Passos, Ph.D., investigates the role of senescent cells in aging and age-related disease, with a particular focus on the role of mitochondria and telomeres in the process. His work demonstrates how cellular senescence depends on chronic DNA-damage signaling that results from irreparable damage to telomeres. Furthermore, Dr. Passos uncovered a key role for mitochondria in the induction of cellular senescence.

The goal of Dr. Passos' current work is to develop new therapies that target mitochondrial dysfunction to counteract the detrimental impact of senescent cells with aging and age-related diseases.