Researcher on different aging related diseases.
The major research focus of James L. Kirkland, M.D., Ph.D., is the impact of cellular aging (senescence) on age-related dysfunction and chronic diseases, especially developing methods for removing these cells and alleviating their effects. Senescent cells accumulate with aging and in such diseases as dementias, atherosclerosis, cancers, diabetes and arthritis.
The goal of Dr. Kirkland's current work is to develop methods to remove these cells to delay, prevent, alleviate or partially reverse age-related chronic diseases as a group and extend health span, the period of life free of disability, pain, dependence and chronic disease.
See also: Mayo Clinic
James Kirkland Blog Posts
Highlights of Ending Age-Related Diseases 2020
10-Sep-2020 Key points from 20 presentations from world-leading researchers
James Kirkland News
Comprehensive history and explanation of senescent cells
The Scientist - 01-Mar-2020
Including the latest on clinical trials of first-generation senolyticsRead more...
Senolytics and their impact on anti-ageing
Technology Networks - 19-Sep-2019
Once more confirmed, senolytics reduce senescent cells by that preventing their effect of ageingRead more...
Small Mayo Clinic trial successfully removes senescent cells from humans
Mayo Clinic - 18-Sep-2019
Occasional senolytic use may be enough to keep senescent cells at bayRead more...
Senescent cells: short safety trial on humans successful
Science Daily - 07-Jan-2019
Next step is to go to an actual large-scale human trialRead more...
Senolytics for IPF human clinical trial results released
Life Extension Advocacy Foundation (LEAF) - 07-Jan-2019
Physical improvements recorded, but pulmonary function was unchcangedRead more...
Fisetin destroys senescent cells, but safe dosage not determined yet
Life Extension Advocacy Foundation (LEAF) - 26-Dec-2018
Includes table of fisetin content in range of fruits and vegetablesRead more...