Key points from 20 presentations from world-leading researchers
Researcher on different aging related diseases
Dr. James L. Kirkland is a renowned medical researcher focused on cellular aging and its impact on age-related dysfunction and chronic diseases. His primary goal is to develop methods to remove senescent cells, which accumulate with aging and in diseases such as dementias, atherosclerosis, cancers, diabetes, and arthritis, to extend health span and improve quality of life.
Dr. Kirkland's research spans cellular senescence, senolytic drugs, and the relationship between diabetes, chronic diseases, and cellular senescence. He pioneered the concept of removing senescent cells to enhance health span and devised the first senolytic drugs, which selectively eliminate senescent cells.
His work has significant implications for patient care, as it aims to enhance health span and delay the onset of chronic age-related diseases collectively, rather than individually. This has the potential to reduce morbidity, mortality, and healthcare costs worldwide.
He's founder of Academy for Health & Lifespan Research.
See also: Mayo Clinic - Non-profit American academic medical center focused on health care, education, and research
Mentioned in this Resource
James Kirkland is also referenced in the following:
31-Aug-2021 to 03-Sep-2021
Online event about latest progress in the molecular, cellular and organismal basis of aging organized by University of Copenhagen chaired by Morten Scheibye-Knudsen, Daniela Bakula and Alex Zhavoronkov, and with many speakers.
28-Aug-2023 to 01-Sep-2023
Event about latest progress in the molecular, cellular and organismal basis of aging organized by University of Copenhagen
Online webinar focused on longevity extension without health related issues organized by The New York Academy of Sciences with Nir Barzilai and Pinchas Cohen as keynote speakers.
James Kirkland Blog Posts
James Kirkland News
Lifespan.io reports back from Aging Research and Drug Discovery Meeting (ARDD 2023)
Lifespan.io (LEAF) - 26-Sep-2023
Key points from Arkadi Mazin's summary of 5 days of talks by geroscientists and biotech leadersRead more...
Healthy Longevity Medicine Society launches to promote longevity medicine
Longevity Technology - 27-Sep-2022
Looks like it will act as an interface between longevity researchers and cliniciansRead more...
Oral senolytics boosts geroprotective protein in mice and humans
Mayo Clinic - 15-Mar-2022
Dasatinib+Quercetin restores a-klotho protein, which could combat ageing and disease in older peopleRead more...
Whole-body senescent cell removal improved brain health in mice
Lifespan.io (LEAF) - 22-Jan-2021
Senolytic drug and cancer drug with quercetin improved age-related cognitionRead more...
Nature Biotechnology reviews the state of play of senolytics
Nature Biotechnology - 12-Nov-2020
In August, Unity announced that its lead drug candidate had failed to beat a placebo in reducing ...Read more...
Comprehensive history and explanation of senescent cells
The Scientist - 01-Mar-2020
Including the latest on clinical trials of first-generation senolyticsRead more...
Senolytics and their impact on anti-ageing
Technology Networks - 19-Sep-2019
Once more confirmed, senolytics reduce senescent cells by that preventing their effect of ageingRead more...
Small Mayo Clinic trial successfully removes senescent cells from humans
Mayo Clinic - 18-Sep-2019
Occasional senolytic use may be enough to keep senescent cells at bayRead more...
Senolytics for IPF human clinical trial results released
Lifespan.io (LEAF) - 07-Jan-2019
Physical improvements recorded, but pulmonary function was unchcangedRead more...
Senescent cells: short safety trial on humans successful
Science Daily - 07-Jan-2019
Next step is to go to an actual large-scale human trialRead more...
Fisetin destroys senescent cells, but safe dosage not determined yet
Lifespan.io (LEAF) - 26-Dec-2018
Includes table of fisetin content in range of fruits and vegetablesRead more...
Oral senolytics have big impact on old mice
Mayo Clinic - 09-Jul-2018
Senolytic cocktail caused improved physical condition of elderly miceRead more...
Why a drug for aging would challenge Washington
Politico - 13-Dec-2017
What if just one medical treatment could stave off heart disease, cancer and Alzheimer’s? First ...Read more...
To stay young, kill zombie cells
Nature - 24-Oct-2017
Proof-of-concept trials starting that pit senolytic drugs against a range of age-related ailments...Read more...
The first senolytic drugs to target senescent cells
Mayo Clinic - 05-Sep-2017
New platform will help to identify additional drugs that target ageing processes more quicklyRead more...
Secret to old age health could lie in purging worn-out cells
New Scientist - 16-Sep-2015
Cells eventually stop dividing to replace damaged neighbours and to into senescence. Senescent c...Read more...
Senolytics, A New Class Of Drugs, Slows Aging Process
Medical Daily - 11-Mar-2015
Senolytics, a new class of drugs, might dramatically slow the aging process and so change the fac...Read more...