New research links DNA damage to incomplete gene transcription in aging
Lifespan.io (LEAF) - 15-Feb-2024DNA damage accumulated with age worsens gene expression, affecting lifespan-determining pathways
Josh Conway
Programmer and long-time supporter of rejuvenation biotechnology. Editor for LEAF.
Visit website: https://www.leafscience.org/author/josh/
See also: 
Lifespan.io (LEAF)
- Supporting the development of biotechnologies focused on ending age-related diseases
Details last updated 23-Oct-2019
Articles written by Josh Conway
Metrnl, a protein that rises with exercise and shields against heart disease
Lifespan.io (LEAF) - 11-Jan-2024It unlocks a potent anti-inflammatory defense mechanism within the body
Metformin may minimize muscle loss in extended periods of bed rest
Lifespan.io (LEAF) - 24-Jul-2023Improvements seen in muscle size and collagen deposits in older people with atrophy
Novel method facilitates single-cell expansion of gene edited stem cells
Lifespan.io (LEAF) - 17-Jul-2023Its polymer-supplemented culture system enables cell expansion without harmful mutations
Revitalizing ageing stem cells: Unveiling the key to lasting youthfulness
Lifespan.io (LEAF) - 05-Jun-2023Combination of factors that rejuvenate stem cells holds promise for aging and muscle-wasting diseases
AI-driven breakthrough in senolytic drug discovery
Lifespan.io (LEAF) - 04-May-2023Machine learning successfully identifies promising senolytic compounds to target ageing and age-related diseases
Gut Microbiome: The Secret to Longevity in Centenarians
Lifespan.io (LEAF) - 06-Apr-2023A youthful gut microbiome may contribute to enhanced longevity and overall health in people living past 100
Correlation found between biological aging and cognitive decline using epigenetic clocks
Lifespan.io (LEAF) - 21-Nov-2022The midlife study showed that the cognitive decliners age faster
Therapeutic plasma exchange (TPE) rejuvenates multiple markers of gene expression
Lifespan.io (LEAF) - 25-Aug-2022TPE causes systematic rejuvenation in human body by influencing multiple factors
Senolytics may abate accelerated aging of cancer patients as seen in mice
Lifespan.io (LEAF) - 06-Jun-2022Radiation-induced damage may lessen by removing senescent cells but senolytics may not reverse the damage
The anti-malarial drug chloroquine increases lifespan in male mice
Lifespan.io (LEAF) - 30-May-2022Chloroquine significantly interferes with the fundamental mechanisms behind autophagy
New algorithm recognises senescent cells using physical morphology
Lifespan.io (LEAF) - 26-May-2022in vivo analysis in mice confirms the imaging results against p21 biomarker
Epigenetic age varies when people are exposed to significant stress
Lifespan.io (LEAF) - 23-May-2022PhenoAge and GrimAge show epigenetic aging has downstream biological consequences
Viral-vector gene therapies could unlock healthy life extension in humans
Lifespan.io (LEAF) - 12-May-2022Lifespan of mice greatly extended even when treatment only started at the equivalent of 56 years old
Alzheimers' treatment with stem cells is proven safer in Phase 1 clinical trial
Lifespan.io (LEAF) - 07-Apr-2022Lomecel-B targets homing and microglia recruitment rather than differentiation
Dasatinib plus quercetin combination may help preserve cognitive abilities in elderly people
Lifespan.io (LEAF) - 27-Jan-2022Senolytics showed positive effects on rats but trials must confirm these findings on human brain
Serum from older adults increased ageing markers and killed brain stem cells in humans
Lifespan.io (LEAF) - 16-Dec-2021Brain volume and lifestyle can increase difference between chronological and biological age
New study leading towards permanent youthful immune function
Lifespan.io (LEAF) - 18-Oct-2021Significant alteration in lineage potential by NR treatment in mice
/calorie-restriction-cr-thumbnail.jpg "Click to read article")
Calorie restriction slows age-related stem cell exhaustion, improving overall health
Lifespan.io (LEAF) - 29-Sep-2021Many studies underlined beneficial effects of calorie restriction in various tissues of mice
Role of mature dendritic cells in thymic involution
Lifespan.io (LEAF) - 13-Sep-2021Reversal of thymic aging possible through signaling based interventions
Display all articles
