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Josh Conway

Programmer and long-time supporter of rejuvenation biotechnology. Editor for LEAF.

Visit website: https://www.leafscience.org/author/josh/

See also: Institute Lifespan.io (LEAF) - Supporting the development of biotechnologies focused on ending age-related diseases

Details last updated 23-Oct-2019

Articles written by Josh Conway

New research links DNA damage to incomplete gene transcription in aging

New research links DNA damage to incomplete gene transcription in aging

Lifespan.io (LEAF) - 15-Feb-2024

DNA damage accumulated with age worsens gene expression, affecting lifespan-determining pathways

Metrnl, a protein that rises with exercise and shields against heart disease

Metrnl, a protein that rises with exercise and shields against heart disease

Lifespan.io (LEAF) - 11-Jan-2024

It unlocks a potent anti-inflammatory defense mechanism within the body

Metformin may minimize muscle loss in extended periods of bed rest

Metformin may minimize muscle loss in extended periods of bed rest

Lifespan.io (LEAF) - 24-Jul-2023

Improvements seen in muscle size and collagen deposits in older people with atrophy

Novel method facilitates single-cell expansion of gene edited stem cells

Novel method facilitates single-cell expansion of gene edited stem cells

Lifespan.io (LEAF) - 17-Jul-2023

Its polymer-supplemented culture system enables cell expansion without harmful mutations

Revitalizing ageing stem cells: Unveiling the key to lasting youthfulness

Revitalizing ageing stem cells: Unveiling the key to lasting youthfulness

Lifespan.io (LEAF) - 05-Jun-2023

Combination of factors that rejuvenate stem cells holds promise for aging and muscle-wasting diseases

AI-driven breakthrough in senolytic drug discovery

AI-driven breakthrough in senolytic drug discovery

Lifespan.io (LEAF) - 04-May-2023

Machine learning successfully identifies promising senolytic compounds to target ageing and age-related diseases

Gut Microbiome: The Secret to Longevity in Centenarians

Gut Microbiome: The Secret to Longevity in Centenarians

Lifespan.io (LEAF) - 06-Apr-2023

A youthful gut microbiome may contribute to enhanced longevity and overall health in people living past 100

Correlation found between biological aging and cognitive decline using epigenetic clocks

Correlation found between biological aging and cognitive decline using epigenetic clocks

Lifespan.io (LEAF) - 21-Nov-2022

The midlife study showed that the cognitive decliners age faster

Therapeutic plasma exchange (TPE) rejuvenates multiple markers of gene expression

Therapeutic plasma exchange (TPE) rejuvenates multiple markers of gene expression

Lifespan.io (LEAF) - 25-Aug-2022

TPE causes systematic rejuvenation in human body by influencing multiple factors

Senolytics may abate accelerated aging of cancer patients as seen in mice

Senolytics may abate accelerated aging of cancer patients as seen in mice

Lifespan.io (LEAF) - 06-Jun-2022

Radiation-induced damage may lessen by removing senescent cells but senolytics may not reverse the damage

The anti-malarial drug chloroquine increases lifespan in male mice

The anti-malarial drug chloroquine increases lifespan in male mice

Lifespan.io (LEAF) - 30-May-2022

Chloroquine significantly interferes with the fundamental mechanisms behind autophagy

New algorithm recognises senescent cells using physical morphology

New algorithm recognises senescent cells using physical morphology

Lifespan.io (LEAF) - 26-May-2022

in vivo analysis in mice confirms the imaging results against p21 biomarker

Epigenetic age varies when people are exposed to significant stress

Epigenetic age varies when people are exposed to significant stress

Lifespan.io (LEAF) - 23-May-2022

PhenoAge and GrimAge show epigenetic aging has downstream biological consequences

Viral-vector gene therapies could unlock healthy life extension in humans

Viral-vector gene therapies could unlock healthy life extension in humans

Lifespan.io (LEAF) - 12-May-2022

Lifespan of mice greatly extended even when treatment only started at the equivalent of 56 years old

Alzheimers' treatment with stem cells is proven safer in Phase 1 clinical trial

Alzheimers' treatment with stem cells is proven safer in Phase 1 clinical trial

Lifespan.io (LEAF) - 07-Apr-2022

Lomecel-B targets homing and microglia recruitment rather than differentiation

Dasatinib plus quercetin combination may help preserve cognitive abilities in elderly people

