Jonathan, a 192-year-old tortoise, has unique genes that help him live longer
Live Forever Club - 10-Feb-2025His unique genes that help repair damage, maintain energy, and slow ageing
bioRxiv
The preprint server for biology
bioRxiv (pronounced "bio-archive") is a free online archive and distribution service for unpublished preprints in the life sciences. It is operated by Cold Spring Harbor Laboratory, a not-for-profit research and educational institution. By posting preprints on bioRxiv, authors are able to make their findings immediately available to the scientific community and receive feedback on draft manuscripts before they are submitted to journals.
Visit website: https://www.biorxiv.org/
Details last updated 02-Nov-2019
bioRxiv News
Tissue clocks reveal how organs age at different speeds
Live Forever Club - 24-Nov-2024Larger age gaps in tissues link to diseases like heart disease and diabetes
New mRNA therapy could reverse signs of skin ageing
Live Forever Club - 20-Nov-2024Scientists used mRNA therapy targeting ATF3 to rejuvenate skin
Can machine learning discover lifespan-extending drugs for mice?
Live Forever Club - 09-Nov-2024This highlights promising paths for potential anti-ageing therapies
Epigenetic clocks reveal hidden health risks linked to biological ageing
Live Forever Club - 27-Sep-2024This study may help personalise health strategies for individuals at higher risk
Axolotls, known for their regeneration skills, show early-life epigenetic ageing
Live Forever Club - 26-Sep-2024Their abilities help reset biological age, offering insights for human longevity research
Bats and their remarkable resistance to age-related hearing loss
Live Forever Club - 20-Aug-2024This discovery offers potential clues for preserving hearing in humans
Partial reprogramming rejuvenates the ageing mouse brain, improving memory
Live Forever Club - 09-Aug-2024This breakthrough offers hope for combating age-related cognitive decline
PEDF protein, found in young blood, rejuvenates aging cells and tissues in mice
Live Forever Club - 24-May-2024More research is needed, but this discovery offers hope for anti-aging therapies
Researchers explore the potential of sound waves for anti-ageing
Lifespan.io (LEAF) - 09-Feb-2024Originally used to fight cancer, sound waves surprisingly revive old cells
A new method called FAST studies cellular ageing in cultured cells
Live Forever Club - 18-Jan-2024FAST is precise and works with different cell types and microscopes
Blue zones: new data casts doubt on longevity hotspots
Slate - 29-Nov-2023A Brit's skeptical take on Blue Zones and the search for eternal life
System Age epigenetic clock captured different patterns of ageing
Lifespan.io (LEAF) - 21-Jul-2023Novel method for precise estimation of biological age and disease risks with a single blood sample
The bowhead whale's secret to living over 200 years: Remarkable DNA repair mechanisms
Live Forever Club - 30-May-2023Exceptional longevity and resistance to cancer holds potential implications for human health and ageing
GPT-3 and similar AI models can generate speech, using brain implants at a record-breaking speed
Singularity Hub - 31-Jan-2023The ultimate goal is to restore rapid communications to people who can no longer speak
Reversal of cell senescence using low frequency ultrasound
Live Forever Club - 27-Jan-2023Novel therapy killed some senescent cells, rejuvenated others, without harming healthy cells
Dissociation of longevity targeted cell reprogram and somatic identity loss: An exploration
Live Forever Club - 17-Jan-2023Most genes regulating cellular rejuvenation were not related to the increased occurrence of cancer
Epigenetic age varies when people are exposed to significant stress
Lifespan.io (LEAF) - 23-May-2022PhenoAge and GrimAge show epigenetic aging has downstream biological consequences
Synergy of stem cell rejuvenation and senolytics promote longevity in fruit flies
Live Forever Club - 14-May-2022Combined approach surprisingly eliminated the negative effects of individual treatments
Feeding dogs once daily might improve health and cognitive function
Newsweek - 16-Nov-2021This is another indicator that time restricted eating (TRE) has benefits in mammals
Frailty in old mice disappears with small extracellular vesicles from young mice stem cells
Fight Aging! - 09-Aug-2021Molecular level benefits observed (inflammation, senescence) as well as physical ones
Galapagos giant tortoises kill damaged cells to resist cancer and ageing
New Scientist - 20-Jul-2021Large, long living animals offer insights on natural ways of cancer resistance
Restoration of youthful gene expression can be achieved alternatively
Lifespan.io (LEAF) - 11-Jun-2021Possible ways of using reprogramming techniques to develop therapies
Detailed map of connections within the human brain created by Google
New Scientist - 07-Jun-2021Benefit to explore how the cell map differs in people with mental illness
Scientists decoded a human genome entirely for the first time
Popular Mechanics - 03-Jun-2021New technologies uncovered missing genes in human genome - yet to be peer-reviewed
Could diluting blood with recombinant serum albumin reverse ageing?
Fight Aging! - 06-Apr-2021Disappointingly, no impact was observed on maximum lifespan - still looking for the next bridge
Reason reviews the research behind One Skin's senotherapeutic skin-care spray
Fight Aging! - 06-Nov-2020The anti-ageing peptide promotes skin health and reduces senescent cell markers
Mechanism underlying telomere restoration in T cells discovered
Lifespan.io (LEAF) - 20-Oct-2020Telomere transfer from APCs boosts T cells lifespan-helpful in immunosenescence
Ageing seems to increase the number of repetitive elements in our DNA
Lifespan.io (LEAF) - 07-Jul-2020Even if it's an effect (not a cause) then REs could act as another biological clock
Experts devise newest epigenetic clock for anti-ageing drugs discovery
Lifespan.io (LEAF) - 03-Jun-2020Showed impressive results based on experiments in vitro and in vivo, but more work to be done
Stress causes hair to become grey but it's a reversible process
Medical Xpress - 02-Jun-2020If the stress is removed soon after greying has started, reversal is still possible
Scientists develop a new epigenetic clock
Lifespan.io (LEAF) - 02-Jun-2020The clock accurately predicts biological age & can help develop anti ageing drugs
A protein that plays a key role in the making of cholesterol plaques: TRB1
Lifespan.io (LEAF) - 11-Nov-2019Still at an early stage in research - working on mouse models
Why do some regions have many “supercentenarians” while other regions don't?
VOX - 09-Aug-2019Poor record-keeping might be the reason why some countries have more supercentenarians than others
bioRxiv Blog Posts
21-May-2020
Age Reversal in Mammals – Has This Now Been Achieved?
Biological age and biomarkers improved to that of rats half their age
