In this episode, host Buck Joffrey speaks with Dr. Greg Fahy, a trailblazing researcher in ageing and regenerative medicine, about his groundbreaking work on reversing biological age by regenerating the thymus. Dr. Fahy shares how this small gland could hold the key to unlocking longer, healthier lives.

Key Points:

Dr. Greg Fahy reveals how thymus gland can restore immune function and reverse biological ageing, as shown in the groundbreaking TRIM study. He explains the role of growth hormone in this process, the need to balance it with insulin sensitivity, and addresses concerns around its use. The episode also explores futuristic advances like cryopreservation and their potential to transform longevity and transplant medicine.

• Ageing May Be Programmed—Not Just Wear and Tear: Dr. Fahy argues that ageing isn't purely random deterioration but a biologically programmed process. The thymus, which shrinks drastically after puberty, may kick-start ageing through immune decline—suggesting that reversing this process could delay ageing itself.
• The TRIM Trial- Reversing Age with a Drug Cocktail: The TRIM study (Thymus Regeneration, Immunorestoration, and Insulin Mitigation) showed that a combination of growth hormone, DHEA, and metformin could regenerate the thymus, improve immune function, and reduce participants’ biological age by an average of 2.5 years.
• Thymus Health - Immune Health - Longevity: A functional thymus produces T cells crucial for fighting infections and cancer. Its decline leads to "immunosenescence"—a weakening of the immune system. Regenerating the thymus could not only extend lifespan but improve healthspan by boosting immunity.
• Growth Hormone Risks & How Fahy’s Protocol Balances Them: Growth hormone alone can cause insulin resistance and other issues. By combining it with DHEA and metformin, Dr. Fahy mitigated those side effects—demonstrating that careful, time-limited ("pulsed") treatment is key to avoiding long-term harm.
• Future Frontiers- Cryopreservation & Organ Rejuvenation: Beyond ageing, Fahy envisions using thymus regeneration to eliminate transplant rejection and autoimmune diseases. His work in cryopreservation aims to store organs—and possibly humans—for extended periods, hinting at futuristic applications like space travel and medical time suspension.