Ultrasound may help the body remove ageing cells naturally

This non-invasive method could be useful in treating age-related conditions

Scientists can’t agree on what ageing is or how to stop it

Some think ageing starts at birth; others say it begins later, like during puberty

Reason reviews progress made in ageing research and potential rejuvenation treatments

Biotech industries and ageing clocks offer new ways to tackle ageing

Reason reports back from Rejuvenation Startup Summit 2024

A great summary of 25 speakers who are in various stages of platform building, drug discovery and clinical trials

Senolytic drugs offered mixed clues about their potential impact on ageing

While modifying immune cell populations, the drugs also increased ageing biomarkers

Reason reports back from Age-Related Disease Therapeutics Summit 2023

Many people believe lots of clinical trials of novel therapeutics targeting mechanisms of aging will start up in the next few years

Reason reports back from October's Rejuvenation Startup Summit

Some really exciting developments with quite a few in clinical trials

Negative impacts of khavinson peptides and melatonin on thymic regrowth

Self-experiment results- detrimental due to frequent doses or simply bad combo

Reason reviews progress in longevity research and treatments from 2021

There is a phenomenal amount of work going on across the spectrum of ageing - something is going to work eventually!

The Rejuvenome project plans to combine multiple anti-ageing interventions in mice

One drug doesn't fit all; combination therapies to address multiple ageing processes at once

Role of Neuromuscular junction in ageing and neuro muscular diseases

Neuromuscular junction: A potential therapeutic target in neuromuscular injury

Frailty in old mice disappears with small extracellular vesicles from young mice stem cells

Molecular level benefits observed (inflammation, senescence) as well as physical ones

DNAm GrimAge is a strong predictor of mortality independent of genetic influences

Twin study allowed impact of lifestyle factors on epigenetic aging to be determined

Geography affects gut microbiome in healthspan and longevity

One treatment does not fit all - diversified gut microbiota needs customizable medicine

Men (and, strangely, only men) in physical jobs live longer than their peers

Physically active work life and better lifestyle choices linked to long-term survival in men

Youthful gut microbiome rejuvenates ageing immune system

Restoring gut microbial health can reverse declining age-related immune fitness

Supplementation with nicotinamide riboside slows age-related bone loss

Long-term use of this supplement boosts NAD+ levels, lowering the risk of osteoporosis in mice

Could diluting blood with recombinant serum albumin reverse ageing?

Disappointingly, no impact was observed on maximum lifespan - still looking for the next bridge

A low-calorie diet maintains youthful gut state & improves lifespan

Calorie restriction prevents age-related changes to the gut microbiome in mice

Flagellin vaccine can help reduce harmful gut bacteria

Favorable results in single person experiment calls for a larger and formal research

Has Metformin received too much of an attention as an anti ageing drug?

Studies show promise with metformin - tiny positive outcomes with side effects

Cancer survivors have a greater risk of developing & dying from new cancers

Reinforce importance of surveillance & preventive measures to tackle cancers

Reason reviews the research behind One Skin's senotherapeutic skin-care spray

The anti-ageing peptide promotes skin health and reduces senescent cell markers

Reason examines the failure of Unity Biotechnology's phase 2 senolytics trial

Disappointing first result - but lessons learnt and plenty of other strategies available

Gut microbiome of centenarians changes a few months before death

Causation vs correlation to be confirmed - but death affects ALL cells in the body, not just YOUR cells

Exercise reduces inflammation caused by SASP but not the number of senescent cells

Given senolytics are unlikely to ever clear every senescent cell, exercise will still minimise bad effects of those remaining

Mice given ethanol in drinking water show many metabolic benefits

Perhaps all the benefits come their their increased physical activity - worth further investigation

Cohort study: Glucosamine reduces mortality by 15%

Supplementation with this anti-inflammatory drug can give us more benefits than we know

Biological age of heart tissue 10 years younger then white blood cells

We need a single biological age figure as mortality risk applies to the whole body

What are the odds of living up to 100 years?

Study of environmental factors leading to becoming centenarian opposes previous literature

Harmful effects of senolytic drug Navitoclax in aged mice

Short-term treatment of this drug demonstrated cytotoxicity among other risks

Could sea urchins hold the secrets of senescence and longevity?

