Assistant Professor at ETH Zurich, Founder of Swiss Society for Aging Research
I have a longstanding interest in understanding the aging process and how to alter this process to slow age-related functional decline, damage accumulation and age-dependent diseases. Everybody ages, but not at the same rate. Some live a healthy and youthful life. My interest is to determine the molecular components that enable a youthful life by using the model organism Caenorhabditis elegans. There are several interventions (dietary restriction, altering hormonal signaling, or altering growth pathways) that increase youthfulness and lifespan in a conserved spectrum of organisms including C. elegans. By comparing long-lived animals to normal lived animals, we found that essentially all longevity interventions invest in enhancing the extracellular matrix (ECM), which is the scaffolding framework that surrounds and supports cells, tissues, organs, and bones. Damage to the ECM during aging could lead to structural defects impairing organ integrity and stem cell function, ultimately leading to organ failure and death. Longevity interventions prevent weakening of the ECM by replenishing the ECM with new components, such as collagens. We demonstrated that impairing this ECM replenishing of collagens prevented longevity of all otherwise long-lived animals, suggesting that ECM remodeling is a fundamental process to stay youthful. These findings will open up a whole new and exciting avenue of research investigation in the field of aging research.
Visit website: https://www.ewaldlab.com/
Swiss Federal Institute of Technology (ETH Zurich)
- Public research university for technology and science
Collin Ewald is also referenced in the following:
31-Aug-2021 to 03-Sep-2021
Online event about latest progress in the molecular, cellular and organismal basis of aging organized by University of Copenhagen chaired by Morten Scheibye-Knudsen, Daniela Bakula and Alex Zhavoronkov, and with many speakers.
28-Aug-2023 to 01-Sep-2023
Event about latest progress in the molecular, cellular and organismal basis of aging organized by University of Copenhagen
Live Longer World podcast #10 with Dr. Collin Ewald as a guest
05-Nov-2022 to 06-Nov-2022
Healthy Masters conference about living longer and healthier life
21-Jan-2022 to 23-Jan-2022
Online event about longevity boosting organized by Longevity Hackathon with many speakers from the biotech, pharma and other fields
Collin Ewald News
Maximon announces 50,000 CHF (approx. £40K) Longevity Prize for Translational Research
Maximon - 01-Mar-2022
And by longevity it means "substantially increase health span or life span" - apply now!
Extracellular matrix gene expression: a novel approach to find geroprotective drugs
Lifespan.io (LEAF) - 11-Aug-2021
ECM reprogramming to identify drugs which can slow-down or prevent age-related diseases