Dasatinib plus quercetin combination may help preserve cognitive abilities in elderly people

Lifespan.io (LEAF) - 27-Jan-2022

Senolytics showed positive effects on rats but trials must confirm these findings on human brain

Serum from older adults increased ageing markers and killed brain stem cells in humans

Serum from older adults increased ageing markers and killed brain stem cells in humans

Lifespan.io (LEAF) - 16-Dec-2021

Brain volume and lifestyle can increase difference between chronological and biological age

New study leading towards permanent youthful immune function

New study leading towards permanent youthful immune function

Lifespan.io (LEAF) - 18-Oct-2021

Significant alteration in lineage potential by NR treatment in mice

Calorie restriction slows age-related stem cell exhaustion, improving overall health

Calorie restriction slows age-related stem cell exhaustion, improving overall health

Lifespan.io (LEAF) - 29-Sep-2021

Many studies underlined beneficial effects of calorie restriction in various tissues of mice

Role of mature dendritic cells in thymic involution

Role of mature dendritic cells in thymic involution

Lifespan.io (LEAF) - 13-Sep-2021

Reversal of thymic aging possible through signaling based interventions

Hyperactivation of senescent cells can trigger cytokine storm

Hyperactivation of senescent cells can trigger cytokine storm

Lifespan.io (LEAF) - 13-Aug-2021

Stimulated senescent human umbilical vein cells showed high susceptibility to inflammatory diseases

In-silico drug modelling for treatment of stroke

In-silico drug modelling for treatment of stroke

Lifespan.io (LEAF) - 10-Aug-2021

Rapamycin analogs may help prevent cerebral ischemia/reperfusion injury (CIRI)

Levels of fatty acids in blood predict death in older people

Levels of fatty acids in blood predict death in older people

Lifespan.io (LEAF) - 26-Jul-2021

Myristic acid, benehic acid, and omega 3 increase lifespan; palmitoleic acid lowers lifespan

Zoledronate - accidental discovery of drug use for life extension

Zoledronate - accidental discovery of drug use for life extension

Lifespan.io (LEAF) - 30-Jun-2021

Too early to tell whether off-patent drug's effects in fruit flies will be seen in humans

Youthful stem cells delayed ageing through their secretions in mice

Youthful stem cells delayed ageing through their secretions in mice

Lifespan.io (LEAF) - 23-Jun-2021

Potential stem cell treatment for age-related diseases, if succeded in human trials

A 12-week strength-endurance training lowered senescence proteins in older people

A 12-week strength-endurance training lowered senescence proteins in older people

Lifespan.io (LEAF) - 14-Jun-2021

New study using biomarkers proved the importance of regular exercise again

Injecting new mitochondria to replace old, damaged mitochondrial DNA in humans

Injecting new mitochondria to replace old, damaged mitochondrial DNA in humans

Lifespan.io (LEAF) - 02-Jun-2021

Potential treatment for mitochondrial diseases & dysfunction, and extends lifespan

Excessive alcohol consumption makes women age faster

Excessive alcohol consumption makes women age faster

Lifespan.io (LEAF) - 31-May-2021

GrimAge clock presented accurate results on biological age than other epigenetic clocks

SIRT6 overexpression delays ageing of heart cells in mice

SIRT6 overexpression delays ageing of heart cells in mice

Lifespan.io (LEAF) - 17-May-2021

Anti-ageing therapies targeting sirtuins may slow down multiple effects of human ageing

Diet and lifestyle changes reversed epigenetic ageing in males

Diet and lifestyle changes reversed epigenetic ageing in males

Lifespan.io (LEAF) - 19-Apr-2021

Dietary, exercise, sleep, supplements, and breathing regimen for 8 weeks reduced epigenetic age by 2 years.

Colorectal cancer cells turn to normal-like cells - halting cancer spread

Colorectal cancer cells turn to normal-like cells - halting cancer spread

Lifespan.io (LEAF) - 29-Mar-2021

New therapeutic alternative to prevent cancer progression by suppressing the causative agent SETDB1

A new epigenetic clock that can predict your mortality risk

A new epigenetic clock that can predict your mortality risk

Lifespan.io (LEAF) - 26-Nov-2020

GrimAge can accurately predict all cause-mortality than any other clock

Exposure to old cells can make young cells old

Exposure to old cells can make young cells old

Lifespan.io (LEAF) - 12-Nov-2020

Path to a new therapy- replacing blood with youthful factors might reverse ageing

Metformin with Resistance Training- To do or not to do?