Possible as these highly regenerative echinoids show extremes of biological ageing

Study reviews NMN as a therapy for NAD+ metabolism disorders

500 mg shown safe in clinical trials - lots more research underway

Calorie restriction rejuvenates 'brain immune cells' in mice

Still one of the most reliable interventions when improving long-term health

The effect of gut microbiota on cognitive decline in aged rats

First study investigating its effects in the normal ageing process

Addressing treatment-related ageing in cancer with senolytics

Hopes are up for it to directly help the cancer research community and patients

Navitoclax improved, now a safer senolytic drug choice

They found efficient way to increase its senolytic specificity, reduce platelet toxicity

Those with genetic variants for hypertension and obesity have shorter lifespans

Trans-ethnic biobanks are very useful to calculate polygenic risk scores

Benefits of intermittent rapamycin treatment in late-life

Minimizes off-target effects along with boosting healthspan, as studied in old mice

Study determines impact of lifestyle choices on expected age of death

Easier to understand in years, rather than percentages. Whole milk a surprisingly big factor.

Stability of splicing regulation, key to naked mole-rat longevity

Mechanism behind their exceptional lifespan and prolonged healthspan becoming clear

Cognitive and motor function improve with mitotherapy in aged mice

These are among other benefits revealing new insights into anti-aging research

Werner syndrome and normal aging epigenetic signatures differ

Werner syndrome, not merely accelerated normal aging as previously thought

Repletion of NAD+ has some degree of improvement on ageing in mice

Needs to study more on NAD+ interventions in order to achieve significant benefits

Ageing in mice - the systemic burden of senescent cells matters

Senescent cell burden is a marker of disease free years ahead of life

Association between lung function and epigenetic age

Association with acceleration is strongly expressed in women above the age of 50 years

Fight Aging! reports back from SENS Research Foundation Pitch Day

When some of these succeed in human trials even more money will pile in to fund further advances

Berberine: the new entity that slowed down ageing in mice

Just like rapamycin, berberine also slows down the senescent process

Cryonicists get together in New York - Reason reports back

No surprise there is a big overlap in interest in life extension from the cryonics community

Autophagy may be the reason behind benefits of calorie restriction

Better to read on best practices of calorie restriction with optimal nutrition before you start

Aspirin as a prophylactic measure: reduces mortality in older adult participants

Greatest reduction in colorectal cancer mortality by using aspirin more than 3 times per week

Blind mole rats can prevent age-related chronic inflammation

They have a natural mechanism against cellular senescence and ageing

TAME Metformin Trial: An Editorial by Aubrey de Grey

Is it really the best use of $75M in the crusade against aging?

A potential genetic shield against ionizing radiation: Dsup

Picking up genes and proteins from other species to make a superhuman

Revitalizing the aged brain - research evidence in animal models

Will this increase the tendency towards young blood transfusion?

Long term physical exercise: protective against cardiovascular disease

Better to start exercising regularly at a pre-elderly age

Possible future of transplantation medicine

LyGenesis is developing a technique for implanting cells into lymph nodes for future transplantation

Reason analyses a new review paper on metformin - he's not keen

There have been more negative results in mice than positive - surprising given the press it gets

Minoxidil's potential to restore elastin - can it be more useful?

Needs to find minoxidil analogues that can restore elastin without side effects

Research into klotho is at a very interesting point

Research community is littered with interesting, promising foundations for therapies to treat aging

Halfway-house stem cells may be as effective as iPSCs

Turn.bio testing new in vivo therapy - good results for sarcopenia in mice

Calorie restriction drugs may help you live longer

BHB therapeutics develops treatment to mimic the effects of good diet

Naked Mole Rats Repair DNA Super Efficiently

These rats seem to be almost immune to cancer for unknown reasons

No Heart Benefits From Common Dietary Supplements

Some supplements can actually be harmful in the long term

Alcor Receives $5 Million Donation

Donation came from a private individual involved with cryptocurrencies

Human Trial of Mitochondrially Targeted Antioxidant MitoQ

Aortic stiffness was lower in participants with elevated baseline levels. Ordinary antioxidants ...

No Benefits of Higher Protein Intake in Older Individuals

Possible cause of sarcopenia impaired processing of the essential amino acid leucine. Study sugg...

Aerobic Fitness Correlates with Better Memory in Later Life

Brain is reliant on the vascular system in many ways. Reduction in capillary formation reduces s...

Gene Therapies to Greatly Reduce the Incidence of Cardiovascular Disease

Gene therapy could disable genes that sustain levels of lipids in the bloodstream. Number of cre...

Recent Advances in Regenerative Medicine

Progressing towards the ability to build complex tissues from a cell sample. Transplants of cell...

How to Plan and Carry Out a Simple Self-Experiment

Process of setting up and running a self-experiment of candidate senolytic drugs. Optimized for ...

