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Paul D. Robbins

Professor of Biochemistry, Molecular Biology and Biophysics at the University of Minnesota.

The pathways important for driving autoimmune and inflammatory diseases as well as age related degeneration are surprisingly similar. For example, inhibition of the transcription factor NF-κB is therapeutic in mouse models of autoimmunity and inflammation as well as Duchenne muscular dystrophy and aging. Similarly, inhibition of IL-1ß signaling by gene transfer of the IL-1 receptor antagonist protein is therapeutic in multiple models of diseases. The Robbins laboratory is developing novel approaches to treat autoimmune (type 1 diabetes, rheumatoid arthritis), inflammatory (inflammatory bowel disease, delayed type hypersensitivity) and age-related degenerative diseases using biologics and small molecules.

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See also: Academia University of Minnesota - Public Research university.

Paul D. Robbins is also referenced in the following:

Undoing Aging 2022 CANCELLED
26-May-2022 to 28-May-2022

Focused on the cellular and molecular repair of age-related damage (Berlin)

Paul D. Robbins News

Nature Biotechnology reviews the state of play of senolytics

Nature Biotechnology - 12-Nov-2020

In August, Unity announced that its lead drug candidate had failed to beat a placebo in reducing ...


Comprehensive history and explanation of senescent cells

The Scientist - 01-Mar-2020

Including the latest on clinical trials of first-generation senolytics


Fisetin destroys senescent cells, but safe dosage not determined yet (LEAF) - 26-Dec-2018

Includes table of fisetin content in range of fruits and vegetables


Natural product Fisetin slows aging in mice

ScienceDaily - 02-Oct-2018

Fisetin is a very common natural product that has positive effects over health and aging