Senescence fuels heart disease: new ways to tackle ageing cells
Live Forever Club - 09-Nov-2024Targeting senescent cells may prevent disease progression and show promise
Aging
Bio-medical journal covering research on all aspects of gerontology
Aging publishes research papers in all fields of aging research including but not limited, aging from yeast to mammals, cellular senescence, age-related diseases such as cancer and Alzheimer’s diseases and their prevention and treatment, anti-aging strategies and drug development and especially the role of signal transduction pathways such as mTOR in aging and potential approaches to modulate these signaling pathways to extend lifespan.
The journal aims to promote treatment of age-related diseases by slowing down aging, validation of anti-aging drugs by treating age-related diseases, prevention of cancer by inhibiting aging. Cancer and COVID-19 are age-related diseases.
Visit website: https://www.aging-us.com/
Details last updated 30-Aug-2019
Aging News
Fibroblasts lose ability to support skin structure as we age
Live Forever Club - 10-Sep-2024Aged fibroblasts accumulate proteins internally instead of secreting them
Body's repair system falters with age as stem cells lose their regenerative power
Live Forever Club - 12-Apr-2024Machine learning reveals widespread decline in stem cell potency with age
Gut bacteria and blood molecules offer clues to why grip strength weakens with age
Live Forever Club - 21-Feb-2024Research opens doors for future interventions to prevent muscle loss
Metrnl, a protein that rises with exercise and shields against heart disease
Lifespan.io (LEAF) - 11-Jan-2024It unlocks a potent anti-inflammatory defense mechanism within the body
Activating SIRT6, a DNA repair protein, reduces damage in ageing cells
Live Forever Club - 01-Jan-2024SIRT6 activation may be a potential therapeutic target for osteoarthritis
Alcohol linked to changes in DNA that could lead to earlier ageing
Live Forever Club - 02-Nov-2023Effects of alcohol on DNA ageing are not limited to specific demographics
Insilico Medicine identifies potential targets for ageing and disease using AI
EurekAlert! - 27-Sep-2023Highlights the potential of AI to accelerate drug discovery for several diseases
Chemical cocktail able to reprogram cells to reverse ageing, without the need for gene therapy
Live Forever Club - 13-Jul-2023David Sinclair and team discovers potential new approach to treat age-related diseases and promote healthy aging
Correlation found between biological aging and cognitive decline using epigenetic clocks
Lifespan.io (LEAF) - 21-Nov-2022The midlife study showed that the cognitive decliners age faster
People with vulnerable mental state age faster than smokers
Interesting Engineering - 27-Sep-2022Psychological component should not be ignored in aging studies as they impact on biological age
The anti-malarial drug chloroquine increases lifespan in male mice
Lifespan.io (LEAF) - 30-May-2022Chloroquine significantly interferes with the fundamental mechanisms behind autophagy
New algorithm recognises senescent cells using physical morphology
Lifespan.io (LEAF) - 26-May-2022in vivo analysis in mice confirms the imaging results against p21 biomarker
Epigenetic age identifies risk of dementia later in life
Feinberg School of Medicine - 20-Apr-2022Epigenitic and brain aging markers provide insights on accelerated cognitive decline
Dasatinib plus quercetin combination may help preserve cognitive abilities in elderly people
Lifespan.io (LEAF) - 27-Jan-2022Senolytics showed positive effects on rats but trials must confirm these findings on human brain
In-silico drug modelling for treatment of stroke
Lifespan.io (LEAF) - 10-Aug-2021Rapamycin analogs may help prevent cerebral ischemia/reperfusion injury (CIRI)
DNA-damage or telomere shortening may not cause normal ageing
EurekAlert! - 08-Jun-2021Rapamycin fails to extend lifespan in telomerase-deficient mice, while improving lifespan by 39% in normal mice
SIRT6 overexpression delays ageing of heart cells in mice
Lifespan.io (LEAF) - 17-May-2021Anti-ageing therapies targeting sirtuins may slow down multiple effects of human ageing
Low magnitude vibration to prevent/delay age-related bone loss in rats
Lifespan.io (LEAF) - 05-May-2021Vibration treatment eliminates senescence of bone cells - may not be applicable to other tissues
Diet and lifestyle changes reversed epigenetic ageing in males
Lifespan.io (LEAF) - 19-Apr-2021Dietary, exercise, sleep, supplements, and breathing regimen for 8 weeks reduced epigenetic age by 2 years.
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A low-calorie diet maintains youthful gut state & improves lifespan
Fight Aging! - 24-Mar-2021Calorie restriction prevents age-related changes to the gut microbiome in mice
Less than 5 hours of sleep can double your risk of memory loss
Independent - 13-Feb-2021Too much or too little sleep increases the risk of Alzheimer's disease in older adults
Scientists find the reason for impaired DNA repair in aged cells
Lifespan.io (LEAF) - 06-Jan-2021Unveiled the mechanisms for DNA impairment; laid foundation for future research
AI based aging clock predicts psychological age
Longevity Technology - 16-Dec-2020Deep longevity's psychological clock might help you feel younger and live longer
Oxygen therapy reversed the human age biologically
YAHOO! - 18-Nov-2020Not as easy as taking a pill, but a stunning result on both telomeres and senescent cells
Metformin with Resistance Training- To do or not to do?
