Paul D. Robbins
Professor of Biochemistry, Molecular Biology and Biophysics at the University of Minnesota.
The pathways important for driving autoimmune and inflammatory diseases as well as age related degeneration are surprisingly similar. For example, inhibition of the transcription factor NF-κB is therapeutic in mouse models of autoimmunity and inflammation as well as Duchenne muscular dystrophy and aging. Similarly, inhibition of IL-1ß signaling by gene transfer of the IL-1 receptor antagonist protein is therapeutic in multiple models of diseases. The Robbins laboratory is developing novel approaches to treat autoimmune (type 1 diabetes, rheumatoid arthritis), inflammatory (inflammatory bowel disease, delayed type hypersensitivity) and age-related degenerative diseases using biologics and small molecules.
Visit website: https://cbs.umn.edu/contacts/paul-d-robbins
See also: University of Minnesota - Public Research university.
Paul D. Robbins is also referenced in the following:
Focused on the cellular and molecular repair of age-related damage (Berlin)
Paul D. Robbins News
Nature Biotechnology reviews the state of play of senolytics
Nature Biotechnology - 12-Nov-2020
In August, Unity announced that its lead drug candidate had failed to beat a placebo in reducing ...Read more...
Comprehensive history and explanation of senescent cells
The Scientist - 01-Mar-2020
Including the latest on clinical trials of first-generation senolyticsRead more...
Fisetin destroys senescent cells, but safe dosage not determined yet
Lifespan.io (LEAF) - 26-Dec-2018
Includes table of fisetin content in range of fruits and vegetablesRead more...
Natural product Fisetin slows aging in mice
ScienceDaily - 02-Oct-2018
Fisetin is a very common natural product that has positive effects over health and agingRead more...