise there is a big overlap in interest in life extension from the cryonics community
Autophagy may be the reason behind benefits of calorie restriction
Fight Aging! - 19-Dec-2019Better to read on best practices of calorie restriction with optimal nutrition before you start
Aspirin as a prophylactic measure: reduces mortality in older adult participants
Fight Aging! - 13-Dec-2019Greatest reduction in colorectal cancer mortality by using aspirin more than 3 times per week
Blind mole rats can prevent age-related chronic inflammation
Fight Aging! - 01-Nov-2019They have a natural mechanism against cellular senescence and ageing
TAME Metformin Trial: An Editorial by Aubrey de Grey
Fight Aging! - 22-Oct-2019Is it really the best use of $75M in the crusade against aging?
A potential genetic shield against ionizing radiation: Dsup
Fight Aging! - 11-Oct-2019Picking up genes and proteins from other species to make a superhuman
Revitalizing the aged brain - research evidence in animal models
Fight Aging! - 08-Oct-2019Will this increase the tendency towards young blood transfusion?
Long term physical exercise: protective against cardiovascular disease
Fight Aging! - 07-Oct-2019Better to start exercising regularly at a pre-elderly age
Reason analyses a new review paper on metformin - he's not keen
Fight Aging! - 27-Sep-2019There have been more negative results in mice than positive - surprising given the press it gets
Calorie restriction drugs may help you live longer
Fight Aging! - 15-Feb-2019BHB therapeutics develops treatment to mimic the effects of good diet
Molecular clock reversed in mice using SIRT3 infusion
Fight Aging! - 31-Jan-2013Could SIRT3 promotion in humans help with age-related oxidative stress?
Topics mentioned on this page:
Ageing Research
