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James Kirkland

Researcher on different aging related diseases

Dr. James L. Kirkland is a renowned medical researcher focused on cellular aging and its impact on age-related dysfunction and chronic diseases. His primary goal is to develop methods to remove senescent cells, which accumulate with aging and in diseases such as dementias, atherosclerosis, cancers, diabetes, and arthritis, to extend health span and improve quality of life.

Dr. Kirkland's research spans cellular senescence, senolytic drugs, and the relationship between diabetes, chronic diseases, and cellular senescence. He pioneered the concept of removing senescent cells to enhance health span and devised the first senolytic drugs, which selectively eliminate senescent cells.

His work has significant implications for patient care, as it aims to enhance health span and delay the onset of chronic age-related diseases collectively, rather than individually. This has the potential to reduce morbidity, mortality, and healthcare costs worldwide.

He's founder of Academy for Health & Lifespan Research.

Visit website:

See also: Health Organisation Mayo Clinic - Non-profit American academic medical center focused on health care, education, and research

Details last updated 01-Nov-2019

Mentioned in this Resource

Academy for Health and Lifespan Research (AHLR)

World's aging researchers unite to accelerate breakthroughs in longevity

James Kirkland is also referenced in the following:

Academy for Health and Lifespan Research (AHLR)

World's aging researchers unite to accelerate breakthroughs in longevity

ARDD 2021 - 8th Aging Research and Drug Discovery Meeting

31-Aug-2021 to 03-Sep-2021

Online event about latest progress in the molecular, cellular and organismal basis of aging organized by University of Copenhagen chaired by Morten Scheibye-Knudsen, Daniela Bakula and Alex Zhavoronkov, and with many speakers.

ARDD 2023 - 10th Aging Research & Drug Discovery Meeting

28-Aug-2023 to 01-Sep-2023

Event about latest progress in the molecular, cellular and organismal basis of aging organized by University of Copenhagen

BSRA Annual Scientific Meeting 2023

06-Sep-2023 to 08-Sep-2023

A compelling lineup of speakers from all areas of the biology of ageing

Extending Human Healthspan and Longevity


Online webinar focused on longevity extension without health related issues organized by The New York Academy of Sciences with Nir Barzilai and Pinchas Cohen as keynote speakers.

Global Healthspan Summit 2023

29-Nov-2023 to 30-Nov-2023

Longevity summit organised by Hevolution Foundation (Riyadh,Saudi Arabia)

Healthy Longevity Medicine Society (HLMS)

Medical society with focus on promoting longevity as a specialty area of modern healthcare

Longevity Leaders World Congress 2021

04-May-2021 to 07-May-2021

The virtual event for leaders in longevity science, technology, business and finance organized by Longevity Leaders (LSX).

Longevity Leaders World Congress 2022

26-Feb-2022 to 27-Feb-2022

Event for leaders in longevity science, technology, business and finance organized by Longevity Leaders (LSX)

Targeting Metabesity 2022

10-Oct-2022 to 13-Oct-2022

The Kitalys Institute virtual conference about going beyond treating individual diseases to extending healthy lifespan

James Kirkland Blog Posts

Highlights of Ending Age-Related Diseases 2020

Highlights of Ending Age-Related Diseases 2020

Key points from 20 presentations from world-leading researchers

James Kirkland Creations



Second Edition: Geroscience as the New Public Health Frontier, book edited by James Kirkland

James Kirkland News reports back from Aging Research and Drug Discovery Meeting (ARDD 2023) (LEAF) - 26-Sep-2023

Key points from Arkadi Mazin's summary of 5 days of talks by geroscientists and biotech leaders


Healthy Longevity Medicine Society launches to promote longevity medicine

Longevity Technology - 27-Sep-2022

Looks like it will act as an interface between longevity researchers and clinicians


Oral senolytics boosts geroprotective protein in mice and humans

Mayo Clinic - 15-Mar-2022

Dasatinib+Quercetin restores a-klotho protein, which could combat ageing and disease in older people


Whole-body senescent cell removal improved brain health in mice (LEAF) - 22-Jan-2021

Senolytic drug and cancer drug with quercetin improved age-related cognition


Nature Biotechnology reviews the state of play of senolytics

Nature Biotechnology - 12-Nov-2020

In August, Unity announced that its lead drug candidate had failed to beat a placebo in reducing ...


Comprehensive history and explanation of senescent cells

The Scientist - 01-Mar-2020

Including the latest on clinical trials of first-generation senolytics


Senolytics and their impact on anti-ageing

Technology Networks - 19-Sep-2019

Once more confirmed, senolytics reduce senescent cells by that preventing their effect of ageing


Small Mayo Clinic trial successfully removes senescent cells from humans

Mayo Clinic - 18-Sep-2019

Occasional senolytic use may be enough to keep senescent cells at bay


Senolytics for IPF human clinical trial results released (LEAF) - 07-Jan-2019

Physical improvements recorded, but pulmonary function was unchcanged


Senescent cells: short safety trial on humans successful

Science Daily - 07-Jan-2019

Next step is to go to an actual large-scale human trial


Fisetin destroys senescent cells, but safe dosage not determined yet (LEAF) - 26-Dec-2018

Includes table of fisetin content in range of fruits and vegetables


Oral senolytics have big impact on old mice

Mayo Clinic - 09-Jul-2018

Senolytic cocktail caused improved physical condition of elderly mice


Why a drug for aging would challenge Washington

Politico - 13-Dec-2017

What if just one medical treatment could stave off heart disease, cancer and Alzheimer’s? First ...


To stay young, kill zombie cells

Nature - 24-Oct-2017

Proof-of-concept trials starting that pit senolytic drugs against a range of age-related ailments...


The first senolytic drugs to target senescent cells

Mayo Clinic - 05-Sep-2017

New platform will help to identify additional drugs that target ageing processes more quickly


Secret to old age health could lie in purging worn-out cells

New Scientist - 16-Sep-2015

Cells eventually stop dividing to replace damaged neighbours and to into senescence. Senescent c...


Senolytics, A New Class Of Drugs, Slows Aging Process

Medical Daily - 11-Mar-2015

Senolytics, a new class of drugs, might dramatically slow the aging process and so change the fac...