Josh Conway
Programmer and long-time supporter of rejuvenation biotechnology. Editor for LEAF.
Visit website: https://www.leafscience.org/author/josh/
See also: 
Lifespan.io (LEAF)
- Supporting the development of biotechnologies focused on ending age-related diseases
Details last updated 23-Oct-2019
Articles written by Josh Conway
New research links DNA damage to incomplete gene transcription in aging
Lifespan.io (LEAF) - 15-Feb-2024
DNA damage accumulated with age worsens gene expression, affecting lifespan-determining pathways
Read more...Metrnl, a protein that rises with exercise and shields against heart disease
Lifespan.io (LEAF) - 11-Jan-2024
It unlocks a potent anti-inflammatory defense mechanism within the body
Read more...Metformin may minimize muscle loss in extended periods of bed rest
Lifespan.io (LEAF) - 24-Jul-2023
Improvements seen in muscle size and collagen deposits in older people with atrophy
Read more...Novel method facilitates single-cell expansion of gene edited stem cells
Lifespan.io (LEAF) - 17-Jul-2023
Its polymer-supplemented culture system enables cell expansion without harmful mutations
Read more...Revitalizing ageing stem cells: Unveiling the key to lasting youthfulness
Lifespan.io (LEAF) - 05-Jun-2023
Combination of factors that rejuvenate stem cells holds promise for aging and muscle-wasting diseases
Read more...AI-driven breakthrough in senolytic drug discovery
Lifespan.io (LEAF) - 04-May-2023
Machine learning successfully identifies promising senolytic compounds to target ageing and age-related diseases
Read more...Gut Microbiome: The Secret to Longevity in Centenarians
Lifespan.io (LEAF) - 06-Apr-2023
A youthful gut microbiome may contribute to enhanced longevity and overall health in people living past 100
Read more...Correlation found between biological aging and cognitive decline using epigenetic clocks
Lifespan.io (LEAF) - 21-Nov-2022
The midlife study showed that the cognitive decliners age faster
Read more...Therapeutic plasma exchange (TPE) rejuvenates multiple markers of gene expression
Lifespan.io (LEAF) - 25-Aug-2022
TPE causes systematic rejuvenation in human body by influencing multiple factors
Read more...Senolytics may abate accelerated aging of cancer patients as seen in mice
Lifespan.io (LEAF) - 06-Jun-2022
Radiation-induced damage may lessen by removing senescent cells but senolytics may not reverse the damage
Read more...The anti-malarial drug chloroquine increases lifespan in male mice
Lifespan.io (LEAF) - 30-May-2022
Chloroquine significantly interferes with the fundamental mechanisms behind autophagy
Read more...New algorithm recognises senescent cells using physical morphology
Lifespan.io (LEAF) - 26-May-2022
in vivo analysis in mice confirms the imaging results against p21 biomarker
Read more...Epigenetic age varies when people are exposed to significant stress
Lifespan.io (LEAF) - 23-May-2022
PhenoAge and GrimAge show epigenetic aging has downstream biological consequences
Read more...Viral-vector gene therapies could unlock healthy life extension in humans
Lifespan.io (LEAF) - 12-May-2022
Lifespan of mice greatly extended even when treatment only started at the equivalent of 56 years old
Read more...Alzheimers' treatment with stem cells is proven safer in Phase 1 clinical trial
Lifespan.io (LEAF) - 07-Apr-2022
Lomecel-B targets homing and microglia recruitment rather than differentiation
Read more...Dasatinib plus quercetin combination may help preserve cognitive abilities in elderly people
Lifespan.io (LEAF) - 27-Jan-2022
Senolytics showed positive effects on rats but trials must confirm these findings on human brain
Read more...Serum from older adults increased ageing markers and killed brain stem cells in humans
Lifespan.io (LEAF) - 16-Dec-2021
Brain volume and lifestyle can increase difference between chronological and biological age
Read more...New study leading towards permanent youthful immune function
Lifespan.io (LEAF) - 18-Oct-2021
Significant alteration in lineage potential by NR treatment in mice
Read more...Calorie restriction slows age-related stem cell exhaustion, improving overall health
Lifespan.io (LEAF) - 29-Sep-2021
Many studies underlined beneficial effects of calorie restriction in various tissues of mice
Read more...Role of mature dendritic cells in thymic involution
Lifespan.io (LEAF) - 13-Sep-2021
Reversal of thymic aging possible through signaling based interventions
Read more...Hyperactivation of senescent cells can trigger cytokine storm
Lifespan.io (LEAF) - 13-Aug-2021
Stimulated senescent human umbilical vein cells showed high susceptibility to inflammatory diseases
Read more...In-silico drug modelling for treatment of stroke
Lifespan.io (LEAF) - 10-Aug-2021
Rapamycin analogs may help prevent cerebral ischemia/reperfusion injury (CIRI)
Read more...Levels of fatty acids in blood predict death in older people
Lifespan.io (LEAF) - 26-Jul-2021
Myristic acid, benehic acid, and omega 3 increase lifespan; palmitoleic acid lowers lifespan
Read more...Zoledronate - accidental discovery of drug use for life extension
Lifespan.io (LEAF) - 30-Jun-2021
Too early to tell whether off-patent drug's effects in fruit flies will be seen in humans
Read more...Youthful stem cells delayed ageing through their secretions in mice
Lifespan.io (LEAF) - 23-Jun-2021
Potential stem cell treatment for age-related diseases, if succeded in human trials
Read more...A 12-week strength-endurance training lowered senescence proteins in older people
Lifespan.io (LEAF) - 14-Jun-2021
New study using biomarkers proved the importance of regular exercise again
Read more...Injecting new mitochondria to replace old, damaged mitochondrial DNA in humans
Lifespan.io (LEAF) - 02-Jun-2021
Potential treatment for mitochondrial diseases & dysfunction, and extends lifespan
Read more...Excessive alcohol consumption makes women age faster
Lifespan.io (LEAF) - 31-May-2021
GrimAge clock presented accurate results on biological age than other epigenetic clocks
Read more...SIRT6 overexpression delays ageing of heart cells in mice
Lifespan.io (LEAF) - 17-May-2021
Anti-ageing therapies targeting sirtuins may slow down multiple effects of human ageing
Read more...Diet and lifestyle changes reversed epigenetic ageing in males
Lifespan.io (LEAF) - 19-Apr-2021
Dietary, exercise, sleep, supplements, and breathing regimen for 8 weeks reduced epigenetic age by 2 years.
