Join us every quarter as we explore topics related to the diseases of ageing and how the latest science is showing we can avoid them. We interview world renowned scientists and clinicians with the latest discoveries from lab bench and practitioner’s clinic. 

Professor Sadoshima's laboratory is one of the first groups to show the functional significance of autophagy in the heart (PNAS 2006; Circ Res 2007). He discovered that autophagy in the heart is negatively regulated by mTOR and Mst1 and that suppression of autophagy by these mechanisms is detrimental during metabolic stress and heart failure (Circulation 2012; Nature Medicine 2013; JACC 2018). Professor Sadoshima has been leading the field of autophagy in the heart through publications (69 papers) and meeting presentations, including at NIH organized conferences for autophagy in 2018 and mitophagy in 2019. 

Professor Choudhury's translational science laboratory aims to understand how cells of the innate immune system are involved in processes of tissue homeostasis, injury and repair.

Areas of particular interest focus around: (1) understanding the role of monocytes, macrophages and neutrophils in acute myocardial infarction; myocardial regeneration vs repair and in atherosclerosis and (2) how these cells are 'programmed' e.g. by extracellular vesicles and through by genetic / epigenetic and metabolic mechanisms.