Small molecules target mitochondrial DNA depletion to treat energy-related diseases
Inside Precision Medicine - 10-Apr-2025Their compound PZL-A shows promise and a related drug has entered trials
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Their compound PZL-A shows promise and a related drug has entered trials
New research reveals how Parkin, PINK1, and OMA1 act as guardians of cellular energy centres
This breakthrough could lead to faster, more effective treatments for osteoarthritis
However, calcium handling worsens with age, affecting performance
Blocking stress response restored cell identity in mice, suggesting new treatment possibilities
Rats with fresh mitochondria survived more and recovered faster than those without
Mitochondrial NAD reservoirs may hold the key to ageing and therapy
Drugs like FGF21 analogs and metformin may extend lifespan
Early tests have shown VNA-318 could improve brain function and reduce brain cell damage
Long-term follow-up data and post-hoc analyses fuel optimism for treating mitochondrial diseases
Phase 2 trial on sonlicromanol to test its ability in improving patient's symptoms & quality of life
Chronic inflammation and fibrosis further damage the heart health
New research from Texas A&M develops nanoflowers to restore cellular energy
Boosting fat loss and preserving muscle with cutting-edge mitochondrial therapy
New funding propels innovative mitophagy-inducing lead compound into clinical trials targeting Alzheimer’s and Parkinson’s
Company is developing therapies for Alzheimer's, Parkinson's, and Rett syndrome
Research underscores potential to revolutionise approach to healthy ageing
Research aims to extend lifespan and unlock new levels of human health
The discovery may improve inflammation treatment and anti-ageing interventions
It reduced blood sugar spikes and overall levels in healthy individuals
Making small changes to your lifestyle can have a significant impact on health
This discovery paves the way for potential anti-ageing therapies
Company's drug targets the root cause of diseases like Duchenne and COPD
Mitophagy-boosting drug candidate VNA-318 preps for clinical trials
Potential therapeutic approach for mitochondrial and other genetic diseases