New study leading towards permanent youthful immune function
Lifespan.io (LEAF) - 18-Oct-2021Significant alteration in lineage potential by NR treatment in mice
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Investigator at National Institute on Aging / National Institutes of Health
Dedicated to gaining insight into the complex phenotypes associated with aging in the blood system. Though her PhD thesis was work defining a genetic locus that contributes to IgA Nephropathy, her postdoctoral research is focused on gaining insight into the complex phenotypes associated with aging in the blood system. To address this, she is focusing on changes that occur in the adult hematopoietic stem cell compartment, which is responsible for maintaining the blood system throughout life. Her research has demonstrated the murine hematopoietic stem cell population is heterogeneous and the composition of this pool changes with age, becoming dominated by stem cells that are predisposed to make myeloid cells as opposed to lymphoid cells. This change in composition could contribute to the reduced immune-competence seen in the aged population. More recently she had published findings of epigenetic changes, in the form of DNA methylation, that underlie many of the phenotypes associated with advancing age.
Visit website: https://irp.nih.gov/pi/isabel-beerman
See also: National Institute on Aging (NIA) - Conducting and supporting research on aging and the health and well-being of older people
Details last updated 19-Oct-2021
Significant alteration in lineage potential by NR treatment in mice