Metformin with Resistance Training- To do or not to do?

Lifespan.io (LEAF) - 29-Oct-2020

Metformin might inhibit muscle building but makes gene expression more youthful

Continuous trickle of genomic instability can lead to multiple age-related diseases

Continuous trickle of genomic instability can lead to multiple age-related diseases

Lifespan.io (LEAF) - 16-Jul-2020

Analysing mutations in individual cells will help determine its burden on ageing damage

Increasing ovarian NAD+ improved mitochondrial function in mice egg cells

Increasing ovarian NAD+ improved mitochondrial function in mice egg cells

Lifespan.io (LEAF) - 11-Jun-2020

Supplementation also shown to reverse ovarian ageing

Experts develop new novel detection method for mitophagy

Experts develop new novel detection method for mitophagy

Lifespan.io (LEAF) - 28-May-2020

A discovery proven to be of help in therapeutic studies of neurodegeneration

Metformin alleviates inflammaging by promoting autophagy

Metformin alleviates inflammaging by promoting autophagy

Lifespan.io (LEAF) - 14-May-2020

With the positive results, drug holds great promise for promoting healthy ageing

Altering macrophage epigenetics to prevent lumbar disc degeneration

Altering macrophage epigenetics to prevent lumbar disc degeneration

Lifespan.io (LEAF) - 04-May-2020

Findings can lead future treatments for age-related conditions caused by inflammaging

Metformin repairs metabolic and mitochondrial defects in myotonic dystrophy

Metformin repairs metabolic and mitochondrial defects in myotonic dystrophy

Lifespan.io (LEAF) - 16-Apr-2020

New hope for sufferers of disorders that negatively impact metabolism

Positive feedback look identified with ATM via NF-κB pathway back to cellular senescence

Positive feedback look identified with ATM via NF-κB pathway back to cellular senescence

Lifespan.io (LEAF) - 02-Apr-2020

As always, it's complicated, but controlling levels of ATM could be part of a therapy to combat ageing

Senescent marker levels in different tissues among different age groups

Senescent marker levels in different tissues among different age groups

Lifespan.io (LEAF) - 19-Mar-2020

We need to recognize normal patterns in order to identify what's abnormal

Illumina aiming to deliver $100 Genome Sequencing

Illumina aiming to deliver $100 Genome Sequencing

Lifespan.io (LEAF) - 05-Mar-2020

Not here yet, but will expand research capabilities and change the way medicine is practiced

Skin microbiome provides the best prediction of age

Skin microbiome provides the best prediction of age

Lifespan.io (LEAF) - 14-Feb-2020

It will be more easy and convenient to take samples from skin and saliva, rather than fecal samples

Calorie restriction can restore myelin on demyelinated nerves

Calorie restriction can restore myelin on demyelinated nerves

Lifespan.io (LEAF) - 22-Nov-2019

Tested in mouse model - but it's a good starting point

Mr Senescence explains how to speed up ageing research

Mr Senescence explains how to speed up ageing research

Lifespan.io (LEAF) - 05-Nov-2019

Long validation times in ageing research – experimental time is a bottleneck

Novo Biosciences CEO talks about drug candidate for tissue regeneration

Novo Biosciences CEO talks about drug candidate for tissue regeneration

Lifespan.io (LEAF) - 29-Oct-2019

Regrowing damaged organs would help many people live longer, healthier lives

Huda Suliman explains the nuances of drug discovery in ageing research

Huda Suliman explains the nuances of drug discovery in ageing research

Lifespan.io (LEAF) - 23-Oct-2019

Indications are less clear with anti-ageing compounds than with disease specific drugs

OncoSenX targets solid tumours with senolytics

OncoSenX targets solid tumours with senolytics

Lifespan.io (LEAF) - 22-Oct-2019

Phase 1 clinical trial starting early 2020

Lysoclear is making progress towards a cure for macular degeneration

Lysoclear is making progress towards a cure for macular degeneration

Lifespan.io (LEAF) - 25-Sep-2019

Has cleared protein build up in vivo - has funding to develop clinical candidates

Michael West examines how to safely revive telomerase

Michael West examines how to safely revive telomerase

Lifespan.io (LEAF) - 12-Sep-2019

It powers foetal development and telomere length, but also cancers