In this episode, Matt Kaeberlein tackles widespread myths about longevity and healthspan.

Key Points:

The podcast debunks several myths about longevity, such as the benefits of intermittent fasting, metformin, and resveratrol. It emphasizes that while genetics influence lifespan, lifestyle factors like diet and exercise are more crucial for longevity.

• Intermittent Fasting and Longevity: The impact of intermittent fasting (like one meal a day) on longevity is unclear, especially in humans. While it reduces lifespan in lab animals, the key benefit may come from calorie restriction rather than fasting itself.
• Metformin and Longevity: While metformin may help pre-diabetics, Matt Kaeberlein does not recommend its use for healthy individuals, citing risks like lowered testosterone and potential interference with exercise benefits.
• Alcohol and Resveratrol: The belief that red wine and resveratrol boost longevity has been debunked, and moderate alcohol consumption should be approached cautiously due to its potential negative health effects.
• Antioxidants and Ageing: While antioxidants like vitamin C can help with free radical damage, the idea that they significantly prevent ageing has been disproven. Their broader benefits in ageing remain uncertain.
• Genetics and Longevity: Although genes play a role in lifespan, environmental factors like diet, exercise, and lifestyle are far more influential in determining longevity.