Lifespan.io (LEAF) - 29-Oct-2020Metformin might inhibit muscle building but makes gene expression more youthful
Flavonoid found in redcurrants reduces senescence in brain cells
Lifespan.io (LEAF) - 28-Sep-2020Mice study also saw improved cognitive abilities
Mice given ethanol in drinking water show many metabolic benefits
Fight Aging! - 29-Jul-2020Perhaps all the benefits come their their increased physical activity - worth further investigation
Brain ageing reversed by Israeli doctor through an oxygen chamber
The times of Israel - 15-Jul-2020Don't try this at home! Too much oxygen (hyperoxia) is definitely bad for you
Humanin is a regulator peptide of healthspan and lifespan
Science Daily - 24-Jun-2020Longer life results in less offspring - sounds like the ideal compromise to me!
Antiageing antibiotic targets senescent human fibroblasts
Health Europa - 10-Jun-2020Could lead to new drug discovery against senescent cells and extend lifespan
Diluting blood rejuvenates old tissues in mice
Aging Matters - 08-Jun-2020There are things in blood that drives our ageing
Mice blood proteome analysis reveals new therapeutic target for osteoporosis
Lifespan.io (LEAF) - 26-May-2020A different perspective for preventing age-related bone loss that affects many
A new novel senolytic agent, R406, discovered
Lifespan.io (LEAF) - 22-May-2020Intriguingly destroys senescent cells without inducing cell destruction
Age-related changes in gut microbiota cause cognitive decline in aged rats
Lifespan.io (LEAF) - 20-May-2020Restoring microbiome could be one strategy to support healthy longevity
The effect of gut microbiota on cognitive decline in aged rats
Fight Aging! - 14-May-2020First study investigating its effects in the normal ageing process
NAD+ more than doubled after 10 weeks of resistance training
Lifespan.io (LEAF) - 13-May-2020Not yet too late to reap the benefits of exercise as seen in middle-aged individuals
Altering macrophage epigenetics to prevent lumbar disc degeneration
Lifespan.io (LEAF) - 04-May-2020Findings can lead future treatments for age-related conditions caused by inflammaging
Metformin repairs metabolic and mitochondrial defects in myotonic dystrophy
Lifespan.io (LEAF) - 16-Apr-2020New hope for sufferers of disorders that negatively impact metabolism
Proposed strategy to protect elderly from gerolavic infections like COVID-19
Forbes - 31-Mar-2020To benefit long term global health and longevity, and enhance economic recovery
Benefits of intermittent rapamycin treatment in late-life
Fight Aging! - 23-Mar-2020Minimizes off-target effects along with boosting healthspan, as studied in old mice
Healthy old-people's poo improves gut microbiome of mice
Lifespan.io (LEAF) - 20-Mar-2020Healthy gut means healthy body. Thought there are alternative ways of increasing probiotic bacteria!
Senescent marker levels in different tissues among different age groups
Lifespan.io (LEAF) - 19-Mar-2020We need to recognize normal patterns in order to identify what's abnormal
Werner syndrome and normal aging epigenetic signatures differ
Fight Aging! - 17-Feb-2020Werner syndrome, not merely accelerated normal aging as previously thought
High levels of glucuronic acid is a biomarker of ageing
Lifespan.io (LEAF) - 07-Oct-2019Glucuronic acid levels in the blood can be correlated with a lifespan, healthspan in humans and mice
Drinking tea could be good for your brain
Independent - 17-Sep-2019People who drank tea at least 4 times a week for 25 years have better-connected brain regions
Recalibration of signalling factors to more youthful levels in the blood
Lifespan.io (LEAF) - 03-Sep-2019Adjusting the levels of just two molecules in the blood could lead to significant rejuvenation
Leukocyte telomere length found to be linked to DNA methylation (DNAm)
News Medical - 02-Sep-2019Yet more evidence that hallmarks of ageing are inter-related, not standalone actions
Electrical stimulation therapy to ears improved body, sleep and mood
BBC - 30-Jul-2019Newly discovered benefit of transcutaneous electrical nerve stimulation
Telomerase therapy for neurodegeneration
Lifespan.io (LEAF) - 04-Jun-2019Telomerase gene therapy may be a potential solution for age-related neurodegenerative diseases
What if the rich lived forever?
Korea Times - 19-Aug-2018New research may promote social inequality by allowing the rich live forever
Cellular aging halted by hydrogen sulfide gas
Medical News Today - 07-Aug-20183 compounds designed to deliver minute amounts of hydrogen to mitochondria inhibit cellular aging
Naked Mole Rats Repair DNA Super Efficiently
Fight Aging! - 27-Jun-2018These rats seem to be almost immune to cancer for unknown reasons
17 new genes linked to longer lifespan identified
Times Now News - 08-Nov-2017A team of researchers have discovered 17 new genes linked to longer lifespan, which they say coul...
False Positives in Senescent Cell Detection
Lifespan.io (LEAF) - 19-Aug-2017Researchers commonly determine the presence of senescent cells through the use of the p16ink4a (p...
Epigenetic clock predicts life expectancy
United Press International - 28-Sep-2016Study led UCLA analyzed over 13,000 blood samples. Aging of blood calculated by tracking DNA alt...
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Ageing Research
