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A blood test to personalize treatment for depression & bipolar disorder

RNA biomarker-based test identifies severity and future risk of developing mood disorders

08-Apr-2021

Key points from article :

Researchers offers a promising blood test aimed at a precision medicine approach to treatment.

Composed of RNA biomarkers that can distinguish depression, risk of developing severe depression, and future bipolar disorder.

The test also informs tailored medication choices for patients.

Study took place over four years, with over 300 participants.

Observing both high and low mood states–each time recording biological markers in their blood.

Validated top 26 candidate biomarkers of clinically severe people with depression or mania.

“These blood tests can open the door to precise, personalized medications, and objective monitoring of response to treatment," - Alexander B. Niculescu, lead researcher.

Found that mood disorders are underlined by circadian clock genes.

“Blood biomarkers offer real-world clinical practice advantages,” -Niculescu.

Research by Indiana University School of Medicine published in Molecular Psychiatry.

Mentioned in this article:

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Alexander B. Niculescu

Professor of Psychiatry and Medical Neuroscience at Indiana University School of Medicine

Indiana University School of Medicine

University in Indianapolis, Indiana

Molecular Psychiatry

Peer-reviewed, open access journal

Topics mentioned on this page:
Mental Wellbeing, Diagnostics