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Longevity Roadmap Podcast

Podcast on science-backed strategies to slow aging and boost health with Buck Joffrey

The Longevity Roadmap Podcast, hosted by Dr. Buck Joffrey, is a weekly show focused on helping listeners live longer, healthier lives by unpacking the latest science in aging and wellness. Drawing from his background as a board-certified surgeon and longevity expert, Dr. Joffrey engages in insightful conversations with leading researchers, doctors, and biohackers.

Each episode covers cutting-edge topics such as stem cell therapy, mitochondrial health, immune system aging, fasting, and personalized medicine. The podcast emphasizes practical, science-backed strategies that listeners can incorporate into their daily routines to slow aging, prevent chronic disease, and enhance overall vitality.

Visit website: https://www.youtube.com/@longevity_roadmap

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 LRMpodcast

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Details last updated 09-May-2025

Mentioned in this Resource

Buck Joffrey

Longevity expert and physician with a board-certified surgical background

Longevity Roadmap Podcast Creations

Protein Folding Errors Contribute to Aging and Disease

Longevity Roadmap Podcast- Judith Frydman explores proteostasis

Best of 2025

Longevity Roadmap Podcast- A quick roundup of 2025’s top longevity insights

The Cutting Edge of Stem Cell Therapy

Longevity Roadmap Podcast- Eric Stoffers and Karolyn Halpert discusses real regenerative medicine versus hype

Why Bats Don’t Age and Why You Should Care

Longevity Roadmap Podcast- Emma Teeling explains bats’ unusually long, healthy lives

Does Red Light Improve Mitochondrial Health?

Longevity Roadmap Podcast- Buck and Glen Jeffery explore the science behind red light therapy in depth

Metformin: Miracle Longevity Drug or Hype?

Longevity Roadmap Podcast- Buck Joffery debates metformin’s longevity promise

Improving Cellular Cleanup to Extend Healthspan with Dr. Ana Maria Cuervo

Longevity Roadmap Podcast- Ana Maria Cuervo highlights the age-related decline of CMA

Young Blood Can Rejuvenate Old Brains w/ Dr. Tony Wyss-Coray

Longevity Roadmap Podcast- Tony Wyss-Coray on his groundbreaking work in brain resilience and ageing

Inflammaging

Longevity Roadmap Podcast- Buck Joffrey provides an overview of his research insights on chronic inflammation

Aging Skin and How to Fight It

Longevity Roadmap Podcast- Corey Frucht discusses ageing skin and the development of skin cancer

Is a Vegan Diet Healthy?

Longevity Roadmap Podcast- Buck Joffrey and Linda Tyler discuss vegan diets

Keto Diet 101

Longevity Roadmap Podcast- Amy Berger explains the fundamental principles of the ketogenic diet

Stem Cells - Myth vs Reality with Hans Keirstead, PhD

Longevity Roadmap Podcast- Understanding Stem Cells: Myth vs. Fact with expert Hans Keirstead

Martin Gibala Reveals the Benefits of HIIT for Longevity and Healthspan

Longevity Roadmap Podcast- Martin Gibala highlights the longevity and health benefits of HIIT

A Thermostat for Your Body Fat

Longevity Roadmap Podcast Episode-Stephan J. Guyenet and Dr. Buck Joffrey discuss the science of body fat regulation

The Gut-Muscle Axis with Dr. Michael Lustgarten

Longevity Roadmap Podcast- Michael Lustgarten studies how the gut and blood impact muscle health in ageing

How Mitochondrial Decline Drives Brain Aging

Longevity Roadmap Podcast- Francisco González-Lima examines how metabolism affects brain aging

The Habits of Healthy Aging with Dr. Kate Wolin

Longevity Roadmap Podcast- Dr. Kate Wolin on building habits for healthy ageing

The Future of Tissue Regeneration w/ Dr. Jennifer Elisseeff

Longevity Roadmap Podcast- Jennifer Elisseeff explores advances in tissue engineering and regenerative medicine

Molecular Secrets of Aging Told Through Worms w/ Dr. Heidi Tissenbaum

Longevity Roadmap Podcast- Dr. Heidi Tissenbaum explores what C. elegans reveal about aging biology

The Role of Vitamin A in Brain Health

Longevity Roadmap Podcast- Peter McCaffery and Buck Joffrey explore Vitamin A’s impact on brain health

T Cells, Aging, and Extreme Life Extension

Longevity Roadmap Podcast- Derya Unutmaz joins Dr. Buck Joffrey to discuss T cells, aging, and chronic disease

How DNA Mutations and Epigenetic Drift Cause Aging with Prof. Jan Vijg

Longevity Roadmap Podcast- Prof. Jan Vijg explains how genetic and epigenetic changes lead to ageing

Is Telomere Length Shortening the Master Switch of Aging?