Read more...Colorectal cancer cells turn to normal-like cells - halting cancer spread
Lifespan.io (LEAF) - 29-Mar-2021
New therapeutic alternative to prevent cancer progression by suppressing the causative agent SETDB1
Read more...A new epigenetic clock that can predict your mortality risk
Lifespan.io (LEAF) - 26-Nov-2020
GrimAge can accurately predict all cause-mortality than any other clock
Read more...Exposure to old cells can make young cells old
Lifespan.io (LEAF) - 12-Nov-2020
Path to a new therapy- replacing blood with youthful factors might reverse ageing
Read more...Metformin with Resistance Training- To do or not to do?
Lifespan.io (LEAF) - 29-Oct-2020
Metformin might inhibit muscle building but makes gene expression more youthful
Read more...Continuous trickle of genomic instability can lead to multiple age-related diseases
Lifespan.io (LEAF) - 16-Jul-2020
Analysing mutations in individual cells will help determine its burden on ageing damage
Read more...Increasing ovarian NAD+ improved mitochondrial function in mice egg cells
Lifespan.io (LEAF) - 11-Jun-2020
Supplementation also shown to reverse ovarian ageing
Read more...Experts develop new novel detection method for mitophagy
Lifespan.io (LEAF) - 28-May-2020
A discovery proven to be of help in therapeutic studies of neurodegeneration
Read more...Metformin alleviates inflammaging by promoting autophagy
Lifespan.io (LEAF) - 14-May-2020
With the positive results, drug holds great promise for promoting healthy ageing
Read more...Altering macrophage epigenetics to prevent lumbar disc degeneration
Lifespan.io (LEAF) - 04-May-2020
Findings can lead future treatments for age-related conditions caused by inflammaging
Read more...Metformin repairs metabolic and mitochondrial defects in myotonic dystrophy
Lifespan.io (LEAF) - 16-Apr-2020
New hope for sufferers of disorders that negatively impact metabolism
Read more...Positive feedback look identified with ATM via NF-κB pathway back to cellular senescence
Lifespan.io (LEAF) - 02-Apr-2020
As always, it's complicated, but controlling levels of ATM could be part of a therapy to combat ageing
Read more...Senescent marker levels in different tissues among different age groups
Lifespan.io (LEAF) - 19-Mar-2020
We need to recognize normal patterns in order to identify what's abnormal
Read more...Illumina aiming to deliver $100 Genome Sequencing
Lifespan.io (LEAF) - 05-Mar-2020
Not here yet, but will expand research capabilities and change the way medicine is practiced
Read more...Skin microbiome provides the best prediction of age
Lifespan.io (LEAF) - 14-Feb-2020
It will be more easy and convenient to take samples from skin and saliva, rather than fecal samples
Read more...Calorie restriction can restore myelin on demyelinated nerves
Lifespan.io (LEAF) - 22-Nov-2019
Tested in mouse model - but it's a good starting point
Read more...Mr Senescence explains how to speed up ageing research
Lifespan.io (LEAF) - 05-Nov-2019
Long validation times in ageing research – experimental time is a bottleneck
Read more...Novo Biosciences CEO talks about drug candidate for tissue regeneration
Lifespan.io (LEAF) - 29-Oct-2019
Regrowing damaged organs would help many people live longer, healthier lives
Read more...Huda Suliman explains the nuances of drug discovery in ageing research
Lifespan.io (LEAF) - 23-Oct-2019
Indications are less clear with anti-ageing compounds than with disease specific drugs
Read more...OncoSenX targets solid tumours with senolytics
Lifespan.io (LEAF) - 22-Oct-2019
Phase 1 clinical trial starting early 2020
Read more...Lysoclear is making progress towards a cure for macular degeneration
Lifespan.io (LEAF) - 25-Sep-2019
Has cleared protein build up in vivo - has funding to develop clinical candidates
Read more...Michael West examines how to safely revive telomerase
Lifespan.io (LEAF) - 12-Sep-2019
It powers foetal development and telomere length, but also cancers
Read more...
