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The Microbiome’s Role in Aging and Healthspan

Longevity Roadmap Podcast- Dr. Sean Gibbons on the gut microbiome and longevity

In this episode of Longevity Roadmap, Dr. Buck Joffrey speaks with microbiome expert Dr. Sean Gibbons about how the trillions of microbes living in our gut influence immunity, inflammation, aging, and overall healthspan. The discussion explores the science of gut health and how nurturing a balanced microbiome can support longer, healthier lives.

Key Points:

A healthy, diverse microbiome is key to slowing aging and extending healthspan. Diet and lifestyle choices that support gut microbes may help prevent disease and promote longevity.

  • Microbiome and Longevity : Dr. Gibbons explains how gut microbes regulate immune function and inflammation, central to aging and chronic disease.
  • Diversity Matters : A diverse gut microbiome is tied to resilience, metabolic health, and slower biological aging.
  • Diet and Lifestyle : Fiber-rich foods, plants, and fermented products nurture good microbes, while processed foods and antibiotics disrupt them.
  • Personalized Microbiome Health : The conversation covers how testing and tailored interventions may one day optimize diets for individual gut health.
  • Future Research : Emerging studies are linking gut health to Alzheimer’s, cardiovascular disease, cancer, and other age-related conditions.

Visit website: https://www.youtube.com/watch?v=MP0ox_TDTi8

See also

Longevity Roadmap Podcast

Podcast on science-backed strategies to slow aging and boost health with Buck Joffrey

Details last updated 28-Aug-2025

Mentioned in this Resource

Sean Gibbons

Associate Professor of at the Institute for Systems Biology

Topics mentioned on this page:
Microbiome, Diet and Nutrition