In this episode of Longevity Roadmap, Dr. Buck Joffrey speaks with Dr. Barrie Tan, a leading researcher in vitamin E, to uncover why most people may be taking the wrong kind. They explore how a lesser-known form—tocotrienols—can play a key role in reducing inflammation, preventing chronic disease, and supporting healthy aging.

Key Points:

Many common vitamin E supplements contain tocopherols, which research suggests may interfere with health benefits and even pose risks in some cases. In contrast, tocotrienols—a lesser-known form—have shown powerful anti-inflammatory and antioxidant effects, making them a safer and more effective option for promoting longevity and preventing chronic diseases.

• Not All Vitamin E Is Equal: Most supplements contain tocopherols, which may not only be ineffective but could counteract the benefits of tocotrienols, the more potent form of vitamin E.
• Tocotrienols vs. Chronic Disease: Clinical studies show tocotrienols improve markers of metabolic syndrome, lower triglycerides, and help reduce liver fat in patients with NAFLD, with effects comparable to mild statin therapy.
• Anti-inflammatory Power: Tocotrienols significantly reduce systemic inflammation markers like C-reactive protein (CRP) and interleukin-6, suggesting a strong role in preventing inflammation-related diseases.
• Weight Loss & Liver Health: Long-term studies on tocotrienols show not only reduced liver fat but also modest weight loss and improved insulin sensitivity in people with fatty liver disease.
• Safe & Synergistic: Tocotrienols work well alongside supplements like resveratrol and CoQ10, with no known adverse interactions. They may even enhance antioxidant and metabolic effects when combined.