Genes vs. diet: what really drives longevity?
The Conversation (UK) - 17-Oct-2024New study finds calorie restriction aids longevity, but genetics may hold the ultimate key
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New study finds calorie restriction aids longevity, but genetics may hold the ultimate key
A major study shows genetics and immunity are key to the lifespan benefits of calorie restriction
Energy expenditure, not just eating less, lead to 20% longer life in mice
Clearly, eating less may not be a straightforward path to slowing ageing
Complexities spark hope for health benefits beyond telomere length
Research sheds light on the benefits of calorie restriction
Modest calorie reduction can activate genes for healthy ageing
Analysis of CALERIE trial shows a slowing down in the pace of ageing, but no immediate reduction in biological age
Will look at whether health and ageing improves with calorie restriction or intermittent fasting
Triple the effect seen over simply restricting calorie intake
Protein produced by macrophages was identified as a key player of calorie restriction
Many studies underlined beneficial effects of calorie restriction in various tissues of mice
Targeting SA-T cells: A promising intervention to control age-related chronic diseases
Long-term safety of the diet is questionable as it alters the healthy gut microbiome
You may have to avoid smelling, not just eating, food for CR to be effective
Calorie restriction prevents age-related changes to the gut microbiome in mice
Failed to mimic dietary restriction pathways on extending lifespan in progeroid mice
Metabolites vital for pro-longevity effect of calorie restriction can help develop drugs
Helps us to understand the mechanism behind CR - and that it has an effect within weeks
One should still consume adequate nutrition while reducing calorie intake
Good genes combined with healthy lifestyle choices can truly make you look younger
Life extending benefit of dietary restriction might depend upon genetic makeup
Still one of the most reliable interventions when improving long-term health
Better to read on best practices of calorie restriction with optimal nutrition before you start
Tested in mouse model - but it's a good starting point
Would we be able to achieve effects of lifestyle changes by just taking a pill?
Mice who exercised and ate less also had a decrease in bone quantity due to the cut in calories
ADF does not weaken our immune system like other fasting regimens do
This method is already being used to extend the lifespan in lab animals
Athletes starving themselves causes hormone and bone problems
Good health should never be the cost of success in sports
Short-term diets may accelerate the manifestation of aging symptoms
New study shows caloric restriction in lemurs extended lifespan up to 50%.
CALERIE multi-centre trial tested 200 healthy, non-obese adults over 2 years.
Research pinpoints the cell responsible for improved regenerative abilities in the intestines.
Epigenetic drift occurs more rapidly in monkeys than in humans.
Trial in macaques has found that CR makes them live 3 years longer than normal – equivalent to 9 years in people.
Greater longevity for those who reduce their calorie intake.
CR changes near everything in the operation of metabolism and slows near every measure of aging making it difficult to figure out chains of cause and effect.