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Scientists uncover the secret behind cancer cell's immortality

10-Sep-2018

Key points from article :

Gene regulator called the TERT promoter enables cancer cells to live forever and keep dividing.

TERT promoter is the third most common mutation among all human cancers.

Also the most common mutation in glioblastoma - a deadly brain cancer type.

Removing a protein subunit called GABP-ß1L that activates TERT slows down cancer cell division.

Plus side is that it has no effect on normal cells.

ß1L subunit is a promising new drug target for cancers with TERT promoter mutations.

A collaborative research published in the journal Cancer Cell.

Doesn't seem to harm normal cells unlike telomerase blocking drugs that are too toxic

Mentioned in this article:

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Academic

Research Scientist at Genentech

Academic

Field Application Scientist at MaxCyte specializing in Cell and Gene Therapy

Journal

Research journal that promotes major advances in cancer research and oncology

Company

Research and develop pharmaceutical medicines, vaccines and consumer healthcare products

Academic

Professor of Biochemistry & Molecular Biology at UC Berkeley

Academic

Professor, Neurological Surgery at UCSF Weill Institute for Neurosciences

Academic

Assistant professor at Department of Bioengineering, University of Illinois

Company Representative

Co-founder and CEO of Telo Therapeutics

Company

A company developing therapies for cancers

Academia

Public research university that is part of the University of California system and dedicated entirely to health science