Alpha-2-Macroglobulin in the Cancer Immunity of Naked Mole-Rats

Naked mole-rats are near immune to cancer. So far this resistance has been put down to greater e...

Aging Research Half a Lifetime Ago: the Lost Decades of the 20th Century

Mitochondrial Contribution to Aging and Age-Related Disease

Mitochondria are primarily responsible for generating chemical energy stores. Small number of ge...

Young Plasma Improves Cell Recycling in Old Rats

Injections of blood plasma from young rats improved autophagy and liver function in old rats. A...

Gene Therapies as a Basis to Control Aging

In principle, a gene therapy can do everything a drug can. Should perform more effectively and m...

Evidence Against a Late Life Mortality Plateau

Mortality rates seen to flatten out in flies and other short-lived species. Old individuals ceas...

Protein Signalling Implicated in Age-Related Hair Graying

Hair follicle undergoes repetitive cyclic regeneration. Aging phenotypes include irreversible ha...

Stem Cell Transplants Trialed for Age-Related Frailty

Mesenchymal stem cells grown and engineered for transplantation with minimal risk. Reduction see...

Could age related muscle loss be preventable?

Sarcopenia is a significant contribution to the frailty of later aging. A few recent papers sugg...

Planning Your Own Trial of Senolytic Drugs

A guide for anyone considering self-experimentation. Obtain a Cooperative Physician Obtain a Co...

Induced Pluripotency to Enable Rejuvenation of Blood Production

Induced pluripotency appears to produce a form of cellular rejuvenation. How do old gamete cells...

Moderate Drinking Effect on Health may be Explained by Wealth and Status

Secondary analysis of data from 2,908 participants in the New Zealand Longitudinal Study of Agein...

Quantifying the Anti-Inflammatory Effects of Exercise

Rising chronic inflammation is characteristic of aging and the failing immune system. Less infla...

A Look at Ascendance Biomedical, Packaging Medical Tourism for Longevity Therapies

It is focused on the twofold path of (a) establishing patient-funded trials of potentially usefu...

Exercise Differences Do Not Produce Longevity Differences in Identical Twins

Life expectancy and exercise are linked robustly in many data sets. Accelerometers are cheap and...

Looking Back and Ahead in the Use of Pluripotent Stem Cells in Medicine

Therapies that deliver fresh new stem cell populations will take up the work of lost cells, e.g. ...

Poor Correlation Between Telomere Length and Health

Telomeric DNA decreases with age and when they get too short cells self-destruct or become senesc...

Heavy Isotopes and Slowed Aging

Raising short-lived species on a low dosage of heavy water appears to modestly slow aging. May p...

Target Genes for Slowing Aging

75 potential targets for gene therapy in the near future. Rapid advances in genetic editing tech...

Telomere Length Does Not Predict Atherosclerosis Risk

Epidemiological studies have demonstrated shorter leukocyte telomere length (LTL) in patients suf...

Visceral Fat Tissue Will Kill You

Visceral fat is the fat around the organs, rather than under the skin (subcutaneous fat). Viscer...

Time Spent Sitting and Mortality Rates

Sitting responsible for 3.8% of deaths. Periods of moderate or vigorous physical activity might ...

Do Current Stem Cell Therapies Produce Rejuvenation?

Therapies available in clinics vary in type and quality of cells used. Transplanted cells don’t ...

Youthful bone marrow transplants increases lifespan in mice

Mice received bone marrow transplants from young donors every 3 months from age 6 months. Saw in...

Investigating the Mechanisms of Remyelination

As well as diseases such as multiple sclerosis everyone suffers demyelination as part of aging. ...

Stem Cell Transplants Extend Life in Rats

Monthly intravenous stem cells transplantations extend life span of rats by 31.3%. Specific mech...

Rejuvenation Biotechnology 2015 : Thoughts on Thymus Regeneration

Regeneration of the thymus is one of a number of possible ways to introduce much larger numbers o...

BioViva Moving Ahead With Human Gene Therapy for Telomerase Activation

First company to treat a person with gene therapy to reverse biological aging. Patient to be mon...

Review of Mechanisms that Slow Aging from Calorie Restriction

CR changes near everything in the operation of metabolism and slows near every measure of aging m...

Existing Longevity Therapies that are Technically Feasible, but Difficult and Expensive to Obtain

Gene therapies Stem cell therapies Enhancing native stem cell activities Thymus restoration I...

Molecular clock reversed in mice using SIRT3 infusion

Could SIRT3 promotion in humans help with age-related oxidative stress?