In 2008, Efrati founded and now directs the Sagol Center for Hyperbaric Medicine and Research at Tel Aviv University and Yitzhak Shamir Medical Center, where he oversees and collaborates with other scientists and manages a large hyperbaric medicine and research facility. The center currently treats up to 200 patients per day.

Efrati has initiated a research program focusing on neuroplasticity and  cognitive rehabilitation by the use of Hyperbaric Oxygen Therapy (HBOT). The clinical results gained from the research program have led to ongoing cooperation between a multidisciplinary team focused on the regenerative effects of hyperbaric oxygen in various brain injuries.