Nature Biotechnology reviews the state of play of senolytics
Nature Biotechnology - 12-Nov-2020In August, Unity announced that its lead drug candidate had failed to beat a placebo in reducing ...
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Professor of Biochemistry, Molecular Biology and Biophysics at the University of Minnesota
The pathways important for driving autoimmune and inflammatory diseases as well as age related degeneration are surprisingly similar. For example, inhibition of the transcription factor NF-κB is therapeutic in mouse models of autoimmunity and inflammation as well as Duchenne muscular dystrophy and aging. Similarly, inhibition of IL-1ß signaling by gene transfer of the IL-1 receptor antagonist protein is therapeutic in multiple models of diseases. The Robbins laboratory is developing novel approaches to treat autoimmune (type 1 diabetes, rheumatoid arthritis), inflammatory (inflammatory bowel disease, delayed type hypersensitivity) and age-related degenerative diseases using biologics and small molecules.
Visit website: https://cbs.umn.edu/contacts/paul-d-robbins
See also: University of Minnesota - Public Research university.
Details last updated 09-Jan-2020
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In August, Unity announced that its lead drug candidate had failed to beat a placebo in reducing ...
Including the latest on clinical trials of first-generation senolytics
Includes table of fisetin content in range of fruits and vegetables
Fisetin is a very common natural product that has positive effects over health and aging