Longevity Roadmap Podcast- Bill Andrews joins Buck Joffrey to explain telomeres’ impact on aging

Sitting Is the New Smoking with Dr. Keith Diaz

Longevity Roadmap Podcast- Keith Diaz highlights the serious health dangers linked to extended periods of sitting

The Role of Surgery in Diabetes and Obesity

Longevity Roadmap Podcast- Mitchell Roslin delves into the intricate challenges surrounding obesity

Investing in the Business of Aging

Longevity Roadmap Podcast- Karl Pfleger discusses longevity’s evolving science and investment scene

Can Psilocybin Extend Cellular Lifespan?

Longevity Roadmap Podcast- Dr. Louise Hecker explores her innovative research on psilocybin

Reversing Skin Age - Tackling Senescence with OS-01

Longevity Roadmap Podcast- Dr. Carolina Reis Oliveira discusses her work in ageing research and the creation of the OS-01 peptide

How the Gut Influences Health and Longevity ‪

Longevity Roadmap Podcast- Scientists from the University of Illinois explore the true science behind the gut microbiome

Long-Lived Species Could Revolutionize Human Aging

Longevity Roadmap Podcast- Dr. Vera Gorbunova reveals the biological secrets behind nature’s longest-living species

The Aging Brain - From Memory Lapses to Measurable Prevention

Longevity Roadmap Podcast- Mitchell Clionsky outlines normal vs. concerning memory changes with age

Why is Vitamin D So Important in Health and Longevity?

Longevity Roadmap Podcast- The Importance of Vitamin D in Health and Longevity

Dr. Joan Mannick - Targeting mTOR to Improve Immune Function and Healthspan

Longevity Roadmap Podcast- Joan Mannick explores how targeting mTOR can boost immune function and extend healthspan

Sleep Impact on Longevity and Health

Longevity Roadmap Podcast- Michael Breus explains how sleep is key to a longer, healthier life

Inside the Inflammatory Clock - Measuring and Reversing Biological Age with Dr. David Furman

Longevity Roadmap Podcast Episode-David Furman on Tracking and Reversing Biological Age

The Longevity Dividend with Prof S. Jay Olshansky

Longevity Roadmap Podcast- Jay Olshansky explores the development of aging science over time

Why the Brain is Especially Vulnerable to Aging

Longevity Roadmap Podcast- Dr. Buck Joffrey and Dr. Julie Andersen explore the roots of brain disease

Why Some Animals Live Longer Than Others w/ Dr. Steven Austad

Longevity Roadmap Podcast- Exploring Lifespan Differences in Animals with Dr. Steven Austad

Healthspan-Centric Medical Care in America w/ AMA President Dr. Bobby Mukkamala

Longevity Roadmap Podcast- Dr. Bobby Mukkamala on Shifting U.S. Medicine Toward Healthspan-Focused Care

The Wrong Vitamin E Supplement Can Hurt You

Longevity Roadmap Podcast- Dr. Barrie Tan discusses tocotrienols' role in aging and disease prevention

Stimulating the Vagus Nerve to Reduce Inflammation and Improve Healthspan w/ Dr. Kevin J. Tracey

Longevity Roadmap Podcast- Dr. Kevin J. Tracey on Vagus Nerve Stimulation for Better Healthspan

How Dental Health Impacts Longevity

Longevity Roadmap Podcast- Dr. Ellie Phillips discusses oral pathogens driving inflammation and disease

The Microbiome’s Role in Aging and Healthspan

Longevity Roadmap Podcast- Dr. Sean Gibbons on the gut microbiome and longevity

Does Astaxanthin Increase Longevity?

Longevity Roadmap Podcast- Dave Watumull explores the benefits and mechanisms of astaxanthin

Can We Reverse Immune System Aging? T Cells, Telomeres, and the Fight Against Senescence

Longevity Roadmap Podcast- Alessio Lanna explores the science behind immune system ageing

Dr. Mark Tarnopolsky’s Mitochondrial Cocktail for Cellular Health

Longevity Roadmap Podcast- Mark Tarnopolsky unpacks the pivotal role mitochondria play in ageing

Does Too Much Muscle Shorten Your Life?

Longevity Roadmap Podcast- Keith Baar explores how exercise and diet influence the ageing process

C15 - The Most Underrecognized Anti-Aging Supplement?

Longevity Roadmap Podcast -Stephanie Venn-Watson unveils the pioneering research driving the discovery of C15

Fahy Protocol - Regrow the Thymus, Reverse Your Age

Longevity Roadmap Podcast- Greg Fahy discusses his groundbreaking work on the thymus and its impact on ageing reversal

Can You Boost Stem Cells Naturally?

Dr. Christian Drapeau explains the science behind stem cell therapy

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