In this episode, Dr. Carolina Reis Oliveira, co-founder of OneSkin, joins host Buck Joffrey to explore the science behind reversing skin ageing. They dive into the development of OS-01, a peptide that targets senescent cells, and discuss how healthy skin may be key to longevity.

Key Points:

Dr. Carolina Reis Oliveira discusses her work in ageing science and the creation of OS-01. The OS-01 peptide offers a novel way to reverse skin ageing by reducing senescent cells and inflammation. More than just cosmetic, this approach could play a surprising role in systemic health and longevity.

• The OS-01 Peptide -Targeting Zombie Cells: Dr. Oliveira’s team discovered OS-01 after screening over 900 peptides. It reduces senescent (zombie) skin cells by up to 40%, encouraging collagen production, DNA repair, and reducing inflammation—essentially rejuvenating the skin at the cellular level.
• From Skin Deep to Systemic Health: Treating skin senescence isn't just cosmetic. Because skin is the body’s largest organ, reducing its inflammation can lower systemic inflammatory markers like IL-8—pointing to broader health impacts beyond appearance.
• OS-01 vs. Retinoic Acid: Unlike retinoids that increase short-term inflammation before inducing skin renewal, OS-01 selectively targets senescent cells without harming healthy ones, making it gentler and safer—especially for sensitive skin.
• Clinical Evidence & Epigenetic Reversal: Clinical studies showed that consistent use of OS-01 for 12 months reduced skin’s biological age by 3.3 years (measured using epigenetic clocks like PhenoAge). Eye and face products were particularly effective.
• Bigger Vision - From Skincare to Longevity Science: Dr. Oliveira sees skin as a gateway to systemic anti-ageing interventions. OneSkin’s approach may eventually extend beyond cosmetics, using peptides like OS-01 to target ageing throughout the body.